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Sunday, May 08 | 4:00PM - 8:00PM
Arrival and Registration
Room: Foyer


Sunday, May 08 | 6:00PM - 8:00PM
Welcome Mixer
Room: Foyer
No registration fees are used to fund alcohol served at this function.

Monday, May 09 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotels


Monday, May 09 | 8:00AM - 8:30AM
Poster Setup
Room: Saal 4/5


Monday, May 09 | 8:30AM - 7:00PM
Poster Viewing
Room: Saal 4/5


Monday, May 09 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Saal 4/5
Key Discoveries
Speaker 1 of 2
* Thomas Tuschl, HHMI/Rockefeller University, USA

Monday, May 09 | 8:30AM - 9:30AM
Welcome and Keynote Address
Room: Saal 4/5
Key Discoveries
Speaker 2 of 2
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
The cGAS Pathway of Cytosolic DNA Sensing and Its Role in Health and Diseases

Monday, May 09 | 9:30AM - 12:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System

Room: Saal 4/5

Speaker 1 of 4
Kensuke Miyake, Institute of Medical Science, University of Tokyo, Japan
RNA-Sensing and Trafficking of TLR7 in Plasmacytoid Dendritic Cells

Monday, May 09 | 9:30AM - 12:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System

Room: Saal 4/5

Speaker 2 of 4
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Regulation of Inflammation by Long Non-Coding RNAs

Monday, May 09 | 9:30AM - 12:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System

Room: Saal 4/5

Speaker 3 of 4
Petro Starokadomskyy, University of Texas Southwestern Medical Center, USA
Short Talk: DNA Polymerase-alpha Regulates Type I Interferon Activation through Cytosolic RNA:DNA Synthesis

Monday, May 09 | 9:30AM - 12:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System

Room: Saal 4/5

Speaker 4 of 4
Kachiko Hayashi, Yale University, USA
Short Talk: Toll-Like Receptor 9 Trafficking and Signaling for Type I Interferons Requires PIKfyve Activity

Monday, May 09 | 10:10AM - 10:30AM
Coffee Break
Room: Foyer


Monday, May 09 | 12:00PM - 12:45PM
Lunch
Room: Conference Ctr Restaurant


Monday, May 09 | 12:30PM - 2:30PM
Poster Session 1
Room: Saal 4/5


Monday, May 09 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, May 09 | 5:00PM - 7:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System II

Room: Saal 4/5

Speaker 1 of 4
* Veit Hornung, Ludwig-Maximilians-University Munich, Germany
Molecular Mechanisms of Nucleic Acid Pattern Recognition

Monday, May 09 | 5:00PM - 7:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System II

Room: Saal 4/5

Speaker 2 of 4
Timothy W. Behrens, Genentech, Inc., USA
Nucleic Acid Sensing and Interferon Signatures

Monday, May 09 | 5:00PM - 7:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System II

Room: Saal 4/5

Speaker 3 of 4
Russell E. Vance, University of California, Berkeley, USA
No Perfect PAMPs? Innate Immune Recognition of Nucleic Acids versus Proteins

Monday, May 09 | 5:00PM - 7:00PM
Sensing of Microbial and Viral RNA and DNA by the Innate Imm
une System II

Room: Saal 4/5

Speaker 4 of 4
Tan Nguyen, Walter and Eliza Hall Institute, Australia
Short Talk: Sidt2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

Monday, May 09 | 7:00PM - 7:00PM
On Own for Dinner


Tuesday, May 10 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotels


Tuesday, May 10 | 8:30AM - 11:45AM
Structural Biology of Innate Immune Sensing
Room: Saal 4/5

Speaker 1 of 6
* Karl-Peter Hopfner, Ludwig-Maximilians-University Munich, Germany
Integrated ATP Dependent Mechanism for RIG-I’s Distinction between Self and Non-Self RNA

Tuesday, May 10 | 8:30AM - 11:45AM
Structural Biology of Innate Immune Sensing
Room: Saal 4/5

Speaker 2 of 6
Sun Hur, Harvard Medical School, USA
Molecular Mechanism of RIG-I-Like Receptors

Tuesday, May 10 | 8:30AM - 11:45AM
Structural Biology of Innate Immune Sensing
Room: Saal 4/5

Speaker 3 of 6
Alexei Korennykh, Princeton University, USA
Innate Immune Signaling via RNA Cleavage

Tuesday, May 10 | 8:30AM - 11:45AM
Structural Biology of Innate Immune Sensing
Room: Saal 4/5

Speaker 4 of 6
Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Structural Elucidation of Inflammasome Activation and Regulation

Tuesday, May 10 | 8:30AM - 11:45AM
Structural Biology of Innate Immune Sensing
Room: Saal 4/5

Speaker 5 of 6
Pingwei Li, Texas A&M University, USA
Short Talk: The Structural Basis of IRF-3 Recruitment, Activation, and Targeting in Innate Immunity

