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This meeting took place in 2011
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Genomic Instability and DNA Repair (B4)
Organizer(s) Junjie Chen, Karlene A. Cimprich and Michael B. Yaffe
January 30—February 4, 2011
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 30, 2010
Late Abstract Deadline: Nov 2, 2010
Scholarship Deadline: Sep 30, 2010
Early Registration Deadline: Nov 30, 2010
Supported by the Directors’ Fund
Summary of Meeting:
The maintenance of genomic integrity following DNA damage depends on the coordination of DNA repair, cell cycle progression, transcriptional and post-transcriptional regulation and apoptosis. The integrity of the DNA damage response pathways plays a critical role in human health. This meeting will present the most recent advances in the field and reveal how a complex network of signaling transduction pathways are involved in DNA damage response. The topics include early detection of DNA lesions, DNA damage checkpoint control, DNA repair, genotoxic damage in cancer stem cells, modulation of DNA damage signaling by microRNAs, systems biology approaches to DNA damage and the use of cutting edge technologies in the study of DNA damage responses.
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The maintenance of genomic integrity following DNA damage depends on the coordination of DNA repair, cell cycle progression, transcriptional and post-transcriptional regulation and apoptosis. The integrity of the DNA damage response pathways plays a critical role in human health. This meeting will present the most recent advances in the field and reveal how a complex network of signaling transduction pathways are involved in DNA damage response. The topics include early detection of DNA lesions, DNA damage checkpoint control, DNA repair, genotoxic damage in cancer stem cells, modulation of DNA damage signaling by microRNAs, systems biology approaches to DNA damage and the use of cutting edge technologies in the study of DNA damage responses.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 30
MONDAY, JANUARY 31
TUESDAY, FEBRUARY 1
WEDNESDAY, FEBRUARY 2
THURSDAY, FEBRUARY 3
FRIDAY, FEBRUARY 4
Conference Program Print | View meeting in 24 hr (international) time
SUNDAY, JANUARY 30
7:15—9:30 PM
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.
*
Junjie Chen,
University of Texas MD Anderson Cancer Center, USA
David M. Livingston,
Dana-Farber Cancer Institute, USA
Genomic Instability and Breast Cancer
Genomic Instability and Breast Cancer
Stephen J. Elledge,
Harvard Medical School, USA
The DNA Damage Response: Making it Safe to Play with Knives
The DNA Damage Response: Making it Safe to Play with Knives
8:00—11:15 AM
DNA Damage Signaling: Networks and Systems Approaches
Meeting has ended...abstracts no longer viewable online.
*
Stephen J. Elledge,
Harvard Medical School, USA
Yosef Shiloh,
Tel Aviv University, Israel
The ATM-Mediated DNA Damage Response: The System and the Pathways
The ATM-Mediated DNA Damage Response: The System and the Pathways
Trey Ideker,
University of California, San Diego, USA
Widespread Induction of Genetic Networks in Response to DNA Damage
Widespread Induction of Genetic Networks in Response to DNA Damage
Claus Storgaard Sørensen,
University of Copenhagen, Denmark
Short Talk: Generation of ssDNA at Stalled DNA Replication Forks is Mediated by hFBH1 Helicase
Short Talk: Generation of ssDNA at Stalled DNA Replication Forks is Mediated by hFBH1 Helicase
