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Tuesday, January 05 | 3:00PM - 7:30PM
Registration
Room: Zia Concourse


Tuesday, January 05 | 6:30PM - 7:30PM
Refreshments
Room: Zia Concourse


Tuesday, January 05 | 7:30PM - 8:30PM
Keynote Address
Room: Anasazi Ballroom

Speaker 1 of 2
* Michelle A. Kelliher, University of Massachusetts Medical School, USA

Tuesday, January 05 | 7:30PM - 8:30PM
Keynote Address
Room: Anasazi Ballroom

Speaker 2 of 2
Vishva M. Dixit, Genentech, Inc., USA
The Importance of Restraint – Ubiquitin Hydrolases – Brakes in Signaling

Wednesday, January 06 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Wednesday, January 06 | 8:00AM - 11:00AM
Regulation of the NF-kappaB Pathway
Room: Anasazi Ballroom

Speaker 1 of 6
* Michael Karin, University of California, San Diego, USA

Wednesday, January 06 | 8:00AM - 11:00AM
Regulation of the NF-kappaB Pathway
Room: Anasazi Ballroom

Speaker 2 of 6
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Mechanism of Protein Kinase Activation by Ubiquitin in the NFkappaB Pathways

Wednesday, January 06 | 8:00AM - 11:00AM
Regulation of the NF-kappaB Pathway
Room: Anasazi Ballroom

Speaker 3 of 6
Ivan Dikic, Goethe University Medical School, Germany
Ubiquitin Chains in NFkappaB Signaling

Wednesday, January 06 | 8:00AM - 11:00AM
Regulation of the NF-kappaB Pathway
Room: Anasazi Ballroom

Speaker 4 of 6
Kazuhiro Iwai, Osaka University, Japan
Short Talk: Linear Polyubiquitination: A Newly Identified Regulator of NF-kappaB Signaling

Wednesday, January 06 | 8:00AM - 11:00AM
Regulation of the NF-kappaB Pathway
Room: Anasazi Ballroom

Speaker 5 of 6
David Komander, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Specificity of TAB2 Ubiquitin Interaction

Wednesday, January 06 | 8:00AM - 11:00AM
Regulation of the NF-kappaB Pathway
Room: Anasazi Ballroom

Speaker 6 of 6
Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Crystal Structures of TRAF2, cIAP2 and TRAF1:TRAF2:cIAP Complexes

Wednesday, January 06 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Wednesday, January 06 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room/Eldorado Court


Wednesday, January 06 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Wednesday, January 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room/Eldorado Court


Wednesday, January 06 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB Regulation
Room: Anasazi Ballroom

Speaker 1 of 7
* Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA

Wednesday, January 06 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB Regulation
Room: Anasazi Ballroom

Speaker 2 of 7
Trevor William Siggers, Boston University, USA
Examining the DNA Binding Specificity Landscape of NF-kB Dimers using Protein-Binding Microarrays

Wednesday, January 06 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB Regulation
Room: Anasazi Ballroom

Speaker 3 of 7
Noula D. Shembade, University of Miami Sylvester Comprehensive Cancer Centre, USA
A20 Downregulates NF-kappaB Signaling by Disrupting E2:E3 Ubiquitin Enzyme Complexes

Wednesday, January 06 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB Regulation
Room: Anasazi Ballroom

Speaker 4 of 7
Alain Chariot, University of Liege, CHU, Belgium
Insights into the BCL-3 Oncogene Through Interactomic Studies

Wednesday, January 06 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB Regulation
Room: Anasazi Ballroom

Speaker 5 of 7
Mireille Y. Delhase, Belgium
Insights into the Anti-Apoptotic Function of the Protein Kinase TBK1

Wednesday, January 06 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB Regulation
Room: Anasazi Ballroom

Speaker 6 of 7
Dirk Brenner, Luxembourg Institute of Health, Luxembourg
Phosphorylation of CARMA1 by HPK1 is Critical for NF-kappaB Activation in T Cells

Wednesday, January 06 | 2:30PM - 4:30PM
Workshop 1: NF-kappaB Regulation
Room: Anasazi Ballroom

