Malnutrition, Gut-Microbial Interactions and Mucosal Immunity to Vaccines
Organizer(s): Cecil Czerkinsky, William Petri Jr., Yasmine Belkaid, Gagandeep Kang and Maharaj Kishan BhanDate: November 07 - 11, 2011
Location: Le Meridien New Delhi, New Delhi, India
Malnutrition is among the most devastating health conditions worldwide, affecting one of three children in developing countries and contributing more than ten million deaths annually. The relationship between nutrition and immunity has been a topic of study for more than five decades. Seminal developments in our understanding of the organization and regulation of the immune system have indicated a close relationship between host nutritional status and systemic immunity. However, surprisingly little is known regarding the impact of nutrition on the mucosal immune system of the digestive tract, a system that functions almost independently from the systemic immune apparatus. Recent research also suggests that the composition and metabolic activity of the gut microbiota modulates intestinal barrier function and immune responsiveness (and vice-versa), and can be affected by specific nutrients or lack of these. This meeting will focus on understanding the role of nutrition in modulating gut immunity to vaccines in order to formulate strategies for improving the performance of enteric vaccines in malnourished children. The objective of this symposium is to formulate innovative hypotheses regarding specific mechanisms by which nutrients and defined microbiota affect gut immunity. A better understanding of the links between nutrients, the gut microbiome and the intestinal immune system is likely to pave the way to the development of innovative approaches that target activation of specific immunological pathways for promoting host’s gut defense. Such knowledge should impact on the development of vaccine formulations and intervention strategies for improved control of enteric infections in developing countries. The Keystone Symposia meeting on Malnutrition, Gut-Microbial Interactions and Mucosal Immunity to Vaccines will benefit from a partnership with the Bill & Melinda Gates Foundation (BMGF), whereby the 2011 business meeting of the BMGF Grand Challenges in Global Health awardees will be held in conjunction with the Keystone Symposia meeting.
Global Health Travel Award Deadline: June 7 2011
Scholarship Deadline: July 11 2011
Discounted Abstract Deadline: July 11 2011
Abstract Deadline: August 10 2011
Discounted Registration Deadline: September 23 2011
We gratefully acknowledge additional support for this conference from:
We gratefully acknowledge the generous grant for this conference provided by:National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI096802-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.