Westin Miyako Kyoto Floorplan

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This meeting took place in 2018


Here are the related meetings in 2019:
Mitochondria in Aging and Age-Related Disease (J2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Mitochondrial Biology (Z1)


Organizer(s) Jodi Nunnari, Anu Suomalainen-Wartiovaara and Koji Okamoto
April 22—26, 2018
Westin Miyako Kyoto • Kyoto, Japan
Discounted Abstract Deadline: Dec 19, 2017
Abstract Deadline: Jan 16, 2018
Scholarship Deadline: Dec 19, 2017
Discounted Registration Deadline: Feb 22, 2018

Sponsored by Astellas Pharma Inc. and Nestlé Institute of Health Sciences

Joint Meeting: Selective Autophagy (Z2)

Summary of Meeting:
Mitochondria perform fundamental diverse functions in eukaryotic cells, including ATP production and ion and phospholipid homeostasis. They also serve as platforms to integrate signaling pathways and cellular processes, such as innate immunity and autophagy. Mitochondrial functions are tightly linked to mitochondrial form, which is established through coordinated machines that control dynamics, positioning, motility and mitochondrial DNA transmission. Contact sites between mitochondrial with diverse organelles have emerged as key and pervasive regulators of mitochondrial form and function. These contact sites, as well as metabolites, fully integrate mitochondria into the cell and organism. It is therefore not surprising that mitochondrial dysfunction has emerged as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders. This conference will provide a cutting-edge view of how mitochondrial form and function is controlled and how its myriad of functions impinge on health and disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, April 22 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 26 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, April 27 in order to fully experience the meeting.

SUNDAY, APRIL 22

4:00—8:00 PM
Arrival and Registration

Mizuho Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Mizuho Foyer

MONDAY, APRIL 23

7:30—8:00 AM
Poster Setup

Mizuho
8:00 AM—5:00 PM
Poster Viewing

Mizuho
8:00—9:30 AM
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Mizuho
* Ivan Dikic, Goethe University Medical School, Germany

* Jodi Nunnari, University of California, Davis, USA

David M. Sabatini, Whitehead Institute for Biomedical Research, USA
mTOR and Lysosomes in Growth Control

Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA
Autophagy's Role in Mitochondrial Function and Dysfunction

Coffee Break

10:00 AM—12:15 PM
Mitochondrial Dynamics
Meeting has ended...abstracts no longer viewable online.

Mizuho
* Aleksandra Trifunovic, University of Cologne, Germany

Orian S. Shirihai, University of California, Los Angeles, USA
Lipid Droplet Mitochondria: Mitochondria With Agenda

David C. Chan, California Institute of Technology, USA
Mitochondrial Fusion and Fission in Health and Disease

Thomas Langer, CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Membrane Homeostasis

Hiromi Sesaki, Johns Hopkins University School of Medicine, USA
Short Talk: Human Brain Evolution Driven by Drp1

Naotada Ishihara, Kurume University, Japan
Short Talk: Selective Mitochondrial Fusion by Heterotypic Action between OPA1 and Cardiolipin


Following Session is for Selective Autophagy (Z2)

10:00 AM—12:15 PM
Aggrephagy and Neurodegenerative Disease
Meeting has ended...abstracts no longer viewable online.

Yamashiro
* Masaaki Komatsu, School of Medicine Niigata University, Japan

Ai Yamamoto, Columbia University, USA
Selective Autophagy in the CNS

Hong Zhang, Chinese Academy of Sciences, China
Loss of Collagen Related to the Cuticle Annular Furrow Activates Systemic Autophagy

Anne Simonsen, University of Oslo, Norway
Regulation of Selective Autophagy

Maneka Chitiprolu, University of Ottawa, Canada
Short Talk: A Complex of C9ORF72 and p62 Uses Arginine Methylation to Eliminate FUS and Stress Granules by Autophagy

Santosh Chauhan, Institute of Life Sciences, India
Short Talk: TRIM16 Control Protein Aggregates Turnover by Regulating NRF2-p62 Axis and Autophagy Process

12:15—1:45 PM
Lunch

Mizuho
12:45—2:45 PM
Poster Session 1

Mizuho
2:45—4:45 PM
Workshop 1: Dynamics

Mizuho
* Laura L. Lackner, Northwestern University, USA

Suzanne Hoppins, University of Washington, USA
Identification of a New Functional Domain in the Mitofusin Proteins