Speaker 7 of 7
Markus Brechmann, German Cancer Research Center, Germany
Genetic Screening for Phosphatases that Regulate NF-kappB Activity in T Lymphocytes

Wednesday, January 06 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Wednesday, January 06 | 5:00PM - 7:00PM
Transcriptional Regulation by NF-kappaB
Room: Anasazi Ballroom

Speaker 1 of 5
* David Baltimore, California Institute of Technology, USA

Wednesday, January 06 | 5:00PM - 7:00PM
Transcriptional Regulation by NF-kappaB
Room: Anasazi Ballroom

Speaker 2 of 5
Gioacchino Natoli, Humanitas University, Italy
The Epigenome and the Control of the NF-kB Transcriptional Responses in Innate Immunity and Inflammation

Wednesday, January 06 | 5:00PM - 7:00PM
Transcriptional Regulation by NF-kappaB
Room: Anasazi Ballroom

Speaker 3 of 5
Sankar Ghosh, Columbia University, USA
Regulation of Gene Expression by NFkappaB and Regulation of Inflammation by NFkappaB

Wednesday, January 06 | 5:00PM - 7:00PM
Transcriptional Regulation by NF-kappaB
Room: Anasazi Ballroom

Speaker 4 of 5
Alexander Hoffmann, University of California, Los Angeles, USA
Short Talk: Two Roles of IkBs: Inhibitors and Generators of NFkappaB

Wednesday, January 06 | 5:00PM - 7:00PM
Transcriptional Regulation by NF-kappaB
Room: Anasazi Ballroom

Speaker 5 of 5
Michael R.H. White, University of Manchester, UK
Short Talk: Control of Gene Expression by NF-kappaB Oscillations: A Source and Function for Cellular Heterogeneity?

Wednesday, January 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Wednesday, January 06 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunset Room/Eldorado Court


Thursday, January 07 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Thursday, January 07 | 8:00AM - 11:00AM
Innate Immune Receptor Signaling to NF-kappaB
Room: Anasazi Ballroom

Speaker 1 of 6
* Vishva M. Dixit, Genentech, Inc., USA

Thursday, January 07 | 8:00AM - 11:00AM
Innate Immune Receptor Signaling to NF-kappaB
Room: Anasazi Ballroom

Speaker 2 of 6
Jürg Tschopp, University of Lausanne, Switzerland
The NALP3 Inflammasome: A Sensor for Metabolic Danger

Thursday, January 07 | 8:00AM - 11:00AM
Innate Immune Receptor Signaling to NF-kappaB
Room: Anasazi Ballroom

Speaker 3 of 6
Michelle A. Kelliher, University of Massachusetts Medical School, USA
RIP Proteins Mediate Diverse Stress Responses

Thursday, January 07 | 8:00AM - 11:00AM
Innate Immune Receptor Signaling to NF-kappaB
Room: Anasazi Ballroom

Speaker 4 of 6
Laurence Arbibe, Institut Pasteur, France
Innate Immune Subversion by Chromatin Manipulation: A New Face of Host-Bacterial Pathogen Interaction

Thursday, January 07 | 8:00AM - 11:00AM
Innate Immune Receptor Signaling to NF-kappaB
Room: Anasazi Ballroom

Speaker 5 of 6
Jun-Ichiro Inoue, University of Tokyo, Japan
Short Talk: Two Mechanistically and Temporally Distinct NF-kappaB Activation Pathways in IL-1 Signaling

Thursday, January 07 | 8:00AM - 11:00AM
Innate Immune Receptor Signaling to NF-kappaB
Room: Anasazi Ballroom

Speaker 6 of 6
Mikyoung Chang, Brige Biotherapeutics, Inc., USA
Short Talk: Peli1 Facilitates TRIF-Dependent Toll-like Receptor Signaling and Proinflammatory Cytokine Production

Thursday, January 07 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Thursday, January 07 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room/Eldorado Court


Thursday, January 07 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Thursday, January 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room/Eldorado Court


