Fairmont Banff Springs Floorplan

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This meeting took place in 2019



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Epigenetics and Human Disease (X5)


Organizer(s) Cheryl H. Arrowsmith, Anne Schaefer and Mark A. Dawson
March 17—21, 2019
Fairmont Banff Springs • Banff, Alberta Canada
Discounted Abstract Deadline: Nov 29, 2018
Abstract Deadline: Dec 12, 2018
Scholarship Deadline: Nov 29, 2018
Discounted Registration Deadline: Jan 22, 2019

Sponsored by Cell Research, Incyte Corporation, Novartis Institutes for BioMedical Research and Pfizer Inc.


Summary of Meeting:
Epigenetics is a major mechanism in human health and disease. Data from a range of diseases (cancer, neurological and immunological disorders) have uncovered altered epigenomes arising from mutations, altered expression and/or copy number alterations of numerous epigenetic factors (histones, DNA and chromatin modifying enzymes, reader proteins, chromatin modulators and noncoding RNAs). Genome-wide analyses have illustrated the relationship between altered epigenetic states (e.g., modified DNA, histones and chromatin packaging) and disease onset and progression. Furthermore, both local and long-range nuclear chromatin architecture are increasingly recognized as major contributors to normal and pathologic epigenetic states. This conference, held jointly with a conference on “3D Genome”, will cover the most current knowledge of epigenetic events modulating nuclear function (gene expression regulation, enhancer modulation, domains and structural organization as well as cell division and differentiation), while relating this to normal and disease models. In addition, this conference will highlight the impact that preclinical and clinical epigenetic therapeutics have on multiple diseases including cancer, immunological and neurological disorders. An interdisciplinary panel of speakers including both thought leaders in the field as well as young investigators will survey the latest research results and conceptual understanding of fundamental mechanisms of epigenetic signaling, especially as they relate to regulation of gene expression programs. Presentations and workshops will highlight the latest technologies and methodologies for studying epigenetic states and 3D chromatin architecture in cells, tissues and organisms.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Sunday, March 17 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 21 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, March 22 in order to fully experience the meeting.

SUNDAY, MARCH 17

4:00—8:00 PM
Arrival and Registration

Van Horne Foyer
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Van Horne Foyer

MONDAY, MARCH 18

7:00—8:00 AM
Breakfast

Mezzanine 2
8:00—9:30 AM
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Cheryl Arrowsmith, University of Toronto, Canada

* Bing Ren, Ludwig Institute for Cancer Research, USA

Richard A. Young, Whitehead Institute for Biomedical Research, USA
Transcriptional Regulation, Epigenetics and Disease

Wendy A. Bickmore, University of Edinburgh, UK
Spatial Organization of the Human Genome in Disease and Senescence

Coffee Break

9:50 AM—12:15 PM
3D Epigenome/Epigenetics and Disease (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Anne Schaefer, Mount Sinai School of Medicine, USA

Matthias Merkenschlager, Imperial College London, UK
Quantitative Approaches to Cohesin-Dependent Regulation of Transcription

Mathieu Lupien, University Health Network, Canada
Epigenetics Variants in Cancer

Joanna Wysocka, Stanford University, USA
Epigenetic Regulation of Craniofacial Development

John Alan Wildenthal, NCI, National Institutes of Health, USA
Short Talk: Elucidating Enhancers Governing Human Pancreas Cell Identity and Function

Yin Shen, University of California, San Francisco, USA
Short Talk: Charting Cell-Specific 3D Epigenomes during Corticogenesis to Understand Human Brain Development and Complex Disorders

Evgeny Kvon, Lawrence Berkeley National Laboratory, USA
Short Talk: Saturation Mutagenesis Reveals Functional Impact of Enhancer Mutations in vivo

12:15—5:00 PM
On Own for Lunch

12:15—1:00 PM
Poster Setup

Mezzanine 2
1:00—10:00 PM
Poster Viewing

Mezzanine 2
2:30—4:30 PM
Workshop 1: Epigenetic Memory and Inheritance in Health and Disease

Van Horne A/B
* Mathieu Lupien, University Health Network, Canada

Berkley Eric Gryder, NCI, National Institutes of Health, USA
Chemical Disruption of Core Regulatory Architecture in Rhabdomyosarcoma

Navneet Matharu, University of California, San Francisco, USA
CRISPRa-Mediated Activation of Promoter or Enhancer Corrects Haploinsufficiency

