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This meeting took place in 2017
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Lipidomics and Bioactive Lipids in Metabolism and Disease (B6)
Organizer(s) Alfred H. Merrill, Walter Allen Shaw, Sarah Spiegel and Michael J.O.Wakelam
February 26—March 2, 2017
Granlibakken Tahoe • Tahoe City, California USA
Discounted Abstract Deadline: Oct 26, 2016
Abstract Deadline: Dec 12, 2016
Scholarship Deadline: Oct 26, 2016
Discounted Registration Deadline: Jan 9, 2017
Sponsored by Abide Therapeutics Inc.
Summary of Meeting:
The ability to analyze large numbers of lipids from different categories (e.g., fatty acyls, glycerolipids, sphingolipids and sterols) has greatly advanced our understanding of their biochemical functions and roles in disease, but has also created challenges of scale. This Keystone Symposia meeting will cover areas of lipid research that have been particularly impacted by these technologies. It will specifically address the challenge of managing the large data sets generated by lipidomic technologies and conceptually studying them given how interconnected and cross-regulated lipid metabolic pathways are. Bringing together an outstanding group of scientists with expertise in the lipid categories as well as in lipidomic approaches, it will summarize recent findings for the major lipid categories from state-of-the-art technologies and lay the foundation for a broader understanding of new methods and the technical capabilities and limitations of these methods, as well as where better approaches are needed.
View Scholarships/Awards
The ability to analyze large numbers of lipids from different categories (e.g., fatty acyls, glycerolipids, sphingolipids and sterols) has greatly advanced our understanding of their biochemical functions and roles in disease, but has also created challenges of scale. This Keystone Symposia meeting will cover areas of lipid research that have been particularly impacted by these technologies. It will specifically address the challenge of managing the large data sets generated by lipidomic technologies and conceptually studying them given how interconnected and cross-regulated lipid metabolic pathways are. Bringing together an outstanding group of scientists with expertise in the lipid categories as well as in lipidomic approaches, it will summarize recent findings for the major lipid categories from state-of-the-art technologies and lay the foundation for a broader understanding of new methods and the technical capabilities and limitations of these methods, as well as where better approaches are needed.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 26 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Thursday, March 2 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Friday, March 3 in order to fully experience the meeting.
SUNDAY, FEBRUARY 26
MONDAY, FEBRUARY 27
TUESDAY, FEBRUARY 28
WEDNESDAY, MARCH 1
THURSDAY, MARCH 2
FRIDAY, MARCH 3
Conference Program Print | View meeting in 24 hr (international) time
The meeting will begin on Sunday, February 26 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Thursday, March 2 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Friday, March 3 in order to fully experience the meeting.
SUNDAY, FEBRUARY 26
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
8:00—9:00 AM
Welcome and Keynote Address (Organizers)
Meeting has ended...abstracts no longer viewable online.
Edward A. Dennis,
University of California, San Diego, USA
Lipidomics Highlights Infection and Inflammation Progression
Lipidomics Highlights Infection and Inflammation Progression
9:00—11:30 AM
Lipidomics in Inflammation
Meeting has ended...abstracts no longer viewable online.
*
Sarah Spiegel,
Virginia Commonwealth University, USA
*
Alfred H. Merrill, Jr.,
Georgia Institute of Technology, USA
Garret A. FitzGerald,
University of Pennsylvania, USA
Prostaglandins and Their Inhibitors
Prostaglandins and Their Inhibitors
Coffee Break
Valerie B. O'Donnell,
Cardiff University, UK
Lipidomics Characterization of Oxidation during Platelet Activation and Physiological Blood Clotting
Lipidomics Characterization of Oxidation during Platelet Activation and Physiological Blood Clotting
Richard L. Proia,
National Institutes of Health, USA
Visualizing Sphingosine-1-Phosphate G Protein-Coupled Receptor Signaling in Living Animals
Visualizing Sphingosine-1-Phosphate G Protein-Coupled Receptor Signaling in Living Animals
Charles E. Chalfant,
Virginia Commonwealth University, School of Medicine, USA
Short Talk: The Lipidome in Inflammation, Wound Healing, and Pre-Eclampsia
Short Talk: The Lipidome in Inflammation, Wound Healing, and Pre-Eclampsia
Veronica G. Anania,
Genentech, Inc., USA
Short Talk: Bioactive Lipids as Pharmacodynamic Biomarkers of Mast Cell Activity in the Clinic
Short Talk: Bioactive Lipids as Pharmacodynamic Biomarkers of Mast Cell Activity in the Clinic
11:30—11:45 AM
Description of LIPID MAPS and Website Tools
Meeting has ended...abstracts no longer viewable online.
