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Sunday, January 20 | 4:00PM - 8:00PM
Arrival and Registration
Room: Pacific Ballroom Foyer


Sunday, January 20 | 6:00PM - 8:00PM
Welcome Mixer
Room: Pacific Ballroom Foyer
No registration fees are used to fund alcohol served at this function.

Monday, January 21 | 7:30AM - 8:30AM
Breakfast
Room: Vancouver Island/Waddington


Monday, January 21 | 8:30AM - 10:00AM
Welcome and Keynote Session
Room: Pacific Ballroom

Speaker 1 of 6
* Lélia Delamarre, Genentech, Inc., USA

Monday, January 21 | 8:30AM - 10:00AM
Welcome and Keynote Session
Room: Pacific Ballroom

Speaker 2 of 6
* Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA

Monday, January 21 | 8:30AM - 10:00AM
Welcome and Keynote Session
Room: Pacific Ballroom

Speaker 3 of 6
* Robert A. Seder, NIAID, National Institutes of Health, USA

Monday, January 21 | 8:30AM - 10:00AM
Welcome and Keynote Session
Room: Pacific Ballroom

Speaker 4 of 6
Glenn Dranoff, Novartis Institutes for BioMedical Research, USA
Cancer Vaccines: Overview

Monday, January 21 | 8:30AM - 10:00AM
Welcome and Keynote Session
Room: Pacific Ballroom

Speaker 5 of 6
Ira Mellman, Genentech, Inc., USA
The Mechanistic Basis of Cancer Immunotherapy

Monday, January 21 | 8:30AM - 10:00AM
Welcome and Keynote Session
Room: Pacific Ballroom


Coffee Break

Monday, January 21 | 10:20AM - 12:30PM
Identification of Mutated Neoantigens
Room: Pacific Ballroom

Speaker 1 of 6
* Glenn Dranoff, Novartis Institutes for BioMedical Research, USA

Monday, January 21 | 10:20AM - 12:30PM
Identification of Mutated Neoantigens
Room: Pacific Ballroom

Speaker 2 of 6
Timothy A. Chan, Memorial Sloan Kettering Cancer Center, USA
Mutations and Neoantigens in Cancer Immunotherapy

Monday, January 21 | 10:20AM - 12:30PM
Identification of Mutated Neoantigens
Room: Pacific Ballroom

Speaker 3 of 6
Karin U. Jooss, Gritstone Oncology, USA
Driving CD8+ T Cell Responses to Mutational Neoantigens in Tumors - Harnessing Immunogenic Viral Vectors

Monday, January 21 | 10:20AM - 12:30PM
Identification of Mutated Neoantigens
Room: Pacific Ballroom

Speaker 4 of 6
Lélia Delamarre, Genentech, Inc., USA
Determinants of Cancer Neoantigen Immunogenicity

Monday, January 21 | 10:20AM - 12:30PM
Identification of Mutated Neoantigens
Room: Pacific Ballroom

Speaker 5 of 6
Binbin Chen, Stanford Medical School, USA
Short Talk: MARIA: Deep Neural Network Predicting HLA Class II Antigen Presentation for Personalized Cancer Vaccines

Monday, January 21 | 10:20AM - 12:30PM
Identification of Mutated Neoantigens
Room: Pacific Ballroom

Speaker 6 of 6
Lisa McNeil, Genocea Biosciences, USA
Short Talk: ATLAS™ Identifies Stimulatory and Inhibitory Neoantigens with Opposing Effects in a Murine Challenge Model

Monday, January 21 | 12:30PM - 5:00PM
On Own for Lunch


Monday, January 21 | 12:30PM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Monday, January 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Monday, January 21 | 2:30PM - 4:30PM
Workshop 1: Cancer Antigens and Immune Monitoring
Room: Pacific Ballroom

Speaker 1 of 6
Samuel J. Landry, Tulane University Health Sciences Center, USA
CD4+ Epitope Prediction Limited by Analysis of Antigen Conformational Flexibility