Mickael Cohen, CNRS-UPMC, France
Mechanism and Regulation of Homotypic Fusion between Outer Membranes

Alessandra Maresca, IRCCS Istituto Scienze Neurologiche, Italy
OPA3 Mutations Highlight a Patho-Mechanism Involving Fission and Autophagy

Cecilia Patitucci, Université de Paris Descartes, France
The Role of MTP18 in Mitochondrial Dynamics and Metabolism

Ken Nakamura, Gladstone Institutes and University of California, San Francisco, USA
A High-Throughput Screen of Real-Time ATP Levels in Individual Cells Reveals Mechanisms of Energy Failure

Juliette Lee, University of Cambridge, UK
Basal Mitophagy Is Widespread in Drosophila but Minimally Affected by Loss of Pink1 or Parkin

Thomas Rival, Aix-Marseille Université, France
Mitofusin Mutations Commonly Associated with Charcot-Marie-Tooth Neuropathy Have Opposite Effects on Mitochondrial Fusion

Ramona Schuster, Institute for Genetics, University of Cologne, Germany
Cdc48 Regulates a Deubiquitylase Cascade Critical for Mitochondrial Fusion


Following Session is for Selective Autophagy (Z2)

3:00—4:30 PM
Workshop 1

Yamashiro
* Hong Zhang, Chinese Academy of Sciences, China

Christian Behl, University Medical Center of the Johannes Gutenberg University, Germany
RAB18 Modulates Autophagosome Formation and is Functionally Compensated by ATG9A

Yasin Dagdas, Gregor Mendel Institute, Austria
Role of Autophagy in Phenotypic Plasticity Responses in Plants

Marie Witt, Max-Delbrück-Center for Molecular Medicine, Germany
Structure-Function Studies on FIP200 Reveal Mechanistic Insights into Selective Autophagy

Liang Ge, Tsinghua University, China
Endomembrane Remodeling in Autophagic Membrane Formation

Maho Hamasaki, Osaka University, Japan
Chemical Activation of LC3 Conjugation System Uncover the New Insight of LC3 Lipidation Site

4:30—5:00 PM
Coffee Available

Mizuho Foyer
5:00—7:15 PM
Mitochondrial Quality Control
Meeting has ended...abstracts no longer viewable online.

Mizuho
* Richard J. Youle, NINDS, National Institutes of Health, USA

Luca Scorrano, University of Padova, Italy
Localized Accumulation of Autophagosomes at Axonal Hillocks Depletes Axons from Damaged Mitochondria

Andrew G. Dillin, University of California, Berkeley, USA
Mitochondrial Unfolded Protein Responses

Aleksandra Trifunovic, University of Cologne, Germany
Quality Control of Mitochondrial Complex I

Adam L. Hughes, University of Utah, USA
Short Talk: The Nucleus Is a Common Quality Control Destination for Failed Mitochondrial Import Substrates

Felix Boos, University of Kaiserslautern, Germany
Short Talk: Dissolving the Traffic Jam – How Cells Counteract the Blockage of Mitochondrial Protein Entry Gates


Following Session is for Selective Autophagy (Z2)

5:00—7:00 PM
Autophagy Receptors and Other Machinery in Selective Autophagy
Meeting has ended...abstracts no longer viewable online.

Yamashiro
* Noboru Mizushima, University of Tokyo, Japan

Sascha Martens, University of Vienna, Austria
Templating Autophagosomal Membrane Growth during Selective Autophagy

Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain
Mitophagy as a Regulator of Metabolism and Cell Differentiation

Christian Behrends, Ludwig Maximilians University München, Germany
Autophagosomal Content Profiling as a Tool to Dissect the Contribution of Autophagy to Proteostasis

Michael Lazarou, Monash University, Australia
Short Talk: LC3/GABARAPs Drive Ubiquitin-Independent Recruitment of Optineurin and NDP52 to Amplify Mitophagy

7:15 PM
On Own for Dinner


TUESDAY, APRIL 24

8:00—11:15 AM
Mitophagy (Joint)
Meeting has ended...abstracts no longer viewable online.