Benjamin A. Nacev, Memorial Sloan Kettering Cancer Center, USA
Expanding the Landscape of "Oncohistone" Mutations in Human Cancers

Kirsten C. Sadler, New York University Abu Dhabi, United Arab Emirates
Epigenetic Compensation Promotes Liver Regeneration

Shu-Ping Wang, Academia Sinica, Taiwan
Critical Roles of the MLL4 Complex in Establishing an Active Enhancer Landscape in Normal and Pathological Conditions

Yael David, Memorial Sloan Kettering Cancer Center, USA
Reversible Histone Glycation Drives Cancer- Associated Changes in Chromatin Architecture

Joel B. Berletch, University of Washington, USA
Differential Epigenetic Regulation of Maternal and Paternal Alleles by the Histone Demethylase KDM6A

2:30—4:30 PM
Workshop 1: 4DN Nucleome Consortium Resources
In 2019, the 4DN Nucleosome project will enter its 4th year. A significant amount of resources, including new technologies, data standards, biological materials, and datasets, will have been produced. The workshop will provide a valuable platform for the community to become familiar with these resources and maximally benefit from them.

Van Horne C
Judy Mietz, NCI, National Institutes of Health, USA
4DN Current Scope and Outlook

Olivier Blondel, NIDDK, National Institutes of Health, USA
4DN Current Scope and Outlook

Burak H. Alver, Harvard Medical School, USA
4DN Data Portal

Feng Yue, Pennsylvania State University, USA
Introduction to 4DN Joint Analysis

Nick Gilbert, University of Edinburgh, UK
Chromatin-Associated RNA Recycling by XRN2 Regulates Transcription and Chromosome Structure

Rieke Kempfer, Max Delbrück Center, Germany
Higher-Order Chromatin Contacts and Regulatory Networks in the ESC Genome.

* Sheng Zhong, University of California, San Diego, USA
RNA as Proximity Labeling Media for Connecting Microscopic and Omics Data of Nuclear Organization

Zhen Chen, City of Hope, USA
Endothelial Functional Regulation by Enhancer-Associated Long Non-Coding RNAs

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
Epigenetic Dysregulation in Neurobiology
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Wendy A. Bickmore, University of Edinburgh, UK

Anne Schaefer, Mount Sinai School of Medicine, USA
Epigenetic Regulation of Neurodevelopment and Neurodegeneration

Danny F. Reinberg, HHMI/New York University, USA
The Epigenetic Status of Some Histone Post-Translational Modifications

Shelley L. Berger, University of Pennsylvania, USA
Epigenetic Pathways as Targets in Human Cancer

Gonçalo Castelo-Branco, Karolinska Institutet, Sweden
Short Talk: Single-Cell Transcriptomics and Epigenomics Reveal Disease-Specific States of Oligodendroglia in Multiple Sclerosis

Lorna Farrelly, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Glutamine 5 Serotonylation on Histone H3 Is a Permissive Modification that Functions Combinatorially with H3K4me3 to Potentiate Gene Expression

5:00—7:30 PM
Single Cell Analysis of Genome Architecture
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Xiaowei Zhuang, Harvard University, USA

Alistair Boettiger, Stanford University, USA
Visualizing 3D Genome Architecture and Gene Expression during Embryogenesis

Peter Fraser, Florida State University, USA
Cell Cycle Dynamics of Chromosomal Organization at Single-Cell Resolution

Ibrahim Cissé, Massachusetts Institute of Technology, USA
Super-Resolution Imaging of Transcription in Live Mammalian Cells

Blanca Pijuan-Sala, University of Cambridge, UK
Short Talk: Using Single-Cell Chromatin Accessibility Profiling to Study the Regulatory Mechanisms Underlying Early Mouse Organogenesis

Akihito Harada, Kyushu University, Japan
Short Talk: High-Throughput Single Cell Epigenomic Profiling using Chromatin Integration Labeling-Sequence

Seungsoo Kim, University of Washington, USA
Short Talk: A Combination of Transcription Factors Mediates Inducible Interchromosomal Contacts

Jesse M. Engreitz, Harvard University and Broad Institute, USA
Short Talk: Activity-by-Contact Model of Enhancer Specificity from Thousands of CRISPR Perturbations

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
7:30—10:00 PM
Poster Session 1

