Integrating Metabolism and Immunity

joint with Cell Death and Inflammation

Organizer(s): Hongbo Chi, Erika L. Pearce, Richard A. Flavell and Luke A.J. O'Neill

Organized in Collaboration with Science Foundation Ireland
Sponsored by AbbVie Inc., MSD, Novo Nordisk A/S and Pfizer Inc.

Summary of Meeting:

The coordination of metabolic programs with immune cell fate is a fundamental event in immunity. Immune cells are known for their ability to rapidly transition from resting to activated states in response to external stimuli. Typically, their activation is accompanied by increased expression of large panels of immune effector molecules, and in the case of lymphocytes, is also accompanied by extensive and rapid cellular proliferation. Recent studies have revealed the fundamental importance of metabolic reprogramming, including dynamic regulation of aerobic glycolysis (the Warburg effect), lipid synthesis and degradation, and mitochondrial activity, in immune cell activation and differentiation and the outcome of immune responses. This process depends upon the interplay between the metabolic machinery and immune signaling and transcriptional pathways, and is further shaped by the availability of metabolic substrates and nutrients within the cells and in the microenvironment, including those produced by microbiota. The critical link between metabolism and immunity is indicated by findings that aberrant immune cell metabolism not only affects inflammatory responses and adaptive immunity, but also contributes to metabolic disorders. The goal of this Keystone Symposia meeting is to bring together leading investigators working on metabolism (organismal, cellular, and microbial metabolism) and immunobiology. Additional opportunities for interdisciplinary interactions will be provided by the discussion on central metabolism and the contribution of key metabolic substrates by the microbiota. The latest discoveries will be discussed in the context of basic biology and how it can be exploited to design new therapeutics targeting inflammatory and metabolic disorders.

Scholarship Deadline: January 31 2017

Discounted Abstract Deadline: January 31 2017

Abstract Deadline: March 1 2017

Discounted Registration Deadline: March 29 2017

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

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We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI131607-01
Funding for this conference was made possible (in part) by AI131607-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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