Shunichi Takeda,
Kyoto University, Japan
Short Talk: SLX4 Links Fanconi anemia Pathway to Structure Specific Endonucleases, MUS81, SLX1 and XPF in Interstrand Crosslink Repair
Short Talk: SLX4 Links Fanconi anemia Pathway to Structure Specific Endonucleases, MUS81, SLX1 and XPF in Interstrand Crosslink Repair
2:30—4:30 PM
Workshop 1: Checkpoint Controls
James A. Borowiec,
New York University School of Medicine, USA
Single Molecule Analysis Demonstrates that RPA Phosphorylation is Necessary for Efficient Fork Movement during Replication Stress
Single Molecule Analysis Demonstrates that RPA Phosphorylation is Necessary for Efficient Fork Movement during Replication Stress
Samuel Sidi,
Mount Sinai School of Medicine, USA
Chk1 Regulates PIDDosome Assembly and Function after DNA Damage
Chk1 Regulates PIDDosome Assembly and Function after DNA Damage
Nathan A. Ellis,
University of Illinois, Chicago, USA
BLM SUMOylation Regulates ssDNA Accumulation at Stalled Forks
BLM SUMOylation Regulates ssDNA Accumulation at Stalled Forks
Jen-Wei Huang,
Fred Hutchinson Cancer Research Center, USA
The microRNAs, miR-103 and miR-107, Target RAD51D and Regulate Homologous Recombination and Sensitivity to DNA Damaging Agents
The microRNAs, miR-103 and miR-107, Target RAD51D and Regulate Homologous Recombination and Sensitivity to DNA Damaging Agents
Susana Gonzalo,
Saint Louis University School of Medicine, USA
Nurturing the Genome: Roles for A-type Lamins in Telomere Maintenance and Regulation of Mechanisms of DNA DSBs Repair
Nurturing the Genome: Roles for A-type Lamins in Telomere Maintenance and Regulation of Mechanisms of DNA DSBs Repair
Sandy Giuliano,
INSERM U895 Equipe 1, France
MITF Controls the DNA Damage Response Signaling Pathway and Cellular Senescence
MITF Controls the DNA Damage Response Signaling Pathway and Cellular Senescence
Kareem N. Mohni,
University of Connecticut Health Center, USA
Herpes Simplex Virus Type 1 Infection Disables ATR Signaling
Herpes Simplex Virus Type 1 Infection Disables ATR Signaling
5:00—7:00 PM
Mechanism of DNA Damage Signaling and DNA Repair
Meeting has ended...abstracts no longer viewable online.
Simon J. Boulton,
London Research Institute, Clare Hall Laboratories, UK
Regulating Recombination at Telomeres
Regulating Recombination at Telomeres
Daniel Durocher,
Lunenfeld-Tanenbaum Research Institute, Canada
The Ubiquitous Role of Ubiquitin in DNA Double-Strand Break Signaling and Repair
The Ubiquitous Role of Ubiquitin in DNA Double-Strand Break Signaling and Repair
Junjie Chen,
University of Texas MD Anderson Cancer Center, USA
DNA Damage Signaling and DNA Repair
DNA Damage Signaling and DNA Repair
Xiaohua Wu†,
The Scripps Research Institute, USA
Short Talk: MRN and CtIP are Important for Processing DNA Ends with Secondary Structures in Mammalian Cells
Short Talk: MRN and CtIP are Important for Processing DNA Ends with Secondary Structures in Mammalian Cells
8:00—11:15 AM
Advance in DNA Damage Response
Meeting has ended...abstracts no longer viewable online.
Alan D. D'Andrea,
Dana-Farber Cancer Institute, USA
Regulation of the Fanconi Anemia Pathway by Ubiquitin and SUMO
Regulation of the Fanconi Anemia Pathway by Ubiquitin and SUMO
Karlene A. Cimprich,
Stanford University, USA
Mechanisms for Maintaining Genome Stability at the Replication Fork
Mechanisms for Maintaining Genome Stability at the Replication Fork
John A. Tainer,
The Scripps Research Institute, USA
Extreme Allostery, Mre11-Rad50-Nbs1 Conformations, and the Control of Sensing, Signaling, and Effector Responses at DNA Double-Strand Breaks
