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Web Desc
Aging - Pushing the Limits of Cellular Quality Control
Organizer(s): Andrew G. Dillin, Daniel E. Gottschling and Thomas Nyström
Date: January 12 - 17, 2014
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA
Supported by the Directors' Fund
Summary of Meeting:
Aging is one of the highest risk factors known for most diseases of the modern era of humanity. Such age-related diseases are linked to the loss of performance of a large variety of homeostatic processes protecting the genome, proteome, lipidome or metabolome. One of the greatest challenges facing any organism is to coordinate the operation and maintenance of these different homeostatic processes and, in multicellular organisms, also to harmonize these functions across all cells and tissues. However, the highly interconnected nature of homeostatic machineries makes the system vulnerable to perturbations as the breakdown of one specific homeostatic process during aging or stress brings forth repercussions on other maintenance activities. In addition, as each cell or tissue must remain aware of the performance and wellbeing of distal cells and organelles, a breakdown in cell-to-cell and organelle-to-organelle communication can lead to critical macromolecular perturbations, including a loss of genome, proteome, lipidome, metabolome and endocrine functions leading to the inception of age-related disorders. The goal of this meeting is to bridge interdisciplinary approaches studying different aspects of cellular quality control and homeostasis with research on the aging soma and germline. We believe that deciphering the mechanisms of homeostatic control, its interconnective nature and homeostatic communication between cells and organelles may lead to a deeper understanding of the aging process – its onset, sequence of events and critical targets.
Scholarship Deadline: October 3 2013
Discounted Abstract Deadline: October 3 2013
Abstract Deadline: October 28 2013
Discounted Registration Deadline: November 13 2013
We gratefully acknowledge additional support for this conference from:
The Ellison Medical FoundationGlenn Foundation for Medical Research
MitoKyne
Proteostasis Therapeutics, Inc.
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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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