Nuclear Receptors: Full Throttle
joint with Metabolism, Transcription and Disease
Organizer(s): Carol A. Lange, Jennifer K. Richer and Karen E. KnudsenDate: January 10 - 14, 2016
Location: Snowbird Resort, Snowbird, UT, USA
Nuclear receptors (NRs) represent a large superfamily of ligand-dependent transcription factor “sensors” for a diverse set of fat-soluble hormones, vitamins and dietary lipids. NRs orchestrate genetic response programs critical for normal homeostasis, and are required for reproduction, development, metabolism and immune function. For this reason, NRs have been investigated for over 30 years as promising targets for drugs to treat a broad spectrum of diseases including cancer, diabetes and other endocrine or metabolic disorders, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. Research on NRs has led to numerous successful therapies for deadly diseases that have improved both longevity and quality of life. However, significant hurdles remain that involve further detailed understanding of the major gene regulatory networks regulated by NRs, how these differ in normal relative to pre-disease and disease states, and the complex problems associated with targeting tissue-specific effects (to reduce side effects) and circumventing mechanisms of resistance. Thus, further insight into the full range of NR functions and interactions with co-regulatory molecules and signaling pathways is necessary for combinatorial approaches involving NRs in health and disease, and development of next-generation therapies. This meeting on “Nuclear Receptors: Full Throttle” continues the Keystone Symposia tradition of bringing together a diverse array of our leading scientists, including senior and junior investigators and their trainees, from academic, clinical and pharmaceutical settings, to showcase the latest science, highlight the use of innovative and emerging technologies, explore new directions, and develop collaborative and synergistic efforts in the exciting field of NR biology.
Scholarship Deadline: September 23 2015
Discounted Abstract Deadline: September 23 2015
Abstract Deadline: October 22 2015
Discounted Registration Deadline: November 12 2015
We gratefully acknowledge the generous grant for this conference provided by:National Cancer Institute (NCI)
Grant No. 1R13CA200226-01
Funding for this conference was made possible (in part) by 1R13CA200226-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.