Registration (4:00–8:00 PM)
Welcome Mixer (6:00–8:00 PM)
Tuesday, January 28, 2025
Welcome and Keynote Address (Joint) (8:30–9:45 AM)
* Sebastian Kadener, Brandeis University
Session Chair
V. Narry Kim, Seoul National University Institute for Basic Science
Cellular Regulation of Exogenous Rnas: from Viral Rnas to Mrna Therapeutics
Coffee Break (9:45–10:05 AM)
RNA Biology and Immune System Diseases (Joint) (10:05–12:05 PM)
* Sun Hur, Harvard Medical School
Session Chair
Noam Stern-Ginossar, Weizmann Institute of Science
Viral Pathogenesis and RNAs
Schraga Schwartz, Weizmann Institute of Science
Charting the Ribosomal Epitranscriptome
Judy Lieberman, Boston Children's Hospital; Harvard University
RNA Therapeutics to Modulate Tumor Immunity
Max Lauring, Columbia University Medical Center
Short Talk: An Anti-Retrotransposon Silencing Mechanism Promotes Antibody Diversification
Ignacio Ruiz Fernández, Spanish National Centre for Cardiovascular Research
Short Talk: T Cell-derived miR-721 as a Key Player in Inflammaging and Age-related Diseases
Award Recipient Acknowledgement (Joint) (10:20–10:25 AM)
On Own for Lunch (12:00–2:30 PM)
Poster Setup (12:00–1:00 PM)
Poster Viewing (1:00–10:00 PM)
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions (2:30–4:30 PM)
* Andrea Ventura, Memorial Sloan Kettering Cancer Center
Session Chair
Philippe J Batut, Columbia University
Non-coding RNAs and Genome Organization Control the Dynamics of Gene Expression during Development
Jazmin Morales, Brandeis University
Investigating the Role of circMbl in Neural Function and Development
Joseph Rosenbluh, Monash University
Systematic Loss-of-function Screens Identify Pathway-specific Functional Circular RNAs
Debraj Manna, Indian Institute of Science
Regulation of the Expression of Ribosomal Proteins by Small Downstream ORFs
Jinbiao Ma, Fudan University
Cryo-EM Structures of IStron-encoded Group I Intron Reveal Molecular Mechanism of Antagonistic Conflict with TnpB Associated Guide RNA
Neve Auperin, Pasteur Institute
Soma-to-Germline miRNA Inheritance via Yolk Promotes Stress Resilience in Progeny
Karine G Le Roch, University of California, Riverside
Novel Insights into the Role of Long Non-coding RNA in the Human Malaria Parasite, Plasmodium Falciparum
Coffee Available (4:30–5:00 PM)
Non-Coding RNA and Chromatin (5:00–7:00 PM)
* Philippe J Batut, Columbia University
Session Chair
Donal O'Carroll, University of Edinburgh
Small RNAs and De Novo DNA Methylation
Yehu Moran, Hebrew University of Jerusalem
Characterization of the Antiviral RNAi in Cnidarians Sheds Light on Mechanistic Evolution and Diversity
Tim Hasenbein, Technical University of Munich (TUM)
Short Talk: X-linked Deletion of Crossfirre, Firre, and Dxz4 in vivo Uncovers Diverse Phenotypes and Combinatorial Effects on Autosomes
Claire Rougeulle, CNRS / Institut Curie
Non-coding RNAs Controlling X Chromosome Activity in Primates
Social Hour with Lite Bites (7:00–8:00 PM)
Poster Session 1 (7:30–10:00 PM)
Wednesday, January 29, 2025
Post-Transcriptional Control by Non-Coding RNAs (8:00–11:00 AM)
* Irene Bozzoni, University La Sapienza, Rome
Session Chair
Luisa Cochella, Johns Hopkins University School of Medicine
Quantitative microRNA-Mediated Repression in Animal Development
Joshua T Mendell, University of Texas Southwestern Medical Center
Regulation and Function of Mammalian Noncoding RNAs
Gaspare La Rocca, University of Palermo
Non-Coding RNAs in Cancer and Development
Peter Wang, MIT
Short Talk: The Structural Basis for RNA Slicing by Human Argonaute2
Mariangela Morlando, Sapienza University of Rome
Short Talk: Functional Insights into circDlc1(2): A Key Regulator of microRNA Localization and Synaptic Translation in Neurons
Martin J Simard, CHU de Québec-Université Laval Research Center
Short Talk: Dipeptidyl Peptidase DPF-3 is a Gatekeeper of MicroRNA Argonaute Compensation in Animals
Francesca Briganti, UCSD
Short Talk: The Use of miRNA for the Identification of Etiology Specific Compensatory Mechanisms in Heart Disease
Coffee Break (9:00–9:20 AM)
On Own for Lunch (11:00–2:45 PM)
Poster Setup (11:00–1:00 PM)
Poster Viewing (1:00–10:00 PM)
Career Roundtable (Joint) (1:00–2:30 PM)
Damian Refojo, Max Planck Partner Institute - Buenos Aires
Principal Investigator
Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
Professor
Emily M Anderson, Revvity, Inc.