Thursday, January 07 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB and Innate Immunity
Room: Anasazi Ballroom

Speaker 1 of 7
* Gioacchino Natoli, Humanitas University, Italy

Thursday, January 07 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB and Innate Immunity
Room: Anasazi Ballroom

Speaker 2 of 7
Ido Amit, Weizmann Institute, Israel
Reconstructing the Regulatory Circuit of Pathogen Sensing in Mammals

Thursday, January 07 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB and Innate Immunity
Room: Anasazi Ballroom

Speaker 3 of 7
Mathieu JM Bertrand, VIB / Ghent University, Belgium
Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

Thursday, January 07 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB and Innate Immunity
Room: Anasazi Ballroom

Speaker 4 of 7
Ee Tsin Wong, Institute of Molecular and Cell Biology, Singapore
Identification of a Factor Essential for Toll-like Receptor Signaling

Thursday, January 07 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB and Innate Immunity
Room: Anasazi Ballroom

Speaker 5 of 7
Christine S. Cheng, University of California, San Diego, USA
The NF-kappaB p50 Homodimer is a Regulator of Interferon Regulatory Elements (IRE) and Anti-Viral Innate Immune Responses

Thursday, January 07 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB and Innate Immunity
Room: Anasazi Ballroom

Speaker 6 of 7
Marc Riemann, Leibniz Institute on Aging - Fritz Lipmann Institute, Germany
Role of RelA and RelB in Medullary Thymic Epithelial Cells for the Establishment of Immunological Self-Tolerance

Thursday, January 07 | 2:30PM - 4:30PM
Workshop 2: NF-kappaB and Innate Immunity
Room: Anasazi Ballroom

Speaker 7 of 7
Lawrence P. Kane, University of Pittsburgh, USA
Recruitment of the IKK Complex to TCR Microclusters during T Cell Activation

Thursday, January 07 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Thursday, January 07 | 5:00PM - 7:00PM
NF-kappaB in the Immune Response
Room: Anasazi Ballroom

Speaker 1 of 5
* Sankar Ghosh, Columbia University, USA

Thursday, January 07 | 5:00PM - 7:00PM
NF-kappaB in the Immune Response
Room: Anasazi Ballroom

Speaker 2 of 5
David Baltimore, California Institute of Technology, USA
MicroRNAs and Regulation of NF-kB

Thursday, January 07 | 5:00PM - 7:00PM
NF-kappaB in the Immune Response
Room: Anasazi Ballroom

Speaker 3 of 5
Margot Thome, University of Lausanne, Switzerland
MALT1: Role of its Protease Activity in T cell Activation and Lymphoma Development

Thursday, January 07 | 5:00PM - 7:00PM
NF-kappaB in the Immune Response
Room: Anasazi Ballroom

Speaker 4 of 5
Bruce H. Horwitz, Brigham and Women's Hospital, USA
Short talk: Regulation of Inflammation by p50/p105

Thursday, January 07 | 5:00PM - 7:00PM
NF-kappaB in the Immune Response
Room: Anasazi Ballroom

Speaker 5 of 5
Ashish K. Jain, National Institutes of Health, USA
Short Talk: CYLD Regulates TGFâ Signaling in T cells

Thursday, January 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Thursday, January 07 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunset Room/Eldorado Court


Friday, January 08 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Friday, January 08 | 8:00AM - 11:00AM
NF-kappaB in Disease
Room: Anasazi Ballroom

Speaker 1 of 6
* Jürg Tschopp, University of Lausanne, Switzerland

Friday, January 08 | 8:00AM - 11:00AM
NF-kappaB in Disease
Room: Anasazi Ballroom

Speaker 2 of 6
Manolis Pasparakis, University of Cologne, Germany
IKK/NFkappaB Signaling in Mouse Models of Inflammatory Disease and Cancer

Friday, January 08 | 8:00AM - 11:00AM
NF-kappaB in Disease
Room: Anasazi Ballroom

Speaker 3 of 6
Jorge Moscat, Sanford Burnham Prebys Institute, USA
The p62/atypical PKC Complex in Cancer and Metabolism

