Granlibakken Tahoe Floorplan

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This meeting took place in 2019



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Transcription and RNA Regulation in Inflammation and Immunity (B1)


Organizer(s) Silvia Monticelli, K. Mark Ansel, Sarah Teichmann and Gioacchino Natoli
February 2—5, 2019
Granlibakken Tahoe • Tahoe City, California USA
Discounted Abstract Deadline: Oct 18, 2018
Abstract Deadline: Oct 30, 2018
Scholarship Deadline: Oct 18, 2018
Discounted Registration Deadline: Nov 29, 2018

Supported by Directors' Fund

Summary of Meeting:
The immune system is a heavily armed but carefully tuned defense mechanism that must mount protective responses against invading pathogens, while at the same time avoiding excessive inflammation and inappropriate responses that can lead to severe tissue damage and disease. Properly regulated immune responses are the result of a complex interplay between chromatin modifications, transcription factors and post-transcriptional regulators that operate collectively within each cell to regulate the gene expression programs that control immune cell differentiation, maintenance of cell identity, and the orchestration of functional responses in a dynamic environment. Recent technical advances in genomics and single-cell analyses have brought new ideas and perspectives to investigation of the regulation of gene expression, and our understanding of the mechanisms and regulatory networks that operate in the immune system is advancing at an unprecedented rate. This meeting will be important to define the most impactful questions and future challenges in the field of transcriptional and post-transcriptional control of immune cells, and it will bring together rapidly expanding and evolving communities. The exchange of scientific knowledge and technical capabilities will foster opportunities for collaborations and interdisciplinary interactions among groups of scientists working on disparate aspects of regulation of gene expression in inflammation and immunity, highlighting the latest innovations and discoveries while shaping future directions for the field.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


The meeting will begin on Saturday, February 2 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Tuesday, February 5 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Wednesday, February 6 in order to fully experience the meeting.

SATURDAY, FEBRUARY 2

4:00—8:00 PM
Arrival and Registration

Pre Function
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Granhall
6:00—8:00 PM
Light Meal - Provided by Granlibakken

Granhall

SUNDAY, FEBRUARY 3

7:00—8:00 AM
Breakfast

Granhall
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Silvia Monticelli, Institute for Research in Biomedicine, Switzerland

Stephen T. Smale, University of California, Los Angeles, USA
Bridging the Layers: An Integrative Approach to Transcriptional Regulation of Inflammation

9:00—11:45 AM
Transcriptional Mechanisms of Immune Cell Development
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Sarah Teichmann, Wellcome Sanger Institute, UK

Ellen V. Rothenberg, California Institute of Technology, USA
Transcriptional Control of Lineage Choice in Lymphocyte Commitment

Coffee Break

Ichiro Taniuchi, RIKEN Center for Integrative Medical Sciences, Japan
Gene Regulation by Local and Long-Range Chromatin Loops during CD4/CD8 Lineage Choice

Amanda G. Fisher, Imperial College London, UK
Epigenetics and Inheritance

Sarah L. Hayward, Emory University, USA
Short Talk: Environmental Cues Regulate Transcriptional Reprogramming of Airway-Resident Memory CD8 T Cells

Jinyong Choi, La Jolla Institute for Immunology, USA
Short Talk: Bcl6 Controls the Follicular Helper T Cell (Tfh) Genetic Program via Inhibition-of-Inhibitor Mechanisms and Exhibits Autoregulation

Marissa C. Franke, University of California, Davis, USA
Short Talk: Role of SET-Like Domain of Blimp-1 in Plasma Cell Differentiation

11:45 AM—5:00 PM
On Own for Lunch

11:45 AM—1:00 PM
Poster Setup

Bay
1:00—10:00 PM
Poster Viewing

Bay
2:30—4:30 PM
Workshop 1: Innovative Technologies: New Ways to Interrogate Immune Regulation

Mountain/Lake
* Ido Amit, Weizmann Institute, Israel

Ye Zheng, The Salk Institute for Biological Studies, USA
Novel Foxp3 Regulators Discovered by a Genome-Wide CRISPR Screen

Huitian Diao, The Scripps Research Institute, USA
Defining Chromatin Regulator Function in CD8 T Cells and in vivo Systems for Inducible and Reversible RNA Interference in Naive T Cells

Michael Sikora, Stanford University, USA
Select-Sequencing of Clonally Expanded CD8+ T Cells Reveals Limits to Clonal Expansion

