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Sunday, March 01 | 4:00PM - 8:00PM
Arrival and Registration
Room: Sea to Sky Foyer


Sunday, March 01 | 6:00PM - 8:00PM
Welcome Mixer
Room: Sea to Sky Foyer
No registration fees are used to fund alcohol served at this function.

Monday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Monday, March 02 | 7:30AM - 8:00AM
Poster Setup
Room: Sea to Sky A


Monday, March 02 | 8:00AM - 5:00PM
Poster Viewing
Room: Sea to Sky A


Monday, March 02 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 1 of 4
* Simon J. Boulton, Francis Crick Institute, UK

Monday, March 02 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 2 of 4
* Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada

Monday, March 02 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 3 of 4
Stephen P. Jackson, University of Cambridge, UK
Assembly and Disassembly of Protein Complexes at Sites of DNA Damage

Monday, March 02 | 8:00AM - 9:30AM
Keynote Session (Joint)
Room: Sea to Sky B/C

Speaker 4 of 4
John F.X. Diffley, Francis Crick Institute, UK
Right Place, Right Time: Eukaryotic DNA Replication Mechanism and Regulation

Monday, March 02 | 9:30AM - 10:00AM
Coffee Break
Room: Foyer


Monday, March 02 | 10:00AM - 12:15PM
Animal Models and Syndromes
Room: Sea to Sky C

Speaker 1 of 6
* André Nussenzweig, NCI, National Institutes of Health, USA

Monday, March 02 | 10:00AM - 12:15PM
Animal Models and Syndromes
Room: Sea to Sky C

Speaker 2 of 6
Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Regulation of Homologous Recombination in Vertebrates

Monday, March 02 | 10:00AM - 12:15PM
Animal Models and Syndromes
Room: Sea to Sky C

Speaker 3 of 6
Jos Jonkers, Netherlands Cancer Institute, Netherlands
BRCA1 Deficiency in Pre-Clinical Models

Monday, March 02 | 10:00AM - 12:15PM
Animal Models and Syndromes
Room: Sea to Sky C

Speaker 4 of 6
Agata Smogorzewska, Rockefeller University, USA
Molecular Genetics of Fanconi Anemia

Monday, March 02 | 10:00AM - 12:15PM
Animal Models and Syndromes
Room: Sea to Sky C

Speaker 5 of 6
Bing Xia, Rutgers Cancer Institute of New Jersey, USA
Functional and Mutational Landscape of BRCA1 for Homology-Directed Repair and Drug Resistance

Monday, March 02 | 10:00AM - 12:15PM
Animal Models and Syndromes
Room: Sea to Sky C

Speaker 6 of 6
Uri Tabori, Hospital for Sick Children, Canada
Short Talk: Combined Hereditary and Somatic Mutations of Replication Error Repair Result in Rapid Onset of Ultra Hypermutated Cancers

Monday, March 02 | 10:00AM - 12:15PM
Initiation and/or Helicase Activation
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 1 of 6
* Simon J. Boulton, Francis Crick Institute, UK


Monday, March 02 | 10:00AM - 12:15PM
Initiation and/or Helicase Activation
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 2 of 6
Stephen D. Bell, Indiana University, USA
Archaeal DNA Replication Initiator Proteins


Monday, March 02 | 10:00AM - 12:15PM
Initiation and/or Helicase Activation
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 3 of 6
Daniel Duzdevich, Columbia University, USA
Short Talk: The Dynamics of Eukaryotic Replication Initiation: Origin Specificity, Licensing and Firing at the Single-Molecule Level


Monday, March 02 | 10:00AM - 12:15PM
Initiation and/or Helicase Activation
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 4 of 6
Michael E. O'Donnell, Rockefeller University, USA
Architecture and Function of the Eukaryotic Replisome


