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Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:
- Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting
(You can edit your own abstract from My Account page as well)
NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.
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NOTES:
This meeting will be conducted in English.
All programs are subject to change. Check this site for updates.
Download Flyer
Twitter hashtag for this meeting: #KSbiochem
This meeting will be conducted in English.
All programs are subject to change. Check this site for updates.
Download Flyer
Twitter hashtag for this meeting: #KSbiochem
Biomolecular Condensates: Phase-Separated Organizers of Cellular Biochemistry (D5)
Scientific Organizers: Michael K. Rosen and Anthony Hyman
April 10—13, 2019
Snowbird Resort, Snowbird, Utah, USA
Supported by the Directors' Fund
IT’S NOT TOO LATE TO SUBMIT YOUR ABSTRACT. Abstracts received can no longer be considered for oral short talks. Abstracts for poster display opportunities will be accepted until 6 weeks before meeting start date midnight MST.
BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.
Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.
DEADLINES:Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.
*All deadlines end at 11:59 PM US Mountain Standard Time
Scholarship Deadline: Dec 13, 2018 [details]
Discounted Abstract Deadline: Dec 13, 2018 [details]
Abstract Deadline: Jan 10, 2019 [details]
Discounted Registration Deadline: Feb 12, 2019 [details]
If you have missed a deadline due to the US government shutdown, please contact our office.
Click here to view Cancellation Policy
Discounted Abstract Deadline: December 13, 2018
*All deadlines end at 11:59 PM US Mountain Standard TimeAbstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register
Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.
Submitting your abstract early allows us to:
- submit your abstract to organizers to be considered for a short talk
- accept your abstract online
- include your abstract on our website and in our secure mobile app
- reserve your space at the meeting for a poster presentation.**
(The Abstract Deadline: is January 10, 2019)
Global Health Travel Award Deadline:
*All deadlines end at 11:59 PM US Mountain Standard Time
Global Health Travel Award Details:
You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline
and complete the other required steps (verify your contact information and submit a recommendation letter)
to be considered for a travel award.
Click here to learn more about Global Health Travel Awards.
Scholarship Deadline: December 13, 2018
*All deadlines end at 11:59 PM US Mountain Standard Time
Scholarship Details:
You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.
Abstract Deadline: January 10, 2019
*All deadlines end at 11:59 PM US Mountain Standard Time
Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register
Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.
Submitting your abstract by the Abstract Deadline allows us to:
- submit your abstract to organizers to be considered for a short talk
- include your abstract on our website and in our secure mobile app
- reserve your space at the meeting for a poster presentation.**
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.
(Discounted Abstract Deadline: is December 13, 2018)
Discounted Registration Deadline: February 12, 2019
*All deadlines end at 11:59 PM US Mountain Standard Time
Registration Fee: 795.00 USD* (includes 200.00 USD discount)
Student Registration Fee: 570.00 USD* (must complete student verification form)
*Includes 50.00 USD of your abstract submission fee
After the Discounted Registration Deadline:
Registration Fee: 995.00 USD*
Student Registration Fee: 770.00 USD* (must complete student verification form)
*Includes 50.00 USD of your abstract submission fee
Registration spaces are limited and may fill prior to discounted registration deadline.
Please be advised that some meeting participants have received calls and emails from a number of different housing services,
including "Exhibitors Housing Services," “Expo Housing Services,” "Global Housing," etc. THESE COMPANIES ARE NOT AFFILIATED
WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting
is filling, without any actual knowledge to that effect, and pressure you into giving them your credit card number to make a
lodging reservation with them.
We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report any calls or correspondence you might have received to Keystone Symposia and book only through lodging links in your Keystone Symposia account, an established travel agency or directly with the hotel(s) listed on our website.
We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report any calls or correspondence you might have received to Keystone Symposia and book only through lodging links in your Keystone Symposia account, an established travel agency or directly with the hotel(s) listed on our website.
