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Sunday, January 19 | 4:00PM - 8:00PM
Arrival and Registration
Room: Riverview Lounge


Sunday, January 19 | 6:00PM - 8:00PM
Welcome Mixer
Room: Riverview Lounge
No registration fees are used to fund alcohol served at this function.

Monday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick


Monday, January 20 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Cascade Ballroom

Speaker 1 of 2
* William R. Sellers, Broad Institute of MIT and Harvard, USA

Monday, January 20 | 8:00AM - 9:00AM
Welcome and Keynote Address
Room: Cascade Ballroom

Speaker 2 of 2
Charles Swanton, Francis Crick Institute, UK
Cancer Evolution and Immune Escape: TRACERx

Monday, January 20 | 9:00AM - 11:30AM
The Evolution of Cancer I
Room: Cascade Ballroom

Speaker 1 of 6
* Jens Lagergren, KTH Royal Institute of Technology, Sweden

Monday, January 20 | 9:00AM - 11:30AM
The Evolution of Cancer I
Room: Cascade Ballroom

Speaker 2 of 6
Carlo Maley, Arizona State University, USA
Lessons in Cancer Prevention from Whales and Other Animals

Monday, January 20 | 9:00AM - 11:30AM
The Evolution of Cancer I
Room: Cascade Ballroom


Coffee Break

Monday, January 20 | 9:00AM - 11:30AM
The Evolution of Cancer I
Room: Cascade Ballroom

Speaker 4 of 6
Trevor A. Graham, Queen Mary University of London, UK
Evolution of Copy Number Alterations in Colon Cancer

Monday, January 20 | 9:00AM - 11:30AM
The Evolution of Cancer I
Room: Cascade Ballroom

Speaker 5 of 6
Natalie Andersson, Lund University, Sweden
Short Talk: High-Risk Pediatric Cancer Genomes are Shaped by Intense Phylogenetic Branching Emerging at Specific Points in Evolutionary History


Monday, January 20 | 9:00AM - 11:30AM
The Evolution of Cancer I
Room: Cascade Ballroom

Speaker 6 of 6
Floris P. Barthel, The Jackson Laboratory, USA
Short Talk: Longitudinal Molecular Trajectories of Diffuse Glioma in Adults

Monday, January 20 | 11:30AM - 5:00PM
On Own for Lunch


Monday, January 20 | 11:30AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick


Monday, January 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick


Monday, January 20 | 2:30PM - 4:30PM
Career Roundtable
Room: New Brunswick
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 1 of 4
Sohrab Shah, Memorial Sloan Kettering Cancer Center, USA

Monday, January 20 | 2:30PM - 4:30PM
Career Roundtable
Room: New Brunswick
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 2 of 4
Jeffrey A. Engelman, Novartis Institutes for BioMedical Research, USA

Monday, January 20 | 2:30PM - 4:30PM
Career Roundtable
Room: New Brunswick
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 3 of 4
Amanda Magara, American Association for Cancer Research, USA

Monday, January 20 | 2:30PM - 4:30PM
Career Roundtable
Room: New Brunswick
Interested participants must sign up at the registration desk on a first-come, first-serve basis.
Maximum attendance: 60.
Speaker 4 of 4
Tatiana Prowell, U.S. FDA and Johns Hopkins University, USA

Monday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Riverview Lounge


Monday, January 20 | 5:00PM - 7:00PM
The Evolution of Cancer II
Room: Cascade Ballroom

Speaker 1 of 6
* Lisa Tucker-Kellogg, Duke-NUS Medical School Singapore, Singapore

Monday, January 20 | 5:00PM - 7:00PM
The Evolution of Cancer II
Room: Cascade Ballroom

Speaker 2 of 6
Andrea Sottoriva, Institute of Cancer Research, UK
Harnessing Evolutionary Steering in Cancer Therapy to Control Drug Resistance

Monday, January 20 | 5:00PM - 7:00PM
The Evolution of Cancer II
Room: Cascade Ballroom

Speaker 3 of 6
Giovanni Ciriello, University of Lausanne, Switzerland
Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Monday, January 20 | 5:00PM - 7:00PM
The Evolution of Cancer II
Room: Cascade Ballroom

Speaker 4 of 6
Christina Curtis, Stanford University, USA
Quantifying Clonal Evolution Through Treatment and Metastasis

Monday, January 20 | 5:00PM - 7:00PM
The Evolution of Cancer II
Room: Cascade Ballroom

Speaker 5 of 6
Sarah J. Aitken, University of Cambridge, UK
Short Talk: Pervasive Segregation of DNA Lesions Generates Genetic Diversity in Cancer

Monday, January 20 | 5:00PM - 7:00PM
The Evolution of Cancer II
Room: Cascade Ballroom

Speaker 6 of 6
James R. Torpy, Garvan Institute of Medical Research, Australia
Short Talk: Copy Number Variation Profiles Derived from Single Cell RNA-Sequencing Data Reveals Diverse Intra-Tumour Heterogeneity across Multiple Breast Cancer Subtypes

Monday, January 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta/New Brunswick
No registration fees are used to fund alcohol served at this function.