Monday, March 02 | 10:00AM - 12:15PM
Initiation and/or Helicase Activation
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 5 of 6
James M. Berger, Johns Hopkins University School of Medicine, USA
Bending, Twisting, Popping: Protein and Nucleic-Acid Remodeling by ATP-Dependent Machines and Switches


Monday, March 02 | 10:00AM - 12:15PM
Initiation and/or Helicase Activation
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 6 of 6
Aline C. Simon, University of Cambridge, UK
Short Talk: Structure of Human Cdc45 and its Interactions within the CMG Helicase Complex


Monday, March 02 | 12:15PM - 1:15PM
Lunch
Room: Sea to Sky A


Monday, March 02 | 12:45PM - 3:15PM
Poster Session 1
Room: Sea to Sky A


Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 1 of 8
* Maria Jasin, Memorial Sloan Kettering Cancer Center, USA

Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 2 of 8
James K. Nuñez, University of California, San Francisco, USA
Integrase-Mediated Spacer Acquisition during CRISPR–Cas Adaptive Immunity

Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 3 of 8
Cecilia Cotta-Ramusino, Tessera Therapeutics, USA
Gene Targeting of the HBB Locus by Crispr/Cas9 to Investigate Repair Pathway Choice in Response to Different Types of DNA Lesions

Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 4 of 8
Jordan B. Pinder, Dalhousie University, Canada
Enhancing Efficiency of Cas9-Stimulated Homology-Directed Repair

Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 5 of 8
Megan van-Overbeek, Caribou Biosciences, Inc., USA
Methods to Enhance Homology-Directed Repair at CRISPR-Cas9 Induced Double-Strand Breaks

Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 6 of 8
Jeremy M. Stark, Beckman Research Institute of the City of Hope, USA
DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 7 of 8
Bernard S. Lopez, Institut Gustave Roussy, France
The Joining of Distal Double-Strand Breaks Favors Complex Alternative End-Joining Rearrangements; Impact of the Cohesin Complex on the Joining of Distant Double Strand Ends

Monday, March 02 | 3:15PM - 5:15PM
Workshop 1: DNA Repair and Genome Editing
Room: Sea to Sky C
The aim of this workshop is to cross-fertilize the fields of genome editing and DNA double-strand break repair. Indeed, genome editing harnesses the property of designer nucleases to generate breaks that are either mis-repaired (by canonical or alternative end-joining pathways) or that serve as substrate for homology-dependent repair. Conversely, genome editing nucleases can be used as tools to study the repair and response to DNA double-strand breaks. Furthermore, by their ability to label specific genomic loci, genome editing techniques enable dynamic imaging of repair processes directly in living cells with unprecedented spatial and temporal resolution. By fostering interaction between these two fields, we hope to improve the efficiency and applicability of genome editing applications based on a better understanding of DNA double-strand break repair.
Speaker 8 of 8
Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology, France
Double Strand Break Repair within Heterochromatin, Revealed with the CRISPR/Cas9 System

Monday, March 02 | 5:00PM - 5:30PM
Coffee Available
Room: Foyer


Monday, March 02 | 5:30PM - 7:30PM
Telomeres, Aging and Stem Cells
Room: Sea to Sky C

Speaker 1 of 5
* Agata Smogorzewska, Rockefeller University, USA

Monday, March 02 | 5:30PM - 7:30PM
Telomeres, Aging and Stem Cells
Room: Sea to Sky C

Speaker 2 of 5
Titia de Lange, Rockefeller University, USA
The LINC Complex Mediates 53BP1-Driven DSB Mobility and Non-Homologous End Joining

Monday, March 02 | 5:30PM - 7:30PM
Telomeres, Aging and Stem Cells
Room: Sea to Sky C

Speaker 3 of 5
Emmanuelle Passegué, Columbia University, USA
DNA Repair in Stem Cells

Monday, March 02 | 5:30PM - 7:30PM
Telomeres, Aging and Stem Cells
Room: Sea to Sky C