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Wednesday, April 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, April 13 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, April 14 in order to fully experience the meeting.
WEDNESDAY, APRIL 10
THURSDAY, APRIL 11
FRIDAY, APRIL 12
SATURDAY, APRIL 13
SUNDAY, APRIL 14
Conference Program Print | View meeting in 24 hr (international) time
The meeting will begin on Wednesday, April 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, April 13 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, April 14 in order to fully experience the meeting.
WEDNESDAY, APRIL 10
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
8:30—9:30 AM
Clifford P. Brangwynne,
Princeton University, USA
Moving through Intracellular Phase Space
Moving through Intracellular Phase Space
9:30 AM—12:15 PM
Physical Mechanisms of Macromolecular Phase Separation and Regulation
Registered attendees can view abstracts starting on 03/10/2019
Registered attendees can view abstracts starting on 03/10/2019
To introduce the physical mechanisms of macromolecular phase separation, as well as its regulation.
Frank Jülicher,
Max-Planck-Institute for the Physics of Complex Systems, Germany
The Physics of Protein Condensates
The Physics of Protein Condensates
Coffee Break
Robert Tycko,
NIDDK, National Institutes of Health, USA
Structure of Low-Complexity Protein Assemblies
Structure of Low-Complexity Protein Assemblies
Rohit V. Pappu,
Washington University in St. Louis, USA
Multiscale Structure of Biomolecular Condensates
Multiscale Structure of Biomolecular Condensates
Nicolas L. Fawzi†,
Brown University, USA
Short Talk: Structure/function of LC Domain Phase Separation in RNA-Binding Proteins FUS and TDP-43
Short Talk: Structure/function of LC Domain Phase Separation in RNA-Binding Proteins FUS and TDP-43
Diana M. Mitrea,
St Jude Children's Research Hospital, USA
Short Talk: Dynamic Rearrangements within NPM1-Mediated Scaffolds: Implications for Ribosome Biogenesis Regulation
Short Talk: Dynamic Rearrangements within NPM1-Mediated Scaffolds: Implications for Ribosome Biogenesis Regulation
2:30—4:30 PM
Workshop
Krishna Shrinivas,
Massachussets Institute of Technology, USA
Enhancer Features that Mediate Formation of Localized Transcription Condensates
Enhancer Features that Mediate Formation of Localized Transcription Condensates
Miriam Linsenmeier,
ETH Zurich, Switzerland
A Droplet-Based Microfluidic Platform to Investigate the Kinetics of Synthetic Membraneless Organelles in Cell-Like Volumes
A Droplet-Based Microfluidic Platform to Investigate the Kinetics of Synthetic Membraneless Organelles in Cell-Like Volumes
Matthias Altmeyer,
University of Zurich, Switzerland
Phase Separation of 53BP1 Ascertains Liquid-Like Behaviour of DNA Repair Compartments
Phase Separation of 53BP1 Ascertains Liquid-Like Behaviour of DNA Repair Compartments
Liang Wang,
Tsinghua University, China
Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism
Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism
Cong Yu,
Southern University of Science and Technology，China, China
Biomolecular Condensates in Focal Adhesion
Biomolecular Condensates in Focal Adhesion
Christoph Zechner†,
Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Noise Buffering by Phase Separated Compartments
Noise Buffering by Phase Separated Compartments
Meta Heidenreich,
Weizmann Institute of Science, Israel
A Synthetic Minimal System Connects Atomic Structure to Mesoscale Phenotypes of Protein Phase Separation
A Synthetic Minimal System Connects Atomic Structure to Mesoscale Phenotypes of Protein Phase Separation
5:00—7:00 PM
Structure and Substructure of Biomolecular Condensates
Registered attendees can view abstracts starting on 03/10/2019
Registered attendees can view abstracts starting on 03/10/2019
To introduce the idea that many condensates are not homogeneous, and often contain subcompartments.
