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Web Desc
AAA+ and Related ATP-Driven Protein Machines: Structure, Function and Mechanism
Organizer(s): Andreas Matouschek, Robert T. Sauer and Phyllis I. Hanson
Date: March 20 - 24, 2011
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Sponsored by Bayer USA Foundation
Summary of Meeting:
AAA+ protein machines catalyze basic biological processes: they degrade proteins, remodel protein complexes and nucleic acids, transport macromolecules across membranes, and shape membranes. They are at the center of cellular processes such as cell cycle control, protein sorting, DNA replication, cytoskeleton dynamics, and membrane budding. Thus, AAA+ machines play roles in a wide range of disease including cancer, neurodegeneration and infection. Despite the diversity of function, there appears to be a common operating mode of AAA+ proteins and we are at the cusp of acquiring a deep understanding of their molecular mechanism. However, different aspects of the mechanism are understood in different systems. At this conference we bring together speakers who have elucidated critical aspects of different AAA+ proteins. The group transcends molecular scales and methodology. We add a smaller number of speakers who have made breakthroughs in the understanding of proteins that do not belong to the AAA+ family but are either functionally or structurally related. We aniticipate that this combination will lead to insights into the common mechanism of these proteins and inspire novel experimental approaches and discoveries.
Scholarship Deadline: November 18 2010
Discounted Abstract Deadline: November 18 2010
Abstract Deadline: December 21 2010
Discounted Registration Deadline: January 20 2011
We gratefully acknowledge additional support for this conference from:
Bayer USA Foundation
We gratefully acknowledge the generous grant for this conference provided by:

National Science Foundation (NSF)
Grant No. MCB-1112682
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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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