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Web Desc
Genome Engineering: From Mechanisms to Therapies
Organizer(s): Andrew May, Rodolphe Barrangou and Knut Woltjen
Date: February 19 - 23, 2019
Location: Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Sponsored by BlueRock Therapeutics, Editas Medicine, Thermo Fisher Scientific Inc. and Vertex Pharmaceuticals Incorporated
Summary of Meeting:
The use of programmable nucleases such as CRISPR-Cas systems, ZFNs and TALENs has revolutionized cell biology by providing the ability to manipulate specific genetic and epigenetic states within living cells. These systems have been broadly applied as tools in research settings and increasingly are being developed to create improved models of disease and engineer cells for therapeutic purposes. Together with other DNA modifying systems such as recombinases, integrases and transposases, it is now possible to introduce mutations that will model human disease, build complex synthetic signaling networks to perform regulated functions and design cells to target specific disease states. Improvements to the methods involved requires understanding enzyme structures and mechanisms and how they intersect with cellular DNA repair systems. The intersection of this basic science with engineering approaches and improved cellular models is revolutionizing our understanding and treatment of human disease. The goal of this Keystone Symposium is to bring together people developing and studying genome engineering tools with groups who are applying them to build new disease models, identify disease mechanisms and drug targets, and develop cell-based therapeutics and genetic medicines. In addition to covering engineering of human and animal cells, this meeting will also highlight the emerging field of genome engineering to identify new anti-microbial and anti-viral drugs and applications towards next generation antibiotics. Invited talks will explore a broad range of topics covering new technologies, fundamental basic research, through the development of screening approaches, stem cell-based models of disease and design and development of cellular therapeutics.
Scholarship Deadline: October 23 2018
Discounted Abstract Deadline: October 23 2018
Abstract Deadline: November 20 2018
Discounted Registration Deadline: December 19 2018
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
BlueRock TherapeuticsEditas MedicineThermo Fisher Scientific Inc.Vertex Pharmaceuticals Incorporated
We gratefully acknowledge additional support from these exhibitors at this conference:
Agilent Technologies, Inc.BEX CO., LTD.Horizon DiscoveryMilliporeSigmaSynthego
We gratefully acknowledge additional support for this conference from:
AddgeneAmerican Society of Gene & Cell Therapy (ASGCT)Integrated DNA Technologies
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

bluebird bio
$10,000 - $24,999
Mary Ann Liebert, Inc. Publishers
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
CRISPR Journal, published by Mary Ann Liebert, Inc. publishers
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

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