This meeting took place in 2014



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Developmental Pathways and Cancer: Wnt, Notch and Hedgehog (J7)


Organizer(s) Frederic J. de Sauvage, Mariann Bienz and Jon C. Aster
February 2—7, 2014
Fairmont Banff Springs • Banff, AB Canada
Discounted Abstract Deadline: Oct 11, 2013
Abstract Deadline: Nov 6, 2013
Scholarship Deadline: Oct 11, 2013
Discounted Registration Deadline: Dec 3, 2013

Sponsored by Bayer HealthCare Pharmaceuticals, Cell Research, Genentech, Inc., OncoMed Pharmaceuticals, Inc., and Pfizer Inc.


Summary of Meeting:
Aberrant activation of the Wnt, Notch and Hedgehog pathways via mutations or ligand overexpression has been implicated in a large number of cancer types where they are involved in functions ranging from tumor initiation to cancer stem cell maintenance and angiogenesis. These findings have triggered intensive efforts in both academia and industry to identify targets in these pathways and develop drugs for the treatment of certain tumors. Agents targeting each one of these three pathways have now reached clinical trials, and the first one of these, Vismodegib, a Hedgehog Pathway Inhibitor, was approved in 2012 for the treatment of advanced basal cell carcinoma. This meeting will allow scientists from both academia and industry to review the latest results on the role of these pathways in cancer and share their experience with the development of drugs in preclinical models and in the clinic. Issues ranging from predicting clinical efficacy in animal models to identification of predictive diagnostics and potential mechanisms of acquired resistance are key to the success of these agents and will require a combined effort from the entire community studying these pathways.

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Scholarships/Awards

Keystone Symposia Future of Science Fund Scholarship Recipients

Taran S. Gujral
Harvard Medical School, USA

Yulu Cherry Liu
University of Toronto, Canada

National Institute of General Medical Sciences (NIGMS) Ancillary Training Program Scholarship Recipients

Kwame Osei-Sarfo
Weill Cornell Medical Center, USA

Cynthia Tilley
University of Colorado Denver, USA