Immunologic Memory and Host Defense Organizer(s): Daniel C. Douek, Robert A. Seder, Stephen P. Schoenberger and Susan M. Kaech Date: February 08 - 13, 2009 Location: Keystone Resort, Keystone, CO, USAImmune memory has a critical role in mediating protection against infections as well as potentiating certain allergic and autoimmune diseases. Hence a thorough understanding of the cellular and molecular mechanisms regulating adaptive immune memory will have important clinical application. In this regard, there has been great progress in understanding how the innate immune response influences adaptive immunity. Furthermore, improved methods to visualize immune responses in vivo, characterize the phenotypic and functional properties of adaptive immune responses and how lymphoid and non-lymphoid compartments influence the maintenance of such responses has substantially improved our understanding in this area. However, major hurdles still relate to difficulties in eliciting sustained T cell responses sufficient to mediate protection in humans with current vaccines. The goal of the meeting will be to focus on basic mechanisms for how T and B cells are programmed to induce and sustain immunity. The program is designed to integrate information from mouse, non-human primate and human studies to encompass all relevant areas related to control of memory T and B cell responses. In summary, this meeting should facilitate translational research that will impact vaccines and interventions for infectious disease, cancer and autoimmune/allergic disease. Scholarship Deadline: October 8 2008 Discounted Abstract Deadline: October 8 2008 Abstract Deadline: November 6 2008 Discounted Registration Deadline: December 8 2008 We gratefully acknowledge additional support for this conference from:   We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:  |