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Web Desc
NF-kappaB in Inflammation and Disease
Organizer(s): Michelle A. Kelliher, Manolis Pasparakis and Jürg Tschopp
Date: January 05 - 10, 2010
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Sponsored by Amgen Inc.
Summary of Meeting:
In the past 10 years, impressive progress has been made on how the NF- kappaB transcription factor is regulated and how diverse signals frequently use ubiquitin-dependent mechanisms to activate NF- kappaB. Many of the signal transducers and regulatory enzymes have been identified and their essential roles in NF- kappaB regulation revealed through genetic analyses in mice. More recent work highlights the importance of NF- kappaB in innate immune signaling by cell surface Toll-like receptors and cytosolic Nod-like receptors. Although current research clearly implicates NF- kappaB in diabetes, inflammatory diseases and cancer, a challenge for the future will be to reveal the precise molecular and cellular mechanisms of NF- kappaB dysfunction in disease. The realization that NF- kappaB activity is regulated by kinases and ubiquitin modifying enzymes presents multiple opportunities for therapeutic intervention. In addition to highlights from basic research, results from clinical trials using IKK and other NF- kappaB inhibitors are expected to be presented at this meeting.
Scholarship Deadline: September 14 2009
Discounted Abstract Deadline: September 14 2009
Abstract Deadline: October 5 2009
Discounted Registration Deadline: November 2 2009
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Educational donation provided by Amgen
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI084376-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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