Monday, January 21 | 2:30PM - 4:30PM
Workshop 1: Cancer Antigens and Immune Monitoring
Room: Pacific Ballroom

Speaker 2 of 6
* Aude-Helene Capietto, Genentech, Inc., USA
Characterization of the Immunogenic Determinants of Tumor Neoantigens Improves their Identification

Monday, January 21 | 2:30PM - 4:30PM
Workshop 1: Cancer Antigens and Immune Monitoring
Room: Pacific Ballroom

Speaker 3 of 6
Cansu Cimen Bozkus, Icahn School of Medicine at Mount Sinai, USA
Immune Checkpoint Blockade Enhances Mutated Calreticulin-Induced T Cell Immunity in Myeloproliferative Neoplasms

Monday, January 21 | 2:30PM - 4:30PM
Workshop 1: Cancer Antigens and Immune Monitoring
Room: Pacific Ballroom

Speaker 4 of 6
Russell Kent Pachynski, Washington University in St. Louis, USA
A Pilot Trial of Neoantigen DNA Vaccine in Combination with Nivolumab/Ipilimumab and Prostvac in Metastatic Hormone-Sensitive Prostate Cancer

Monday, January 21 | 2:30PM - 4:30PM
Workshop 1: Cancer Antigens and Immune Monitoring
Room: Pacific Ballroom

Speaker 5 of 6
Brandon Coder, Advaxis, USA
Neoantigen Prioritization for Use in a Listeria Monocytogenes Cancer Vaccine

Monday, January 21 | 2:30PM - 4:30PM
Workshop 1: Cancer Antigens and Immune Monitoring
Room: Pacific Ballroom

Speaker 6 of 6
Ghislain Bonamy, immunoSCAPE, Singapore
Leveraging the Multi-Parametric Profiling Capacity of Mass Cytometry to Query the Specificity of Tumor-Infiltrating T-Cells

Monday, January 21 | 4:30PM - 5:00PM
Coffee Available
Room: Pacific Ballroom Foyer


Monday, January 21 | 5:00PM - 7:00PM
Other Cancer Antigens
Room: Pacific Ballroom

Speaker 1 of 5
* Lélia Delamarre, Genentech, Inc., USA

Monday, January 21 | 5:00PM - 7:00PM
Other Cancer Antigens
Room: Pacific Ballroom

Speaker 2 of 5
Stephen B. Baylin, Johns Hopkins University School of Medicine, USA
Immunogenicity of Transposable Elements in Cancer – Relevance to Epigenetic Therapy

Monday, January 21 | 5:00PM - 7:00PM
Other Cancer Antigens
Room: Pacific Ballroom

Speaker 3 of 5
Victor H. Engelhard, University of Virginia, USA
Post-Translationally Modified Cancer Neoantigens

Monday, January 21 | 5:00PM - 7:00PM
Other Cancer Antigens
Room: Pacific Ballroom

Speaker 4 of 5
Cornelia Liu Trimble, Johns Hopkins University School of Medicine, USA
Targeting HPV Antigens by Vaccination

Monday, January 21 | 5:00PM - 7:00PM
Other Cancer Antigens
Room: Pacific Ballroom

Speaker 5 of 5
Haiyin Chen, Genentech, Inc., USA
Short Talk: Transposable Element Expression in Tumors Is Associated with Immune Infiltrate and Increased Antigenicity

Monday, January 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Vancouver Island/Waddington
No registration fees are used to fund alcohol served at this function.

Monday, January 21 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Tuesday, January 22 | 7:30AM - 8:30AM
Breakfast
Room: Vancouver Island/Waddington


Tuesday, January 22 | 8:00AM - 8:30AM
Poster Setup
Room: Pacific Ballroom


Tuesday, January 22 | 8:30AM - 5:00PM
Poster Viewing
Room: Pacific Ballroom


Tuesday, January 22 | 8:30AM - 11:30AM
Priming T Cells
Room: Pacific Ballroom

Speaker 1 of 8
* Sebastian Amigorena, Institut Curie, France

Tuesday, January 22 | 8:30AM - 11:30AM
Priming T Cells
Room: Pacific Ballroom

Speaker 2 of 8
Rafi Ahmed, Emory University School of Medicine, USA
T Cell Exhaustion and PD-1 Immunotherapy