Mizuho
* Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain

* Nikolaus Pfanner, University of Freiburg, Germany

Richard J. Youle, NINDS, National Institutes of Health, USA
Pink1-Parkin Pathway

Ivan Dikic, Goethe University Medical School, Germany
Ubiquitin and TBK1 interplay in Selective Autophagy

Coffee Break

Erika L. F. Holzbaur, University of Pennsylvania, USA
Dynamics of Autophagy and Mitophagy in Neurons

Koji Okamoto, Osaka University, Japan
Regulation of Mitochondrial Clearance via ER Factors

Jane E. Craig, St. Jude Children's Research Hospital, USA
Short Talk: MEK5/ERK5-Mediated Regulation of Mitophagy

Thomas McWilliams, University of Helsinki, Finland
Short Talk: Resolving Endogenous PINK1-Parkin Activation to in vivo Mitophagy

11:15 AM—12:15 PM
Meet the Editors (Joint)

* Jodi Nunnari, University of California, Davis, USA

* Anne Simonsen, University of Oslo, Norway

Stella M. Hurtley, Science, UK

Tim Spencer, Journal of Cell Biology, USA

Sharon Ahmad, Journal of Cell Science, UK

Robert Kruger, Cell, USA

Christina Kary, Nature Cell Biology, USA

Petra Gross, Journal of Cell Science, UK

Niki Scaplehorn, Nature Communications, UK

Sadaf Shadan, Nature, UK

Srividya Chandramouli, Cell Press, USA

Paulina Jadwiga Strzyz, Nature Reviews Molecular Cell Biology, UK

Elisabetta Argenzio, EMBO Journal, Germany

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Mizuho
1:00—10:00 PM
Poster Viewing

Mizuho
4:30—5:00 PM
Coffee Available

Mizuho Foyer
5:00—7:15 PM
Mitochondrial Motility and Distribution
Meeting has ended...abstracts no longer viewable online.

Mizuho
* Luca Scorrano, University of Padova, Italy

Thomas L. Schwarz, Children's Hospital Boston and Harvard Medical School, USA
Mitochondrial Motility

Benoit Kornmann, ETH Zurich, Switzerland
Mechanical Force Induces Mitochondrial Fission via the Canonical Fission Machinery

Laura L. Lackner, Northwestern University, USA
Mitochondrial Anchors: Positioning Mitochondria and More

Guillermo López-Doménech, University College London, UK
Short Talk: Miro Proteins Coordinate Microtubule and Actin-Dependent Mitochondrial Transport and Distribution

Dane M. Wolf, University of California, Los Angeles, USA
Short Talk: Milton1 Coordinates Mitochondrial Motility, Form, and Function with Nutrient Status in β Cells


Following Session is for Selective Autophagy (Z2)

5:00—7:00 PM
Xenophagy and Autophagy in Immunity
Meeting has ended...abstracts no longer viewable online.

Yamashiro
* Eric H. Baehrecke, UMass Medical School, USA

Vojo Deretic, University of New Mexico Health Sciences Center, USA
GALTOR Regulates mTOR and AMPK and Links Metabolic and Quality Control Functions of Autophagy in Endomembrane Damage

John Hunter Brumell, Hospital for Sick Children, Canada
How ATG Proteins Limit Listeria Spread

Laure-Anne Ligeon, University of Zürich – Institute of Experimental Immunology, Switzerland
Short Talk: Mechanisms of LC3-Associated Phagocytosis for MHC Class II Presentation

Rachel Ulferts, University of Cambridge, UK
Short Talk: Influenza A Infection Triggers a Cellular Response that Resembles Autophagy but has a Distinct Molecular Basis

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mizuho
7:30—10:00 PM
Poster Session 2

Mizuho

WEDNESDAY, APRIL 25

8:00—11:15 AM
Metabolism (Joint)
Meeting has ended...abstracts no longer viewable online.

Mizuho
* Marja Jäättelä, Danish Cancer Society Research Center, Denmark

* Jared Rutter, University of Utah, USA

Andrea Ballabio, Telethon Institute of Genetics and Medicine, Italy
An mTOR-TFEB Feedback Loop Controls the Response to Starvation and Physical Exercise and Is Deregulated in Cancer

Masaaki Komatsu, School of Medicine Niigata University, Japan
Selective Autophagy Regulates Lipid Metabolism

Coffee Break

Anu Suomalainen Wartiovaara, University of Helsinki, Finland
Metabolic Basis of Mitochondrial Disease

Norbert Perrimon, Harvard Medical School, USA
Physiological Regulation of Organismal Homeostasis

Myung-Shik Lee, Yonsei University College of Medicine, South Korea
Short Talk: Role of Mitophagy in Pancreatic Beta Cell Function

