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This meeting took place in 2003



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Toward Understanding Islet Biology (J1)


Organizer(s) Lydia Aguilar-Bryan and Markus Stoffel
January 21—26, 2003
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 23, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 21, 2002

Sponsored by Pfizer Global Research and Development


Summary of Meeting:
The pancreatic islet supplies insulin in response to increased blood glucose and is a key player in glucose homeostasis. Immunologic destruction of islets is causative of type I diabetes, while insulin resistance and islet dysfunction are generally ascribed to be the main defects in common type II diabetes. This is the first Keystone symposium focused on islet biology and is designed to highlight and integrate the scientific progress occurring in multiple areas relevant to islet biology, including Beta Cell Differentiation, Growth, Regeneration and Death; Gene Expression in Islets and Transcription Factors; Insulin synthesis, conversion, trafficking and granule biogenesis; Stimulus-Secretion Coupling and Genetics, Autoantigens and Transplantation for type 1 diabetes. The meeting will bring together clinicians and basic researchers from disciplines that traditionally have not had an opportunity to interact with the goal of promoting a cross-fertilization of ideas relevant to islet cell biology. The ultimate objective is to promote bench-to-bedside translation of research to advance management of diabetes.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 24 hr (international) time


TUESDAY, JANUARY 21

3:00—7:00 PM
Registration

Longs Peak Foyer
6:15—7:15 PM
Welcome

Longs Peak Foyer
7:15—7:30 PM
Orientation

Quandary Peak 3
7:30—8:30 PM
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 3
Erol Cerasi, Hebrew University, Hadassah Medical School, Israel
The Islet in Diabetes: Back to Center Stage

7:30—8:30 PM
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 1-2
Luciano Rossetti, Merck Research Laboratories, USA
Novel Mechanisms Linking Insulin Resistance to Obesity


WEDNESDAY, JANUARY 22

7:00—8:00 AM
Breakfast

Grays Peak
8:00—11:00 AM
Beta Cell Differentiation, Growth, Regeneration and Death I
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 3
* Doris A. Stoffers, Perelman School of Medicine, University of Pennsylvania, USA

* Helena Edlund, Umeå University, Sweden
Factors Controlling Beta Cell Differentiation and Function

Susan Bonner-Weir, Joslin Diabetes Center, USA
Life and Death of the Pancreatic Beta Cell

Matthias Hebrok, University of California, San Francisco, USA
Pancreatic Hedgehog Signaling: From Development to Disease

Michael German, University of California, San Francisco, USA
Molecular Control of Islet Cell Genesis

Ulupi S. Jhala, University of California, San Diego, USA
Short Talk: Disruption of CREB in Pancreatic Beta cells of Transgenic Mice Leads to Severe Diabetes due to Apoptosis

Jake A. Kushner, Baylor College of Medicine, USA
Short Talk: Ptp1b Disruption Improves Peripheral Insulin Sensitivity, Preserves Beta-Cell Function, and Delays Onset of Diabetes in Irs2 Knockout Mice

8:00—11:00 AM
Humoral Regulation of the Hypothalamus and Obesity Pathogenesis. Session Sponsored in part by Research Diets, Inc.
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 1-2
* Daniel Porte Jr., University of California, San Diego, USA

Stephen C. Woods, University of Cincinnati, USA
Insulin and Leptin as Adiposity Signals to the Hypothalamus

Gerald I. Shulman, HHMI/Yale University School of Medicine, USA
Mechanisms of Fatty Acid Induced Insulin Resistance in Liver and Muscle

Kevin D. Niswender, University of Washington, USA
Insulin and Leptin Signaling in the Hypothalamus: Role of Phosphatidylinositol 3-Kinase

Richard B. Simerly, Vanderbilt University, USA
Developmental Regulation of Arcuate Projection Pathways

Julie E. McMinn, University of Medicine & Dentistry, New Jersey Medical School, USA
Short Talk: Role of Neuronal Leptin Receptor in the Regulation of Body Weight and Adiposity

