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Web Desc
Cellular Plasticity: Reprogramming, Regeneration and Metaplasia
joint with Signal Dynamics and Signal Integration in Development and Disease
Organizer(s): Jason C. Mills, Maike Sander and Ben Z. Stanger
Date: January 27 - 31, 2019
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Novartis Institutes for BioMedical Research
Summary of Meeting:
Traditionally, differentiated cells were thought to be post-mitotic. However, now we know mature cells in diverse tissues can reprogram, re-enter the cell cycle, and spawn other lineages (e.g., they revert back to stem cells or adopt other identities). The scientific and health implications are substantial. For one, cellular plasticity might be harnessed to regenerate damaged tissue (e.g., insulin-secreting cells, liver, gut), but repeated reprogramming events – as cells respond to inflammation/injury – can also cause tissue derangement (metaplasia) that predisposes to cancer. Furthermore, cancer cells can harness such plasticity mechanisms to subvert therapy. Thus, defining the mechanisms that allow mature cells to switch identities holds great promise for understanding disease pathogenesis and developing new therapies. This conference gathers the diverse, dynamic field of plasticity/reprogramming together for the first time with the aim of understanding if similar mechanisms underlie plasticity in diverse organs and organisms. The hypothesis is that cellular reprogramming occurs via evolutionarily conserved cellular processes as fundamental to a multicellular organism as apoptosis. Specifically, the conference aims to: 1) Elucidate mechanisms of plasticity in diverse adult tissues; 2) Explore plasticity’s evolutionary context; 3) Elucidate its role in metaplasia/cancer; and 4) Investigate how it can be harnessed therapeutically.
Scholarship Deadline: October 17 2018
Discounted Abstract Deadline: October 17 2018
Abstract Deadline: October 25 2018
Discounted Registration Deadline: November 28 2018
Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:
Novartis Institutes for BioMedical Research
We gratefully acknowledge additional support from these exhibitors at this conference:
10x Genomics
We gratefully acknowledge additional support for this conference from:
Integra Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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