This meeting took place in 2001



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Mechanisms of Eukaryotic Transcriptional Regulation (C5)


Organizer(s) Beverly M. Emerson and Joan W. Conaway
February 26—March 4, 2001
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Abstract Deadline: Oct 26, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 27, 2000

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
Transcriptional regulation is a multi-step process that involves modulation of chromatin structure to facilitate the interaction of RNA polymerase and transcription factors with the DNA template, as well as direct regulation of polymerase during the preinitiation, initiation, and elongation stages of transcription. Recently, high-resolution crystallographic and NMR structures of the nucleosome, RNA polymerase, and complexes that regulate transcriptional activation, elongation, and histone acetylation have been determined. The information from these structural studies, together with ongoing biochemical analyses of transcriptional initiation and elongation, are providing an ever-clearer picture of the molecular interactions underlying transcriptional control. Additionally, the discovery and subsequent characterization of protein complexes and enzymatic activities that function as chromatin remodeling machines, co-activators, co-repressors, or mediators of transcription factors are unraveling many of the sophisticated regulatory mechanisms that integrate physiological signals within higher organisms. The focus of this meeting is to examine each major level of transcriptional regulation in detail and develop a coherent understanding of how specificity of gene expression is achieved in a chromosomal context.

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Scholarships/Awards

Scholarship / Award Information


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Scholarships

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Review Criteria


Criteria for Abstract Review:

  1. Relevance to the meeting topic
  2. Significance of the scientific question and results
  3. Style
    • Organization (e.g. the abstract has a clear beginning, middle and end)
    • Grammar and spelling
  4. Clarity of scientific presentations
    • Clear question or hypothesis
    • Sufficient background
    • The experimental approach and rationale for the approach are clear
    • The results are clearly presented
    • The interpretation and conclusions are reasonable and logical

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