Tuesday, May 10 | 8:30AM - 11:45AM
Structural Biology of Innate Immune Sensing
Room: Saal 4/5

Speaker 6 of 6
Philip J. Kranzusch, University of California, Berkeley, USA
Short Talk: Ancient cGAS-STING Pathways Reveal Evolution of Human Innate Immunity

Tuesday, May 10 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Tuesday, May 10 | 11:45AM - 3:00PM
On Own for Lunch


Tuesday, May 10 | 11:45AM - 1:00PM
Poster Setup
Room: Saal 4/5


Tuesday, May 10 | 1:00PM - 8:30PM
Poster Viewing
Room: Saal 4/5


Tuesday, May 10 | 3:00PM - 3:30PM
Coffee Available
Room: Foyer


Tuesday, May 10 | 3:30PM - 5:30PM
Virology and Innate Inflammatory Responses
Room: Saal 4/5

Speaker 1 of 5
Jae U. Jung, Keck School of Medicine of University of Southern California, USA
Host Nucleic Acid Sensing and Viral Evasion

Tuesday, May 10 | 3:30PM - 5:30PM
Virology and Innate Inflammatory Responses
Room: Saal 4/5

Speaker 2 of 5
Ian Thomas Lamborn, NIAID, National Institutes of Health, USA
Short Talk: Human MDA5 Protects Against Severe Respiratory Infections

Tuesday, May 10 | 3:30PM - 5:30PM
Virology and Innate Inflammatory Responses
Room: Saal 4/5

Speaker 3 of 5
* Nicolas Manel, Institut Curie, France
Sensing Mechanisms of Viral Infection

Tuesday, May 10 | 3:30PM - 5:30PM
Virology and Innate Inflammatory Responses
Room: Saal 4/5

Speaker 4 of 5
Fanxiu Zhu, Florida State University, USA
Short Talk: KicGAS, KSHV Inhibitor of cGAS

Tuesday, May 10 | 3:30PM - 5:30PM
Virology and Innate Inflammatory Responses
Room: Saal 4/5

Speaker 5 of 5
Kareen Bartsch, Christian-Albrechts-University, Germany
Short Talk: RNaseH2 Deficiency Leads to Cytosolic Accumulation of Immunostimulatory DNA that is Removed by Autophagy

Tuesday, May 10 | 5:30PM - 6:30PM
Social Hour with Lite Bites
Room: Conference Ctr Restaurant
No registration fees are used to fund alcohol served at this function.

Tuesday, May 10 | 6:00PM - 8:30PM
Poster Session 2
Room: Saal 4/5


Wednesday, May 11 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotels


Wednesday, May 11 | 7:30AM - 8:00AM
Poster Setup
Room: Saal 4/5


Wednesday, May 11 | 8:00AM - 5:00PM
Poster Viewing
Room: Saal 4/5


Wednesday, May 11 | 8:30AM - 11:30AM
Nucleic Acid Chemistry and Biology in Stress and Innate Immu
ne Response

Room: Saal 4/5

Speaker 1 of 5
Thomas Tuschl, HHMI/Rockefeller University, USA
Intra- and Extracellular Diagnostic RNAseq Approaches and Their Use in Inflammatory Diseases

Wednesday, May 11 | 8:30AM - 11:30AM
Nucleic Acid Chemistry and Biology in Stress and Innate Immu
ne Response

Room: Saal 4/5

Speaker 2 of 5
Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Structure and Function of Innate Immune Sensors and Adaptors

Wednesday, May 11 | 8:30AM - 11:30AM
Nucleic Acid Chemistry and Biology in Stress and Innate Immu
ne Response

Room: Saal 4/5

Speaker 3 of 5
Charles E. Samuel, University of California, Santa Barbara, USA
Roles of A-to-I RNA Editing by Adenosine Deaminase ADAR1 in Innate Immunity RNA Sensing

Wednesday, May 11 | 8:30AM - 11:30AM
Nucleic Acid Chemistry and Biology in Stress and Innate Immu
ne Response

Room: Saal 4/5

Speaker 4 of 5
* Andreas Pichlmair, Max-Planck Institute of Biochemistry, Germany
Defects in mRNA Maturation and Localization

Wednesday, May 11 | 8:30AM - 11:30AM
Nucleic Acid Chemistry and Biology in Stress and Innate Immu
ne Response

Room: Saal 4/5

Speaker 5 of 5
Swapnil Devarkar, Rutgers University, USA
Short Talk: Structural and Mechanistic Basis for Self Versus Non-self RNA Discrimination by the Innate Immune Receptor RIG-I

Wednesday, May 11 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Wednesday, May 11 | 11:30AM - 12:30PM
Lunch
Room: Conference Ctr Restaurant