Monday, January 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Alberta/New Brunswick


Tuesday, January 21 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick


Tuesday, January 21 | 8:00AM - 11:15AM
Cancer Heterogeneity
Room: Cascade Ballroom

Speaker 1 of 9
* Karin Jirström, Lund University, Sweden

Tuesday, January 21 | 8:00AM - 11:15AM
Cancer Heterogeneity
Room: Cascade Ballroom

Speaker 2 of 9
Sorana Morrissy, University of Calgary, Canada
Tracking Intra-Tumor Heterogeneity in Brain Tumors

Tuesday, January 21 | 8:00AM - 11:15AM
Cancer Heterogeneity
Room: Cascade Ballroom

Speaker 3 of 9
Jeffrey A. Engelman, Novartis Institutes for BioMedical Research, USA
The Therapeutic Implications for Cancer Heterogeneity

Tuesday, January 21 | 8:00AM - 11:15AM
Cancer Heterogeneity
Room: Cascade Ballroom


Coffee Break

Tuesday, January 21 | 8:00AM - 11:15AM
Cancer Heterogeneity
Room: Cascade Ballroom

Speaker 5 of 9
Sohrab Shah, Memorial Sloan Kettering Cancer Center, USA
Clonal Genotype and Population Structure Inference from Single-Cell Tumor Sequencing

Tuesday, January 21 | 8:00AM - 11:15AM
Cancer Heterogeneity
Room: Cascade Ballroom

Speaker 6 of 9
Thomas G. Graeber, University of California, Los Angeles, USA
Pan-Cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies

Tuesday, January 21 | 8:00AM - 11:15AM
Cancer Heterogeneity
Room: Cascade Ballroom

Speaker 7 of 9
Anneleen Daemen, ORIC Pharmaceuticals, USA
Short Talk: Transcriptional Subtypes Resolve Tumor Heterogeneity and Identify Therapeutic Vulnerabilities in Lung Cancer

Tuesday, January 21 | 8:00AM - 11:15AM
Cancer Heterogeneity
Room: Cascade Ballroom

Speaker 8 of 9
David Gisselsson Nord, Lund University, Sweden
Short Talk: Clonal Dynamics Under Therapy in Neuroblastoma

Tuesday, January 21 | 8:00AM - 11:15AM
Cancer Heterogeneity
Room: Cascade Ballroom

Speaker 9 of 9
Hunter Shain, University of California, San Francisco, USA
Short Talk: The Genetic Evolution of Metastatic Uveal Melanoma


Tuesday, January 21 | 11:15AM - 5:00PM
On Own for Lunch


Tuesday, January 21 | 11:15AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick


Tuesday, January 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick


Tuesday, January 21 | 4:30PM - 5:00PM
Coffee Available
Room: Riverview Lounge


Tuesday, January 21 | 5:00PM - 7:00PM
Understanding Checkpoints and Resistance in Immuno-Oncology
Room: Cascade Ballroom

Speaker 1 of 5
* Anna Vilgelm, Ohio State University, USA

Tuesday, January 21 | 5:00PM - 7:00PM
Understanding Checkpoints and Resistance in Immuno-Oncology
Room: Cascade Ballroom

Speaker 2 of 5
Marios Giannakis, Dana-Farber Cancer Institute, USA
Identification of Modulators of Immune Response from the Clinic: Implications for Combining I/O Agents


Tuesday, January 21 | 5:00PM - 7:00PM
Understanding Checkpoints and Resistance in Immuno-Oncology
Room: Cascade Ballroom

Speaker 3 of 5
Elisabeth G.E. de Vries, Universitair Medisch Centrum Groningen, Netherlands
Molecular Imaging for Immunotherapy

Tuesday, January 21 | 5:00PM - 7:00PM
Understanding Checkpoints and Resistance in Immuno-Oncology
Room: Cascade Ballroom

Speaker 4 of 5
Ashley DiMarco, Duke University, USA
Short Talk: APOBEC Mutagenesis as a Driver of Tumor Evolution through Tumor Cell-Intrinsic Mechanisms and by Modulating Tumor-Immune System Interactions


Tuesday, January 21 | 5:00PM - 7:00PM
Understanding Checkpoints and Resistance in Immuno-Oncology
Room: Cascade Ballroom

Speaker 5 of 5
Fernando Souza-Fonseca-Guimaraes, University of Queensland, Australia
Short Talk: Therapeutic Blockade of TGF-ß Superfamily Members Improves NK Cell Function and Anti-Tumor Immunity

Tuesday, January 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta/New Brunswick
No registration fees are used to fund alcohol served at this function.