*
Valerie B. O'Donnell,
Cardiff University, UK
Eoin Fahy,
University of California, San Diego, USA
5:00—7:00 PM
Lipidomics and Infection
Meeting has ended...abstracts no longer viewable online.
*
Charles R. Brown,
University of Missouri, USA
Markus R. Wenk,
National University of Singapore, Singapore
Natural Variation of Blood Plasma Lipids in Healthy Asian Individuals
Natural Variation of Blood Plasma Lipids in Healthy Asian Individuals
Dennis R. Voelker,
National Jewish Health, USA
Journal of Lipid Research Lectureship: Pulmonary Surfactant Phospholipids Regulate Innate Immunity
Journal of Lipid Research Lectureship: Pulmonary Surfactant Phospholipids Regulate Innate Immunity
Frances Platt,
University of Oxford, UK
The Niemann-Pick Type C Disease Pathway and its Unanticipated Role in Infection
The Niemann-Pick Type C Disease Pathway and its Unanticipated Role in Infection
8:00—11:15 AM
Cancer Lipidomics
Meeting has ended...abstracts no longer viewable online.
*
Markus R. Wenk,
National University of Singapore, Singapore
*
Andrew J. Morris,
University of Kentucky, USA
Sarah Spiegel,
Virginia Commonwealth University, USA
Targeting the Sphingosine-1-Phosphate Axis and Development of a Novel Therapy for Endocrine-Resistant Breast Cancer
Targeting the Sphingosine-1-Phosphate Axis and Development of a Novel Therapy for Endocrine-Resistant Breast Cancer
Coffee Break
Michael J.O. Wakelam,
Babraham Institute, UK
Lipidomic Changes Predict Novel Therapeutic Targets in Colorectal Cancer and Other Diseases
Lipidomic Changes Predict Novel Therapeutic Targets in Colorectal Cancer and Other Diseases
Christian Metallo,
University of California, San Diego, USA
Understanding the Interplay between Amino Acid and Lipid Metabolism
Understanding the Interplay between Amino Acid and Lipid Metabolism
Tzipora Goldkorn,
University of California, Davis, USA
Short Talk: nSMase2 Conveys Oncogenic Advantages to Tumors of Lung Adenocarcinoma in Smokers via SphK1
Short Talk: nSMase2 Conveys Oncogenic Advantages to Tumors of Lung Adenocarcinoma in Smokers via SphK1
David A. Potter,
University of Minnesota, USA
Short Talk: Heme Binding Biguanides Target Cytochrome P450 Dependent Cancer Cell Mitochondria
Short Talk: Heme Binding Biguanides Target Cytochrome P450 Dependent Cancer Cell Mitochondria
5:00—7:15 PM
Cardiovascular Lipidomics
Meeting has ended...abstracts no longer viewable online.