Didi S. Zhu, University of California, San Francisco, USA
A Global Map of RNA-Binding Protein Occupancy Guides Functional Dissection of Post-Transcriptional Regulation of the T Cell Transcriptome

Deborah R. Winter, Northwestern University, USA
Synovial Macrophages Demonstrate Heterogeneity in their Transcriptional Response to Joint Inflammation in Mouse Models of Arthritis

Muzaffer Ahmad Kassab, City of Hope, USA
RNA 2’O-Methylation in B Cell Function

4:30—5:00 PM
Coffee Available

Pre Function
5:00—7:00 PM
Single Cell Approaches to Immune System Complexity
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Matthias Merkenschlager, Imperial College London, UK

Sarah Teichmann, Wellcome Sanger Institute, UK
Immunogenomics One Cell at a Time

Ido Amit, Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics

Muzlifah A. Haniffa, Newcastle University, UK
Functional Heterogeneity of Human Mononuclear Phagocytes

Chrysothemis Brown, Sloan Kettering Institute, USA
Short Talk: Single-Cell Transcriptomics Reveals Novel Dendritic Cell Subsets and their Transcriptional Regulators

Douglas A. Bell, NIEHS, National Institutes of Health, USA
Short Talk: Single Cell RNA Sequencing Reveals Altered Effector CD8+ T Lymphocytes in Smokers

7:00—8:00 PM
Dinner

Granhall
7:30—10:00 PM
Poster Session 1

Bay
8:00—9:00 PM
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

MONDAY, FEBRUARY 4

7:00—8:00 AM
Breakfast

Granhall
8:00—11:15 AM
Transcriptional and Epigenomic Control of Immune Responses
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Ellen V. Rothenberg, California Institute of Technology, USA

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
TET Methylcytosine Oxidases, Immune Responses and Cancer

Yuka Kanno, NIAMS, National Institutes of Health, USA
Genomic Views of Lymphocyte Differentiation and Activation

Coffee Break

Gioacchino Natoli, Humanitas University, Italy
Access to the Genomic Regulatory Information and the Control of Inflammatory Gene Expression

Christopher K. Glass, University of California, San Diego, USA
Roles of Tissue Environment in Shaping Macrophage Identities in Health and Disease

Diana Hargreaves, The Salk Institute for Biological Studies, USA
Short Talk: Control of Inflammatory Responses by BAF Chromatin Remodeling Complexes

Matthias Merkenschlager, Imperial College London, UK
Short Talk: Quantitative Single Cell Analysis of Macrophage Gene Expression as a Mechanistic Approach to Cohesin-Dependent Regulation of Transcription

Jessica Bouviere, Institut NeuroMyogène, France
Short Talk: Selenoproteins Regulate Macrophage Polarization and Function

11:15 AM—5:00 PM
On Own for Lunch

11:15 AM—1:00 PM
Poster Setup

Bay
1:00—10:00 PM
Poster Viewing

Bay
2:30—4:30 PM
Workshop 2: Transcriptional Control in Physiology and Disease

Mountain/Lake
* Gioacchino Natoli, Humanitas University, Italy

Alejandro Villarino, NIAMS, National Institutes of Health, USA
Transcriptional Programming of T Cell Metabolism Downstream of Cytokine-STAT Signaling

Rahul Roychoudhuri, Babraham Institute, UK
A Treg-Specific Distal Transcriptional Enhancer that Mediates Resistance to Gut Inflammation

Ning Wang, University of California, Los Angeles, USA
On the Identifiability of Gene Regulatory Strategies by Combinations of Signal-Dependent Transcription Factors

Andrew Scott, Memorial Sloan Kettering Cancer Center, USA
Thymocyte Selection-Associated HMG Box Protein TOX is a Master Regulator of Tumor-Specific T Cell Disfunction

Renato Ostuni, Ospedale San Raffaele S.r.l., Italy
Integration of Immune Stimuli Expands the Spectrum of Macrophage Activation States and Identifies Targets for Functional Reprogramming

Mashito Sakai, University of California, San Diego, USA
Deciphering Liver-Environmental Signalling Pathways for Kupffer Cell Identity

Florence Mailhot-Léonard, University of Montreal/University of Chicago, USA
Gene Activation Precedes DNA Demethylation in Response to Infection in Human Dendritic Cells

Kelly M. Banks, Weill Cornell Graduate School, USA
Epigenetic Regulation of Neutrophil Development and Neutrophil Extracellular Trap Formation by Tet Enzymes

4:30—5:00 PM
Coffee Available

Pre Function
5:00—7:00 PM
Pathologic Dysregulation of Transcription
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Christopher K. Glass, University of California, San Diego, USA