Mezzanine 2

TUESDAY, MARCH 19

7:00—8:00 AM
Breakfast

Mezzanine 2
8:00—11:15 AM
Understanding and Targeting Epigenetic Dysregulation
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA

Mark A. Dawson, Peter MacCallum Cancer Centre, Australia
Mechanisms of Epigenetic Therapeutics in Leukemia

Johannes Zuber, Research Institute of Molecular Pathology, Austria
Decoding Transcriptional Dependencies in Leukemia

Coffee Break

Cheryl Arrowsmith, University of Toronto, Canada
Probing the Epigenome for Therapeutic Opportunities

Marie Classon, , USA
Epigenetic Mechanisms of Drug Resistance

Sarah Attwell, Zenith Epigenetics Corp., Canada
Short Talk: The BET Inhibitor ZEN-3694 Blocks Multiple Tumor Immune Suppressive Factors and Has the Potential to Increase the Efficacy of Anti-PD1 Treatment

M. Ryan Corces, Stanford University, USA
Short Talk: The Chromatin Accessibility Landscape of Primary Human Cancers

Céline Vallot, Institut Curie, France
Short Talk: Single-Cell Chromatin Profiling Reveals Heterogeneity of Chromatin States in Breast Cancer

8:00—11:00 AM
Analysis of 3D Genome with Advanced Microscopy
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany

Cornelis Murre, University of California, San Diego, USA
The Role of Non-Coding Transcription in Compartmentalization

Andrew S. Belmont, University of Illinois at Urbana-Champaign, USA
Nuclear Speckle Association Modulates Transcription Revealed through Live-Cell Imaging

Coffee Break

Hanhui Ma, Shanghaitech University, China
Short Talk: “CRISPRadius” Reveals that DNA and Histone Modifications Cooperatively Regulate Heterochromatin Condensates

Clodagh C. O'Shea, The Salk Institute for Biological Studies, USA
Cracking the Nucleus: Visualizing the Higher Coding Structures of DNA

Magda Bienko, Karolinska Institutet, Sweden
Short Talk: Radial Organization of the Genome Revealed by GPSeq

Erez Lieberman-Aiden, Baylor College of Medicine, USA
Tracking Genome Architecture in Space, in Time and in Single Cells

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Mezzanine 2
1:00—10:00 PM
Poster Viewing

Mezzanine 2
2:30—4:30 PM
Workshop 2: Novel Modifications of Chromatin & RNA: Detection, Quantification and Functional Significance

Van Horne A/B
* François Fuks, Université Libre de Bruxelles, Belgium
Transcriptome-Wide Distribution and Function of RNA Modifications

Adriana Z. Corvalan, University of California, Los Angeles, USA
Understanding the Role of H4K20me3 and Suv4-20h2 in Cellular Quiescence

Harrison W. Gabel, Washington University School of Medicine, USA
Non-CG DNA Methylation in Neurodevelopmental Disorders

Simão Teixeira Rocha, Instituto de Medicina Molecular Joao Lobo Antunes, Portugal
Exploring the Role of Polycomb Recruitment in Xist-Mediated Silencing of the X Chromosome in ES Cells

Rohan Nishant Shah, University of Chicago, USA
Quantitative Studies of Histone Modifications

Zibo Zhao, Northwestern University, USA
Regulation of MLL/COMPASS Stability Through Its Proteolytic Cleavage by Taspase1 as a Possible Approach for Clinical Therapy of Leukemia

2:30—4:30 PM
Workshop 2: ENCODE Consortium Resources
The phase 4 of the highly successful ENCODE project will not only produce maps of functional elements, but also delineate chromatin organization in over 100 human cell types and tissues. This workshop will feature tutorials and presentations that help the community better access the valuable resources produced by the ENCODE consortium.