Extreme Allostery, Mre11-Rad50-Nbs1 Conformations, and the Control of Sensing, Signaling, and Effector Responses at DNA Double-Strand Breaks
Zhenkun Lou,
Mayo Clinic, USA
Short Talk: Histone Methyltransferase MMSET Regulates Histone H4 Lysine 20 Methylation and 53BP1 Accumulation at DNA Damage Sites
Short Talk: Histone Methyltransferase MMSET Regulates Histone H4 Lysine 20 Methylation and 53BP1 Accumulation at DNA Damage Sites
Shaun E. Peterson,
Columbia University, USA
Short Talk: Regulation of Chromosomal DSB Resection in Vertebrate S- and M-Phases
Short Talk: Regulation of Chromosomal DSB Resection in Vertebrate S- and M-Phases
2:30—4:30 PM
Workshop 2: DNA Repair
*
Junjie Chen,
University of Texas MD Anderson Cancer Center, USA
Sharon B. Cantor,
University of Massachusetts Medical School, USA
An Acetylation Switch Modulates BACH1/FANCJ Function in DNA Damage Repair
An Acetylation Switch Modulates BACH1/FANCJ Function in DNA Damage Repair
Jeremy M. Stark,
Beckman Research Institute of the City of Hope, USA
The DNA Damage Response is Important for Faithful End Utilization during NHEJ of Multiple Chromosome Breaks
The DNA Damage Response is Important for Faithful End Utilization during NHEJ of Multiple Chromosome Breaks
Jianyuan Jack Luo,
University of Maryland Baltimore, USA
SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
Ali Nowrouzi,
NCT, Deutsches Krebsforschungszentrum Heidelberg, Germany
Genome–Wide Detection of DNA Double Strand Breaks (DSB) at Single Nucleotide Resolution
Genome–Wide Detection of DNA Double Strand Breaks (DSB) at Single Nucleotide Resolution
Lisa Postow,
Rockefeller University, USA
Ubiquitylation of DNA-Bound Ku80 by the SCF Complex
Ubiquitylation of DNA-Bound Ku80 by the SCF Complex
Ralph Scully,
Beth Israel Deaconess Medical Center, USA
Real Time Imaging of the Mammalian Double Strand Break Response
Real Time Imaging of the Mammalian Double Strand Break Response
Wojciech Piwko,
Swiss Federal Institute of Technology, ETH Zurich, Switzerland
Identification of the Mms22L – Nfkbil2 Complex as a Novel Regulator of DNA Replication in Human Cells
Identification of the Mms22L – Nfkbil2 Complex as a Novel Regulator of DNA Replication in Human Cells
Junran Zhang,
Ohio State University, USA
A Dual Role of BRCA1 in Two Distinct Homologous Recombination Mediated Repairs in Response to Replication Arrest
A Dual Role of BRCA1 in Two Distinct Homologous Recombination Mediated Repairs in Response to Replication Arrest
5:00—7:00 PM
DNA Repair, Stem Cells, Senescence and Aging. Session Sponsored by The Ellison Medical Foundation.
Meeting has ended...abstracts no longer viewable online.
*
Laura J. Niedernhofer,
The Scripps Research Institute, USA
Michael F. Clarke,
Stanford University, USA
Effects of Genomic Instability on the Epigenetic and Transcriptional Programs of Breast Cancer Cells
Effects of Genomic Instability on the Epigenetic and Transcriptional Programs of Breast Cancer Cells
David A. Sinclair,
Harvard Medical School, USA
DNA Damage as a Trigger for the Relocalization of Chromatin Factors during Aging and the Role of Fluctuating NAD+
DNA Damage as a Trigger for the Relocalization of Chromatin Factors during Aging and the Role of Fluctuating NAD+
Joris Pothof,
Erasmus MC, Netherlands
Short Talk: MicroRNAs and the DNA Damage Response
Short Talk: MicroRNAs and the DNA Damage Response
8:00—11:15 AM
Models of DNA Damage Repair and Therapy
Meeting has ended...abstracts no longer viewable online.