*
Julian L. Griffin,
University of Cambridge, UK
L. Ashley Cowart,
Virginia Commonwealth University, USA
Advances in Understanding the Roles of Ceramide Synthase Isoforms in the Cardiac Response to Dyslipidemia
Advances in Understanding the Roles of Ceramide Synthase Isoforms in the Cardiac Response to Dyslipidemia
Jeffrey G. McDonald,
University of Texas Southwestern Medical Center, USA
Analysis of ELOVL Enzyme Activity by Infusion-Based Lipidomics Using MS/MSALL
Analysis of ELOVL Enzyme Activity by Infusion-Based Lipidomics Using MS/MSALL
Andrew J. Morris,
University of Kentucky, USA
Short Talk: Lysophosphatidic Acid Metabolism and Signaling in Atherosclerosis
Short Talk: Lysophosphatidic Acid Metabolism and Signaling in Atherosclerosis
Rheem A. Totah,
University of Washington, USA
Short Talk: cis- and trans-Epoxyeicosatrienoic Acids in Patients with Cardiovascular Disease
Short Talk: cis- and trans-Epoxyeicosatrienoic Acids in Patients with Cardiovascular Disease
7:15—7:30 PM
Recognition of Scholarship Awardees
Meeting has ended...abstracts no longer viewable online.
*
Alfred H. Merrill, Jr.,
Georgia Institute of Technology, USA
Patricia Rodrigues,
Cardiff University, UK
GATA6 Transcription Factor Regulates Lipid Metabolism in Tissue Resident Macrophages
GATA6 Transcription Factor Regulates Lipid Metabolism in Tissue Resident Macrophages
Opeyemi Stella Ademowo,
University of Cambridge, UK
Phospholipid Oxidation and Carotenoid Supplementation in Alzheimer’s Disease Patients
Phospholipid Oxidation and Carotenoid Supplementation in Alzheimer’s Disease Patients
8:00—9:00 AM
Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Michael J.O. Wakelam,
Babraham Institute, UK
Vytas A. Bankaitis,
Texas A&M University, USA
Phosphatidylinositol Transfer Protein-Dependent Golgi Positioning Controls Cell Polarity in Neural Stem Cells and Projection Neurons in Developing Mammalian Forebrain
Phosphatidylinositol Transfer Protein-Dependent Golgi Positioning Controls Cell Polarity in Neural Stem Cells and Projection Neurons in Developing Mammalian Forebrain
9:00—11:30 AM
Lipid Localization and Implications for Cell Regulation
Meeting has ended...abstracts no longer viewable online.
*
Rosalind A. Coleman,
University of North Carolina at Chapel Hill, USA
*
Junken Aoki,
Tohoku University, Japan
Per Haberkant,
European Molecular Biology Laboratory, Germany
A Quantitative Map of Cellular Protein-Sphingolipid Complexes and their Lipid-Binding Profile
A Quantitative Map of Cellular Protein-Sphingolipid Complexes and their Lipid-Binding Profile
Coffee Break
Erwin London,
SUNY Stony Brook, USA
Using Cyclodextrins to Control the Lipid Composition, Lipid Asymmetry, and Membrane Properties of Artificial Vesicles and Living Cells
Using Cyclodextrins to Control the Lipid Composition, Lipid Asymmetry, and Membrane Properties of Artificial Vesicles and Living Cells
John Katsaras,
Oak Ridge National Laboratory, USA
Model Membranes, Bacteria and Lateral Membrane Organization
Model Membranes, Bacteria and Lateral Membrane Organization
Alexander Kros,
Leiden University Medical Center, Netherlands
Short Talk: Quantifying Membrane Compound Exchange Between Live Mammalian Cells
Short Talk: Quantifying Membrane Compound Exchange Between Live Mammalian Cells
Kuniyuki Kano,
Graduate School of Pharmaceutical Sciences, Tohoku University, Japan
Short Talk: Imaging MS Analysis of Lysophospholipids using AP-MALDI-MS
Short Talk: Imaging MS Analysis of Lysophospholipids using AP-MALDI-MS
3:30—4:30 PM
Workshop: LIPID MAPS Tools
*
Eoin Fahy,
University of California, San Diego, USA
The LIPID MAPS Lipidomics Gateway
The LIPID MAPS Lipidomics Gateway
5:00—7:00 PM
Lipidomics
Meeting has ended...abstracts no longer viewable online.
