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This meeting took place in 2019
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Biomolecular Condensates: Phase-Separated Organizers of Cellular Biochemistry (D5)
Organizer(s) Michael K. Rosen and Anthony Hyman
April 10—13, 2019
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Dec 13, 2018
Abstract Deadline: Jan 10, 2019
Scholarship Deadline: Dec 13, 2018
Discounted Registration Deadline: Feb 12, 2019
Supported by the Directors' Fund
Summary of Meeting:
Biomolecular condensates are cellular compartments that concentrate proteins and nucleic acids without an encapsulating membrane. They act in processes across the biological spectrum, from RNA metabolism to signaling and gene regulation. Macromolecular phase separation, akin to the separation of oil from water, has emerged over the past several years as a key organizer both of condensates, and of micron-scale cell organization in general. This conference brings together for the first time at Keystone Symposia scientists studying biomolecular condensates and macromolecular phase separation from varied perspectives and across scales of length and time. Theory, biophysics, biochemistry, cell biology and developmental biology will be joined together to address central questions in the field—how is molecular specificity in condensates achieved, how are the material properties and spatial structure of condensates controlled, how do composition and physical properties lead to emergent functions, how does aberrant formation of condensates lead to diseases such as neurodegeneration and cancer? By bringing together leading scientists from diverse areas impacted by phase separation, we hope to clarify the current state of knowledge in this exciting new field and identify important future directions.
View Scholarships/Awards
Biomolecular condensates are cellular compartments that concentrate proteins and nucleic acids without an encapsulating membrane. They act in processes across the biological spectrum, from RNA metabolism to signaling and gene regulation. Macromolecular phase separation, akin to the separation of oil from water, has emerged over the past several years as a key organizer both of condensates, and of micron-scale cell organization in general. This conference brings together for the first time at Keystone Symposia scientists studying biomolecular condensates and macromolecular phase separation from varied perspectives and across scales of length and time. Theory, biophysics, biochemistry, cell biology and developmental biology will be joined together to address central questions in the field—how is molecular specificity in condensates achieved, how are the material properties and spatial structure of condensates controlled, how do composition and physical properties lead to emergent functions, how does aberrant formation of condensates lead to diseases such as neurodegeneration and cancer? By bringing together leading scientists from diverse areas impacted by phase separation, we hope to clarify the current state of knowledge in this exciting new field and identify important future directions.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Wednesday, April 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, April 13 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, April 14 in order to fully experience the meeting.
WEDNESDAY, APRIL 10
THURSDAY, APRIL 11
FRIDAY, APRIL 12
SATURDAY, APRIL 13
SUNDAY, APRIL 14
Conference Program Print | View meeting in 24 hr (international) time
The meeting will begin on Wednesday, April 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, April 13 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, April 14 in order to fully experience the meeting.
WEDNESDAY, APRIL 10
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
8:30—9:30 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Michael K. Rosen,
University of Texas Southwestern Medical Center, USA
*
Anthony Hyman,
Max Planck Institute of Molecular Cell Biology & Genetics, Germany
9:30 AM—12:00 PM
Physical Mechanisms of Macromolecular Phase Separation and Regulation
Meeting has ended...abstracts no longer viewable online.
To introduce the physical mechanisms of macromolecular phase separation, as well as its regulation.
*
Julia Mahamid,
European Molecular Biology Laboratory, Germany
Frank Jülicher,
Max-Planck-Institute for the Physics of Complex Systems, Germany
The Physics of Protein Condensates
The Physics of Protein Condensates
Nicolas L. Fawzi,
Brown University, USA
Short Talk: Structure/Function of LC Domain Phase Separation in RNA-Binding Proteins FUS and TDP-43
Short Talk: Structure/Function of LC Domain Phase Separation in RNA-Binding Proteins FUS and TDP-43
Coffee Break
Robert Tycko,
NIDDK, National Institutes of Health, USA
Structure of Low-Complexity Protein Assemblies
Structure of Low-Complexity Protein Assemblies
Diana M. Mitrea,
St. Jude Children's Research Hospital, USA
Short Talk: Dynamic Rearrangements within NPM1-Mediated Scaffolds: Implications for Ribosome Biogenesis Regulation
Short Talk: Dynamic Rearrangements within NPM1-Mediated Scaffolds: Implications for Ribosome Biogenesis Regulation
Rohit V. Pappu,
Washington University in St. Louis, USA
Multiscale Structure of Biomolecular Condensates
Multiscale Structure of Biomolecular Condensates
2:30—4:30 PM
Workshop
*
Michael K. Rosen,
University of Texas Southwestern Medical Center, USA
Krishna Shrinivas,
Massachussets Institute of Technology, USA
Enhancer Features that Mediate Formation of Localized Transcription Condensates
Enhancer Features that Mediate Formation of Localized Transcription Condensates
Liang Wang,
Tsinghua University, China
Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism
Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism
Matthias Altmeyer,
University of Zurich, Switzerland
Phase Separation of 53BP1 Ascertains Liquid-Like Behaviour of DNA Repair Compartments
Phase Separation of 53BP1 Ascertains Liquid-Like Behaviour of DNA Repair Compartments
Christoph Zechner,
Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Noise Buffering by Phase Separated Compartments
Noise Buffering by Phase Separated Compartments
Miriam Linsenmeier,
ETH Zurich, Switzerland
A Droplet-Based Microfluidic Platform to Investigate the Kinetics of Synthetic Membraneless Organelles in Cell-Like Volumes
A Droplet-Based Microfluidic Platform to Investigate the Kinetics of Synthetic Membraneless Organelles in Cell-Like Volumes
Meta Heidenreich,
Weizmann Institute of Science, Israel
A Synthetic Minimal System Connects Atomic Structure to Mesoscale Phenotypes of Protein Phase Separation
A Synthetic Minimal System Connects Atomic Structure to Mesoscale Phenotypes of Protein Phase Separation
Cong Yu,
Southern University of Science and Technology, China
Biomolecular Condensates in Focal Adhesion
Biomolecular Condensates in Focal Adhesion
5:00—7:00 PM
Structure and Substructure of Biomolecular Condensates
Meeting has ended...abstracts no longer viewable online.