Martin Graef, Max Planck Institute for Biology of Aging, Germany
Short Talk: Autophagy Functions in Mitochondrial DNA Maintenance and Copy Number Regulation

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Mizuho
1:00—10:00 PM
Poster Viewing

Mizuho
2:30—4:30 PM
Workshop 2: Communication

Mizuho
* Adam L. Hughes, University of Utah, USA

Yusuke Hirabayashi, Columbia University, USA
ER-Mitochondria Tethering by PDZD8 Regulates Ca2+ Dynamics in Mammalian Neurons

Yvette C. Wong, Northwestern University, USA
Mitochondria-Lysosome Contacts Regulate Mitochondrial Fission via Rab7 GTP Hydrolysis

Thomas Ryan Hurd, New York University School of Medicine, USA
Mitochondrial Fragmentation Drives the Selective Removal of Deleterious Mitochondrial DNA in the Drosophila Germline

Lena Pernas, University of Padua, Italy
Mitochondria Limit Toxoplasma Growth by Competing for Fatty Acids

Keisuke Takeda, Tokyo University of Pharmacy and Life Sciences, Japan
MITOL Prevents ER Stress-Induced Apoptosis via IRE1α Ubiquitylation at ER-Mitochondria Contact Sites

Michal Turek, University of Warsaw, Poland
Spatial Relationship between Mitochondria and the Protein Quality Control System

Magali R. VanLinden, University of Bergen, Norway
Mitochondrial NAD is a Key Determinant of the Metabolic Profile of Human Cells and is Connected to the Peroxisomal NAD Pool

David A. Stroud, University of Melbourne, Australia
Systems Approaches to Understanding the Assembly of Mitochondrial Machines

4:30—5:00 PM
Coffee Available

Mizuho Foyer
5:00—7:15 PM
Mitochondrial Communication I
Meeting has ended...abstracts no longer viewable online.

Mizuho
* Orian S. Shirihai, University of California, Los Angeles, USA

Gia K. Voeltz, University of Colorado Boulder, USA
ER-Linked Mitochondrial Division

Jared Rutter, University of Utah, USA
Novel Mitochondrial Biochemistry

Peter Walter, HHMI/University of California, San Francisco, USA
Signaling in the Unfolded Protein Response

Peter Rehling, University Medical Centre Göttingen, Germany
Short Talk: Defective Mitochondrial Cardiolipin-Remodeling Dampens HIF1-alpha Transcription

Jakob Daniel Busch, Max-Planck-Institute for Biology of Ageing, Germany
Short Talk: MitoRibo-Tag Mice to Study the Mitochondrial Ribosome in vivo


Following Session is for Selective Autophagy (Z2)

5:00—7:00 PM
Organellophagy Other than Mitophagy
Meeting has ended...abstracts no longer viewable online.

Yamashiro
* Vojo Deretic, University of New Mexico Health Sciences Center, USA

Hitoshi Nakatogawa, Tokyo Institute of Technology, Japan
Molecular Mechanisms of Organellophagy in Yeast

Eric H. Baehrecke, UMass Medical School, USA
Novel Regulators of Organelle Autophagy

Tamotsu Yoshimori, Osaka University, Japan
Dissection of Molecular Mechanisms in Lysophagy

Heeseon An, Harvard Medical School, USA
Short Talk: Systematic Analysis of Ribophagy in Human Cells Reveals Bystander Degradation during Selective Autophagy

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mizuho
7:30—10:00 PM
Poster Session 3

Mizuho

THURSDAY, APRIL 26

7:30—8:00 AM
Poster Setup

Mizuho
8:00 AM—5:00 PM
Poster Viewing

Mizuho
8:00—11:15 AM
Regulation of Mitochondrial Biogenesis
Meeting has ended...abstracts no longer viewable online.

Mizuho
* Thomas Langer, CECAD Research Center, Germany

Nikolaus Pfanner, University of Freiburg, Germany
Protein Biogenesis and Architecture of Mitochondria

Elena I. Rugarli, University of Cologne, Germany
Post-Transcriptional Control of Mitochondrial Function

Coffee Break

Brendan J. Battersby, University of Helsinki, Finland
Selective Mitochondrial Proteotoxicity Triggers a Stress Response on Membrane Dynamics and Ribosomes

Eric A. Shoubridge, McGill University, Canada
Mitochondria 101: Mitochondrial Interaction Network

Stefan Jakobs, Max Planck Institute for Biophysical Chemistry, Germany
Short Talk: Spatial Distribution of Mitochondrial Translation and OXPHOS Complex Assembly

Sofia Zaganelli, University of Geneva, Switzerland
Short Talk: Identification of Mitochondrial RNA Granules Assembly Factors and Regulators using an Image-Based siRNA Screen


Following Session is for Selective Autophagy (Z2)

8:00—11:15 AM
Endo-Lysosome System
Meeting has ended...abstracts no longer viewable online.

