Structural Analysis of Supramolecular Assemblies by Hybrid Methods
Organizer(s): Andrej Sali, Brian T. Chait and David BakerDate: March 03 - 07, 2013
Location: Granlibakken Tahoe, Tahoe City, CA, USA
In order to understand the workings of a living cell, we need to know the structures and dynamics of individual biological macromolecules, their complexes and networks, organelles and whole cells, thus interfacing structural biology with cell biology, systems biology, proteomics, chemical biology and biophysics. The accuracy, precision, completeness and efficiency of structural characterization are maximized by hybrid or integrative approaches that combine data from multiple types of experimental methods through the use of computational analysis and modeling methods. These experimental methods include X-ray crystallography, NMR spectroscopy, electron microscopy, small angle X-ray scattering, mass spectrometry, chemical cross-linking, super-high resolution optical microscopy, optical microscopy and others. The goal of this meeting is to highlight the strengths and limitations of the current hybrid approaches as well as to identify promising new advances in experimental methods for collecting the data and computational methods for converting the data to models. Finally, hybrid approaches will be demonstrated by their applications to important and challenging biological problems, spanning a wide range of length and time scales, from atomic structures of individual proteins to low-resolution representations of whole cells.
Scholarship Deadline: November 5 2012
Discounted Abstract Deadline: November 5 2012
Abstract Deadline: December 3 2012
Discounted Registration Deadline: December 19 2012
We gratefully acknowledge additional support for this conference from:
Rigaku Americas Corporation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
Max Planck Institute of Biochemistry
University of California, San Francisco
We gratefully acknowledge the generous grant for this conference provided by:National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM105010-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.