*
Valerie B. O'Donnell,
Cardiff University, UK
*
Friedrich Spener,
University of Graz, Austria
Walter Allen Shaw,
Avanti Polar Lipids, Inc., USA
When Bad Things Happen to Good Samples: The Good, the Bad, and the Scary of Lipid Mass Spectrometry
When Bad Things Happen to Good Samples: The Good, the Bad, and the Scary of Lipid Mass Spectrometry
Kim Ekroos,
Lipidomics Consulting Ltd., Finland
High-Definition FLUX Lipidomics
High-Definition FLUX Lipidomics
Toyoshi Fujimoto,
Nagoya University Graduate School of Medicine, Japan
Freeze-fracture Electron Microscopy to Define Distribution of Lipids and Lipid Domains at the Nanoscale
Freeze-fracture Electron Microscopy to Define Distribution of Lipids and Lipid Domains at the Nanoscale
Roger Sandhoff,
German Cancer Research Center, Germany
Short Talk: Stereoisomer-Specific Quantification of Simple Bioactive Glycosphingolipids from Bacteria and Mammals
Short Talk: Stereoisomer-Specific Quantification of Simple Bioactive Glycosphingolipids from Bacteria and Mammals
8:00—11:00 AM
Neurological Lipidomics
Meeting has ended...abstracts no longer viewable online.
*
William Griffiths,
Swansea University, UK
*
Tony Futerman,
Weizmann Institute of Science, Israel
Robert C. Murphy,
University of Colorado Denver, USA
High-Throughput Lipidomic Analysis the CTS Method: Application to Neuronal Tissue
High-Throughput Lipidomic Analysis the CTS Method: Application to Neuronal Tissue
Maria Fuller,
SA Pathology, University of Adelaide, Australia
The Brain Lipidome: A Therapeutic Target for Neurodegenerative Disorders
The Brain Lipidome: A Therapeutic Target for Neurodegenerative Disorders
Coffee Break
Steffany A.L. Bennett,
University of Ottawa, Canada
Translational Lipidomics: Can Patients with DLB, AD or MCI be Stratified by Interrogating their Plasma Lipidomes?
Translational Lipidomics: Can Patients with DLB, AD or MCI be Stratified by Interrogating their Plasma Lipidomes?
Janet E. Deane,
University of Cambridge, UK
Short Talk: Aberrant Glycosphingolipid Processing in a Lysosomal Storage Disease
Short Talk: Aberrant Glycosphingolipid Processing in a Lysosomal Storage Disease
Patricia C. Kane,
NeuroLipid Research Foundation, USA
Short Talk: Addressing Neurological Disorders by Clearing Epigenetics and Stabilizing Membranes and Cardiolipin with Bioactive Lipids
Short Talk: Addressing Neurological Disorders by Clearing Epigenetics and Stabilizing Membranes and Cardiolipin with Bioactive Lipids
5:00—6:45 PM
Metabolism
Meeting has ended...abstracts no longer viewable online.
*
Dennis R. Voelker,
National Jewish Health, USA
*
L. Ashley Cowart,
Virginia Commonwealth University, USA
Rosalind A. Coleman,
University of North Carolina at Chapel Hill, USA
Acyl-CoA Metabolism and Partitioning
Acyl-CoA Metabolism and Partitioning
James Mukasa Ntambi,
University of Wisconsin-Madison, USA
Regulation of Adipose Tissue Lipogenesis and Fatty Acid Oxidation
Regulation of Adipose Tissue Lipogenesis and Fatty Acid Oxidation
Nicholas O. Davidson,
Washington University School of Medicine, USA
Fatty Acid Flux and Hepatic Fibrosis: Pathways Linking Lipid Metabolism and Liver Injury
Fatty Acid Flux and Hepatic Fibrosis: Pathways Linking Lipid Metabolism and Liver Injury
6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
7:00—8:00 PM
Social Hour
No registration fees are used to fund alcohol served at this function.
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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