Higher-Order Chromatin Architecture in Time and Space - VIRTUAL CONTENT AVAILABLE ON DEMAND
Organizer(s): Jennifer E. Phillips-Cremins, Job Dekker and Stavros Lomvardas Date: November 15 - 17, 2021
Location: Virtual at your computer. Recorded presentation content is available On Demand.
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Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs, and looping interactions. As genome-wide chromatin architecture maps become widely available, the field is shifting focus from mapping to understanding the dynamics of such structures in development, the cell cycle, and on short time scales in single cells. A critical emerging goal will be to unravel the cause and effect relationship between genome folding and functions such as transcription, replication, recombination, and stability/maintenance. There is also a great need to evaluate the organizing principles governing chromatin topology across many biological conditions and genetic perturbations. Moreover, the role for 3D genome misfolding in the onset and progression of a wide range of human disease states remains an area of high interest across multiple disciplines and organ systems. Overall, this Keystone eSymposia virtual event is meant to highlight new frontiers across disciplines in tackling the dynamics and functional roles of the 3D genome in cellular functions across time and space in development and disease.
We gratefully acknowledge the generous grant for this conference provided by:National Human Genome Research Institute (NHGRI)
Grant No. 1R13HG010979-01
Funding for this conference was made possible (in part) by 1R13HG010979-01 from the National Human Genome Research Institute (NHGRI), with co-funding from National Institute of Biomedical Imaging and Bioengineering (NIBIB). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.