This meeting took place in 2017

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Mononuclear Phagocytes in Health, Immune Defense and Disease (D3)

Organizer(s) Steffen Jung and Miriam Merad
April 30—May 4, 2017
Hyatt Regency Austin • Austin, Texas USA
Discounted Abstract Deadline: Jan 9, 2017
Abstract Deadline: Jan 31, 2017
Scholarship Deadline: Jan 9, 2017
Discounted Registration Deadline: Feb 28, 2017

Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc.

Summary of Meeting:
Mononuclear phagocytes (MNP) are immune cells that are uniquely equipped to sense and respond to environmental cues by promoting tissue homeostasis or initiating tissue repair and immunity. MNP also contribute significantly to tissue pathologies, and their manipulation holds considerable therapeutic potential. MNP display major functional specializations. Most macrophages are established before birth and perform tissue-specific functions in organ development and homeostasis. Short-lived classical dendritic cells (DC) are specialized in triggering adaptive T cell immunity. Monocytes complement macrophages and DC as highly plastic cells, in particular during inflammation. While MNP subsets have been identified, individual contributions to health and disease are not well-defined. Breathtaking technological advance in genomic profiling of populations and single cells is revealing the breadth of MNP functions and identifying molecular checkpoints for targeted therapeutic intervention. These molecular efforts are paralleled by astounding progress in imaging capabilities, enabling the study of the cells in their physiological context. This meeting therefore aims to: 1) Cover recent progress in the field, revealing novel and differential contributions of MNP in physiological processes, and identify critical knowledge gaps; 2) Stimulate scientific exchange, in particular between clinicians and researchers, to better translate findings from animal models into human settings and brainstorm regarding novel therapeutic intervention; and 3) Develop novel conceptual frameworks for future studies of MNP in health and disease.

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National Institute of Allergy and Infectious Diseases (NIAID)/National Cancer Institute (NCI) Scholarship Recipients

Holly M. Akilesh
Benaroya Research Institute at Virginia Mason, USA

Sarah A. Dick
University Health Network, Canada

Harald Lund
Karolinska Institutet, Sweden

Freya Rose Svedberg
University of Manchester, UK

Lucie Van Emmenis
University College London, UK

Shoutang Wang
Institut Gustave Roussy, France