Silvana Obici, University of Cincinnati, USA
Short Talk: Acute Effects of Leptin on Glucose Production Independent of Activation of Central Melanocortin Receptors

9:20—9:40 AM
Coffee Break

Quandary Peak Foyer
11:00 AM—1:00 PM
Poster Setup

Longs Peak
12:00—2:00 PM
Fitness Class (Optional)

Sheila Collins, Vanderbilt University Medical Center, USA

1:00—10:00 PM
Poster Viewing

Longs Peak
4:30—4:45 PM
Coffee & Snacks Available

Quandary Peak Foyer
4:45—7:15 PM
Beta Cell Differentiation, Growth, Regeneration and Death II
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 3
* Helena Edlund, Umeå University, Sweden

* Doris A. Stoffers, Perelman School of Medicine, University of Pennsylvania, USA

Rupangi C. Vasavada, Icahn School of Medicine at Mount Sinai, USA
Regulation of Beta Cell Survival: The Role of PTHrP

Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
IRS Proteins and the Common Path to Diabetes

Palle Serup, University of Copenhagen, Denmark
Control of Pancreatic Development by Notch Signaling

Douglas A. Melton, Harvard University, USA
Reconstructing the Pancreas from Stem Cells

Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
Short Talk: Severe Diabetes in Mice with Beta-Cell-Specific Double Knockout of the Insulin- and IGF-1-Receptors

5:00—7:00 PM
Neuronal Signal Transduction and Energy Homeostasis
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 1-2
* Jeffrey M. Friedman, Rockefeller University, USA

Martin G. Myers, Jr., University of Michigan, USA
Leptin Receptor Signaling and the Control of Physiology

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Role of PTPIB and AMPKinase in Leptin Action

Michael L.J. Ashford, University of Dundee, UK
Signal Transduction in Glucose Responsive Neurons

Makoto Ishii, Rockefeller University, USA
Short Talk: Metabolic Defects in Mice with a Targeted Disruption of a Hypothalamic Orphan G Protein Coupled Receptor

7:00—8:00 PM
Social Hour

Longs Peak
8:00—10:00 PM
Poster Session 1: Beta Cell Differentiation, Growth, Regeneration and Death

Longs Peak

THURSDAY, JANUARY 23

7:00—8:00 AM
Breakfast

Grays Peak
8:00—11:00 AM
Gene Expression in Islets and Transcription Factors I: Preproinsulin Synthesis, Conversion, Trafficking and Granule Biogenesis
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 3
Markus Stoffel, ETH Zürich, Switzerland
Gene Expression on Pancreatic Beta Cell Development

John C. Hutton, University of Colorado Health Sciences Center, USA
Membrane Trafficking and Dense Core Granule Biogenesis: Fishing with Worms

* Peter Arvan, Albert Einstein College of Medicine, USA
Folding/Assembly, Expression and Processing of Insulin and Insulin Analogs

* Christopher J. Rhodes, MedImmune, USA
Tracking Beta-Granule Transport and Exocytosis

Kristen A. Lantz, Genaera Corporation, USA
Short Talk: Foxa2 is Essential for Normal Beta-Cell Function

Jonathan C. Schisler, Duke University Medical Center, USA
Short Talk: Identification and Characterization of Genes that Define Beta-Cell Phenotype and Confer Glucose-Stimulated Insulin Secretion

8:00—11:00 AM
Adipocyte Biology. Session Sponsored by EAS.
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 1-2
* Bruce M. Spiegelman, Harvard Medical School, USA

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Adipocyte Regulation of Insulin Action and Glucose Metabolism

Sheila Collins, Vanderbilt University Medical Center, USA
Signaling Networks of the b-ARs in Adipocytes and Roles in Metabolism

Jeffrey Flier, Harvard University, USA
Glucocorticoid Reactivation in the Adipocyte: Role in Obesity and its Complications