Rab K. Prinjha, GlaxoSmithKline, UK
Drugging Transcription: Progress and Potential for Treating Human Immune Dysfunction

Andrea Schietinger, Memorial Sloan Kettering Cancer Center, USA
Transcription Factors and Epigenetic Programs in Cancer Immunology

Camille Marie Syrett, University of Pennsylvania, USA
Short Talk: A Novel Requirement for Xist RNA-Mediated X Chromosome Inactivation Maintenance in Female-Biased Autoimmunity

Prasida Holla, NIAID, National Institutes of Health, USA
Short Talk: Understanding the Transcriptional Program in Atypical Memory B Cells in Chronic Diseases

Alex Marson, University of California, San Francisco, USA
Reprogramming Human Immune Cell Circuitry

7:00—8:00 PM
Dinner

Granhall
7:30—10:00 PM
Poster Session 2

Bay
8:00—9:00 PM
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

TUESDAY, FEBRUARY 5

7:00—8:00 AM
Breakfast

Granhall
8:00—11:00 AM
Non-Coding Genome and Post-Transcriptional Control in Immunity
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Martin Turner, Babraham Institute, UK

K. Mark Ansel, University of California, San Francisco, USA
Mapping RNA Interfaces, Fate and Function in Lymphocytes

Silvia Monticelli, Institute for Research in Biomedicine, Switzerland
Transcriptional and Posttranscriptional Regulation of Human T Lymphocytes

Coffee Break

Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia, USA
Long Non-Coding RNAs

Johannes Schwerk, University of Washington, USA
Short Talk: Dual Role of Zinc-Finger Antiviral Protein Splice Variants: Infiltrating Alphavirus Replication Sites and Resolving Antiviral Inflammation

Philippe Bouillet, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Impaired Post-Transcriptional Regulation of TNF Causes Developmental Defects and Inflammatory Diseases

Takuya Uehata, Kyoto University, Japan
Short Talk: Critical Roles of Endonucleases Regnase-1 and Regnase-3 in Early Lymphopoiesis

Anna-Maria Herzner, Genentech, Inc., USA
Short Talk: Dual Protection from Endogenous dsRNA Induced Type-I-IFN Responses by ADAR and hnRNPC

11:00 AM—5:00 PM
On Own for Lunch

2:30—4:30 PM
Workshop 3: RNA-Mediated Regulation

Mountain/Lake
* Vigo Heissmeyer, University of Munich, Germany

Davia Blake, University of Pennsylvania, USA
CD28 Regulation of Global Alternative Splicing Changes in Activated Human CD4+ T Cells

Wei-Le Wang, City of Hope, USA
MicroRNA-142 Guards against Autoimmunity by Controlling Treg Cell Homeostasis and Function

Marianne Doelz, University of Basel, Switzerland
The Surprising Capacity of the miR17-92 microRNA Cluster to Compensate for CD28 Deficiency

Matilda Toivakka, University of Edinburgh, UK
Identification of RISC-Associated miRNAs and their Targets during T Cell Activation

Osamu Takeuchi, Kyoto University, Japan
Critical Roles of an RNase N4BP1 in Anti-HIV-1 Host Defense and its Control by TCR Signaling

4:30—5:00 PM
Coffee Available

Pre Function
5:00—6:45 PM
RNA-Binding Proteins and RNA Methylation in Immunity
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* K. Mark Ansel, University of California, San Francisco, USA

Vigo Heissmeyer, University of Munich, Germany
Cooperative Regulation of T Cell Fate Decisions by RNA-Binding Proteins

Monika Wolkers, Sanquin Research, Netherlands
Short Talk: Post-Transcriptional Regulation in T Cell Responses to Infection and Tumors is Time- and Context-Dependent

Fraser Soares, University Health Network, Canada
Short Talk: CRISPR/Cas9 Screening Identifies the m6A Methyltransferase METTL3 as a Regulator of PDL-1

Martin Turner, Babraham Institute, UK
An Indispensable Role for Polypyrimidine Tract Binding Proteins in B Cell Development

6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
7:00—8:00 PM
Dinner

Granhall
7:00—8:00 PM
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Granhall

WEDNESDAY, FEBRUARY 6

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support from these exhibitors at this conference:

10x Genomics
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI140575-01

Funding for this conference was made possible (in part) by 1 R13 AI140575-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

American Society of Gene & Cell Therapy (ASGCT)

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



GlaxoSmithKline


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676