Natural Products and Synthetic Biology: Parts and Pathways Organizer(s): Jon Clardy, Yi Tang and Sean F. Brady Date: January 21 - 24, 2018
Location: Resort at Squaw Creek, Olympic Valley, CA, USANatural products, the structurally diverse family of small molecules produced by living organisms in an idiosyncratic fashion, have provided the basis for the majority of our therapeutic agents used to treat infectious diseases, cancer and immune disorders. Whole genome sequencing of producing organisms, especially bacteria and fungi, reveals that we have discovered only a fraction of these biosynthetically derived small molecules; a substantial fraction of natural product chemical space still represents “dark matter” (i.e., molecules predicted by bioinformatics analysis that have yet to be observed experimentally). Diversity springs from variations in genetically encoded biosynthetic enzymes, environmental stimuli that regulate expression of these genes and the inherent combinatorial expansion resulting from multi-enzyme biosynthetic pathways. Closing this gap between our current inventory and the genomic potential has become an important goal for basic and applied science; synthetic biology coupled with bioinformatic analysis has become the primary research tool for this effort. Bioinformatic mining continues to reveal the enzymes and pathways that nature uses, and synthetic biology has begun to reassemble or refactor these pathways to produce known and unknown products in new hosts. This conference brings together researchers in fields ranging from microbiology to botany, bioinformatics, gene synthesis and assembly, covering the spectrum from basic to industrial applications. Scholarship Deadline: September 25 2017 Discounted Abstract Deadline: September 25 2017 Abstract Deadline: October 23 2017 Discounted Registration Deadline: November 21 2017 We gratefully acknowledge additional support for this conference from:  We gratefully acknowledge the generous grant for this conference provided by: National Center for Complementary and Integrative Health (NCCIH)Grant No. 1 R13 AT009821-01 Funding for this conference was made possible (in part) by 1 R13 AT009821-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. |