Yamashiro
* Hitoshi Nakatogawa, Tokyo Institute of Technology, Japan

Noboru Mizushima, University of Tokyo, Japan
ATG Genes in Zebrafish and Mice

Marja Jäättelä, Danish Cancer Society Research Center, Denmark
Lysosomal STAT3 Regulates Intracellular Proton Equilibrium

Coffee Break

Enrique J. Garcia, Columbia University, USA
Short Talk: ESCRT-Mediated Microlipophagy during Lipid Imbalance

Harald Stenmark, Oslo University Hospital, Norway
Lysosome Repair vs Lysophagy

Roberto Zoncu, University of California, Berkeley, USA
A Nutrient-Induced Affinity Switch Controls mTORC1 Capture by its Lysosomal Scaffold

Arnold Y. Seo, Janelia Research Campus, USA
Short Talk: Macroautophagy Enhanced by Mitochondrial Respiration Remodels Vacuole Liquid-Ordered Membrane Domain to Control Micro-Lipophagy

11:15 AM—12:30 PM
Lunch

Mizuho
12:30—2:30 PM
Poster Session 4

Mizuho

Following Session is for Selective Autophagy (Z2)

3:00—4:30 PM
Workshop 2

Yamashiro
* Tamotsu Yoshimori, Osaka University, Japan

Michael Joseph Munson, University of Oslo, Norway
The Regulation of Mitophagy by Lipid-Binding Proteins

Fumiyo Ikeda, IMBA – Institute of Molecular Biotechnology, Austria
The IAP Family Member BRUCE Regulates Autophagosome-Lysosome Fusion

Shigeomi Shimizu, Tokyo Medical and Dental University, Japan
Mechanisms and Biological Roles of Golgi-Stress-Induced Mitophagy

Martina B. Wirth, Francis Crick Institute, UK
Structural Determinants Mediating Selective Binding of Autophagy Adaptors and Receptors to Mammalian ATG8 Proteins

Elena Marcassa, University of Liverpool, UK
Regulation of Basal Mitophagy and Pexophagy by the Mitochondrial Deubiquitylase USP30

4:30—5:00 PM
Coffee Available

Mizuho Foyer
5:00—7:00 PM
Mitochondrial Communication II
Meeting has ended...abstracts no longer viewable online.

Mizuho
* Benoit Kornmann, ETH Zurich, Switzerland

Toshiya Endo, Kyoto Sangyo University, Japan
Mitochondrial Protein and Lipid Trafficking

William A. Prinz, NIDDK, National Institutes of Health, USA
Link between Lipid Synthesis and Transport to Mitochondria

Jodi Nunnari, University of California, Davis, USA
Mitochondrial Behavior

Christoph Uwe Mårtensson, University of Freiburg, Germany
Short Talk: Protein Quality Control at the Main Entry Gate for Precursor Proteins into Mitochondria


Following Session is for Selective Autophagy (Z2)

5:00—6:45 PM
Therapeutic Regulation of Autophagy
Meeting has ended...abstracts no longer viewable online.

Yamashiro
* Ai Yamamoto, Columbia University, USA

Jayanta Debnath, University of California, San Francisco, USA
NBR1, Selective Autophagy and Metastasis

Beat Nyfeler, Novartis Institutes for BioMedical Research, Switzerland
Phenotypic Screening Paradigms for Autophagy Pathway Regulators

Noriyuki Matsuda, Tokyo Metropolitan Institute of Medical Science, Japan
Mitochondria Quality Control Elucidated from Parkinson's Disease

7:00—7:15 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Mizuho

Following Session is for Selective Autophagy (Z2)

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Yamashiro
7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mizuho
8:00—9:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Mizuho

FRIDAY, APRIL 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Astellas Pharma Inc. Nestlé Institute of Health Sciences

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA228548-01

Funding for this conference was made possible (in part) by 1R13CA228548-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

BioElectron Technology Corporation

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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