Arrival and Registration (4:00–8:00 PM)
Welcome Mixer (6:00–8:00 PM)
Welcome and Keynote Address (8:00–9:00 AM)
Ido Amit, Weizmann Institute
Single-Cell Discovery of Disease-Associated Cell States
Genomic Regulators of Cellular Circuitry (9:00–11:15 AM)
Lacramioara Bintu, Stanford University
The Control of Gene Regulation at Single-Cell Resolution
David R. Kelley, Calico Life Sciences
Sequence-Based Deep Learning of Single-Cell Genomics
Michael Lorenzini, Salk Institute
Short Talk: Short Talk: Direct Readout of Genome Perturbations and Transcription Outcomes by Single-Cell Edit Capture
Fabian Müller, Saarland University
Short Talk: Short Talk: Dissecting the Epigenome Dynamics of Human Immune Cells Upon Pathogen Exposure at Single-Cell Resolution
Siddharth S. Dey, University of California, Santa Barbara
Short Talk: Short Talk: Combinatorial Quantification of 5mC and 5hmC at Individual CpG Dyads and the Transcriptome in Single Cells Reveals Modulators of DNA Methylation Maintenance Fidelity in Early Mouse Development
Coffee Break (9:30–9:50 AM)
Poster Setup (11:15–1:00 PM)
On Own for Lunch (11:15–1:00 PM)
Poster Viewing (1:00–10:00 PM)
Career Roundtable (3:00–4:30 PM)
Hongkui Zeng, Allen Institute for Brain Science
Executive Vice President, Director
Ana Gabriela Cristancho, Children's Hospital of Philadelphia
Assistant Professor
Grace Zheng, Arsenal Biosciences
Senior Director of Computational Biology and Machine Learning
Gonçalo Castelo-Branco, Karolinska Institutet
Professor
Coffee Available (4:30–5:00 PM)
Multi-omic Approaches to Study Gene Regulation (5:00–7:00 PM)
Jason Buenrostro, Harvard University
Single-Cell Epigenomics
Peter Smibert, 10x Genomics
An Ecosystem of Complementary Technologies for Analyzing Fresh and Archived Single Cells and Tissues
Gonçalo Castelo-Branco, Karolinska Institutet
Multi-Omic Dynamics of Oligodendroglia in Development and Disease
Mattia Zaghi, Karolinska Institutet
Short Talk: Short Talk: Multi-nano Cut&Tag-RNA,a Novel Approach to Map Transcriptomic and Multiple Epigenetic Modalities from Single Cells
Siran Li, Cold Spring Harbor Laboratory
Short Talk: Short Talk: Associating Cancer and Stromal Genomes with Transcriptomes by High-Throughput Single-Nucleus Multiomic Sequencing
Social Hour with Lite Bites (7:00–8:00 PM)
Poster Session 1 (7:30–10:00 PM)
Tuesday, January 23, 2024
Tissue Organization and Interactions (8:00–11:00 AM)
Barbara Treutlein, ETH Zürich
Reconstructing Brain Development and Regeneration with Single-cell Technologies
Fei Chen, Broad Institute of MIT and Harvard
Tissue Genomics Tools for Probing Cellular Interactions
Hongkui Zeng, Allen Institute for Brain Science
Spatial and Cellular Organization of Mouse and Human Brain
Cassandra Burdziak, Memorial Sloan Kettering Cancer Center
The Environment-plasticity Axis in Tumor Progression
Michal Polonsky, Caltech
Short Talk: Short Talk: Spatial Transcriptomics Defines Injury-Specific Microenvironments in the Adult Mouse Kidney and Novel Cellular Interactions in Regeneration and Disease
Coffee Break (9:00–9:20 AM)
Poster Setup (11:00–1:00 PM)
On Own for Lunch (11:00–1:00 PM)
Poster Viewing (1:00–10:00 PM)
Workshop 1: Mapping Diseases (3:00–4:30 PM)
Samuel Cooper, Phenomic
Single-cell RNA Analysis at Scale Identifies a Conserved Wound Healing Axis in Health and Disease
Siyuan Wang, Yale University
A Genome-Wide Single-Cell 3D Genome Atlas of Lung Cancer Progression
Shreya Menon, University of California, San Francisco / Gladstone Institutes
Leveraging Single-cell Multi-omic Profiling to Investigate Non-coding Variants in Neurodegenerative Disease
Ana Gabriela Cristancho, Children's Hospital of Philadelphia