Tuesday, January 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Alberta/New Brunswick


Wednesday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick


Wednesday, January 22 | 8:00AM - 11:00AM
Leveraging Therapeutic Resistance towards Combination Therap
ies

Room: Cascade Ballroom

Speaker 1 of 8
* Darrin D. Stuart, Novartis, USA

Wednesday, January 22 | 8:00AM - 11:00AM
Leveraging Therapeutic Resistance towards Combination Therap
ies

Room: Cascade Ballroom

Speaker 2 of 8
Poulikos I. Poulikakos, Icahn School of Medicine at Mount Sinai, USA
Adaptive Resistance Mechanisms and Next Generation Therapeutic Strategies for MAPK-Driven Cancers

Wednesday, January 22 | 8:00AM - 11:00AM
Leveraging Therapeutic Resistance towards Combination Therap
ies

Room: Cascade Ballroom

Speaker 3 of 8
Gaddy Getz, Broad Institute, USA
The Elucidation of Drivers of Therapeutic Resistant from Large-Scale Patient Sample Analysis

Wednesday, January 22 | 8:00AM - 11:00AM
Leveraging Therapeutic Resistance towards Combination Therap
ies

Room: Cascade Ballroom


Coffee Break

Wednesday, January 22 | 8:00AM - 11:00AM
Leveraging Therapeutic Resistance towards Combination Therap
ies

Room: Cascade Ballroom

Speaker 5 of 8
Aaron N. Hata, Massachusetts General Hospital, USA
Evolution of Acquired Resistance to Targeted Therapies for Lung Cancer

Wednesday, January 22 | 8:00AM - 11:00AM
Leveraging Therapeutic Resistance towards Combination Therap
ies

Room: Cascade Ballroom

Speaker 6 of 8
Himisha Beltran, Dana Farber Cancer Institute, USA
Lineage Plasticity and the Neuroendocrine Phenotype as a Resistance Mechanism in Prostate Cancer

Wednesday, January 22 | 8:00AM - 11:00AM
Leveraging Therapeutic Resistance towards Combination Therap
ies

Room: Cascade Ballroom

Speaker 7 of 8
Matthew J. Martin, AstraZeneca, UK
Short Talk: Eliminating Osimertinib Drug Tolerant Persister Cells Via Activation of the Extrinsic Apoptosis Pathway


Wednesday, January 22 | 8:00AM - 11:00AM
Leveraging Therapeutic Resistance towards Combination Therap
ies

Room: Cascade Ballroom

Speaker 8 of 8
Sean Misek, Michigan State University, USA
Short Talk: Identification of Pharmacological Vulnerabilities in BRAFi-Resistant Melanoma

Wednesday, January 22 | 11:00AM - 5:00PM
On Own for Lunch


Wednesday, January 22 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick


Wednesday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick


Wednesday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Riverview Lounge


Wednesday, January 22 | 5:00PM - 7:00PM
The Preclinical Modeling and Discovery of Combinations
Room: Cascade Ballroom

Speaker 1 of 6
* Dieter Saur, Technical University Munich, Germany

Wednesday, January 22 | 5:00PM - 7:00PM
The Preclinical Modeling and Discovery of Combinations
Room: Cascade Ballroom

Speaker 2 of 6
William R. Sellers, Broad Institute of MIT and Harvard, USA
Targeting Genetic Redundancy in Cancer through Combinatorial CRISPR Screens

Wednesday, January 22 | 5:00PM - 7:00PM
The Preclinical Modeling and Discovery of Combinations
Room: Cascade Ballroom

Speaker 3 of 6
Jonathan S. Weissman, Whitehead Institute and MIT, USA
Single-Cell-Resolution Lineage Tracing of Tumors in a Mouse Xenograft Model Reveals Rapid and Multidirectional Metastasis

Wednesday, January 22 | 5:00PM - 7:00PM
The Preclinical Modeling and Discovery of Combinations
Room: Cascade Ballroom

