Cytokine JAK-STAT Signaling in Immunity and Disease
Organizer(s): Curt M. Horvath, John J. O'Shea and Stephanie S. WatowichDate: January 10 - 14, 2016
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA
Cytokines are important extracellular factors that direct a variety of biological responses in normal physiology and disease. Cytokine signaling is mediated in large part through four Janus kinase (JAK) proteins and seven Signal Transducer and Activator of Transcription (STAT) proteins, and these molecules intersect with a wide array of additional intracellular signals to drive significant global alterations in gene expression. Cytokine JAK-STAT pathways are intimately associated with innate and adaptive immunity, inflammation, stem cell and developmental biology, and diverse aspects of cancer biology. As JAK-STAT pathways produce both common and unique phenotypes critical for a vast range of biological phenomena, the basic understanding of how these signal transduction cascades are regulated, function and integrate with additional cellular responses has been continuously refined by discoveries of general and pathway-specific mechanisms. Furthermore, drug discovery efforts have produced small molecules targeting JAKs and STATs that are promising agents in clinical treatment of inflammation, arthritis and a variety of cancers. This meeting, coinciding with the 25th year of the discovery of JAK-STAT signaling, will couple invited speakers who have made significant contributions to allied disciplines with cytokine JAK-STAT veterans, with ample opportunities for short talks selected from submitted abstracts.
Scholarship Deadline: September 21 2015
Discounted Abstract Deadline: September 21 2015
Abstract Deadline: October 20 2015
Discounted Registration Deadline: November 10 2015
We gratefully acknowledge the generous grant for this conference provided by:National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI120498-01
The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.