To introduce the idea that many condensates are not homogeneous, and often contain subcompartments.
*
Rohit V. Pappu,
Washington University in St. Louis, USA
Julia Mahamid,
European Molecular Biology Laboratory, Germany
Visualizing the Structural Basis of Liquid-Like Stress Granules in situ
Visualizing the Structural Basis of Liquid-Like Stress Granules in situ
Haiyang Yu,
Ludwig Institute for Cancer Research, USA
Short Talk: Molecular and Structural Mechanisms for Intranuclear Tertiary Phase Separation of TDP-43 Liquid Droplets
Short Talk: Molecular and Structural Mechanisms for Intranuclear Tertiary Phase Separation of TDP-43 Liquid Droplets
Abby F. Dernburg,
University of California, Berkeley, USA
Pattern Formation within a Liquid Crystalline Compartment Regulates Meiotic Recombination
Pattern Formation within a Liquid Crystalline Compartment Regulates Meiotic Recombination
Geeta J. Narlikar,
University of California, San Francisco, USA
Phase-Separation Mechanisms in Heterochromatin
Phase-Separation Mechanisms in Heterochromatin
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:30—11:45 AM
Biochemical and Biological Function of Biomolecular Condensates
Meeting has ended...abstracts no longer viewable online.
To highlight current understanding of the functions of biomolecular condensates.
*
Amy Gladfelter,
University of North Carolina at Chapel Hill, USA
J. Paul Taylor,
St. Jude Children's Research Hospital, USA
Cooperative Interactions between G3BP1 and mRNA Permit Phase Separation that Seeds the Assembly of Stress Granules
Cooperative Interactions between G3BP1 and mRNA Permit Phase Separation that Seeds the Assembly of Stress Granules
Sindhuja Sridharan,
European Molecular Biology Laboratory, Germany
Short Talk: The Many Roles of ATP in Organizing the Cellular Proteome
Short Talk: The Many Roles of ATP in Organizing the Cellular Proteome
Lucas Pelkmans,
University of Zürich, Switzerland
Molecular Regulators of Macromolecular Phase Separation
Molecular Regulators of Macromolecular Phase Separation
Coffee Break
Geraldine Seydoux,
Johns Hopkins School of Medicine, USA
Recruitment of RNA to RNA Granules by Intrinsically-Disordered Proteins
Recruitment of RNA to RNA Granules by Intrinsically-Disordered Proteins
Anatol W. Fritsch,
Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Short Talk: The Heat is On: Controlling Germ Granule Segregation in C. elegans
Short Talk: The Heat is On: Controlling Germ Granule Segregation in C. elegans
Elio Aaron Abbondanzieri,
University of Rochester, USA
Short Talk: A Bacterial DNA-Binding Protein Forms Liquid Crystalline Complexes with DNA Capable of Supporting Unimpeded Transcription
Short Talk: A Bacterial DNA-Binding Protein Forms Liquid Crystalline Complexes with DNA Capable of Supporting Unimpeded Transcription
Songon An,
University of Maryland, Baltimore County, USA
Short Talk: Membraneless Metabolic Granules for Glucose Metabolism and Their Functional Contributions to Cellular Metabolism in Living Cells: The Glucosome
Short Talk: Membraneless Metabolic Granules for Glucose Metabolism and Their Functional Contributions to Cellular Metabolism in Living Cells: The Glucosome
Oliver Mueller-Cajar,
Nanyang Technological University, Singapore
Short Talk: The Distinct Phase Separations Underlying Diverse Pyrenoids- the CO2-Fixing Membraneless Organelles of Green Algae and Diatoms
Short Talk: The Distinct Phase Separations Underlying Diverse Pyrenoids- the CO2-Fixing Membraneless Organelles of Green Algae and Diatoms
11:45 AM—12:45 PM
NIH Grant Writing
Ian M. Fingerman,
NCI, National Institutes of Health, USA
John Satterlee,
NIDA, National Institutes of Health, USA
5:00—7:00 PM
New Phase Separating Systems
Meeting has ended...abstracts no longer viewable online.
