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Wednesday, March 20 | 4:00PM - 8:00PM
Arrival and Registration
Room: North Concourse


Thursday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Thursday, March 21 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Anasazi Ballroom

Speaker 1 of 1
Stuart L. Schreiber, HHMI/Harvard University, USA
Linking Genetic Features of Human Cancers and Histone-Modifying Enzymes for Future Cancer Therapies

Thursday, March 21 | 9:00AM - 11:00AM
Chromosomes, Chromatin and Transcription I
Room: Anasazi Ballroom

Speaker 1 of 6
* Shelley L. Berger, University of Pennsylvania, USA

Thursday, March 21 | 9:00AM - 11:00AM
Chromosomes, Chromatin and Transcription I
Room: Anasazi Ballroom

Speaker 2 of 6
B. Franklin Pugh, Pennsylvania State University, USA
Hemisomes and Nucleosomal Assymeetry across the Saccharomyces cerevisiae Genome

Thursday, March 21 | 9:00AM - 11:00AM
Chromosomes, Chromatin and Transcription I
Room: Anasazi Ballroom

Speaker 3 of 6
Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany
New Insights into the Mechanisms of Transcription and its Regulation

Thursday, March 21 | 9:00AM - 11:00AM
Chromosomes, Chromatin and Transcription I
Room: Anasazi Ballroom

Speaker 4 of 6
Anne Brunet, Stanford University, USA
Epigenetic Regulation of Aging

Thursday, March 21 | 9:00AM - 11:00AM
Chromosomes, Chromatin and Transcription I
Room: Anasazi Ballroom

Speaker 5 of 6
Siavash K. Kurdistani, University of California, Los Angeles, USA
Short Talk: Regulation of Intracellular pH by Histone Acetylation

Thursday, March 21 | 9:00AM - 11:00AM
Chromosomes, Chromatin and Transcription I
Room: Anasazi Ballroom

Speaker 6 of 6
Alejandro Vaquero, Josep Carreras Leukaemia Research Institute (IJC), Spain
Short Talk: SirT2 Regulates Cell Cycle Progression and Genome Stability by Modulating Mitotic Deposition of H4K20 Methylation

Thursday, March 21 | 9:40AM - 10:00AM
Coffee Break
Room: Concourse


Thursday, March 21 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Thursday, March 21 | 11:00AM - 1:00PM
Poster Setup
Room: Pavilion


Thursday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Pavilion


Thursday, March 21 | 2:30PM - 4:30PM
Workshop 1
Room: Anasazi Ballroom

Speaker 1 of 7
* Mary Ann Osley, University of New Mexico School of Medicine, USA

Thursday, March 21 | 2:30PM - 4:30PM
Workshop 1
Room: Anasazi Ballroom

Speaker 2 of 7
Masami Horikoshi, University of Tokyo, Japan
“Modification Web” and “Signal Router” Theories on Histone Modification System and their Application to Development of Cancer Drugs

Thursday, March 21 | 2:30PM - 4:30PM
Workshop 1
Room: Anasazi Ballroom

Speaker 3 of 7
Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School, USA
Reversible Disruption of mSWI/SNF-Like BAF Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma

Thursday, March 21 | 2:30PM - 4:30PM
Workshop 1
Room: Anasazi Ballroom

Speaker 4 of 7
Gary Hon, University of Texas Southwestern Medical Center, USA
Whole Genome Bisulfite Sequencing Reveals Tissue-Specific DNA Methylation in a Normal Mouse

Thursday, March 21 | 2:30PM - 4:30PM
Workshop 1
Room: Anasazi Ballroom

Speaker 5 of 7
Tal H. Salz, Johns Hopkins University, USA
hSET1 Regulates the Canonical Wnt-Signaling Pathway and Plays a Role in Colorectal Cancer

Thursday, March 21 | 2:30PM - 4:30PM
Workshop 1
Room: Anasazi Ballroom

Speaker 6 of 7
Eleni Maniati, Queen Mary University of London, UK
Functional Effect of Aberrant Mll2/3 Gene Expression in Pancreatic Cancer

Thursday, March 21 | 2:30PM - 4:30PM
Workshop 1
Room: Anasazi Ballroom

Speaker 7 of 7
Cheng-Fu Kao, Academia Sinica, Taiwan
H2B Monoubiquitylation Regulates the Replication Stress Response

