Immune Evolution in Cancer
joint with Inflammation, Infection and Cancer
Organizer(s): Suzanne Ostrand-Rosenberg, Olivera J. Finn and Lisa M. CoussensDate: March 09 - 14, 2014
Location: Fairmont Chateau Whistler, Whistler, BC, Canada
Neoplastic progression is initiated by accumulations of somatic mutations in proliferating cells that cause “healthy” cells to sustain survival programs and resist embedded tissue-based programs designed to restrain their unchecked proliferation. Concurrent with neoplastic progression, the immune system sculpts the neoplastic cell repertoire by eliminating immunogenic cells while allowing outgrowth of less immunogenic variants, a process known as immunoediting. As neoplasms undergo early progression, they often resemble a chronic “wound” wherein activated tissue remodeling, and immune and angiogenic programs, facilitate the survival of potentially malignant cells. Cells of the adaptive and innate immune systems are particularly important during wound healing; however, during cancer development, many immune cells are co-opted and effectively “reprogrammed” toward a tumor-promoting phenotype. As a result, malignant cells condition their environment to facilitate their progression by co-opting multiple immune effector cell populations. Presentations at this conference will focus on how the tumor microenvironment perturbs lymphoid and myeloid cells, the mechanisms used by immune cells to promote tumor growth, and the strategies being developed to counteract tumor-induced immune suppression to generate anti-tumor immunity. Many of the tumor-promoting effects of the immune system are regulated by leukocyte infiltration (e.g., chronic inflammation); therefore, this conference, in conjunction with the companion conference on Inflammation, Infection and Cancer, will provide an in-depth examination of the current understanding of tumor progression, and will facilitate interactions between tumor immunologists and cancer biologists.
Scholarship Deadline: November 6 2013
Discounted Abstract Deadline: November 6 2013
Abstract Deadline: December 10 2013
Discounted Registration Deadline: January 9 2014
We gratefully acknowledge additional support for this conference from:
We gratefully acknowledge the generous grant for this conference provided by:National Cancer Institute (NCI)
Grant No. 1R13CA182664-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.