Van Horne C
* Feng Yue, Pennsylvania State University, USA

Michael J. Pazin, NHGRI, National Institutes of Health, USA
Overview of ENCODE Project

Zhiping Weng, University of Massachusetts, USA
ENCODE DAC

Jason Hilton, Stanford University, USA
ENCODE DAC

Jian Ma, Carnegie Mellon University, USA
Comparing 3D Genome Organization in Multiple Species using Phylo-HMRF

Yanxiao Zhang, Ludwig Institute for Cancer Research, USA
Primate-Specific Retrotransposon HERV-H Demarcates Chromatin Domains in Lineage Specification and Evolution

Joe Spidle, Arima Genomics, Inc., USA
Rapid and Sensitive Discovery of Genomic Interactions using Arima-HiC

Michael Christopher Keogh, EpiCypher Inc, USA
Fixing ChIP with Next-Generation Spike-In Controls

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
Infectious Diseases and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Rab K. Prinjha, GlaxoSmithKline, UK

Eric A. Miska, University of Cambridge, UK
RNA Modifications and Novel Antiviral Response

Alexander Tarakhovsky, Rockefeller University, USA
I-BET, Inflammation, Histone Mimicry in Pathogens, Antiviral Response

Madle Sirel, Karolinska Institutet, Sweden
Short Talk: Epigenetics of Parasites Causing Placental Malaria

Colby Zaph, Monash University, Australia
Regulatory T Cell Stability Is Controlled by the Lysine Methyltransferase G9a Independently of DNA Methylation

Timothy M. Johanson, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Pax5 Organizes the B Cell Genome in Three-Dimensions Independent of Transcription

5:00—7:15 PM
Chromatin and Epigenetics
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* X. Shirley Liu, Dana-Farber Cancer Institute, USA

Bas van Steensel, Netherlands Cancer Institute, Netherlands
Rewiring of LADs by Transcription

Mitchell Guttman, California Institute of Technology, USA
3D Genome Organization and X Chromosome Inactivation

Joseph R. Ecker, The Salk Institute for Biological Studies, USA
Single Cell Analysis of DNA Methylation

Chen-Yu Wang, Massachusetts General Hospital, USA
Short Talk: SMCHD1 Regulates the Folding of the Inactive X Chromosome and Select Autosomal loci

Candice Byers, Tufts University, USA
Short Talk: Cellular Systems Genetics Implicates KRAB Zinc Finger Proteins in Mediating Variation in Chromatin State in Pluripotent Stem Cells

Marc Bühler, Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: A Transcription Factor Implicated in Autism Locally Constrains Chromatin Looping

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
7:30—10:00 PM
Poster Session 2

Mezzanine 2

WEDNESDAY, MARCH 20

7:00—8:00 AM
Breakfast

Mezzanine 2
8:00—11:15 AM
Chromatin Signaling and Epigenetic Mechanisms
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Anne Brunet, Stanford University, USA

Christopher Vakoc, Cold Spring Harbor Laboratory, USA
Transcriptional Addiction in Cancer

Cigall Kadoch, Dana-Farber Cancer Institute, Harvard Medical School, USA
Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease

Coffee Break

Paola Scaffidi, Francis Crick Institute, UK
Epigenetics and Functional Intratumor Heterogeneity

Xiaobing Shi, Van Andel Institute, USA
Identification of the ZZ Domain as a Novel Histone Reader

Kelly Barnett, Vanderbilt University, USA
Short Talk: ATAC-Me Captures Spatiotemporal Dynamics of DNA Methylation Across the Chromatin Accessible Genome during a Monocyte-to-Macrophage Transition

Susan J. Clark, Garvan Institute of Medical Research, Australia
Short Talk: DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Mono-Methylation Patterns

Hatice S. Kaya-Okur, Fred Hutchinson Cancer Research Center, USA
Short Talk: CUT&Tag for Efficient Epigenomic Profiling of Small Samples and Single Cells

8:00—11:00 AM
3D Genome and Gene Regulation
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Mathieu Lupien, University Health Network, Canada

Bing Ren, Ludwig Institute for Cancer Research, USA
Systematic Identification and Characterization of Promoter-Enhancer Interactions in the Human Genome

Gerd A. Blobel, Children's Hospital of Philadelphia, USA
Re-Configuration of Chromatin Structure During the Mitosis-G1 Phase Transition

Coffee Break

Jennifer E. Phillips-Cremins, University of Pennsylvania, USA
LADL: Light-­Activated Dynamic Looping for Endogenous Gene Expression Control

Stavros Lomvardas, Columbia University, USA
3D Chromatin Organization of the Olfactory Receptor Locus

X. Shirley Liu, Dana-Farber Cancer Institute, USA
Epigenomic Analysis of Cancer Cells

11:30 AM—12:30 PM
Roundtable Discussion: Women in Science (Joint)

Conservatory
11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Mezzanine 2
1:00—10:00 PM
Poster Viewing

Mezzanine 2
2:30—4:30 PM
Workshop 3: Emerging Therapies to Chromatin and RNA Modifying Enzymes

Van Horne A/B
* Nada Jabado, McGill University Health Centre, Canada
Therapeutic Vulnerability of the K27M Oncohistone: Finding Achilles' Heel in Gliomas?

