This meeting took place in 2005

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Organizer(s) Christopher Glass and Mitchell A. Lazar
April 12—17, 2005
Fairmont Chateau Whistler • Whistler, British Columbia Canada
Abstract Deadline: Dec 13, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 14, 2005

Part of the Translational Medicine Series, Supported by Pfizer Global Research and Development

Summary of Meeting:
The accelerating incidence of obesity, insulin resistance and hyperlipidemia in Westernized societies and the attendant complications of diabetes and atherosclerosis is fueling an explosion of interest in the molecular mechanisms underlying metabolic disease. The PPAR subfamily of nuclear receptors, consisting of PPARa, PPARg, and PPARd, initially became the focus of intense investigation following discoveries of roles of PPARa and PPARg in controlling aspects of lipid and glucose homeostasis. PPARs regulate programs of gene expression by functioning as ligand-dependent transcription factors. Although the range of physiological ligands that regulate the activities of each PPAR in vivo remain to be clearly defined, PPARa and PPARg are the molecular targets of fibrates and thiazolidinediones that were identified empirically to lower circulating triglyceride levels and to improve insulin resistance in diabetic patients, respectively. The recognition that these classes of drugs exert their therapeutic effects by binding to PPARa and PPARg suggests that more effective drugs for the treatment of hyperlipidemia and type 2 diabetes can be developed by optimizing ligand-receptor interactions. Furthermore, recent studies have suggested additional roles of PPARs in a diverse range of physiological and pathophysiological settings, including vascular wall biology, placental physiology, atherosclerosis, inflammatory bowel and skin disorders, metabolic bone disease and cancer. Further exploration of these observations should expand our general understanding of important developmental and homeostatic processes at a molecular level, and may lead to new avenues of therapeutic intervention in common human diseases. Because of the potential biomedical significance of this field of research, studies of PPAR-related processes have resulted in a number of pioneering discoveries of general importance to molecular biology and development. In concert with recent developments in the PPAR field, a parallel of series of discoveries has emerged relating to regulation of cholesterol and triglyceride homeostasis by the LXR subfamily of nuclear receptors, consisting of LXRa and LXRb. The LXRs are activated by cholesterol metabolites and provide the basis for a feed-forward homeostatic control circuit for maintenance of cellular cholesterol levels. The biological actions of LXRs relate in part to their ability to regulate members of the ABC family of lipid transporters, including ABC A1 and ABC G1, which mediate the efflux of cholesterol from cells. These findings raise the possibility that new classes of cholesterol lowering drugs could be developed that would work synergistically with currently available agents. These considerations justify a Keystone Conference focused on PPARs and LXRs in 2005. The PPAR field is entering a new wave of discovery based on the recent success in generating conditional experimental systems for analysis of PPARg and PPARd-null mice. Studies for metabolic pathways regulated for PPARs and LXRs are also benefiting from the application of increasingly powerful genomics and proteomics tools. A 2005 Keystone Meeting on PPARs and LXRs will be well timed to bring together a diverse array of investigators from academia and industry to synthesize the most recent developments and define future directions. This meeting will also provide opportunities to highlight major findings from studies of less well-characterized members of the nuclear receptor family that have recently emerged as potential regulators of lipid metabolism and energy homeostasis, such as FXR. Finally, this meeting will continue to be a valuable opportunity for trainees to present work in a poster session, meet leaders in the field, and explore opportunities for future career development.

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Scholarship / Award Information

Scholarship Deadline: (11:59 PM US Mountain Standard Time)
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Keystone Symposia is offering scholarships of up to 1,200 USD to Students and Postdoctoral fellows. These scholarships are to be used to help defray the expenses associated with conference attendance, including airfare (restrictions may apply based on funding source), ground transportation, lodging costs, and a portion of meeting registration. Receipts will be required to receive reimbursement.

Abstracts submitted for poster presentation will be used as the basis for awarding the scholarships. Scholarship recipients will be selected based on the quality of science of the abstract and the relevance of the abstract to the conference topic. Only one application per abstract is accepted. Only one award per lab will be allocated.


To be eligible for a scholarship, you must be:

A graduate student or postdoctoral fellow currently enrolled in an academic institute at the start of the meeting for which you are applying. Note: a graduate student is defined as a student who is studying for a higher degree at an academic institution. A postdoctoral fellow is defined as an individual with a Ph.D., M.D., or DVM degree who is engaged in a temporary period of mentored research and/or scholarly training for the purpose of acquiring the professional skills needed to pursue their desired career path, and is within 6 years of these degrees.

Review Criteria

Criteria for Abstract Review:

  1. Relevance to the meeting topic
  2. Significance of the scientific question and results
  3. Style
    • Organization (e.g. the abstract has a clear beginning, middle and end)
    • Grammar and spelling
  4. Clarity of scientific presentations
    • Clear question or hypothesis
    • Sufficient background
    • The experimental approach and rationale for the approach are clear
    • The results are clearly presented
    • The interpretation and conclusions are reasonable and logical

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