Single-nucleus Multi-omics Predicts Persistent Functional Deficits in Glutamatergic Neurons after Prenatal Hypoxic Brain Injury
André F Rendeiro, CeMM Research Center for Molecular Medicine
Tissue-level Prediction of Biological Age and Pathology Incidence
Lochlan J. Fennell, Monash University
Traversing The Colorectal Transcriptomic Landscape Through Space, Time and Disease
Coffee Available (4:30–5:00 PM)
Development and Cellular Dynamics (5:00–7:00 PM)
Cole Trapnell, University of Washington
Creating Cellular Diversity During Development
Samantha A. Morris, Washington University School of Medicine in St Louis
Lineage Tracing Cell Fates
Martin Tran, Caltech
Short Talk: Short Talk: Lineage motifs as developmental modules for control of cell type proportions
HaoSheng Sun, Howard Hughes Medical Institute, University of Alabama at Birmingham
Short Talk: Short Talk: Genetic Regulation of the Post-embryonic Post-mitotic Nervous System Maturation in Single Neuron Resolution
Social Hour with Lite Bites (7:00–8:00 PM)
Poster Session 2 (7:30–10:00 PM)
Wednesday, January 24, 2024
Keynote Address (8:00–8:45 AM)
Emma K. Lundberg, Stanford University and Chan Zuckerberg Initiative
From Mapping to Modeling the Subcellular Proteome Architecture of Cells
Single-Cell and Tissue Perturbation Technologies (8:45–11:15 AM)
Bogdan Bintu, University of California, San Diego
Spatial Transcriptomics Reveals the Activation of Quiescent Neurogenic Niches in the Aging Mammalian Brain
Martin Borch Jensen, Gordian Biotechnology
Pooled in vivo Testing of Therapeutics in the Environment you want them to Work
Jonathan S. Weissman, Whitehead Institute, HHMI, and MIT
Genome-Wide Perturbations for Defining Principles of Biological Systems
Grace Zheng, Arsenal Biosciences
Short Talk: Short Talk: Combinatorial High-throughput Genetic Screening of Regulators of T Cell Function to Improve Efficacy of Therapeutic Engineered T Cells
Ceejay Lee, Liau Lab (Harvard University)
Short Talk: Short Talk: Massively Parallel Profiling of Androgen Receptor Protein-coding Variants with SCAnnEd
Coffee Break (9:00–9:20 AM)
On Own for Lunch (11:15–1:00 PM)
Workshop 2: Frontiers in Computation (2:30–4:30 PM)
Joshua Weinstein, University of Chicago
Volumetric Imaging of an Intact Organism by a Distributed Molecular Network
David Wen, Gladstone Institutes/University of California, San Francisco
A Comprehensive Map of Dosage Sensitivity Across Fetal Development
Camilo Espinosa Bernal, Stanford University School of Medicine
Modeling Cell-type-specific Perturbations in Single-cell Omic Datasets with Attention
Peiyao Zhao, Allen Institute
SPARROW: A Sequential Algorithm for Cell Type Inference and Microenvironment Delineation in Spatial Transcriptomics
Salil Bhate, Broad Institute of MIT and Harvard
Deriving Genetic Codes for Tissues from First Principles
Sandeep Kambhampati, Harvard University
Connecting Spatial Organization of Tissues to Cell State and Function using Self-supervised Machine Learning
Coffee Available (4:30–5:00 PM)
Aging and Disease Associated Cell States (5:00–6:15 PM)
Brian D. Brown, Mount Sinai School of Medicine
Single Cell Mapping of Myeloid Cell Targets of Cancer
Wolf Reik, Altos Labs, Cambridge Institute of Science
Single Cell Multi-omics Landscape of Development and Ageing
Ailsa Jeffries, UMass Chan Medical School
Short Talk: Short Talk: The Bidirectional Relationship between the Aging Genome and Transcriptome in the Human Brain
Closing Keynote Address (6:15–7:00 PM)
Michael Elowitz, HHMI/California Institute of Technology
Cellular Circuitry and Dynamics
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45–7:00 PM)
Social Hour with Lite Bites (7:00–8:00 PM)
Thursday, January 25, 2024
Departure (7:00–11:59 PM)