Tuesday, January 22 | 8:30AM - 11:30AM
Priming T Cells
Room: Pacific Ballroom

Speaker 3 of 8
E. John Wherry, University of Pennsylvania, USA
The Developmental Program of Exhausted T Cells

Tuesday, January 22 | 8:30AM - 11:30AM
Priming T Cells
Room: Pacific Ballroom


Coffee Break

Tuesday, January 22 | 8:30AM - 11:30AM
Priming T Cells
Room: Pacific Ballroom

Speaker 5 of 8
Pedro Romero, University of Lausanne, Switzerland
Programming T Cell Memory for Immunotherapy of Cancer

Tuesday, January 22 | 8:30AM - 11:30AM
Priming T Cells
Room: Pacific Ballroom

Speaker 6 of 8
David B. Masopust, University of Minnesota, USA
Repurposing Antiviral T Cells to Fight Tumors

Tuesday, January 22 | 8:30AM - 11:30AM
Priming T Cells
Room: Pacific Ballroom

Speaker 7 of 8
John P. Finnigan, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Molecular and Cellular Properties of Neoantigen-Specific CD8+ T Cells Interacting with Melanoma in situ

Tuesday, January 22 | 8:30AM - 11:30AM
Priming T Cells
Room: Pacific Ballroom

Speaker 8 of 8
Jared Klarquist, University of Colorado Denver, USA
Short Talk: Vaccine-Elicited T Cells Expand and Function Independently of Aerobic Glycolysis: Implications for Therapeutic Cancer Vaccines

Tuesday, January 22 | 11:30AM - 12:30PM
Lunch
Room: Vancouver Island/Waddington


Tuesday, January 22 | 12:00PM - 2:30PM
Poster Session 2
Room: Pacific Ballroom


Tuesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Vaccine Platforms
Room: Pacific Ballroom

Speaker 1 of 8
* Karin Loré, Karolinska Institutet, Sweden

Tuesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Vaccine Platforms
Room: Pacific Ballroom

Speaker 2 of 8
Jaehak Oh, Genentech, Inc., USA
RNA-Lipoplex Vaccine Is Presented on MHCI and MHCII Molecules of Differential Dendritic Cell Subsets in Spleen

Tuesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Vaccine Platforms
Room: Pacific Ballroom

Speaker 3 of 8
Yanling Xiao, Netherlands Cancer Institute, Netherlands
Antigen Cross-Presentation and T-Cell Priming Ability of Human Dendritic Cells Generated in vitro from a Newly Discovered Oligopotent Progenitor of Granulocytes, Macrophages, Osteoclasts and Dendritic Cells

Tuesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Vaccine Platforms
Room: Pacific Ballroom

Speaker 4 of 8
Faezzah Baharom, National Institutes of Health, USA
Route, Dose and Agonist Potency Influence the Induction of TCF1+ Neoantigen-Specific CD8 T Cells by Peptide-TLR7/8 Agonist Nanoparticle Vaccine

Tuesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Vaccine Platforms
Room: Pacific Ballroom

Speaker 5 of 8
Anna Morena D'Alise, Nouscom Srl, Italy
Novel Adenovector Vaccine Targeting Multiple Neoantigens Eeradicates
Large Tumors in Mice in Combination with Checkpoint Blockade


Tuesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Vaccine Platforms
Room: Pacific Ballroom

Speaker 6 of 8
Robert Petit, Advaxis Inc., USA
Magnitude of Anti-PSA T Cell Response Is Associated with Antigen Spreading and Slowing in PSA and PAP Velocity

Tuesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Vaccine Platforms
Room: Pacific Ballroom

Speaker 7 of 8
Alessia Melacarne, Humanitas University, Italy
Antigens Released by Salmonella-Infected Tumor Cells as a Novel Vaccine Platform

