Long Noncoding RNAs: From Evolution to Function
Organizer(s): Leonard Lipovich, Jeannie T. Lee, John L. Rinn and James (Ben) BrownDate: March 15 - 20, 2015
Location: Keystone Resort, Keystone, CO, USA
It has become clear that metazoan genomes are replete with transcription from non-protein-coding regions, generating many long noncoding RNA (lncRNA) transcripts. Recent progress has enabled genome-wide mapping of lncRNAs and has unraveled unifying themes; lncRNAs function as epigenetic regulators, scaffolds, decoys, and enhancers. While these and other themes have been pursued in several meetings, the field has matured in numerous novel directions; the meeting leverages these to characterize lncRNAs comprehensively across metazoan genomes. The aim is to broaden our horizons with emerging data from humans and model systems, empowered by novel genomic technologies, including RNA-protein interaction mapping (CLIP- and RIP-seq), reverse genetics for lncRNAs not conserved in evolution (RNA sequencing in control and lncRNA-perturbed backgrounds), and proteogenomics to empirically bound the translational output of putative lncRNAomes. These topics have recently amassed diverse insights into RNA biology. The meeting should integrate novel findings, enhance previously proposed models of lncRNA function and generate new testable hypotheses. Synthesis of RNA structure, function, evolution and informatics will foster progress in this rapidly growing field.
Scholarship Deadline: November 18 2014
Discounted Abstract Deadline: November 18 2014
Abstract Deadline: December 16 2014
Discounted Registration Deadline: January 15 2015
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
Isis Pharmaceuticals, Inc.
RaNA Therapeutics Inc.
We gratefully acknowledge the generous grant for this conference provided by:National Human Genome Research Institute (NHGRI)
Grant No. 1R13HG008329-01
Funding for this conference was made possible (in part) by 1 R13 HG 008329 - 01 from the National Human Genome Research Institute (NHGRI) and the National Institute for Environmental Health Sciences (NIEHS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.