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This meeting took place in 2019
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Transcription and RNA Regulation in Inflammation and Immunity (B1)
Organizer(s) Silvia Monticelli, K. Mark Ansel, Sarah Teichmann and Gioacchino Natoli
February 2—5, 2019
Granlibakken Tahoe • Tahoe City, California USA
Discounted Abstract Deadline: Oct 18, 2018
Abstract Deadline: Oct 30, 2018
Scholarship Deadline: Oct 18, 2018
Discounted Registration Deadline: Nov 29, 2018
Supported by Directors' Fund
Summary of Meeting:
The immune system is a heavily armed but carefully tuned defense mechanism that must mount protective responses against invading pathogens, while at the same time avoiding excessive inflammation and inappropriate responses that can lead to severe tissue damage and disease. Properly regulated immune responses are the result of a complex interplay between chromatin modifications, transcription factors and post-transcriptional regulators that operate collectively within each cell to regulate the gene expression programs that control immune cell differentiation, maintenance of cell identity, and the orchestration of functional responses in a dynamic environment. Recent technical advances in genomics and single-cell analyses have brought new ideas and perspectives to investigation of the regulation of gene expression, and our understanding of the mechanisms and regulatory networks that operate in the immune system is advancing at an unprecedented rate. This meeting will be important to define the most impactful questions and future challenges in the field of transcriptional and post-transcriptional control of immune cells, and it will bring together rapidly expanding and evolving communities. The exchange of scientific knowledge and technical capabilities will foster opportunities for collaborations and interdisciplinary interactions among groups of scientists working on disparate aspects of regulation of gene expression in inflammation and immunity, highlighting the latest innovations and discoveries while shaping future directions for the field.
View Scholarships/Awards
The immune system is a heavily armed but carefully tuned defense mechanism that must mount protective responses against invading pathogens, while at the same time avoiding excessive inflammation and inappropriate responses that can lead to severe tissue damage and disease. Properly regulated immune responses are the result of a complex interplay between chromatin modifications, transcription factors and post-transcriptional regulators that operate collectively within each cell to regulate the gene expression programs that control immune cell differentiation, maintenance of cell identity, and the orchestration of functional responses in a dynamic environment. Recent technical advances in genomics and single-cell analyses have brought new ideas and perspectives to investigation of the regulation of gene expression, and our understanding of the mechanisms and regulatory networks that operate in the immune system is advancing at an unprecedented rate. This meeting will be important to define the most impactful questions and future challenges in the field of transcriptional and post-transcriptional control of immune cells, and it will bring together rapidly expanding and evolving communities. The exchange of scientific knowledge and technical capabilities will foster opportunities for collaborations and interdisciplinary interactions among groups of scientists working on disparate aspects of regulation of gene expression in inflammation and immunity, highlighting the latest innovations and discoveries while shaping future directions for the field.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Saturday, February 2 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Tuesday, February 5 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Wednesday, February 6 in order to fully experience the meeting.
SATURDAY, FEBRUARY 2
SUNDAY, FEBRUARY 3
MONDAY, FEBRUARY 4
TUESDAY, FEBRUARY 5
WEDNESDAY, FEBRUARY 6
Conference Program Print | View meeting in 24 hr (international) time
The meeting will begin on Saturday, February 2 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Tuesday, February 5 with a closing plenary session from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Wednesday, February 6 in order to fully experience the meeting.
SATURDAY, FEBRUARY 2
6:00—8:00 PM
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
8:00—9:00 AM
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Silvia Monticelli,
Institute for Research in Biomedicine, Switzerland
Stephen T. Smale,
University of California, Los Angeles, USA
Bridging the Layers: An Integrative Approach to Transcriptional Regulation of Inflammation
Bridging the Layers: An Integrative Approach to Transcriptional Regulation of Inflammation
9:00—11:45 AM
Transcriptional Mechanisms of Immune Cell Development
Meeting has ended...abstracts no longer viewable online.