Thursday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Thursday, March 21 | 5:00PM - 7:00PM
Chromosomes, Chromatin and Transcription II
Room: Anasazi Ballroom

Speaker 1 of 6
* Ali Shilatifard, Northwestern University, USA

Thursday, March 21 | 5:00PM - 7:00PM
Chromosomes, Chromatin and Transcription II
Room: Anasazi Ballroom

Speaker 2 of 6
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Connecting Transcription, Chromatin and Cancer

Thursday, March 21 | 5:00PM - 7:00PM
Chromosomes, Chromatin and Transcription II
Room: Anasazi Ballroom

Speaker 3 of 6
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Epigenetic Genome Control by RNAi and Heterochromatin Proteins

Thursday, March 21 | 5:00PM - 7:00PM
Chromosomes, Chromatin and Transcription II
Room: Anasazi Ballroom

Speaker 4 of 6
Anne Schaefer, Mount Sinai School of Medicine, USA
Short Talk: PRC2 is Essential for Adult Brain Function

Thursday, March 21 | 5:00PM - 7:00PM
Chromosomes, Chromatin and Transcription II
Room: Anasazi Ballroom

Speaker 5 of 6
Johnathan R. Whetstine, Fox Chase Cancer Center, USA
Short Talk: Looking at Cancer through the Eyes of Histone Demethylases

Thursday, March 21 | 5:00PM - 7:00PM
Chromosomes, Chromatin and Transcription II
Room: Anasazi Ballroom

Speaker 6 of 6
Charles Lin, Baylor College of Medicine, USA
Short Talk: Transcription Amplification in Tumor Cells with Elevated c-Myc

Thursday, March 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pavilion


Thursday, March 21 | 7:30PM - 10:00PM
Poster Session 1
Room: Pavilion


Friday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Friday, March 22 | 8:00AM - 11:00AM
Polycomb and Trithorax in Gene Expression and Cancer
Room: Anasazi Ballroom

Speaker 1 of 8
* Shiv I. S. Grewal, NCI, National Institutes of Health, USA

Friday, March 22 | 8:00AM - 11:00AM
Polycomb and Trithorax in Gene Expression and Cancer
Room: Anasazi Ballroom

Speaker 2 of 8
Ali Shilatifard, Northwestern University, USA
Chromatin Modifications, Transcriptional Elongation Control and Childhood Leukemia

Friday, March 22 | 8:00AM - 11:00AM
Polycomb and Trithorax in Gene Expression and Cancer
Room: Anasazi Ballroom

Speaker 3 of 8
Danny F. Reinberg, HHMI/New York University, USA
PRC1 in Drosophila and Mammals

Friday, March 22 | 8:00AM - 11:00AM
Polycomb and Trithorax in Gene Expression and Cancer
Room: Anasazi Ballroom

Speaker 4 of 8
Jürg Müller, Max Planck Institute of Biochemistry, Germany
Molecular Mechanisms of the Polycomb System

Friday, March 22 | 8:00AM - 11:00AM
Polycomb and Trithorax in Gene Expression and Cancer
Room: Anasazi Ballroom

Speaker 5 of 8
Peter Verrijzer, Erasmus University Medical Center, Netherlands
Antagonism between Polycomb and Trithorax in Development and Disease

Friday, March 22 | 8:00AM - 11:00AM
Polycomb and Trithorax in Gene Expression and Cancer
Room: Anasazi Ballroom

Speaker 6 of 8
Kami Ahmad, Harvard Medical School, USA
Short Talk: The Chromatin Configuration of Polycomb Response Elements (PREs) Define Epigenetic States

Friday, March 22 | 8:00AM - 11:00AM
Polycomb and Trithorax in Gene Expression and Cancer
Room: Anasazi Ballroom

Speaker 7 of 8
François Fuks, Université Libre de Bruxelles, Belgium
Short Talk: Molecular Basis of Tets: In Search of their Protein Partners

Friday, March 22 | 8:00AM - 11:00AM
Polycomb and Trithorax in Gene Expression and Cancer
Room: Anasazi Ballroom

Speaker 8 of 8
Zhiguo Zhang, Mayo Clinic, USA
Short Talk: Histone Modifications Regulate DNA Replication Coupled Nucleosome Assembly