Friday, January 08 | 8:00AM - 11:00AM
NF-kappaB in Disease
Room: Anasazi Ballroom

Speaker 4 of 6
Etienne Meylan, Koch Institute for Integrative Cancer Research at MIT, USA
Requirement for NFkappaB Signaling in a Mouse Model of Lung Adenocarcinoma

Friday, January 08 | 8:00AM - 11:00AM
NF-kappaB in Disease
Room: Anasazi Ballroom

Speaker 5 of 6
Daniela S. Basseres, University of North Carolina at Chapel Hill, USA
Role of NFkappaB in Ras Induced Lung Tumorigenesis

Friday, January 08 | 8:00AM - 11:00AM
NF-kappaB in Disease
Room: Anasazi Ballroom

Speaker 6 of 6
Yousef Abu-Amer, Washington University School of Medicine, USA
The Role of IKKâ in Skeletal Pathophysiology

Friday, January 08 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Friday, January 08 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room/Eldorado Court


Friday, January 08 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Friday, January 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room/Eldorado Court


Friday, January 08 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Friday, January 08 | 5:00PM - 7:00PM
NF-kappaB and Inhibitors in Preclinical Models
Room: Anasazi Ballroom

Speaker 1 of 4
* Inder M. Verma, The Salk Institute, USA
NF-kB: Regulation and Function

Friday, January 08 | 5:00PM - 7:00PM
NF-kappaB and Inhibitors in Preclinical Models
Room: Anasazi Ballroom

Speaker 2 of 4
Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Roles of NFkappaB in Pathogenesis and Treatment of Type 2 Diabetes

Friday, January 08 | 5:00PM - 7:00PM
NF-kappaB and Inhibitors in Preclinical Models
Room: Anasazi Ballroom

Speaker 3 of 4
Friedrich Thaiss, Univ. Hospital UKE, Germany
Short Talk: Resolution of Renal Inflammation: A New Role for IKK2/ NF-kappaB Pathway in Nephrotoxic Nephritis

Friday, January 08 | 5:00PM - 7:00PM
NF-kappaB and Inhibitors in Preclinical Models
Room: Anasazi Ballroom

Speaker 4 of 4
Lih-Ling Lin, Sanofi, USA
Targeting TPL2 and IKK2 for Treating Rheumatoid Arthritis

Friday, January 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Friday, January 08 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunset Room/Eldorado Court


Saturday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Saturday, January 09 | 8:00AM - 11:00AM
NF-kappaB and Cancer
Room: Anasazi Ballroom

Speaker 1 of 4
Michael Karin, University of California, San Diego, USA
IKK Signaling in Cancer

Saturday, January 09 | 8:00AM - 11:00AM
NF-kappaB and Cancer
Room: Anasazi Ballroom

Speaker 2 of 4
Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
Intricate Control of the p53 Tumor Suppressor Function in the Gut

Saturday, January 09 | 8:00AM - 11:00AM
NF-kappaB and Cancer
Room: Anasazi Ballroom

Speaker 3 of 4
William C. Hahn, Harvard Medical School, USA
Non Canonical IKKs and Cancer

Saturday, January 09 | 8:00AM - 11:00AM
NF-kappaB and Cancer
Room: Anasazi Ballroom

Speaker 4 of 4
Laura Pasqualucci, Columbia University, USA
Mutations of Multiple Signaling Proteins Deregulate NF-kappaB in Diffuse Large B-Cell Lymphoma

Saturday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Saturday, January 09 | 11:00AM - 11:00AM
On Own for Lunch and Recreation


Saturday, January 09 | 2:30PM - 4:30PM
Workshop 3: NF-kappaB in Disease Pathogenesis
Room: Anasazi Ballroom

Speaker 1 of 7
* Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel

Saturday, January 09 | 2:30PM - 4:30PM
Workshop 3: NF-kappaB in Disease Pathogenesis
Room: Anasazi Ballroom

Speaker 2 of 7
Michael Lattke, Francis Crick Institute, UK
Astrocyte-Specific IKK2 Activation is Sufficient to Induce Neuroinflammation and Results in Impaired Brain Development

