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Web Desc
Environmental Epigenomics and Disease Susceptibility
Organizer(s): Randy L. Jirtle, Moshe Szyf and Frederick L. Tyson
Date: March 27 - April 01, 2011
Location: Grove Park Inn Resort & Spa, Asheville, NC, USA
Supported by the Directors' Fund
Summary of Meeting:
There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs in cells are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this conference is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome. Epigenetic research promises to markedly improve our ability to diagnosis, prevent, and treat the pathological conditions of humans; however, it also introduces unique legal and ethical issues. These will also be discussed.
Scholarship Deadline: November 30 2010
Discounted Abstract Deadline: November 30 2010
Abstract Deadline: December 31 2010
Discounted Registration Deadline: January 28 2011
We gratefully acknowledge additional support for this conference from:
Autism SpeaksMarch of Dimes FoundationRete Mirabile Fund of Triangle Community FoundationSociety of Toxicology
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Portland Press LtdStichting iNSnet
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-02

National Institute of Environmental Health Sciences (NIEHS)
Grant No. 1R13ES020113-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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