Friday, March 22 | 9:20AM - 9:40AM
Coffee Break
Room: Concourse


Friday, March 22 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Friday, March 22 | 11:00AM - 1:00PM
Poster Setup
Room: Pavilion


Friday, March 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Pavilion


Friday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Friday, March 22 | 5:00PM - 7:00PM
Histone Marks in Development and Cancer
Room: Anasazi Ballroom

Speaker 1 of 6
* Ramin Shiekhattar, University of Miami, USA

Friday, March 22 | 5:00PM - 7:00PM
Histone Marks in Development and Cancer
Room: Anasazi Ballroom

Speaker 2 of 6
Thomas Jenuwein, Max Planck Institute of Immunobiology and Epigenetics, Germany
Making and Breaking Heterochromatin

Friday, March 22 | 5:00PM - 7:00PM
Histone Marks in Development and Cancer
Room: Anasazi Ballroom

Speaker 3 of 6
Tony Kouzarides, University of Cambridge, UK
Chromatin Modification Pathways and their Role in Cancer

Friday, March 22 | 5:00PM - 7:00PM
Histone Marks in Development and Cancer
Room: Anasazi Ballroom

Speaker 4 of 6
Alexander Tarakhovsky, Rockefeller University, USA
Signaling Control of Epigenetic Fitness

Friday, March 22 | 5:00PM - 7:00PM
Histone Marks in Development and Cancer
Room: Anasazi Ballroom

Speaker 5 of 6
Shelley L. Berger, University of Pennsylvania, USA
Chromatin Landscape in Cellular Aging

Friday, March 22 | 5:00PM - 7:00PM
Histone Marks in Development and Cancer
Room: Anasazi Ballroom

Speaker 6 of 6
Mary Ann Osley, University of New Mexico School of Medicine, USA
Short Talk: The Histone Modification Landscape of Quiescent Yeast Cells Formed during Chronological Aging

Friday, March 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pavilion


Friday, March 22 | 7:30PM - 10:00PM
Poster Session 2
Room: Pavilion


Saturday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Saturday, March 23 | 8:00AM - 11:00AM
DNA Methylation in Development and Cancer
Room: Anasazi Ballroom

Speaker 1 of 8
* B. Franklin Pugh, Pennsylvania State University, USA

Saturday, March 23 | 8:00AM - 11:00AM
DNA Methylation in Development and Cancer
Room: Anasazi Ballroom

Speaker 2 of 8
Yi Zhang, HHMI/Harvard Medical School, Children's Hospital Boston, USA
Role of Tet1-Mediated 5mC Oxidation in PGC Reprogramming and Meiosis

Saturday, March 23 | 8:00AM - 11:00AM
DNA Methylation in Development and Cancer
Room: Anasazi Ballroom

Speaker 3 of 8
Peter A. Jones, Van Andel Research Institute, USA
DNA Methylation and Cancer Therapy

Saturday, March 23 | 8:00AM - 11:00AM
DNA Methylation in Development and Cancer
Room: Anasazi Ballroom

Speaker 4 of 8
Jean-Pierre Issa, Temple University School of Medicine, USA
Epigenetic Reprogramming as Cancer Therapy

Saturday, March 23 | 8:00AM - 11:00AM
DNA Methylation in Development and Cancer
Room: Anasazi Ballroom

Speaker 5 of 8
Roger Greenberg, University of Pennsylvania, USA
Short Talk: Acetylation Determines Double-Strand Break Repair Choice and Response to PARP Inhibition

Saturday, March 23 | 8:00AM - 11:00AM
DNA Methylation in Development and Cancer
Room: Anasazi Ballroom

Speaker 6 of 8
Gregory David, New York University School of Medicine, USA
Short Talk: Epigenetic Regulation of Inflammation Modulates KRas-Driven Pancreatic Cancer Progression

Saturday, March 23 | 8:00AM - 11:00AM
DNA Methylation in Development and Cancer
Room: Anasazi Ballroom

Speaker 7 of 8
Diana Hargreaves, Stanford University, USA
Short Talk: BAF Complexes Cooperate with
Topoisomerase II alpha to Decatenate DNA


