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Keypoint Newsletter: Welcoming the New Fellows Class of 2024
Keystone Symposia is pleased to introduce the Keystone Symposia Fellows Class of 2024! This year we welcome seven...
Due to an inherent fascination with parasitic helminthes, De’Broski R. Herbert earned a B.S. in Microbiology from Xavier University of Louisiana (1994) and a Ph.D. in Immunology from Thomas Jefferson Medical College (2000). His thesis work demonstrated a critical role for IL-5, B-1 lymphocytes, and eosinophils in host-protective immunity against Strongyloides stercoralis (J Immunol. 2000 Oct 15;165(8):4544-51).
As part of a life-long dream, De’Broski spent several years in South Africa to complete his post-doctoral training at the University of Cape Town in the laboratory of Frank Brombacher Ph.D. This resulted in seminal work that demonstrated IL-4/IL-13-driven alternative macrophage activation controls lethal immunopathology during Schistosoma mansoni infection (Immunity. 2004 May;20 (5):623-35).
Subsequently, he joined the laboratory of Fred. D. Finkelman M.D. and published multiple studies focused on the importance of IL-4/IL-13 in driving host-protection against parasitic helminthes through direct regulation of tissue macrophage function (J Immunol. 2010 Jun 1;184(11):6438-46) and mucosal epithelia (J Exp Med. 2009 Dec 21;206(13):2947-57).
As principal investigator of his independent laboratory at Cincinnati Children’s Research Foundation, his work focused upon elucidating mechanisms of innate Type 2 cytokine regulation by Trefoil factor family proteins (J Exp Med. 2012 Mar 12;209 (3):607-22) and immunosuppressivemacrophage subsets in the context of helminth infection and allergic inflammation (Eur J Immunol. 2011 Jul;41(7):2000-9,
Am J Pathol. 2012 May;180(5):2001-8).
Currently positioned as associate professor of Infectious Immunology in the Department of Pathobiology at UPENN, his laboratory is investigating mechanisms of host protection against helminthes, Type 2 inflammation, and the resolution of chronic mucosal inflammation in several model systems.
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Dec 4, 2023 by Keystone Symposia
Keystone Symposia is pleased to introduce the Keystone Symposia Fellows Class of 2024! This year we welcome seven...
Sep 6, 2023 by Keystone Symposia
Established in 2009, Keystone Symposia’s Fellows Program has become a premier professional advancement opportunity for...