Tuesday, January 22 | 2:30PM - 4:30PM
Workshop 2: Vaccine Platforms
Room: Pacific Ballroom

Speaker 8 of 8
Aymen Al-shamkhani, University of Southampton, UK
The Effects of Akt/Protein Kinase B on Effector and Memory CD8 T Cell Differentiation Revealed by Single Cell RNA-Seq

Tuesday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Pacific Ballroom Foyer


Tuesday, January 22 | 5:00PM - 7:00PM
Antigen-Presenting Cells
Room: Pacific Ballroom

Speaker 1 of 6
* Ira Mellman, Genentech, Inc., USA

Tuesday, January 22 | 5:00PM - 7:00PM
Antigen-Presenting Cells
Room: Pacific Ballroom

Speaker 2 of 6
Karin Loré, Karolinska Institutet, Sweden
Understanding Innate Immune Mechanisms Dictating Vaccine Responses

Tuesday, January 22 | 5:00PM - 7:00PM
Antigen-Presenting Cells
Room: Pacific Ballroom

Speaker 3 of 6
Sebastian Amigorena, Institut Curie, France
Dendritic Cell Biology

Tuesday, January 22 | 5:00PM - 7:00PM
Antigen-Presenting Cells
Room: Pacific Ballroom

Speaker 4 of 6
Marc Y. Dalod, Centre National de la Recherche Scientifique, France
Deciphering the Role of cDC1 in Anti-Tumor Immunity

Tuesday, January 22 | 5:00PM - 7:00PM
Antigen-Presenting Cells
Room: Pacific Ballroom

Speaker 5 of 6
Zwi N. Berneman, Antwerp University Hospital, Belgium
Short Talk: Vaccination of Cancer Patients with WT1 mRNA-Electroporated Dendritic Cells: Correlation of Clinical Effect and
Overall Survival with T-Cell Response


Tuesday, January 22 | 5:00PM - 7:00PM
Antigen-Presenting Cells
Room: Pacific Ballroom

Speaker 6 of 6
Matthew G. Booty, SQZ Biotechnologies, USA
Short Talk: SQZ'ing Cells to Engineer a New Generation of Cancer Vaccines

Tuesday, January 22 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, January 23 | 7:30AM - 8:30AM
Breakfast
Room: Vancouver Island/Waddington


Wednesday, January 23 | 8:30AM - 11:30AM
Novel Cancer Vaccine Platforms I
Room: Pacific Ballroom

Speaker 1 of 7
* Catherine J. Wu, Dana-Farber Cancer Institute, USA

Wednesday, January 23 | 8:30AM - 11:30AM
Novel Cancer Vaccine Platforms I
Room: Pacific Ballroom

Speaker 2 of 7
David B. Weiner, Wistar Institute, USA
DNA-Based Vaccines

Wednesday, January 23 | 8:30AM - 11:30AM
Novel Cancer Vaccine Platforms I
Room: Pacific Ballroom

Speaker 3 of 7
John C. Bell, Ottawa Hospital Research Institute, Canada
Virus-Based Vaccines

Wednesday, January 23 | 8:30AM - 11:30AM
Novel Cancer Vaccine Platforms I
Room: Pacific Ballroom


Coffee Break

Wednesday, January 23 | 8:30AM - 11:30AM
Novel Cancer Vaccine Platforms I
Room: Pacific Ballroom

Speaker 5 of 7
Ugur Sahin, BioNTech AG, Germany
RNA-Based Vaccines

Wednesday, January 23 | 8:30AM - 11:30AM
Novel Cancer Vaccine Platforms I
Room: Pacific Ballroom

Speaker 6 of 7
Robert A. Seder, NIAID, National Institutes of Health, USA
Peptide-TLR 7/8 Agonist Vaccines Chemically Programmed to Enhance the Magnitude, Quality and Breadth of Neoantigen CD8 T Cell Responses

Wednesday, January 23 | 8:30AM - 11:30AM
Novel Cancer Vaccine Platforms I
Room: Pacific Ballroom

