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Web Desc
Advances in Islet Biology
Organizer(s): Lori Sussel, Jorge Ferrer and Andrew F. Stewart
Date: March 25 - 30, 2012
Location: Portola Hotel & Spa, Monterey, CA, USA
Sponsored by Merck & Co., Inc. and Sanofi US
Summary of Meeting:
During the past 10 to 15 years, there has been significant progress in our understanding of pancreatic islet development and islet biology. This knowledge has been complemented and accelerated by major advances in diverse fields including islet transplantation, stem cells, small molecule screening, high-throughput sequencing, epigenetics and human genetics. The integration of these divergent disciplines has allowed us to develop a clearer definition of a functional b cell and has elucidated many of the mechanisms underlying the differentiation, survival and death of the b cell. Furthermore, these studies have revealed the potential to generate new b cells through replication or neogenesis. Improvements in differentiation and transdifferentiation protocols have also illustrated the potential of using stem cells and some somatic cell types as sources of islet cells, but these studies have also revealed the challenges associated with generating functional b cells. The purpose of this Keystone Symposia meeting is to highlight the areas of islet biology that have seen the most remarkable advances and to address some of the controversies that still exist in the field, especially with regards to the generation and maintenance of functionally mature b cells for therapeutic purposes. In addition, where it is possible, comparative mouse and human studies will be discussed to illustrate if and when mouse studies can be applied to the human situation.
Scholarship Deadline: November 22 2011
Discounted Abstract Deadline: November 22 2011
Abstract Deadline: January 3 2012
Discounted Registration Deadline: January 25 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Merck & Co., Inc.Sanofi US
We gratefully acknowledge additional support for this conference from:
ALPCO DiagnosticsJDRFMercodia, Inc.ViaCyte, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genomics Institute of the Novartis Research Foundation

ViaCyte, Inc.


Peter Strop
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-03
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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