This meeting took place in 2010



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Role of Inflammation in Oncogenesis (J5)


Organizer(s) Nina Bhardwaj and Giorgio Trinchieri
February 7—12, 2010
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 7, 2009
Late Abstract Deadline: Nov 6, 2009
Scholarship Deadline: Oct 7, 2009
Early Registration Deadline: Dec 7, 2009

Sponsored by Celgene Corporation, Hoffmann-La Roche, Inc. and Pfizer Global Research & Development


Summary of Meeting:
Cancer is characterized by accelerated and uncontrolled growth, dysregulation of apoptosis, invasion and metastasis. While genetic and epigenetic mechanisms may underlie transformation, the tumor microenvironment promotes the neoplastic process. Chronic inflammation and infection, in particular, are linked to the development of cancer. Examples include the association between inflammatory bowel disease and colon cancer, Helicobacter pylori infection with gastric cancer and HPV with cervical cancer. Recent studies have linked the innate immune system, through production of inflammatory cytokines, with cancer progression. Factors such as TNF alpha, IL-6, and TGF beta, produced by macrophages and dendritic cells amongst other cells, enhance tumor growth, invasion, metastasis, and angiogenesis, while simultaneously impairing anti-tumor immune mechanisms. There have been several advances in our understanding of the influences of inflammation on tumorigenesis. However, critical elements of the involved inflammatory pathways that modulate tumor progression still remain to be identified. The complex interrelationship between inflammatory vs. immune suppressive cytokines and their effects on the neoplastic process remain to be defined. The association between DNA damage and inflammation and the link between pathogen associated molecular patterns (PAMPs) and novel pattern recognition molecules (TLRs and NOD like receptors) in driving tumor development require further characterization. How cancer associated inflammation might actively dysregulate the innate immune system, in particular of dendritic cell, NK and NKT cell anti-tumor function, is also an area of interest and intense speculation. This meeting will focus specifically on mechanisms of inflammation-induced carcinogenesis, and will bring together investigators with diverse interests and expertise - immunology, signal transduction, cancer biology and therapeutics. It is anticipated that the pairing with the concurrent Keystone Symposia meeting on Immune Escape in Cancer will attract a large body of scientists who share a common interest in cancer pathogenesis, inflammation and mechanisms underlying immune evasion. The goal of the meeting is to enhance discussion, foster collaborations, report on new paradigms, and ultimately to develop approaches that will modulate inflammation-associated tumor progression.

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Scholarships/Awards

Scholarship / Award Information


Scholarship Deadline: October 7, 2009 (11:59 PM US Mountain Standard Time)
*All deadlines end at 11:59 PM US Mountain Standard Time
NOTE: Please use the button above to Apply for a Scholarship

Scholarships

Keystone Symposia is offering scholarships of up to 1,200 USD to Students and Postdoctoral fellows. These scholarships are to be used to help defray the expenses associated with conference attendance, including airfare (restrictions may apply based on funding source), ground transportation, lodging costs, and a portion of meeting registration. Receipts will be required to receive reimbursement.

Abstracts submitted for poster presentation will be used as the basis for awarding the scholarships. Scholarship recipients will be selected based on the quality of science of the abstract and the relevance of the abstract to the conference topic. Only one application per abstract is accepted. Only one award per lab will be allocated.


Eligibility


To be eligible for a scholarship, you must be:

A graduate student or postdoctoral fellow currently enrolled in an academic institute at the start of the meeting for which you are applying. Note: a graduate student is defined as a student who is studying for a higher degree at an academic institution. A postdoctoral fellow is defined as an individual with a Ph.D., M.D., or DVM degree who is engaged in a temporary period of mentored research and/or scholarly training for the purpose of acquiring the professional skills needed to pursue their desired career path, and is within 6 years of these degrees.


Review Criteria


Criteria for Abstract Review:

  1. Relevance to the meeting topic
  2. Significance of the scientific question and results
  3. Style
    • Organization (e.g. the abstract has a clear beginning, middle and end)
    • Grammar and spelling
  4. Clarity of scientific presentations
    • Clear question or hypothesis
    • Sufficient background
    • The experimental approach and rationale for the approach are clear
    • The results are clearly presented
    • The interpretation and conclusions are reasonable and logical

Application Process


If you are eligible and wish to be considered for a scholarship, you should complete all of the following by the scholarship deadline for the meeting you wish to attend. It is recommended you begin these steps in advance of the deadline date to ensure completion.

Click here to start a scholarship application.

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Underrepresented Trainee Scholarships are also available...
Please Click Here for more information about Underrepresented Trainee Scholarship.

  See the Underrepresented Trainee Scholarship FAQ's


If you have any questions, please contact scholarships@keystonesymposia.org.