*
Sarah Teichmann,
Wellcome Sanger Institute, UK
Ellen V. Rothenberg,
California Institute of Technology, USA
Transcriptional Control of Lineage Choice in Lymphocyte Commitment
Transcriptional Control of Lineage Choice in Lymphocyte Commitment
Coffee Break
Ichiro Taniuchi,
RIKEN Center for Integrative Medical Sciences, Japan
Gene Regulation by Local and Long-Range Chromatin Loops during CD4/CD8 Lineage Choice
Gene Regulation by Local and Long-Range Chromatin Loops during CD4/CD8 Lineage Choice
Sarah L. Hayward,
Emory University, USA
Short Talk: Environmental Cues Regulate Transcriptional Reprogramming of Airway-Resident Memory CD8 T Cells
Short Talk: Environmental Cues Regulate Transcriptional Reprogramming of Airway-Resident Memory CD8 T Cells
Jinyong Choi,
La Jolla Institute for Immunology, USA
Short Talk: Bcl6 Controls the Follicular Helper T Cell (Tfh) Genetic Program via Inhibition-of-Inhibitor Mechanisms and Exhibits Autoregulation
Short Talk: Bcl6 Controls the Follicular Helper T Cell (Tfh) Genetic Program via Inhibition-of-Inhibitor Mechanisms and Exhibits Autoregulation
Marissa C. Franke,
University of California, Davis, USA
Short Talk: Role of SET-Like Domain of Blimp-1 in Plasma Cell Differentiation
Short Talk: Role of SET-Like Domain of Blimp-1 in Plasma Cell Differentiation
2:30—4:30 PM
Workshop 1: Innovative Technologies: New Ways to Interrogate Immune Regulation
*
Ido Amit,
Weizmann Institute, Israel
Ye Zheng,
The Salk Institute for Biological Studies, USA
Novel Foxp3 Regulators Discovered by a Genome-Wide CRISPR Screen
Novel Foxp3 Regulators Discovered by a Genome-Wide CRISPR Screen
Huitian Diao,
The Scripps Research Institute, USA
Defining Chromatin Regulator Function in CD8 T Cells and in vivo Systems for Inducible and Reversible RNA Interference in Naive T Cells
Defining Chromatin Regulator Function in CD8 T Cells and in vivo Systems for Inducible and Reversible RNA Interference in Naive T Cells
Michael Sikora,
Stanford University, USA
Select-Sequencing of Clonally Expanded CD8+ T Cells Reveals Limits to Clonal Expansion
Select-Sequencing of Clonally Expanded CD8+ T Cells Reveals Limits to Clonal Expansion
Didi S. Zhu,
University of California, San Francisco, USA
A Global Map of RNA-Binding Protein Occupancy Guides Functional Dissection of Post-Transcriptional Regulation of the T Cell Transcriptome
A Global Map of RNA-Binding Protein Occupancy Guides Functional Dissection of Post-Transcriptional Regulation of the T Cell Transcriptome
Deborah R. Winter,
Northwestern University, USA
Synovial Macrophages Demonstrate Heterogeneity in their Transcriptional Response to Joint Inflammation in Mouse Models of Arthritis
Synovial Macrophages Demonstrate Heterogeneity in their Transcriptional Response to Joint Inflammation in Mouse Models of Arthritis
Muzaffer Ahmad Kassab,
City of Hope, USA
RNA 2’O-Methylation in B Cell Function
RNA 2’O-Methylation in B Cell Function
5:00—7:00 PM
Single Cell Approaches to Immune System Complexity
Meeting has ended...abstracts no longer viewable online.
*
Matthias Merkenschlager,
Imperial College London, UK
Sarah Teichmann,
Wellcome Sanger Institute, UK
Immunogenomics One Cell at a Time
Immunogenomics One Cell at a Time
Ido Amit,
Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics
The Power of ONE: Immunology in the Age of Single Cell Genomics
Muzlifah A. Haniffa,
Newcastle University, UK
Functional Heterogeneity of Human Mononuclear Phagocytes
Functional Heterogeneity of Human Mononuclear Phagocytes
Chrysothemis Brown,
Sloan Kettering Institute, USA
Short Talk: Single-Cell Transcriptomics Reveals Novel Dendritic Cell Subsets and their Transcriptional Regulators
Short Talk: Single-Cell Transcriptomics Reveals Novel Dendritic Cell Subsets and their Transcriptional Regulators
Douglas A. Bell,
NIEHS, National Institutes of Health, USA
Short Talk: Single Cell RNA Sequencing Reveals Altered Effector CD8+ T Lymphocytes in Smokers
Short Talk: Single Cell RNA Sequencing Reveals Altered Effector CD8+ T Lymphocytes in Smokers
8:00—11:15 AM
Transcriptional and Epigenomic Control of Immune Responses
Meeting has ended...abstracts no longer viewable online.