Danielle Bozek, University of Calgary, Canada
DOT1L Epigenetically Regulates Glioblastoma Cancer Stem Cell Properties

Patrizia Casaccia, Advanced Science Research Center, USA
DNA Hydroxymethylation Impacts Age-Dependent Myelin Regeneration in the Central Nervous System

Bilal N. Sheikh, Max Planck Institute for Immunobiology and Epigenetics, Germany
Neural Metabolic Defects Lead to Inflammation and Brain Haemorrhage

Gabriel Oh, Centre for Addiction and Mental Health, Canada
Circadian DNA Modification Hallmarks of Aging and Disease

Andreas R. Pfenning, Carnegie Mellon University, USA
Epigenomic Profiling of Major Human Brain Cell Types Reveals Sex Specific Differences in Hippocampal Oligodendrocyte Gene Regulation in Alzheimer's Disease

Emmanuelle Vire, University College London, UK
Altered DNA Methylation Signatures to Better Detect, Classify, and Understand Human Prion Diseases

2:30—4:30 PM
Workshop 3: International Human Epigenome Consortium
The IHEC consortium is an international consortium of investigators dedicated to the study of epigenomes in normal and disease cells. It has made major contributions to the development of new technologies and generation of valuable datasets to the field of epigenomics. This workshop will feature short presentations and tutorials aimed at facilitating the dissemination of resources and tools from the IHEC consortium.

Van Horne C
Martin Hirst, BC Cancer Agency, Canada
Introduction to International Human Epigenome Consortium

David Bujold, McGill University, Canada
Epigenomic Data Discovery with the IHEC Data Portal

Charles Dupras, McGill University, Canada
Potential (Mis)use of Epigenetic Age Estimators by Private Companies and Public Agencies: Are Legal Safeguards Required?

* Danny C.Y. Leung, Hong Kong University of Science and Technology, Hong Kong
Epigenomic Analyses of Retrotransposon-Derived cis-Regulatory Elements in Distinct Human Cell-Types

Martin Hirst, BC Cancer Agency, Canada
Polycomb Contraction during Human Granulopoietic Lineage Restriction

4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
Metabolic Diseases and Aging
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Shelley L. Berger, University of Pennsylvania, USA

Ross L. Levine, Memorial Sloan Kettering Cancer Center, USA
Role of Mutations in Epigenetic Regulators in Pathogenesis of AML

Stefan Horvath, University of California, Los Angeles, USA
Epigenetic Aging Clock versus Gene Regulation

Anne Brunet, Stanford University, USA
Epigenetic Regulation of Aging

Louis Coussement, University Ghent, Belgium
Short Talk: The Aging Genome: CpG Depletion throughout Human Evolution

Anita Öst, Linköping University, Sweden
Short Talk: Diet-Sensitive Fragmentation of Sperm tRNA

5:00—7:15 PM
Genome Architecture and Development
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Jennifer E. Phillips-Cremins, University of Pennsylvania, USA

Wei Xie, Tsinghua University, China
Chromatin Reprogramming in Mammalian Gametogenesis and Early Development

Ana Pombo, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Genome Architecture Mapping: Discovering 3D Genome Topology in Rare Cell Types

X. Sunney Xie, Peking University, China
Decoding the 3D Human Genome

Sajad Hamid, University of California, San Francisco, USA
Short Talk: Mapping of Nuclear Lamina-Associated Genome Organization in Developing Mouse and Human Brain

Xiong Ji, Peking University, China
Short Talk: RNAPII Condensates Connect Genome Organization and Gene Regulation

Fulai Jin, Case Western Reserve University, USA
Short Talk: Multi-Scale 3D Genome Analyses in Human Neurogenesis and Brain Tissues with Easy Hi-C

7:00—8:00 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
7:30—10:00 PM
Poster Session 3

Mezzanine 2

THURSDAY, MARCH 21

7:00—8:00 AM
Breakfast

Mezzanine 2
8:00—11:15 AM
Epigenetic Regulation in Immunoncology and Cancer Therapeutics
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Christopher Vakoc, Cold Spring Harbor Laboratory, USA