Speaker 7 of 7
Christian J. Maine, Janssen R&D, USA
Short Talk: Self-Amplifying RNA Polytope Vaccines Can Elicit Anti-Tumor T Cell Responses Against Neoantigens for Cancer Immunotherapy

Wednesday, January 23 | 11:30AM - 5:00PM
On Own for Lunch


Wednesday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Pacific Ballroom Foyer


Wednesday, January 23 | 5:00PM - 7:00PM
Novel Cancer Vaccine Platforms II
Room: Pacific Ballroom

Speaker 1 of 5
* Robert A. Seder, NIAID, National Institutes of Health, USA

Wednesday, January 23 | 5:00PM - 7:00PM
Novel Cancer Vaccine Platforms II
Room: Pacific Ballroom

Speaker 2 of 5
Catherine J. Wu, Dana-Farber Cancer Institute, USA
Building Better Personal Cancer Vaccines

Wednesday, January 23 | 5:00PM - 7:00PM
Novel Cancer Vaccine Platforms II
Room: Pacific Ballroom

Speaker 3 of 5
Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA
DC Targeted Vaccines

Wednesday, January 23 | 5:00PM - 7:00PM
Novel Cancer Vaccine Platforms II
Room: Pacific Ballroom

Speaker 4 of 5
Joshua Tobias, Medical University of Vienna, Austria
Short Talk: A Paradigm Change in Cancer Immunotherapy: Combined B Cell Epitope Peptides of Her-2/neu and Immune
Checkpoint Inhibitors for Active Immunization


Wednesday, January 23 | 5:00PM - 7:00PM
Novel Cancer Vaccine Platforms II
Room: Pacific Ballroom

Speaker 5 of 5
Mubeen M. Mosaheb, Duke University, USA
Short Talk: A Poliovirus-Based Recombinant Vector Activates Antigen-Presenting Cells and Primes Anti-Tumor T Cell Immunity

Wednesday, January 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Vancouver Island/Waddington
No registration fees are used to fund alcohol served at this function.

Thursday, January 24 | 7:30AM - 8:30AM
Breakfast
Room: Vancouver Island/Waddington


Thursday, January 24 | 8:30AM - 11:30AM
Tumor Microenvironment and Combination Therapies
Room: Pacific Ballroom

Speaker 1 of 8
* Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, USA

Thursday, January 24 | 8:30AM - 11:30AM
Tumor Microenvironment and Combination Therapies
Room: Pacific Ballroom

Speaker 2 of 8
Joshua D. Brody, Icahn School of Medicine at Mount Sinai, USA
In situ Vaccination for Cancer

Thursday, January 24 | 8:30AM - 11:30AM
Tumor Microenvironment and Combination Therapies
Room: Pacific Ballroom

Speaker 3 of 8
Shannon J. Turley, Genentech, Inc., USA
TGFbeta in Cancer

Thursday, January 24 | 8:30AM - 11:30AM
Tumor Microenvironment and Combination Therapies
Room: Pacific Ballroom


Coffee Break

Thursday, January 24 | 8:30AM - 11:30AM
Tumor Microenvironment and Combination Therapies
Room: Pacific Ballroom

Speaker 5 of 8
Thomas Gajewski, University of Chicago, USA
Downstream Regulation at the Level of the Tumor Microenvironment

Thursday, January 24 | 8:30AM - 11:30AM
Tumor Microenvironment and Combination Therapies
Room: Pacific Ballroom

Speaker 6 of 8
Darrell J. Irvine, Massachusetts Institute of Technology, USA
Combination Therapies Inducing a Self-Sustaining Vaccinal Cycle

Thursday, January 24 | 8:30AM - 11:30AM
Tumor Microenvironment and Combination Therapies
Room: Pacific Ballroom

Speaker 7 of 8
Linda Hammerich, Icahn School of Medicine at Mount Sinai, USA
Short Talk: In situ Vaccination Improves Efficacy of PD-1 Blockade in Unresponsive Lymphoma Tumors via Induction of
Antigen Cross-Presentation by Dendritic Cells


