Cilia, Signaling and Human Disease Organizer(s): Peter Jackson and Tim Stearns Date: February 21 - 26, 2010
Location: Portola Hotel & Spa, Monterey, CA, USAProteins mediating a host of signaling pathways are organized within primary cilia. Human genetic studies have identified many developmental and degenerative diseases linked to ciliary function. These “ciliopathies” include retinal degeneration, sensory and neurological deficiencies, polycystic kidney disease, and obesity. Molecular genetic studies have connected ciliary transport and assembly mechanisms to developmental pathways, including the Hedgehog pathway, and signaling pathways, including GPCR regulators, but much remains unclear. This meeting will focus on how signaling is organized within cilia. Presentations will span signaling, the cell biology of cilia, human and molecular genetics of ciliopathies, and the biology of ciliated tissues, including morphogen pathways, tissue repair, and links to cell cycle or tumor suppressor control. Drawing on broad expertise and multiple systems, we hope to discuss both well-validated and candidate ciliary genes. The goal is to better define pathways coordinating morphogenesis of ciliated tissue with ciliary assembly and signaling. Scholarship Deadline: October 21 2009 Discounted Abstract Deadline: October 21 2009 Abstract Deadline: November 20 2009 Discounted Registration Deadline: December 21 2009 We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
Genentech, Inc.
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