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Web Desc
PI 3-Kinase and Interplay with Other Signaling Pathways
joint with Tumor Metabolism
Organizer(s): Christian Rommel, Kevan M. Shokat and José Baselga
Date: February 24 - March 01, 2013
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Bayer USA Foundation, Gilead Sciences, Inc., Infinity Pharmaceuticals and Pfizer Inc.
Summary of Meeting:
How metabolic pathways are regulated to meet the unique needs of tumor cells is not well understood, but mounting evidence suggests that metabolic regulation in cancer cells is intimately linked with the signal transduction pathways that control cell growth and proliferation. The PI3K-Akt-mTOR signaling pathway is one of the primary mechanisms for controlling tumor cell growth, survival, and motility in response to oncogenic signaling and extracellular cues. Genetic events resulting in inappropriate activation of this pathway are common in many cancers and, as a result, are a focus of both basic cancer research and drug discovery efforts in oncology. Although originally modeled as an independent and linear signaling cascade, today it is evident that the PI3K pathway also functions as a central hub for cross-talk in both vertical as well as reciprocal feedback regulation with other important signaling pathways. One of the most exciting advances in the field is the development of new inhibitors against this pathway. However, the rationale for inhibiting individual or multiple isoforms of PI3K/Akt/mTOR signaling remains a subject of intense debate. This meeting aims to bring together scientists and clinicians from academia and industry to discuss the opportunities and liabilities of targeting the PI3K- and related pathways in disease, drawing on human pathophysiology and genetics, preclinical models and clinical data with PI3K pathway inhibitors. A joint meeting addressing Tumor Metabolism will enhance opportunities for interdisciplinary interactions.
Scholarship Deadline: October 25 2012
Discounted Abstract Deadline: October 25 2012
Abstract Deadline: November 28 2012
Discounted Registration Deadline: December 19 2012
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Bayer USA FoundationGilead Sciences, Inc.Infinity PharmaceuticalsPfizer Inc.
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Echelon Biosciences, Inc.ROCKLAND IMMUNOCHEMICALS, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA174220-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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