Thursday, January 24 | 8:30AM - 11:30AM
Tumor Microenvironment and Combination Therapies
Room: Pacific Ballroom

Speaker 8 of 8
Bin Liu, University of California, Los Angeles, USA
Short Talk: Combination of in situ Vaccination with Autologous CCL21-Modified Dendritic Cells (CCL21-DC) and Anti-PD1 for Non-Small Cell Lung Cancer (NSCLC)

Thursday, January 24 | 11:30AM - 5:00PM
On Own for Lunch


Thursday, January 24 | 2:30PM - 4:30PM
Workshop 3: Combination Therapies
Room: Pacific Ballroom

Speaker 1 of 6
* Joshua D. Brody, Icahn School of Medicine at Mount Sinai, USA

Thursday, January 24 | 2:30PM - 4:30PM
Workshop 3: Combination Therapies
Room: Pacific Ballroom

Speaker 2 of 6
Selma Bekri, Icahn School of Medicine at Mount Sinai, USA
Mechanisms of CD4 T Cell Tumor Immunity in a Preclinical Model of a Neoantigen Vaccine for Multiple Myeloma

Thursday, January 24 | 2:30PM - 4:30PM
Workshop 3: Combination Therapies
Room: Pacific Ballroom

Speaker 3 of 6
Elham Beyranvand Nejad, Leiden University Medical Center, Netherlands
Non-Curative Immunotherapy Drives the Development of Immune-Deserted Recurrences

Thursday, January 24 | 2:30PM - 4:30PM
Workshop 3: Combination Therapies
Room: Pacific Ballroom

Speaker 4 of 6
Rosmely Hernandez, University of Miami Miller School of Medicine, USA
IL-2-Dependent Amplification of T Effector and Memory Responses to Promote Anti-Tumor Immunity

Thursday, January 24 | 2:30PM - 4:30PM
Workshop 3: Combination Therapies
Room: Pacific Ballroom

Speaker 5 of 6
Zhen Zeng, University of Queensland, Australia
The Involvement of IFN-? and CXCR3 in the CD8+ T-Cell-Mediated Regression of Squamous Cell Carcinoma

Thursday, January 24 | 2:30PM - 4:30PM
Workshop 3: Combination Therapies
Room: Pacific Ballroom

Speaker 6 of 6
Ramin Salehi-Rad, University of California, Los Angeles, USA
Tumor Vaccination with CCL21-Modified Dendritic Cells (CCL21-DC) Combined with Checkpoint Blockade in Murine Models of NSCLC with Varying Mutational Load

Thursday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Pacific Ballroom Foyer


Thursday, January 24 | 5:00PM - 6:45PM
Immune Monitoring of T Cells
Room: Pacific Ballroom

Speaker 1 of 4
Cornelis J. M. Melief, Leiden University Medical Center & ISA Pharmaceuticals BV, Netherlands
Therapeutic HPV16 Vaccination Is Effective as Monotherapy in Pre-Malignant Disease, but Requires Combination Treatment in HPV16-Induced Cancers

Thursday, January 24 | 5:00PM - 6:45PM
Immune Monitoring of T Cells
Room: Pacific Ballroom

Speaker 2 of 4
Sjoerd H. van der Burg, Leiden University Medical Center, Netherlands
NKG2A Blockade Potentiates CD8+ T-Cell Immunity Induced by Therapeutic Cancer Vaccines

Thursday, January 24 | 5:00PM - 6:45PM
Immune Monitoring of T Cells
Room: Pacific Ballroom

Speaker 3 of 4
* Evan W. Newell, Fred Hutchinson Cancer Research Center, USA
Asking T Cells About What They See in Cancer

Thursday, January 24 | 5:00PM - 6:45PM
Immune Monitoring of T Cells
Room: Pacific Ballroom

Speaker 4 of 4
Mark Klinger, Adaptive Biotechnologies, USA
Short Talk: Optimization of Cancer Vaccine Development by using Multiplexed Identification of T-Cell Receptor Antigen Specificity (MIRA)

Thursday, January 24 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Pacific Ballroom


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