Julia Mahamid,
European Molecular Biology Laboratory, Germany
Visualizing the Structural Basis of Liquid-Like Stress Granules in situ
Visualizing the Structural Basis of Liquid-Like Stress Granules in situ
Abby F. Dernburg,
University of California, Berkeley, USA
Pattern Formation within a Liquid Crystalline Compartment Regulates Meiotic Recombination
Pattern Formation within a Liquid Crystalline Compartment Regulates Meiotic Recombination
Geeta J. Narlikar,
University of California, San Francisco, USA
Phase-Separation Mechanisms in Heterochromatin
Phase-Separation Mechanisms in Heterochromatin
Haiyang Yu,
Ludwig Institute for Cancer Research, USA
Short Talk: Molecular and Structural Mechanisms for Intranuclear Tertiary Phase Separation of TDP-43 Liquid Droplets
Short Talk: Molecular and Structural Mechanisms for Intranuclear Tertiary Phase Separation of TDP-43 Liquid Droplets
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:30 AM—12:30 PM
Biochemical and Biological Function of Biomolecular Condensates
Registered attendees can view abstracts starting on 03/10/2019
Registered attendees can view abstracts starting on 03/10/2019
To highlight current understanding of the functions of biomolecular condensates.
J. Paul Taylor,
St. Jude Children's Research Hospital, USA
Cooperative Interactions between G3BP1 and mRNA Permit Phase Separation that Seeds the Assembly of Stress Granules
Cooperative Interactions between G3BP1 and mRNA Permit Phase Separation that Seeds the Assembly of Stress Granules
Lucas Pelkmans,
University of Zürich, Switzerland
Molecular Regulators of Macromolecular Phase Separation
Molecular Regulators of Macromolecular Phase Separation
Coffee Break
Geraldine Seydoux,
Johns Hopkins School of Medicine, USA
RNA Granules in the C. elegans Embryo
RNA Granules in the C. elegans Embryo
Elio Aaron Abbondanzieri,
University of Rochester, USA
Short Talk: A Bacterial DNA-Binding Protein Forms Liquid Crystalline Complexes with DNA Capable of Supporting Unimpeded Transcription
Short Talk: A Bacterial DNA-Binding Protein Forms Liquid Crystalline Complexes with DNA Capable of Supporting Unimpeded Transcription
Songon An,
University of Maryland, Baltimore County, USA
Short Talk: Membraneless Metabolic Granules for Glucose Metabolism and Their Functional Contributions to Cellular Metabolism in Living Cells: The Glucosome
Short Talk: Membraneless Metabolic Granules for Glucose Metabolism and Their Functional Contributions to Cellular Metabolism in Living Cells: The Glucosome
Oliver Mueller-Cajar,
Nanyang Technological University, Singapore
Short Talk: The Distinct Phase Separations Underlying Diverse Pyrenoids- the CO2-Fixing Membraneless Organelles of Green Algae and Diatoms
Short Talk: The Distinct Phase Separations Underlying Diverse Pyrenoids- the CO2-Fixing Membraneless Organelles of Green Algae and Diatoms
Anatol W. Fritsch†,
Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Short Talk: The Heat is On: Controlling Germ Granule Segregation in C. elegans
Short Talk: The Heat is On: Controlling Germ Granule Segregation in C. elegans
Sindhuja Sridharan†,
European Molecular Biology Laboratory, Germany
Short Talk: The Many Roles of ATP in Organizing the Cellular Proteome
Short Talk: The Many Roles of ATP in Organizing the Cellular Proteome
5:00—7:00 PM
New Phase Separating Systems
Registered attendees can view abstracts starting on 03/10/2019
Registered attendees can view abstracts starting on 03/10/2019
To describe recently discovered phase separating systems, beyond canonical RNA granules and signaling clusters.