*
Ellen V. Rothenberg,
California Institute of Technology, USA
Anjana Rao,
La Jolla Institute for Allergy and Immunology, USA
TET Methylcytosine Oxidases, Immune Responses and Cancer
TET Methylcytosine Oxidases, Immune Responses and Cancer
Yuka Kanno,
NIAMS, National Institutes of Health, USA
Genomic Views of Lymphocyte Differentiation and Activation
Genomic Views of Lymphocyte Differentiation and Activation
Coffee Break
Gioacchino Natoli,
Humanitas University, Italy
Access to the Genomic Regulatory Information and the Control of Inflammatory Gene Expression
Access to the Genomic Regulatory Information and the Control of Inflammatory Gene Expression
Christopher K. Glass,
University of California, San Diego, USA
Roles of Tissue Environment in Shaping Macrophage Identities in Health and Disease
Roles of Tissue Environment in Shaping Macrophage Identities in Health and Disease
Diana Hargreaves,
The Salk Institute for Biological Studies, USA
Short Talk: Control of Inflammatory Responses by BAF Chromatin Remodeling Complexes
Short Talk: Control of Inflammatory Responses by BAF Chromatin Remodeling Complexes
Matthias Merkenschlager,
Imperial College London, UK
Short Talk: Quantitative Single Cell Analysis of Macrophage Gene Expression as a Mechanistic Approach to Cohesin-Dependent Regulation of Transcription
Short Talk: Quantitative Single Cell Analysis of Macrophage Gene Expression as a Mechanistic Approach to Cohesin-Dependent Regulation of Transcription
Jessica Bouviere,
Institut NeuroMyogène, France
Short Talk: Selenoproteins Regulate Macrophage Polarization and Function
Short Talk: Selenoproteins Regulate Macrophage Polarization and Function
2:30—4:30 PM
Workshop 2: Transcriptional Control in Physiology and Disease
*
Gioacchino Natoli,
Humanitas University, Italy
Alejandro Villarino,
NIAMS, National Institutes of Health, USA
Transcriptional Programming of T Cell Metabolism Downstream of Cytokine-STAT Signaling
Transcriptional Programming of T Cell Metabolism Downstream of Cytokine-STAT Signaling
Rahul Roychoudhuri,
Babraham Institute, UK
A Treg-Specific Distal Transcriptional Enhancer that Mediates Resistance to Gut Inflammation
A Treg-Specific Distal Transcriptional Enhancer that Mediates Resistance to Gut Inflammation
Ning Wang,
University of California, Los Angeles, USA
On the Identifiability of Gene Regulatory Strategies by Combinations of Signal-Dependent Transcription Factors
On the Identifiability of Gene Regulatory Strategies by Combinations of Signal-Dependent Transcription Factors
Andrew Scott,
Memorial Sloan Kettering Cancer Center, USA
Thymocyte Selection-Associated HMG Box Protein TOX is a Master Regulator of Tumor-Specific T Cell Disfunction
Thymocyte Selection-Associated HMG Box Protein TOX is a Master Regulator of Tumor-Specific T Cell Disfunction
Renato Ostuni,
Ospedale San Raffaele S.r.l., Italy
Integration of Immune Stimuli Expands the Spectrum of Macrophage Activation States and Identifies Targets for Functional Reprogramming
Integration of Immune Stimuli Expands the Spectrum of Macrophage Activation States and Identifies Targets for Functional Reprogramming
Mashito Sakai,
University of California, San Diego, USA
Deciphering Liver-Environmental Signalling Pathways for Kupffer Cell Identity
Deciphering Liver-Environmental Signalling Pathways for Kupffer Cell Identity
Florence Mailhot-Léonard,
University of Montreal/University of Chicago, USA
Gene Activation Precedes DNA Demethylation in Response to Infection in Human Dendritic Cells
Gene Activation Precedes DNA Demethylation in Response to Infection in Human Dendritic Cells
Kelly M. Banks,
Weill Cornell Graduate School, USA
Epigenetic Regulation of Neutrophil Development and Neutrophil Extracellular Trap Formation by Tet Enzymes
Epigenetic Regulation of Neutrophil Development and Neutrophil Extracellular Trap Formation by Tet Enzymes
5:00—7:00 PM
Pathologic Dysregulation of Transcription
Meeting has ended...abstracts no longer viewable online.
*
Christopher K. Glass,
University of California, San Diego, USA
Rab K. Prinjha,
GlaxoSmithKline, UK
Drugging Transcription: Progress and Potential for Treating Human Immune Dysfunction
Drugging Transcription: Progress and Potential for Treating Human Immune Dysfunction
Andrea Schietinger,
Memorial Sloan Kettering Cancer Center, USA
Transcription Factors and Epigenetic Programs in Cancer Immunology
Transcription Factors and Epigenetic Programs in Cancer Immunology
Camille Marie Syrett,
University of Pennsylvania, USA
Short Talk: A Novel Requirement for Xist RNA-Mediated X Chromosome Inactivation Maintenance in Female-Biased Autoimmunity
Short Talk: A Novel Requirement for Xist RNA-Mediated X Chromosome Inactivation Maintenance in Female-Biased Autoimmunity
Prasida Holla,
NIAID, National Institutes of Health, USA
Short Talk: Understanding the Transcriptional Program in Atypical Memory B Cells in Chronic Diseases
Short Talk: Understanding the Transcriptional Program in Atypical Memory B Cells in Chronic Diseases
8:00—11:00 AM
Non-Coding Genome and Post-Transcriptional Control in Immunity
Meeting has ended...abstracts no longer viewable online.