Saturday, March 23 | 8:00AM - 11:00AM
DNA Methylation in Development and Cancer
Room: Anasazi Ballroom

Speaker 8 of 8
Li-Jung Juan, Academia Sinica, Taiwan
Short Talk: Mechanisms of DNA Demethylation Enzymes TET Family Proteins in Suppressing Tumor Malignancy

Saturday, March 23 | 9:20AM - 9:40AM
Coffee Break
Room: Concourse


Saturday, March 23 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Saturday, March 23 | 11:00AM - 1:00PM
Poster Setup
Room: Pavilion


Saturday, March 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Pavilion


Saturday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Saturday, March 23 | 5:00PM - 7:00PM
Enhancers and ncRNAs in Development and Cancer
Room: Anasazi Ballroom

Speaker 1 of 5
* Peter Verrijzer, Erasmus University Medical Center, Netherlands

Saturday, March 23 | 5:00PM - 7:00PM
Enhancers and ncRNAs in Development and Cancer
Room: Anasazi Ballroom

Speaker 2 of 5
Ramin Shiekhattar, University of Miami, USA
Brave New World of Noncoding RNA

Saturday, March 23 | 5:00PM - 7:00PM
Enhancers and ncRNAs in Development and Cancer
Room: Anasazi Ballroom

Speaker 3 of 5
Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA
Xist RNA in the Establishment and Maintenance of X Chromosome Inactivation

Saturday, March 23 | 5:00PM - 7:00PM
Enhancers and ncRNAs in Development and Cancer
Room: Anasazi Ballroom

Speaker 4 of 5
Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Inheritance and Reprogramming of Heterochromatin with Small RNA

Saturday, March 23 | 5:00PM - 7:00PM
Enhancers and ncRNAs in Development and Cancer
Room: Anasazi Ballroom

Speaker 5 of 5
Celso A. Espinoza, AbbVie, Inc., USA
Short Talk: Architectural Studies of Intramolecular Interactions between Enhancers and Promoters via ChIP-HiC

Saturday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pavilion


Saturday, March 23 | 7:30PM - 10:00PM
Poster Session 3
Room: Pavilion


Sunday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Sunday, March 24 | 8:00AM - 11:00AM
Myc, Transcriptional Regulation and Development
Room: Anasazi Ballroom

Speaker 1 of 8
* Kapil N. Bhalla, MD Anderson Cancer Center, USA

Sunday, March 24 | 8:00AM - 11:00AM
Myc, Transcriptional Regulation and Development
Room: Anasazi Ballroom

Speaker 2 of 8
Robert N. Eisenman, Fred Hutchinson Cancer Research Center, USA
Cooperative Transcriptional Regulation of Metabolism Mediated by the Myc-Max/MondoA-Mlx Network

Sunday, March 24 | 8:00AM - 11:00AM
Myc, Transcriptional Regulation and Development
Room: Anasazi Ballroom

Speaker 3 of 8
Michael D. Cole, Dartmouth Medical School, USA
An Epigenetic Model for Myc Autoregulation and Gene Repression

Sunday, March 24 | 8:00AM - 11:00AM
Myc, Transcriptional Regulation and Development
Room: Anasazi Ballroom

Speaker 4 of 8
Bruno Amati, Italian Institute of Technology and European Institute of Oncology, Italy
Epigenome and Transcriptome Regulation in Myc-Driven Tumors

Sunday, March 24 | 8:00AM - 11:00AM
Myc, Transcriptional Regulation and Development
Room: Anasazi Ballroom

Speaker 5 of 8
James E. Bradner, Novartis Institutes for BioMedical Research, USA
Targeting Gene Regulatory Pathways

Sunday, March 24 | 8:00AM - 11:00AM
Myc, Transcriptional Regulation and Development
Room: Anasazi Ballroom

Speaker 6 of 8
Lin-Feng Chen, University of Illinois at Urbana-Champaign, USA
Short Talk: Brd4 Maintains Constitutively Active NF-kappaB in Cancer Cells by Binding to Acetylated RelA

Sunday, March 24 | 8:00AM - 11:00AM
Myc, Transcriptional Regulation and Development
Room: Anasazi Ballroom

Speaker 7 of 8
Junwei Shi, Cold Spring Harbor Laboratory, USA
Short Talk: Collaboration between the BAF Complex and Brd4 Maintains Myc Expression in Leukemia