Richard A. Young,
Whitehead Institute for Biomedical Research, USA
Transcriptional Condensates and Control of Cell Identity
Transcriptional Condensates and Control of Cell Identity
Pietro V. De Camilli,
Yale University School of Medicine, USA
Liquid Phase Separation of Synaptic Vesicles
Liquid Phase Separation of Synaptic Vesicles
Arnaud Hubstenberger,
Institute of Biology Valrose, France
Multiscale and Multiphase Organization of the Transcriptome during Development and in Response to the Environment in C. elegans
Multiscale and Multiphase Organization of the Transcriptome during Development and in Response to the Environment in C. elegans
Marina Feric,
National Cancer Institute/National Institutes of Health, USA
Short Talk: Condensing the Mitochondrial Genome into Gel-Like Droplets
Short Talk: Condensing the Mitochondrial Genome into Gel-Like Droplets
Yacheng Liao,
HHMI Janelia Research Institute, USA
Short Talk: RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Short Talk: RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:30 AM—12:15 PM
Specificity
Registered attendees can view abstracts starting on 03/10/2019
Registered attendees can view abstracts starting on 03/10/2019
To illustrate our current understanding of the factors that determine the recruitment of specific proteins and RNA molecules into particular biomolecular condensates.
Ruth Lehmann,
NYU School of Medicine, USA
RNA Organization within Phase Transitioned Germ Granules
RNA Organization within Phase Transitioned Germ Granules
Amy Gladfelter,
University of North Carolina at Chapel Hill, USA
How RNA Structure Controls Specificity in Intracellular Phase Separation
How RNA Structure Controls Specificity in Intracellular Phase Separation
Coffee Break
Ibrahim Cissé,
Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Live Mammalian Cells
Super-Resolution Imaging of Transcription in Live Mammalian Cells
Maria Hondele,
Institute of Biochemistry, Switzerland
Short Talk: DEAD-box ATPases are Global Regulators of Phase-Separated Organelles and RNA Flux
Short Talk: DEAD-box ATPases are Global Regulators of Phase-Separated Organelles and RNA Flux
Akinori Yamasaki,
Institute of Microbial Chemistry, Japan
Short Talk: Functional and Molecular Insights into Selective Autophagy of Phase Separated Cargo
Short Talk: Functional and Molecular Insights into Selective Autophagy of Phase Separated Cargo
Florian Stengel,
University of Konstanz, Germany
Short Talk: Mass Spectrometry-Based Proteomics for the Structural Characterisation of Biomolecular Condensates
Short Talk: Mass Spectrometry-Based Proteomics for the Structural Characterisation of Biomolecular Condensates
Wenmin Xing,
UT Southwestern Medical Center, USA
Short Talk: A Quantitative Inventory of Yeast P Body Proteins Reveals Principles of Compositional Specificity
Short Talk: A Quantitative Inventory of Yeast P Body Proteins Reveals Principles of Compositional Specificity
5:00—6:45 PM
Biomolecular Condensates in Disease
Registered attendees can view abstracts starting on 03/10/2019
Registered attendees can view abstracts starting on 03/10/2019
To explain how aberrant condensates may lead to human disease.
Speaker to be Announced
Simon Alberti,
Max Planck Institute of Molecular Cell Biology and Genetics, Germany
A Phosphorylation-Controlled Conformational Switch Drives Stress Granule Formation by Unlocking RNA Multivalency
A Phosphorylation-Controlled Conformational Switch Drives Stress Granule Formation by Unlocking RNA Multivalency
D. Allan Drummond,
University of Chicago, USA
Phase Separation as an Adaptive Response to Cell Stress
Phase Separation as an Adaptive Response to Cell Stress
Jay W. Schneider†,
University of Texas Southwestern Medical Center, USA
Short Talk: Pathogenic Biomolecular Condensates Drive Heart Failure in Human RBM20 Cardiomyopathy Gene-Edited Pigs
Short Talk: Pathogenic Biomolecular Condensates Drive Heart Failure in Human RBM20 Cardiomyopathy Gene-Edited Pigs
6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 03/10/2019
Registered attendees can view abstracts starting on 03/10/2019
7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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