Saturday, January 09 | 2:30PM - 4:30PM
Workshop 3: NF-kappaB in Disease Pathogenesis
Room: Anasazi Ballroom

Speaker 3 of 7
Daniel Starczynowski, Cincinnati Children's Hospital Medical Center, USA
miR-145 and miR-146a Mediate the Pathogenesis of 5q- Syndrome by Targeting TRAF6 Signaling

Saturday, January 09 | 2:30PM - 4:30PM
Workshop 3: NF-kappaB in Disease Pathogenesis
Room: Anasazi Ballroom

Speaker 4 of 7
Paul D. Robbins, University of Pittsburgh, USA
Role of IKK/NF-kappaB in Aging

Saturday, January 09 | 2:30PM - 4:30PM
Workshop 3: NF-kappaB in Disease Pathogenesis
Room: Anasazi Ballroom

Speaker 5 of 7
Geert van Loo, VIB-Ghent University, Belgium
Study of A20/tnfaip3 in Mouse Models of Inflammatory Disease

Saturday, January 09 | 2:30PM - 4:30PM
Workshop 3: NF-kappaB in Disease Pathogenesis
Room: Anasazi Ballroom

Speaker 6 of 7
Dietrich B. Conze, National Cancer Institute, National Institutes of Health, USA
Non-Canonical NF-kappB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2

Saturday, January 09 | 2:30PM - 4:30PM
Workshop 3: NF-kappaB in Disease Pathogenesis
Room: Anasazi Ballroom

Speaker 7 of 7
Zhaohui Wu, University of Tennessee Health Science Center, USA
ATM-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation upon Genotoxic Stress

Saturday, January 09 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Saturday, January 09 | 5:00PM - 7:15PM
NF-kappaB Response to Genotoxic and Oxidative Stress
Room: Anasazi Ballroom

Speaker 1 of 7
* Michelle A. Kelliher, University of Massachusetts Medical School, USA

Saturday, January 09 | 5:00PM - 7:15PM
NF-kappaB Response to Genotoxic and Oxidative Stress
Room: Anasazi Ballroom

Speaker 2 of 7
Martin Krönke, Institute of Medical Microbiology, Immunology and Hygiene, Germany
TNF Signaling and Regulation of ROS Production

Saturday, January 09 | 5:00PM - 7:15PM
NF-kappaB Response to Genotoxic and Oxidative Stress
Room: Anasazi Ballroom

Speaker 3 of 7
Richard M. Siegel, NIAMS, National Institutes of Health, USA
ROS and Abnormal TNFR1 Signaling in TRAPS

Saturday, January 09 | 5:00PM - 7:15PM
NF-kappaB Response to Genotoxic and Oxidative Stress
Room: Anasazi Ballroom

Speaker 4 of 7
Renée Johnson, University of Bristol, UK
Short Talk: An Interaction between RelA and Mortalin Regulates Mitochondrial Function and Cellular Respiration

Saturday, January 09 | 5:00PM - 7:15PM
NF-kappaB Response to Genotoxic and Oxidative Stress
Room: Anasazi Ballroom

Speaker 5 of 7
Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Mechanism of IKK Activation by Genotoxic Stress

Saturday, January 09 | 5:00PM - 7:15PM
NF-kappaB Response to Genotoxic and Oxidative Stress
Room: Anasazi Ballroom

Speaker 6 of 7
Shigeki Miyamoto, University of Wisconsin, Madison, USA
Short Talk Autoinhibitory Feedback and SUMO Protease Regulation of NFkappaB Signaling by DNA Damage

Saturday, January 09 | 5:00PM - 7:15PM
NF-kappaB Response to Genotoxic and Oxidative Stress
Room: Anasazi Ballroom

Speaker 7 of 7
Manolis Pasparakis, University of Cologne, Germany
Concluding Remarks

Saturday, January 09 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Saturday, January 09 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado Court/Sunset Room


Saturday, January 09 | 8:15PM - 11:00PM
Cash Bar
Room: Eldorado Court/Sunset Room


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