André Nussenzweig,
NCI, National Institutes of Health, USA
Mechanisms of DNA Damage Detection and Repair in Lymphocytes
Mechanisms of DNA Damage Detection and Repair in Lymphocytes
Michael T. Hemann,
Massachusetts Institute of Technology, USA
A Role for the DNA Damage Response in Tumor Cell Survival and Acquired Chemoresistance
A Role for the DNA Damage Response in Tumor Cell Survival and Acquired Chemoresistance
Maria Jasin,
Memorial Sloan Kettering Cancer Center, USA
Homologous Recombination and Chromosomal Translocation
Homologous Recombination and Chromosomal Translocation
Helen Piwnica-Worms,
Washington University School of Medicine, USA
Exploiting Cell Cycle Checkpoint Control in Cancer Therapy
Exploiting Cell Cycle Checkpoint Control in Cancer Therapy
Anindya Dutta,
University of Virginia, USA
Short Talk: CRL4-Cdt2 Ubiquitin Ligase Pathway in the Response to DNA Damage and as a Target for Chemotherapy
Short Talk: CRL4-Cdt2 Ubiquitin Ligase Pathway in the Response to DNA Damage and as a Target for Chemotherapy
JoAnn M. Sekiguchi,
University of Michigan, USA
Short Talk: Mechanisms Underlying Genome Instability and Aberrant Chromosomal Rearrangements Due to Defective Artemis DNA Nuclease Activity
Short Talk: Mechanisms Underlying Genome Instability and Aberrant Chromosomal Rearrangements Due to Defective Artemis DNA Nuclease Activity
2:30—4:30 PM
Workshop 3: Study of DNA Damage Response at Organism Level
*
André Nussenzweig,
NCI, National Institutes of Health, USA
Olivier J. Becherel,
University of Queensland, Australia
The First Setx-/- Mouse Model for Ataxia Oculomotor Apraxia Type 2 (AOA2) Uncovers a Novel Role for Senataxin in Meiotic DNA Repair, Recombination and Germ Cell Maturation
The First Setx-/- Mouse Model for Ataxia Oculomotor Apraxia Type 2 (AOA2) Uncovers a Novel Role for Senataxin in Meiotic DNA Repair, Recombination and Germ Cell Maturation
Michael Huen,
University of Hong Kong, Hong Kong
Limiting Histone Ubiquitylation Selectively Promotes Homologous Recombination DNA Repair
Limiting Histone Ubiquitylation Selectively Promotes Homologous Recombination DNA Repair
Janneke E. Jaspers,
Netherlands Cancer Institute, Netherlands
Loss of 53BP1 Causes Resistance to PARP Inhibition in BRCA1-Mutated Mouse Mammary Tumors
Loss of 53BP1 Causes Resistance to PARP Inhibition in BRCA1-Mutated Mouse Mammary Tumors
Stephen Meyn,
Hospital for Sick Children, Canada
The Fanconi anemia Pathway Regulates BLM-Dependent Telomeric Recombination and Telomere DNA Synthesis in ALT Human Cells
The Fanconi anemia Pathway Regulates BLM-Dependent Telomeric Recombination and Telomere DNA Synthesis in ALT Human Cells
Tomasz Skorski,
Temple University, School of Medicine, USA
Targeting Phosphotyrosine-315 in RAD51 Recombinase to Prevent BCR-ABL1 Oncogenic Kinase –Mediated Unfaithful Homeologous Recombination Repair
Targeting Phosphotyrosine-315 in RAD51 Recombinase to Prevent BCR-ABL1 Oncogenic Kinase –Mediated Unfaithful Homeologous Recombination Repair
Shan Zha,
Columbia University Medical Center, USA
XLF Has Functional Redundancy with ATM and H2AX in V(D)J Recombination and Non-homologous DNA End-joining
XLF Has Functional Redundancy with ATM and H2AX in V(D)J Recombination and Non-homologous DNA End-joining
Chengming (Ben) Zhu,
University of Texas MD Anderson Cancer Center, USA
Interplay of DNA Repair Pathway and Tumor Suppressor p53 and its Role in Preventing Tumorigenesis and Aging
Interplay of DNA Repair Pathway and Tumor Suppressor p53 and its Role in Preventing Tumorigenesis and Aging
5:00—7:00 PM
Expanding Dimensions of Genomic Instability and Cancer Therapy
Meeting has ended...abstracts no longer viewable online.
