The Hippo Pathway: Signaling, Development and Disease
Organizer(s): Fernando D. Camargo, Kun-Liang Guan and Helen McNeillDate: May 17 - 21, 2015
Location: Sagebrush Inn & Suites, Taos, NM, USA
SIGNIFICANCE - The study of developmental signaling pathways has transformed our understanding of disease. The Hippo signaling pathway is a relatively novel signaling network that controls organ size, stem cell activity, and tumorigenesis. Therefore, the Hippo cascade and its components are attractive targets for the development of regenerative medicine and cancer drugs. The emerging paradigm in the field indicates that the Hippo pathway is a central sensor of multiple biological inputs, including cell adhesion, polarity, mechanical forces, and secreted ligands. These findings highlight the unique interdisciplinary nature of the field as the work from Drosophila geneticists, mammalian signalers, bioengineers, and developmental and cancer biologists needs to be integrated. These emerging paradoxes, the cancer and stem cell relevance of the pathway, and need for a larger forum to bring experts from multiple fields together prompted us to propose this meeting. The specific goals of this conference are to: 1) Identify and integrate evolutionary conserved inputs that control this cascade; 2) Define the transcriptional targets of the pathway that drive growth; 3) Understand the roles of Hippo in the physiology of multiple tissues; and 4) Define targets for chemical inhibitors and activators within pathway components. INNOVATION - This meeting follows on the 2013 Hippo Keystone meeting, which has been received with tremendous interest. This is the only conference specific to the Hippo field. The meeting will bring together Drosophila geneticists, basic and clinical cancer researchers, and the developmental and stem cell research community. It should consolidate the emerging field and have an impact on development of new cancer therapies.
Scholarship Deadline: January 20 2015
Discounted Abstract Deadline: January 20 2015
Abstract Deadline: February 19 2015
Discounted Registration Deadline: March 17 2015
We gratefully acknowledge additional support for this conference from:
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
We gratefully acknowledge the generous grant for this conference provided by:National Cancer Institute (NCI)
Grant No. 1R13CA196195-01
Funding for this conference was made possible (in part) by 1R13CA196195-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.