Speaker 4 of 6
Peter Sorger, Harvard Medical School, USA
Adaptation of BRAF-Mutant Melanoma Cells to RAF/MEK Inhibitors and Subsequent Progression to Drug Resistance

Wednesday, January 22 | 5:00PM - 7:00PM
The Preclinical Modeling and Discovery of Combinations
Room: Cascade Ballroom

Speaker 5 of 6
Kasey L. Couts, University of Colorado Denver, USA
Short Talk: Loss of Innate Immune Sensing Contributes to Mucosal Melanoma Development and Immunotherapy Resistance

Wednesday, January 22 | 5:00PM - 7:00PM
The Preclinical Modeling and Discovery of Combinations
Room: Cascade Ballroom

Speaker 6 of 6
Sophia Wild, University of Cambridge, UK
Short Talk: ClonEx-Seq: Characterising Clonal Evolution in Time and Space with a Toolkit of Expressable Barcodes

Wednesday, January 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta/New Brunswick
No registration fees are used to fund alcohol served at this function.

Wednesday, January 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Alberta/New Brunswick


Thursday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick


Thursday, January 23 | 8:00AM - 11:00AM
Therapeutic Combinations
Room: Cascade Ballroom

Speaker 1 of 7
* Hunter Shain, University of California, San Francisco, USA

Thursday, January 23 | 8:00AM - 11:00AM
Therapeutic Combinations
Room: Cascade Ballroom

Speaker 2 of 7
Lillian L. Siu, Princess Margaret Hospital, Canada
Oncology Drug Combinations - Are We at an Impasse?

Thursday, January 23 | 8:00AM - 11:00AM
Therapeutic Combinations
Room: Cascade Ballroom

Speaker 3 of 7
Steven Stein, Incyte, USA
The Development of IO Combinations

Thursday, January 23 | 8:00AM - 11:00AM
Therapeutic Combinations
Room: Cascade Ballroom


Coffee Break

Thursday, January 23 | 8:00AM - 11:00AM
Therapeutic Combinations
Room: Cascade Ballroom

Speaker 5 of 7
Shumei Kato, University of California, San Diego Moores Cancer Center, USA
N-of-1 Biomarker-Based Customized Combination Therapy: The PREDICT Family of Studies

Thursday, January 23 | 8:00AM - 11:00AM
Therapeutic Combinations
Room: Cascade Ballroom

Speaker 6 of 7
Akash Mitra, University of Texas MD Anderson Cancer Center, USA
Short Talk: Immune Enrichment and T-Cell Receptor (TCR) Frequencies Predict Response to Immune Checkpoint Blockade (ICB) in Sarcoma

Thursday, January 23 | 8:00AM - 11:00AM
Therapeutic Combinations
Room: Cascade Ballroom

Speaker 7 of 7
Anna Vilgelm, Ohio State University, USA
Short Talk: Combination Treatment with MDM2 Antagonist Overcomes Intrinsic Resistance to CDK4/6 Inhibition

Thursday, January 23 | 11:00AM - 5:00PM
On Own for Lunch


Thursday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Riverview Lounge


Thursday, January 23 | 5:00PM - 6:45PM
Clinical Trials and Clinical Trial Design
Room: Cascade Ballroom

Speaker 1 of 4
* Viola Chen, Merck, USA

Thursday, January 23 | 5:00PM - 6:45PM
Clinical Trials and Clinical Trial Design
Room: Cascade Ballroom

Speaker 2 of 4
Tatiana Prowell, U.S. FDA and Johns Hopkins University, USA
The Regulatory View on the Development of Combination Therapeutics

Thursday, January 23 | 5:00PM - 6:45PM
Clinical Trials and Clinical Trial Design
Room: Cascade Ballroom

Speaker 3 of 4
Jeanne Tie, Peter MacCallum Cancer Centre / Walter & Eliza Hall Institute, Australia
Can Circulating Tumor DNA Re-Define the Adjuvant Treatment Paradigm?

Thursday, January 23 | 5:00PM - 6:45PM
Clinical Trials and Clinical Trial Design
Room: Cascade Ballroom

Speaker 4 of 4
Antoni Ribas, University of California, Los Angeles, USA
Testing I/O Combinations in Clinical Trials

Thursday, January 23 | 6:45PM - 7:00PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Room: Cascade Ballroom


Thursday, January 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta/New Brunswick
No registration fees are used to fund alcohol served at this function.

Thursday, January 23 | 8:00PM - 11:00PM
Entertainment
Room: Alberta/New Brunswick
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Friday, January 24 | 10:24AM - 10:24AM
Departure


*Session Chair.

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