Daniel De Carvalho, University Health Network, Canada
DNA Methylation, Viral Mimicry, Epigenetic Therapy

Rab K. Prinjha, GlaxoSmithKline, UK
Drug Discovery and Clinical Progression or Epigenetic Therapies

Coffee Break

Benjamin Nicholson, Merck Research Laboratories, USA
Epigenetics and Immune Modulation in Cancer

Ricky W. Johnstone, Peter MacCallum Cancer Centre, Australia
Epigenetic Modulation of the Immune System for Cancer Treatment

Alison A. Chomiak, Van Andel Research Institute, USA
Short Talk: Polycomb Signaling as a Therapeutic Axis for Enhancing Epigenetic Therapy in Colorectal Cancer

Colum P. Walsh, University of Ulster, UK
Short Talk: UHRF1 Is Required to Suppress Viral Mimicry through Both DNA Methylation-Dependent and -Independent Mechanisms

Andrew Morton, Case Western Reserve University, USA
Short Talk: Lineage-Specific Enhancers Are Co-Opted on Focal Oncogenic Amplifications in Solid Tumors

8:00—11:00 AM
Computational Analysis of 3D Genome
Meeting has ended...abstracts no longer viewable online.

Van Horne C
* Bas van Steensel, Netherlands Cancer Institute, Netherlands

David Hawkins, University of Washington, USA
Short Talk: Epigenome Annotation and Three-Dimensional Genome Architecture Reveal Candidate Silencer Elements for the Human and Mouse Genomes

Frank Alber, University California, Los Angeles, USA
Computational Modeling of 3D Genome

Jill E. Moore, University of Massachusetts Medical School, USA
Short Talk: Evaluating Computational Methods for Predicting Enhancer-Gene Interactions

Coffee Break

Mario Nicodemi, Universita' di Napoli Federico II, Italy
Polymer Physics Predicts the Effects of Structural Variants on Chromatin Architecture

Ferhat Ay, La Jolla Institute, USA
Short Talk: FitHiChIP: Identification of Chromatin Loops from HiChIP/PLAC-Seq Data

Kathleen Keough, Gladstone Institutes, University of California, San Francisco, USA
Short Talk: A Role for Enhancer Hijacking in the Emergence of Human Accelerated Regions

Robert Babak Faryabi, University of Pennsylvania, USA
Short Talk: Notch-Instructed 3D Cancer Genome

11:15 AM—5:00 PM
On Own for Lunch

11:30 AM—12:30 PM
Roundtable Discussion: Careers in Industry (Joint)

Conservatory
4:30—5:00 PM
Coffee Available

Van Horne Foyer
5:00—7:00 PM
3D Genome and Disease (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
* Mark A. Dawson, Peter MacCallum Cancer Centre, Australia

Joseph R. Ecker, The Salk Institute for Biological Studies, USA

Xiaowei Zhuang, Harvard University, USA
Single-Cell Transcriptome and Chromosome Imaging

Bradley E. Bernstein, Massachusetts General Hospital, USA
Epigenetic Plasticity and Selection in Tumorigenesis

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
TET Loss-of-Function and Oncogenesis

Zuzana Tothova, Dana-Farber Cancer Institute, USA
Short Talk: Chromatin Architecture in Leukemia through the Lens of Cohesin Complex Mutations

Jesse Dixon, The Salk Institute for Biological Studies, USA
Short Talk: Identification of Recurrent TAD Fusion Events as a Result of Structural Variation in Cancer Genomes

7:00—7:15 PM
Meeting Wrap-Up: Outcomes and Future Directions (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne A/B
Anne Schaefer, Mount Sinai School of Medicine, USA

Joseph R. Ecker, The Salk Institute for Biological Studies, USA

7:15—8:15 PM
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Mezzanine 2
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Mezzanine 2

FRIDAY, MARCH 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Incyte Corporation
Novartis Institutes for BioMedical Research Pfizer Inc.

We gratefully acknowledge additional support from these exhibitors at this conference:

EpiCypher Illumina
10x Genomics
 
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA236128-01

Funding for this conference was made possible (in part) by 1R13CA236128-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

American Association for Cancer Research (AACR) American Society of Gene & Cell Therapy (ASGCT)
Chroma Technology Corporation Zymo Research Corporation

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



GlaxoSmithKline


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179