Wednesday, May 11 | 12:00PM - 2:30PM
Poster Session 3
Room: Saal 4/5


Wednesday, May 11 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, May 11 | 5:00PM - 7:00PM
Nucleic Acid Drug Developments and Strategies to Suppress In
nate Immunity Responses

Room: Saal 4/5

Speaker 1 of 4
Gunther Hartmann, Universitätsklinikum Bonn, Germany
Targeting RIG-I for the Immunotherapy of Cancer

Wednesday, May 11 | 5:00PM - 7:00PM
Nucleic Acid Drug Developments and Strategies to Suppress In
nate Immunity Responses

Room: Saal 4/5

Speaker 2 of 4
Thomas W. Dubensky, Jr., Tempest Therapeutics, USA
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

Wednesday, May 11 | 5:00PM - 7:00PM
Nucleic Acid Drug Developments and Strategies to Suppress In
nate Immunity Responses

Room: Saal 4/5

Speaker 3 of 4
* Regina Heidenreich, CureVac GmbH, Germany
mRNA Vaccination for the Immunotherapy of Infectious Diseases and Cancer

Wednesday, May 11 | 5:00PM - 7:00PM
Nucleic Acid Drug Developments and Strategies to Suppress In
nate Immunity Responses

Room: Saal 4/5

Speaker 4 of 4
Manuel Ascano, Jr., Vanderbilt University, USA
Short Talk: Towards the Small Molecule Modulation of Cyclic GMP-AMP Synthase Activity

Wednesday, May 11 | 7:00PM - 7:00PM
On Own for Dinner


Thursday, May 12 | 7:30AM - 8:30AM
Breakfast
Room: Individual Hotels


Thursday, May 12 | 8:30AM - 11:30AM
Inborn Genetic Defects in Nucleic Acid Sensing I
Room: Saal 4/5

Speaker 1 of 5
Raphaela Theresia Goldbach-Mansky, NIAID, National Institutes of Health, USA
Activated STING in a Vascular and Pulmonary Syndrome (SAVI) and Treatment Strategies Reducing Interferon Signaling

Thursday, May 12 | 8:30AM - 11:30AM
Inborn Genetic Defects in Nucleic Acid Sensing I
Room: Saal 4/5

Speaker 2 of 5
Yanick Crow, University of Edinburgh, UK
Human Type I Interferonopathies

Thursday, May 12 | 8:30AM - 11:30AM
Inborn Genetic Defects in Nucleic Acid Sensing I
Room: Saal 4/5

Speaker 3 of 5
Min Ae Lee-Kirsch, Technische Universität Dresden, Germany
Human Genetic Alterations Contributing to Systemic Lupus Erythematosus

Thursday, May 12 | 8:30AM - 11:30AM
Inborn Genetic Defects in Nucleic Acid Sensing I
Room: Saal 4/5

Speaker 4 of 5
* Virginia Pascual, Cornell University, USA
Novel Insights into the Role of Innate Immunity in Human SLE

Thursday, May 12 | 8:30AM - 11:30AM
Inborn Genetic Defects in Nucleic Acid Sensing I
Room: Saal 4/5

Speaker 5 of 5
Rayk Behrendt, Faculty of Medicine Carl Gustav Carus TU Dresden, Germany
Short Talk: SAMHD1-Deficiency causes Simultaneous Stimulation of the RLR and cGAS-STING Pathways

Thursday, May 12 | 9:50AM - 10:10AM
Coffee Break
Room: Foyer


Thursday, May 12 | 11:30AM - 5:00PM
On Own for Lunch


Thursday, May 12 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, May 12 | 5:00PM - 6:45PM
Inborn Genetic Defects in Nucleic Acid Sensing II
Room: Saal 4/5

Speaker 1 of 3
Gerald S. Shadel, The Salk Institute for Biological Studies, USA
Mitochondrial DNA Stress in Innate Immune Signalling and Cancer

Thursday, May 12 | 5:00PM - 6:45PM
Inborn Genetic Defects in Nucleic Acid Sensing II
Room: Saal 4/5

Speaker 2 of 3
Daniel B. Stetson, University of Washington, USA
Nucleic Acid Detection in Autoimmunity

Thursday, May 12 | 5:00PM - 6:45PM
Inborn Genetic Defects in Nucleic Acid Sensing II
Room: Saal 4/5

Speaker 3 of 3
* Andrew Jackson, University of Edinburgh, UK
RNase H2 mutations Lead to Defective Ribonucleotide Excision Repair and cGAS/STING-Dependent Innate Immune Activation

Thursday, May 12 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Saal 4/5


Thursday, May 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Saal 3
No registration fees are used to fund alcohol served at this function.

Thursday, May 12 | 8:00PM - 11:00PM
Entertainment
Room: Saal 3
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Thursday, May 12 | 8:00PM - 11:00PM
Cash Bar
Room: Saal 3


Friday, May 13 | 10:25AM - 10:25AM
Departure


*Session Chair.

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