To describe recently discovered phase separating systems, beyond canonical RNA granules and signaling clusters.
*
Lucas Pelkmans,
University of Zürich, Switzerland
Richard A. Young,
Whitehead Institute for Biomedical Research, USA
Transcriptional Condensates and Control of Cell Identity
Transcriptional Condensates and Control of Cell Identity
Arnaud Hubstenberger,
Institute of Biology Valrose, France
Multiscale and Multiphase Organization of the Transcriptome during Development and in Response to the Environment in C. elegans
Multiscale and Multiphase Organization of the Transcriptome during Development and in Response to the Environment in C. elegans
Marina Feric,
NCI, National Institutes of Health, USA
Short Talk: Condensing the Mitochondrial Genome into Gel-Like Droplets
Short Talk: Condensing the Mitochondrial Genome into Gel-Like Droplets
Pallavi Gopal,
Yale School of Medicine, USA
Spatiotemporal Dynamics of TDP-43 Ribonucleoprotein Granules in Neuronal Physiology and Pathologic Transitions in Disease
Spatiotemporal Dynamics of TDP-43 Ribonucleoprotein Granules in Neuronal Physiology and Pathologic Transitions in Disease
Yacheng Liao,
HHMI Janelia Research Institute, USA
Short Talk: RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Short Talk: RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:30—11:30 AM
Specificity
Meeting has ended...abstracts no longer viewable online.
To illustrate our current understanding of the factors that determine the recruitment of specific proteins and RNA molecules into particular biomolecular condensates.
*
Geraldine Seydoux,
Johns Hopkins School of Medicine, USA
Ruth Lehmann,
New York University, USA
RNA Organization within Phase Transitioned Germ Granules
RNA Organization within Phase Transitioned Germ Granules
Amy Gladfelter,
University of North Carolina at Chapel Hill, USA
How RNA Structure Controls Specificity in Intracellular Phase Separation
How RNA Structure Controls Specificity in Intracellular Phase Separation
Wenmin Xing,
University of Texas Southwestern Medical Center, USA
Short Talk: A Quantitative Inventory of Yeast P Body Proteins Reveals Principles of Compositional Specificity
Short Talk: A Quantitative Inventory of Yeast P Body Proteins Reveals Principles of Compositional Specificity
Coffee Break
Florian Stengel,
University of Konstanz, Germany
Short Talk: Mass Spectrometry-Based Proteomics for the Structural Characterisation of Biomolecular Condensates
Short Talk: Mass Spectrometry-Based Proteomics for the Structural Characterisation of Biomolecular Condensates
Maria Hondele,
Institute of Biochemistry, Switzerland
Short Talk: DEAD-box ATPases Are Global Regulators of Phase-Separated Organelles and RNA Flux
Short Talk: DEAD-box ATPases Are Global Regulators of Phase-Separated Organelles and RNA Flux
Ibrahim Cissé,
Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Live Mammalian Cells
Super-Resolution Imaging of Transcription in Live Mammalian Cells
Akinori Yamasaki,
Institute of Microbial Chemistry, Japan
Short Talk: Functional and Molecular Insights into Selective Autophagy of Phase Separated Cargo
Short Talk: Functional and Molecular Insights into Selective Autophagy of Phase Separated Cargo
5:00—6:45 PM
Cell Stress and Disease
Meeting has ended...abstracts no longer viewable online.
To explain how aberrant condensates may lead to human disease.
*
Anthony Hyman,
Max Planck Institute of Molecular Cell Biology & Genetics, Germany
Christine Mayr,
Memorial Sloan Kettering Cancer Center, USA
TIS Granules Enable the Formation of Specific Protein-Protein Interactions
TIS Granules Enable the Formation of Specific Protein-Protein Interactions
D. Allan Drummond,
University of Chicago, USA
Phase Separation as an Adaptive Response to Cell Stress
Phase Separation as an Adaptive Response to Cell Stress
Simon Alberti,
Max Planck Institute of Molecular Cell Biology and Genetics, Germany
A Phosphorylation-Controlled Conformational Switch Drives Stress Granule Formation by Unlocking RNA Multivalency
A Phosphorylation-Controlled Conformational Switch Drives Stress Granule Formation by Unlocking RNA Multivalency
Jay W. Schneider,
University of Texas Southwestern Medical Center, USA
Short Talk: Pathogenic Biomolecular Condensates Drive Heart Failure in Human RBM20 Cardiomyopathy Gene-Edited Pigs
Short Talk: Pathogenic Biomolecular Condensates Drive Heart Failure in Human RBM20 Cardiomyopathy Gene-Edited Pigs
6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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