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Web Desc
Genomic Instability and DNA Repair
joint with DNA Replication and Recombination
Organizer(s): Julia Promisel Cooper, Marco F. Foiani and Geneviève Almouzni
Date: April 02 - 06, 2017
Location: Santa Fe Community Convention Center, Santa Fe, NM, USA
Sponsored by AstraZeneca, Bayer HealthCare Pharmaceuticals, Editas Medicine, Inc., EMD Serono Research and Development Institute, Inc., Journal of Molecular Cell Biology (JMCB) and TESARO, Inc.
Summary of Meeting:
Genome stability is the foundation upon which all cellular and organismal processes depend. This conference will grapple with the intricate array of biochemical reactions orchestrated by the cell to replicate, repair and segregate chromosomes accurately despite constant threats from spontaneous and environmentally-induced damage. Defects in these reactions lead to genomic instability, a confirmed driver of cancer and degenerative diseases. Fascinating and therapeutically crucial questions remain about the mechanisms underlying chromosome stability, and cross-disciplinary approaches are required to address them. How do epigenetic chromatin marks influence repair of underlying DNA sequences, and how can we predict the effects of chemotherapeutic agents that alter such marks? To what extent is the nucleus organized into subdomains with distinct functions; how are these subdomains altered when cells move or differentiate? How are the myriad helicases, nucleases and polymerases coordinated to safeguard genome stability, why are these molecules often mutated in human disease, and how can we ameliorate the effects of such mutations? What is the array of strategies available to cancer cells as they achieve unlimited proliferation? This conference has a history of bringing together investigators from diverse subfields who otherwise rarely meet. Cutting-edge concepts in translational, genomic, cellular, molecular, RNA and structural biology will be dissected to take the conversation to unprecedented levels of depth and breadth. The concurrent conference on “DNA Replication and Recombination” will provide additional opportunities for cross-talk. Both conferences are committed to nurturing interactions among longtime experts in the field with students, postdocs and investigators new to the field.
Scholarship Deadline: December 5 2016
Discounted Abstract Deadline: December 5 2016
Abstract Deadline: January 12 2017
Discounted Registration Deadline: February 2 2017
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
AstraZenecaBayer HealthCare PharmaceuticalsEditas Medicine, Inc.EMD Serono Research and Development Institute, Inc.Journal of Molecular Cell Biology (JMCB)TESARO, Inc.
We gratefully acknowledge additional support for this conference from:
Bethyl Laboratories, Inc.Genomic VisionIntegrated DNA TechnologiesMarch of Dimes Foundation, Grant No. 4-FY16-317
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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