Andrei Thomas-Tikhonenko,
Children's Hospital of Philadelphia and University of Pennsylvania, USA
A MicroRNA Component of the Myc-p53 Axis
A MicroRNA Component of the Myc-p53 Axis
Laura J. Niedernhofer,
The Scripps Research Institute, USA
DNA Repair Protects Against Numerous Age-Related Degenerative Diseases
DNA Repair Protects Against Numerous Age-Related Degenerative Diseases
Xiaochun Yu,
University of Michigan, USA
Short Talk: Protein Neddylation Regulates DNA Damage Response
Short Talk: Protein Neddylation Regulates DNA Damage Response
8:00—11:15 AM
Posttranslational Regulation and Modifications Involved in DNA Damage Response
Meeting has ended...abstracts no longer viewable online.
Michele Pagano,
New York University School of Medicine, USA
Role of SCF Ubiquitin Ligases in the Maintenance of Genomic Stability
Role of SCF Ubiquitin Ligases in the Maintenance of Genomic Stability
Michael B. Yaffe,
Massachusetts Institute of Technology, USA
Modular Domains Mediate the Assembly and Function of DNA Damage Signaling Complexes
Modular Domains Mediate the Assembly and Function of DNA Damage Signaling Complexes
J. Wade Harper,
Harvard Medical School, USA
Genetic and Proteomic Analysis of Damage-Signaling Systems
Genetic and Proteomic Analysis of Damage-Signaling Systems
J. Wade Harper,
Harvard Medical School, USA
Genetic and Proteomic Analysis of Damage-Signaling Systems
Genetic and Proteomic Analysis of Damage-Signaling Systems
René H. Medema,
Netherlands Cancer Institute, Netherlands
A Phosphoproteomic-Based siRNA Screens Uncovers Novel Regulators of Plk1 and p53 that Control Recovery from a DNA Damage-Induced Arrest
A Phosphoproteomic-Based siRNA Screens Uncovers Novel Regulators of Plk1 and p53 that Control Recovery from a DNA Damage-Induced Arrest
Dipanjan Chowdhury,
Dana-Farber Cancer Institute, Harvard Medical School, USA
Short Talk: New Approaches to Study Role of Phosphatases in the DNA Damage Response
Short Talk: New Approaches to Study Role of Phosphatases in the DNA Damage Response
Lee Zou,
Harvard Medical School, USA
Short Talk: Cell Cycle-Regulated and DNA Damage-Induced Chromatin Alterations by CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8
Short Talk: Cell Cycle-Regulated and DNA Damage-Induced Chromatin Alterations by CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8
5:00—7:00 PM
Genomic Instability, Cancer and Therapy
Meeting has ended...abstracts no longer viewable online.
*
Michael T. Hemann,
Massachusetts Institute of Technology, USA
Thomas Helleday,
Karolinska Institutet, Sweden
Novel Players and Pathways for Restarting Stalled Replication Forks
Novel Players and Pathways for Restarting Stalled Replication Forks
Michael B. Kastan,
St. Jude Children's Research Hospital, USA
Modulation of ATM and p53 for Clinical Benefit
Modulation of ATM and p53 for Clinical Benefit
Massimo Squatrito,
Memorial Sloan-Kettering Cancer Center, USA
Short Talk: 53bp1 is a Haploinsufficient Tumor Suppressor that Protects Glioma Cells from Response to Therapy
Short Talk: 53bp1 is a Haploinsufficient Tumor Suppressor that Protects Glioma Cells from Response to Therapy
Jac A. Nickoloff,
Colorado State University, USA
Short Talk: Neoamphimedine, a Novel Topoisomerase IIalpha Inhibitor, Blocks Metnase-Potentiated DNA Decatenation
Short Talk: Neoamphimedine, a Novel Topoisomerase IIalpha Inhibitor, Blocks Metnase-Potentiated DNA Decatenation
Katharina Schlacher,
MD Anderson Cancer Center, USA
Short Talk: BRCA2 Protects Stalled Replication Forks from Nucleolytic Degradation Independent of Homologous Recombination
Short Talk: BRCA2 Protects Stalled Replication Forks from Nucleolytic Degradation Independent of Homologous Recombination
*Session Chair †Invited, not yet responded.
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