Speaker 4 of 5
Jan Karlseder, The Salk Institute for Biological Studies, USA
Cell Death during Crisis Is Mediated by Mitotic Telomere Deprotection

Monday, March 02 | 5:30PM - 7:30PM
Telomeres, Aging and Stem Cells
Room: Sea to Sky C

Speaker 5 of 5
Madalena Tarsounas, University of Oxford, UK
Short Talk: BRCA2 Prevents G-Quadruplex-Induced Replication Stress and Chromosomal Breakage

Monday, March 02 | 5:30PM - 7:30PM
Structural and Single-Molecule Analysis of Replication/Repai
r
This session is from DNA Repl & Recomb

Room: Sea to Sky B

Speaker 1 of 5
* Alessandro Costa, Francis Crick Institute, UK


Monday, March 02 | 5:30PM - 7:30PM
Structural and Single-Molecule Analysis of Replication/Repai
r
This session is from DNA Repl & Recomb

Room: Sea to Sky B

Speaker 2 of 5
Antoine M. van Oijen, University of Wollongong, Australia
Single-Molecule Studies of DNA Replication: The Plasticity of the Replisome


Monday, March 02 | 5:30PM - 7:30PM
Structural and Single-Molecule Analysis of Replication/Repai
r
This session is from DNA Repl & Recomb

Room: Sea to Sky B

Speaker 3 of 5
Thomas A. Steitz, Howard Hughes Medical Institute, Yale University, USA
The Macromolecular Replicating Machinery of Bacteria: Structural Insights into the Replisome


Monday, March 02 | 5:30PM - 7:30PM
Structural and Single-Molecule Analysis of Replication/Repai
r
This session is from DNA Repl & Recomb

Room: Sea to Sky B

Speaker 4 of 5
Franziska Bleichert, Johns Hopkins University School of Medicine, USA
Short Talk: Structural Investigations of the Eukaryotic Origin Recognition Complex


Monday, March 02 | 5:30PM - 7:30PM
Structural and Single-Molecule Analysis of Replication/Repai
r
This session is from DNA Repl & Recomb

Room: Sea to Sky B

Speaker 5 of 5
Stephen C. Kowalczykowski, University of California, Davis, USA
Visualizing Recombination and Replication on Single Molecules of DNA


Monday, March 02 | 7:00PM - 7:00PM
On Own for Dinner


Tuesday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 1 of 7
* John H.J. Petrini, Memorial Sloan-Kettering Cancer Center, USA

Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 2 of 7
John Rouse, University of Dundee, UK
Dissecting the Roles and Regulation of Nucleases Involved in ICL Repair

Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 3 of 7
Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Canada
Cell Cycle Regulation of DNA Double-Strand Break Repair

Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 4 of 7
Simon J. Boulton, Francis Crick Institute, UK
Rad51 Paralogs Remodel Pre-Synaptic Rad51 Filaments to Stimulate Homologous Recombination


Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 5 of 7
Stephen C. West, Francis Crick Institute, UK
Defective DNA Strand Break Repair and Links to Genome Instability and Cancer

Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 6 of 7
Kata Sarlós, University of Copenhagen, Denmark
Short Talk: In vitro Reconstitution of Anaphase Bridge Decatenation Pathways

Tuesday, March 03 | 8:00AM - 11:15AM
Recombination Repair (Joint)
Room: Sea to Sky B/C

Speaker 7 of 7
Ralph Scully, Beth Israel Deaconess Medical Center, USA
Short Talk: Recombination Control at Tus/Ter-Stalled Mammalian Replication Forks: The Good, the Bad and the Ugly

Tuesday, March 03 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, March 03 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Tuesday, March 03 | 11:00AM - 5:00PM
On Own for Lunch


Tuesday, March 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 1 of 9
* Alessandro Vindigni, St. Louis University, USA


Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 2 of 9
Jacques Côté, Laval University Cancer Research Center, Canada
Dynamic Acetylation of PCNA Sliding Surface Differentially Regulates Distinct DNA Polymerases to Promote Genome Stability


Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 3 of 9
Anne D. Donaldson, University of Aberdeen, UK
Replication-Coupled PCNA Unloading by the Elg1 Complex Requires Okazaki Fragment Ligation


Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 4 of 9
Bojk A. Berghuis, Delft University of Technology, Netherlands
Strand Separation Suffices to Establish a Long-Lived, Foolproof DNA-Protein Lock at the Tus-Ter Replication Fork Barrier


Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 5 of 9
Claus Storgaard Sørensen, University of Copenhagen, Denmark
A Novel Mechanism Linking CDC6 Protein Stability, DNA Replication and Genome Integrity


Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 6 of 9
Nynke H. Dekker, Delft University of Technology, Netherlands
Dynamics of Replisome Stoichiometry and Termination Studied at the Single Cell Level


Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 7 of 9
Daniel L. Kaplan, Florida State University College of Medicine, USA
The Dbf4-Cdc7 Kinase Promotes Mcm2-7 Ring Opening to Allow for Single-Stranded DNA Extrusion and Helicase Assembly


Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 8 of 9
Samual D. Dick, Cancer Research UK-London Research Institute, UK
Structural Basis for Activation of Cdc7 Kinase and its Substrate Recognition


Tuesday, March 03 | 2:30PM - 4:30PM
Workshop 1
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 9 of 9
Dirk Remus, Memorial Sloan-Kettering Cancer Center, USA
Mcm2-7 Double Hexamer Mobility Allows Redistribution of Replication Origins by Elongating RNA Polymerase


Tuesday, March 03 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, March 03 | 5:00PM - 7:00PM
Mitotic Progression and DNA Damage
Room: Sea to Sky C

Speaker 1 of 5
* Stephen J. Elledge, Harvard Medical School, USA

Tuesday, March 03 | 5:00PM - 7:00PM
Mitotic Progression and DNA Damage
Room: Sea to Sky C

Speaker 2 of 5
David Pellman, Dana-Farber Cancer Institute, USA
Chromothripsis and other Complex Chromosomal Rearrangements from an Error in Mitosis

Tuesday, March 03 | 5:00PM - 7:00PM
Mitotic Progression and DNA Damage
Room: Sea to Sky C

Speaker 3 of 5
Peter Campbell, Wellcome Trust Sanger Institute, UK
Interrogating the Architecture of Cancer Genomes

Tuesday, March 03 | 5:00PM - 7:00PM
Mitotic Progression and DNA Damage
Room: Sea to Sky C

Speaker 4 of 5
Jiri Lukas, Novo Nordisk Foundation Center for Protein Research, Denmark
Limits and Thresholds of Repair Pathway Choices during the Cell Cycle

Tuesday, March 03 | 5:00PM - 7:00PM
Mitotic Progression and DNA Damage
Room: Sea to Sky C

Speaker 5 of 5
A. John Callegari, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Mutagenic Translesion Polymerases Are Required to Replicate Damaged DNA after the G2/M Checkpoint

Tuesday, March 03 | 5:00PM - 7:00PM
Repair/Replication Interface
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 1 of 5
* Wolf-Dietrich Heyer, University of California, Davis, USA


Tuesday, March 03 | 5:00PM - 7:00PM
Repair/Replication Interface
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 2 of 5
Karlene A. Cimprich, Stanford University, USA
Mechanisms for the Maintenance of Genome Stability


Tuesday, March 03 | 5:00PM - 7:00PM
Repair/Replication Interface
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 3 of 5
Houra Merrikh, Vanderbilt University, USA
Direct Visualization of DNA Replication Conflicts in the Bacterial Cell


Tuesday, March 03 | 5:00PM - 7:00PM
Repair/Replication Interface
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 4 of 5
Jade Wang, University of Wisconsin-Madison, USA
Interplay between Transcription and Replication Machineries


Tuesday, March 03 | 5:00PM - 7:00PM
Repair/Replication Interface
This session is from DNA Repl & Recomb
Room: Sea to Sky B

Speaker 5 of 5
Francesca Storici, Georgia Institute of Technology, USA
Short Talk: Double-Strand Break Repair with Transcript RNA


Tuesday, March 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sea to Sky A
No registration fees are used to fund alcohol served at this function.

