Hybrid Methods in Structural Biology
Organizer(s): Jens Meiler, Patrick Cramer and Ron A. MilliganDate: March 04 - 08, 2015
Location: Granlibakken Tahoe, Tahoe City, CA, USA
As we study the structure and dynamics of more and more complex systems to better understand their biological function, each individual technology in the structural biology toolbox approaches its limitations. These limitations include size of the system, timeline of motions, spatial and/or temporal resolution and ensemble averaging. Further, each individual method perturbs the system in a different way to enable or facilitate its analysis. This includes, for example, the introduction of spin labels to perform EPR experiments, the reconstitution of membrane proteins in micelles for NMR spectroscopy, the introduction of entire domains to stabilize proteins in certain conformations for crystallization, or a simplified force field in computation. As systems become more challenging, the perturbations tend to get more drastic, complicating the interpretation of results. Only at the intersection of several techniques does it become possible to distinguish information that is biologically relevant from perturbations introduced by any individual approach. Moving forward, hybrid methods and integrated methods in structural biology play a key role in studying complex systems verifying each other’s results. The objective of this Keystone Symposia meeting is two-fold: 1) To discuss novel and potentially disruptive technologies and/or combinations thereof to be added to the hybrid methods toolbox; and 2) To illustrate and discuss application of hybrid methods to important biological systems. These objectives will be achieved through oral presentations, poster sessions, discussions in panel format and tutorial sessions introducing new software algorithms.
Scholarship Deadline: November 6 2014
Discounted Abstract Deadline: November 6 2014
Abstract Deadline: December 9 2014
Discounted Registration Deadline: January 8 2015
We gratefully acknowledge additional support for this conference from:
We gratefully acknowledge the generous grant for this conference provided by:National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM113567-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.