Principal Scientist
Xiaoyi Yuan, UTHealth Houston
Assistant Professor
Panel: Methodologies to Study Non-Coding RNAs: Standards and Best Practices (2:45–4:30 PM)
* Luisa Cochella, Johns Hopkins University School of Medicine
Panelist
Roy R. Parker, HHMI/University of Colorado
Panelist
Yunsun Nam, University of Texas Southwestern Medical Center
Panelist
Donal O'Carroll, University of Edinburgh
Panelist
Yehu Moran, Hebrew University of Jerusalem
Panelist
Coffee Available (4:30–5:00 PM)
Granules and RNA Localization (5:00–7:00 PM)
* Scott G. Kennedy, Harvard Medical School
Session Chair
Irene Bozzoni, University La Sapienza, Rome
circRNA in the Control of Translation and RNA Trafficking
Roy R. Parker, HHMI/University of Colorado
Role of RNA in Granule Function and Structure
Marie Laure Baudet, University of Trento
Intracellular Distribution of RNA and Association with Different Organelles
Scott G. Kennedy, Harvard Medical School
Non-Templated Addition of a G-Quadruplex Structure Marks RNA for Small RNA Production
Social Hour with Lite Bites (7:00–8:00 PM)
Poster Session 2 (7:30–10:00 PM)
Thursday, January 30, 2025
Novel Functions of Non-Coding RNAs (8:00–11:00 AM)
* Mariangela Morlando, Sapienza University of Rome
Session Chair
Damian Refojo, Max Planck Partner Institute - Buenos Aires
The Influence of circTulp4 on Emotional Behavior and Synaptic Function
Christine Mayr, Memorial Sloan Kettering Cancer Center
The Location of Protein Synthesis Controls The Activity of Transcriptional Regulators in the Nucleus
Yunsun Nam, University of Texas Southwestern Medical Center
Structure Function Analysis of RNA Modifying Enzymes
Sebastian Kadener, Brandeis University
Molecular and Physiological Functions of circRNAs
Bodu Liu, Cold Spring Harbor Laboratory
Short Talk: A Casein Kinase 2 Interacting LncRNA Regulates Cellular Plasticity of Breast Cancer by Stabilizing c-Myc
Coffee Break (9:00–9:20 AM)
On Own for Lunch (11:00–2:30 PM)
Meet the Editors (Joint) (11:00–12:00 PM)
Mishtu Dey, Cell Chemical Biology, Cell Press
*Session Chair, Editor-in-Chief
Gail Teitzel, Cell Press
Deputy Editor
Iris Marchal, Springer Nature AG & Co. KG
Associate Editor, Reviews
Yehu Moran, Hebrew University of Jerusalem
Academic Editor, EMBO Press
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions (3:00–4:30 PM)
* Yehu Moran, Hebrew University of Jerusalem
Session Chair
Yael Sarusi, Weizmann Institute of Science
CHASERR-targeting antisense oligonucleotides boost CHD2 levels and affect mouse behavior in a model of CHD2 haploinsufficiency
Jackson B Trotman, University of North Carolina at Chapel Hill
Xist Repeat A Coordinates an Assembly of SR Proteins to Mediate Gene Silencing
Guifeng Wei, University of Oxford
N6-methyladenosine and the NEXT complex direct Xist RNA turnover and X inactivation dynamics
Takahisa Furukawa, Osaka University
Single cell/nucleus RNA-Seq analysis revealed in vivo functional mechanisms of central nervous system-specific miR-124a in mouse development
Chelsea Drown, University of Colorado Boulder
Investigation of MeCP2-RNA Targets in Rett Syndrome Neurodevelopmental Disorder
Coffee Available (4:30–5:00 PM)
RNA and Therapeutics (Joint) (5:00–6:45 PM)
* Uttiya Basu, Columbia University
Session Chair
Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
RNA Regulation of Tumor Associated Macrophages
Trey Westbrook, Baylor College of Medicine
Targeting RNA Splicing in Cancer: From Synthetic Lethality to Immuno-Oncology
Michael G Kharas, Memorial Sloan Kettering Cancer Center
RNA Methylation and Control of Cellular Fate in the Blood
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45–7:00 PM)
Social Hour with Lite Bites (7:00–8:00 PM)
Departure (12:00–11:59 PM)