Sunday, March 24 | 8:00AM - 11:00AM
Myc, Transcriptional Regulation and Development
Room: Anasazi Ballroom

Speaker 8 of 8
Katherine A. Jones, The Salk Institute, USA
Short Talk: Beta-Catenin Ubiquitylation and Release from LEF-1/TCF by a Novel alpha-Catenin:APC Complex

Sunday, March 24 | 9:20AM - 9:40AM
Coffee Break
Room: Concourse


Sunday, March 24 | 10:00AM - 10:00AM
On Own for Lunch and Recreation


Sunday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Anasazi Ballroom

Speaker 1 of 6
* Roger Greenberg, University of Pennsylvania, USA

Sunday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Anasazi Ballroom

Speaker 2 of 6
Klaas Kok, University Medical Center Groningen, Netherlands
The Impact of SETD2-Inactivating Mutations and Loss of H3K36 Trimethylation on Gene Expression in Clear Cell Renal Cell Carcinoma Progenitor Cells

Sunday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Anasazi Ballroom

Speaker 3 of 6
Hao A. Duong, Harvard Medical School, USA
Temporal Coordination of Histone De-Acetylase and Methyl-Transferase in Circadian Transcriptional Repression

Sunday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Anasazi Ballroom

Speaker 4 of 6
Seung Hyuk Choi, The Salk Institute, USA
Role for alpha-Catenin in APC-Mediated Repression at Wnt Target Genes

Sunday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Anasazi Ballroom

Speaker 5 of 6
Emily A. Clough, NIDDK, National Institutes of Health, USA
The H4K16 Histone Acetyltransferase Chameau Is a Putative Target of Doublesex

Sunday, March 24 | 2:30PM - 4:30PM
Workshop 2
Room: Anasazi Ballroom

Speaker 6 of 6
Anil K. Panigrahi, Baylor College of Medicine, USA
Dissecting the Role of H3K79 Methylation in Transcription Elongation and Leukemia

Sunday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Concourse


Sunday, March 24 | 5:00PM - 7:15PM
Transcription, Chromatin and Epigenetics in Cancer Therapy
Room: Anasazi Ballroom

Speaker 1 of 6
* Robert N. Eisenman, Fred Hutchinson Cancer Research Center, USA

Sunday, March 24 | 5:00PM - 7:15PM
Transcription, Chromatin and Epigenetics in Cancer Therapy
Room: Anasazi Ballroom

Speaker 2 of 6
Laurie A. Boyer, Massachusetts Institute of Technology, USA
Developmental Transitions in Heart Development

Sunday, March 24 | 5:00PM - 7:15PM
Transcription, Chromatin and Epigenetics in Cancer Therapy
Room: Anasazi Ballroom

Speaker 3 of 6
Robert J. Gould, Fulcrum Therapeutics, USA
Drugging the Human Methylome: Discovery and Characterization of Inhibitors of Protein Methyltransferases for the Treatment of Genetically Defined Cancers

Sunday, March 24 | 5:00PM - 7:15PM
Transcription, Chromatin and Epigenetics in Cancer Therapy
Room: Anasazi Ballroom

Speaker 4 of 6
Patrick Trojer, Constellation Pharmaceuticals, USA
Targeting Histone Lysine Methylation in Cancer

Sunday, March 24 | 5:00PM - 7:15PM
Transcription, Chromatin and Epigenetics in Cancer Therapy
Room: Anasazi Ballroom

Speaker 5 of 6
Marie Classon, USA
Short Talk: Chromatin Modifications and the Establishment of Drug-Tolerance

Sunday, March 24 | 5:00PM - 7:15PM
Transcription, Chromatin and Epigenetics in Cancer Therapy
Room: Anasazi Ballroom

Speaker 6 of 6
Kapil N. Bhalla, MD Anderson Cancer Center, USA
Short Talk: Highly Effective Combination of LSD1 Antagonist SP-2509 and Pan-HDAC Inhibitor Against Human AML Cells

Sunday, March 24 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Pavilion


Sunday, March 24 | 8:00PM - 11:00PM
Entertainment
Room: Pavilion


Sunday, March 24 | 8:15PM - 11:00PM
Cash Bar
Room: Pavilion


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