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Web Desc
Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota
Organizer(s): R. Balfour Sartor, Lloyd F. Mayer, Charles O. Elson and Scott Plevy
Date: January 13 - 18, 2009
Location: Sagebrush Inn & Suites, Taos, NM, USA
Supported by the Directors' Fund
Summary of Meeting:
Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the pathophysiology of chronic intestinal inflammation such as Crohn’s disease, ulcerative colitis and pouchitis and emphasize innate and adaptive immunoregulatory mechanisms that mediate mucosal homeostasis in a hostile environment. Major unresolved issues in mucosal immunology are as follows: (1) understanding how epithelial cells coexist with commensal intestinal bacteria, yet recognize the pathogenic organisms; (2) understanding how effector mechanisms in innate immune cells and T cells are appropriately downregulated; and (3) how understanding of basic immune regulation and inflammation can lead to the development of novel therapeutic agents for chronic inflammatory bowel diseases. This meeting presents state of the art lectures on the most recent research on innate, adaptive and regulatory immune responses to commensal bacteria, promotes interdisciplinary research interactions and explores several novel therapeutic approaches derived from recent pathogenic insights.
Scholarship Deadline: September 18 2008
Discounted Abstract Deadline: September 18 2008
Abstract Deadline: October 15 2008
Discounted Registration Deadline: November 13 2008
We gratefully acknowledge additional support for this conference from:
Crohn
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Schering-Plough Research Institute
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Cell PressUnited European Gastroenterology Federation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI079896-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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