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Web Desc
Genomic Instability and DNA Repair
joint with DNA Replication and Recombination
Organizer(s): Daniel Durocher, Jiri Lukas and Agata Smogorzewska
Date: March 01 - 06, 2015
Location: Whistler Conference Centre, Whistler, BC, Canada
Sponsored by AstraZeneca, Editas Medicine, TESARO, Inc. and Vertex Pharmaceuticals Incorporated
Summary of Meeting:
Far from being a single process, genome maintenance involves the integration of multiple DNA damage repair and signaling pathways that are deeply influenced by cell cycle progression, chromatin composition, gene transcription, genome organization and the differentiation state of the cell. Preservation of genomic integrity is of paramount importance for cellular homeostasis, organismal development and tumor suppression. Accordingly, defects in the pathways that signal and repair DNA damage cause pathologies that include cancer, neurological disorders, premature aging and immunodeficiency. Our understanding of genome maintenance in the context of the multitude of intracellular transactions remains woefully incomplete and topic sessions addressing this issue will comprise a major theme of the conference. The program uniquely connects fields that otherwise rarely meet on a single occasion and will cover genome stability, development, disease, telomere biology and stem cell function. The meeting will highlight the latest trends including how genomic technologies have revolutionized our view of genome integrity and led to the discovery of new types of genome rearrangements whose mechanistic underpinnings remain largely unknown. The unusually broad scope of the conference will bring together scientists operating at the leading edge of multiple disciplines ranging from basic cell biology to pre-clinical oncology. Interactions between junior and seasoned investigators, as well as interdisciplinary contacts, will be fostered through poster presentations, workshops and plenary sessions, some of which are shared with the concurrent Keystone Symposia meeting on DNA Replication and Recombination, which will focus on the highly complementary theme of repair in the setting of DNA replication.
Scholarship Deadline: November 5 2014
Discounted Abstract Deadline: November 5 2014
Abstract Deadline: December 4 2014
Discounted Registration Deadline: January 7 2015
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZenecaEditas MedicineTESARO, Inc.Vertex Pharmaceuticals Incorporated
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA189354-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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