Tuesday, March 03 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky A


Wednesday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky A


Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 1 of 7
* Jiri Lukas, Novo Nordisk Foundation Center for Protein Research, Denmark

Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 2 of 7
Roger Greenberg, University of Pennsylvania, USA
Impact of DNA Damage Responses on Higher Order Chromatin Structure

Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 3 of 7
Anja Groth, University of Copenhagen, Denmark
Chromatin Replication and Epigenome Maintenance

Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 4 of 7
Iestyn Whitehouse, Memorial Sloan Kettering Cancer Center, USA
Chromatin Assembly and Lagging Strand Synthesis

Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 5 of 7
Michelle Debatisse, Institut Curie, France
Respective Roles of Replication and Transcription in Common Fragile Site Instability

Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 6 of 7
Caroline B. Strømme, Biotech Research and Innovation Centre, Denmark
Short Talk: MCM2 Mimics Nucleosomal DNA to Chaperone Canonical and Variant Histones H3-H4

Wednesday, March 04 | 8:00AM - 11:00AM
Interface between Chromatin and Genome Maintenance (Joint)
Room: Sea to Sky B/C

Speaker 7 of 7
Sophie E. Polo, Paris Diderot University, France
Short Talk: New Insights into Epigenome Maintenance in Response to DNA Damage by Real-Time Tracking of Histone Dynamics in Human Cells

Wednesday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, March 04 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky A


Wednesday, March 04 | 11:00AM - 2:30PM
On Own for Lunch


Wednesday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky A


Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
Room: Sea to Sky C

Speaker 1 of 9
* J. Ross Chapman, University of Oxford, UK

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
Room: Sea to Sky C

Speaker 2 of 9
Raphael Ceccaldi, Dana-Farber Cancer Institute, USA
Homologous Recombination (HR)-Deficient Tumors Are Hyper-Dependent on POLQ-Mediated Repair

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
Room: Sea to Sky C

Speaker 3 of 9
Pedro A. Mateos-Gomez, New York University, USA
Mammalian Polymerase Theta Promotes Alternative-NHEJ and Suppresses Recombination

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
Room: Sea to Sky C

Speaker 4 of 9
Saskia Hoffmann, University of Copenhagen, Denmark
TRAIP Is a new PCNA Ubiquitin Ligase in the DNA Damage Response

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
Room: Sea to Sky C

Speaker 5 of 9
Michael Huen, University of Hong Kong, Hong Kong
A PCNA Clamp Unloader at Stressed Replication Forks

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
Room: Sea to Sky C

Speaker 6 of 9
Kyle M. Miller, USA
Screen Identifies Role for Bromodomain Chromatin Reader Proteins in the DNA Damage Response

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
Room: Sea to Sky C

Speaker 7 of 9
Stephan Uphoff, University of Oxford, UK
Stochastic Activation of a DNA Damage Response by a Single Repair Event

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
Room: Sea to Sky C

Speaker 8 of 9
Laura W. Dillon, NHLBI, National Institutes of Health, USA
Extrachromosomal microDNAs in Vertebrate Tissues Arise from Areas with Active Chromatin Marks and High Exon Density by Mismatch Repair and Other Repair Pathways

Wednesday, March 04 | 2:30PM - 4:30PM
Workshop 2: Late-Breaking Research
Room: Sea to Sky C

Speaker 9 of 9
Markus Löbrich, Darmstadt University of Technology, Germany
Nek1 Phoshorylates Rad54 to Promote Homologous Recombination

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