*
Martin Turner,
Babraham Institute, UK
K. Mark Ansel,
University of California, San Francisco, USA
Mapping RNA Interfaces, Fate and Function in Lymphocytes
Mapping RNA Interfaces, Fate and Function in Lymphocytes
Silvia Monticelli,
Institute for Research in Biomedicine, Switzerland
Transcriptional and Posttranscriptional Regulation of Human T Lymphocytes
Transcriptional and Posttranscriptional Regulation of Human T Lymphocytes
Coffee Break
Jorge Henao-Mejia,
University of Pennsylvania and Children's Hospital of Philadelphia, USA
Long Non-Coding RNAs
Long Non-Coding RNAs
Johannes Schwerk,
University of Washington, USA
Short Talk: Dual Role of Zinc-Finger Antiviral Protein Splice Variants: Infiltrating Alphavirus Replication Sites and Resolving Antiviral Inflammation
Short Talk: Dual Role of Zinc-Finger Antiviral Protein Splice Variants: Infiltrating Alphavirus Replication Sites and Resolving Antiviral Inflammation
Philippe Bouillet,
Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Impaired Post-Transcriptional Regulation of TNF Causes Developmental Defects and Inflammatory Diseases
Short Talk: Impaired Post-Transcriptional Regulation of TNF Causes Developmental Defects and Inflammatory Diseases
Takuya Uehata,
Kyoto University, Japan
Short Talk: Critical Roles of Endonucleases Regnase-1 and Regnase-3 in Early Lymphopoiesis
Short Talk: Critical Roles of Endonucleases Regnase-1 and Regnase-3 in Early Lymphopoiesis
Anna-Maria Herzner,
Genentech, Inc., USA
Short Talk: Dual Protection from Endogenous dsRNA Induced Type-I-IFN Responses by ADAR and hnRNPC
Short Talk: Dual Protection from Endogenous dsRNA Induced Type-I-IFN Responses by ADAR and hnRNPC
2:30—4:30 PM
Workshop 3: RNA-Mediated Regulation
*
Vigo Heissmeyer,
University of Munich, Germany
Davia Blake,
University of Pennsylvania, USA
CD28 Regulation of Global Alternative Splicing Changes in Activated Human CD4+ T Cells
CD28 Regulation of Global Alternative Splicing Changes in Activated Human CD4+ T Cells
Wei-Le Wang,
City of Hope, USA
MicroRNA-142 Guards against Autoimmunity by Controlling Treg Cell Homeostasis and Function
MicroRNA-142 Guards against Autoimmunity by Controlling Treg Cell Homeostasis and Function
Marianne Doelz,
University of Basel, Switzerland
The Surprising Capacity of the miR17-92 microRNA Cluster to Compensate for CD28 Deficiency
The Surprising Capacity of the miR17-92 microRNA Cluster to Compensate for CD28 Deficiency
Matilda Toivakka,
University of Edinburgh, UK
Identification of RISC-Associated miRNAs and their Targets during T Cell Activation
Identification of RISC-Associated miRNAs and their Targets during T Cell Activation
Osamu Takeuchi,
Kyoto University, Japan
Critical Roles of an RNase N4BP1 in Anti-HIV-1 Host Defense and its Control by TCR Signaling
Critical Roles of an RNase N4BP1 in Anti-HIV-1 Host Defense and its Control by TCR Signaling
5:00—6:45 PM
RNA-Binding Proteins and RNA Methylation in Immunity
Meeting has ended...abstracts no longer viewable online.
*
K. Mark Ansel,
University of California, San Francisco, USA
Vigo Heissmeyer,
University of Munich, Germany
Cooperative Regulation of T Cell Fate Decisions by RNA-Binding Proteins
Cooperative Regulation of T Cell Fate Decisions by RNA-Binding Proteins
Monika Wolkers,
Sanquin Research, Netherlands
Short Talk: Post-Transcriptional Regulation in T Cell Responses to Infection and Tumors is Time- and Context-Dependent
Short Talk: Post-Transcriptional Regulation in T Cell Responses to Infection and Tumors is Time- and Context-Dependent
Fraser Soares,
University Health Network, Canada
Short Talk: CRISPR/Cas9 Screening Identifies the m6A Methyltransferase METTL3 as a Regulator of PDL-1
Short Talk: CRISPR/Cas9 Screening Identifies the m6A Methyltransferase METTL3 as a Regulator of PDL-1
Martin Turner,
Babraham Institute, UK
An Indispensable Role for Polypyrimidine Tract Binding Proteins in B Cell Development
An Indispensable Role for Polypyrimidine Tract Binding Proteins in B Cell Development
6:45—7:00 PM
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
7:00—8:00 PM
Social Hour
No registration fees are used to fund alcohol served at this function.
8:00—11:00 PM
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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