The Gut Microbiome: The Effector/Regulatory Immune Network
Organizer(s): Lloyd H. Kasper, Javier Ochoa-Repáraz and Sarkis K. MazmanianDate: February 10 - 15, 2013
Location: Sagebrush Inn & Suites, Taos, NM, USA
The mammalian GI track harbors a complex assemblage of microbial organisms that are essential for the development of the immune system. Alterations of the gut microbiota may lead to immune dysregulation both in the gut and in distal effector sites leading to the development of autoimmune disease. This meeting will focus on the role of the microbiota in balancing the effector and regulatory response leading to immune homeostasis. Recent findings suggest that altering certain bacterial populations present in the gut can lead to an inflammatory state associated with Th1/Th17 polarization. In contrast, other commensal bacteria and their antigenic products, when presented in the correct context, are regulatory and protect against inflammation. Particular emphasis will be placed on the biologic dynamics of the microbiota, the interaction with APC, modulation of the regulatory network and the immunologic consequences on experimental and human autoimmune conditions such as IBD, CNS demyelination and RA. The practical application of these novel interactions between the host and gut microbiota may lead to the identification of new therapeutics and novel insights into the mechanisms of human autoimmunity. The opportunity to assemble basic scientists in bacteriology and mucosal immunology with clinicians to explore this rapidly expanding arena is unique as there have been no previous organized meetings to meet this need. How the gut microbiome guides effector and regulatory immune functions will provide new pathways for the development of novel therapeutic targets.
Scholarship Deadline: October 9 2012
Discounted Abstract Deadline: October 9 2012
Abstract Deadline: November 8 2012
Discounted Registration Deadline: December 5 2012
We gratefully acknowledge additional support for this conference from:
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
We gratefully acknowledge the generous grant for this conference provided by:National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 5R13DK084688-04
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