Ingrid A. Dahlman, Karolinska Institutet, Sweden
Short Talk: B-2 Adrenoreceptor Gene Haplotypes Associate with Variations in Adipocyte Lipolysis and Circulating Triglyceride Levels

Jane L. Hoover-Plow, Cleveland Clinic Foundation, USA
Short Talk: Regulation of Adipogenesis by the Plasminogen System

9:20—9:40 AM
Coffee Break

Quandary Peak Foyer
11:00 AM—1:00 PM
Poster Setup

Longs Peak
1:00—10:00 PM
Poster Viewing

Longs Peak
4:30—5:00 PM
Coffee & Snacks Available

Quandary Peak Foyer
5:00—7:00 PM
Gene Expression in Islets and Transcription Factors II: Preproinsulin Synthesis, Conversion, Trafficking and Granule Biogenesis
Meeting has ended...abstracts no longer viewable online.

Quandry Peak 3
* Christopher J. Rhodes, MedImmune, USA

* Peter Arvan, Albert Einstein College of Medicine, USA

Jeffrey E. Pessin, Albert Einstein College of Medicine, USA
Newly-Synthesized GLUT4 Protein Enters the Insulin-Responsive Storage Compartment Independent of Plasma Membrane Endocytosis

Morris J. Birnbaum, Pfizer Inc., USA
Role of Arf6 in Insulin Secretion

Thomas C. Südhof, Stanford School of Medicine, USA
Molecular Mechanisms of Regulated Exocytosis

Susanne M. Clee, University of British Columbia, Canada
Short Talk: Fine-Mapping of a Type-II Diabetes Gene

4:45—7:15 PM
Thermogenesis, Uncoupling and Metabolism
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 1-2
* Eric Ravussin, Louisiana State University, Pennington Biomedical Research Center, USA

Leslie P. Kozak, Polish Academy of Sciences, Poland
Thermogenic Mechanisms of Body Weight Regulation

William I. Sivitz, University of Iowa Health Care, USA
Lipotoxicity, Respiratory Uncoupling, and ROS in Endothelial Cells

Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Control of Oxidative Metabolism and Glucose Homeostasis through the Coactivator PGC-1

Barbara E. Corkey, Boston University, USA
Energy Metabolism in the Pancreatic Beta Cell

7:00—8:00 PM
Social Hour

Longs Peak
8:00—10:00 PM
Poster Session 2: Gene Expression in Islets and Transcription Factors

Longs Peak

FRIDAY, JANUARY 24

7:00—8:00 AM
Breakfast

Grays Peak
8:00—11:00 AM
Stimulus-Secretion Coupling I
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 3
* Michael L. McDaniel, Washington University School of Medicine, USA

* Joseph Bryan, Pacific Northwest Research Institute, USA

Mark A. Magnuson, Vanderbilt School of Medicine, USA
Glucose Sensing Mechanisms

Bo Ahrén, Lund University, Sweden
Autonomic Regulation of Insulin Secretion

Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
Beta-Cell Electrophysiology - A Lot More than Just KATP-Channels

Jean Claude Henquin, University of Louvain, Belgium
Insulin Secretion: What Triggers and What Amplifies?

Donalyn Scheuner, University of Michigan, USA
Short Talk: Dual Glucose Control of Translation in Pancreatic Beta Cells via (de)Phosphorylation of the Eukaryotic Initiation Factor eIF2alpha

Peter J.S. Smith, Marine Biological Laboratory, USA
Short Talk: Electrical Organization of Synchronicity in the Perfused in situ Pancreas

8:00—11:00 AM
Neurobiology of Food Intake
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 1-2
* Michael W. Schwartz, University of Washington, USA

Jeffrey M. Friedman, Rockefeller University, USA
Neurobiology of Leptin Action

Stephen R. Bloom, Imperial College London, UK
Peptide YY 3-36 and the Humoral Control of Food Intake

Harvey J. Grill, University of Pennsylvania, USA
Caudal Brainstem in the Neuroanatomical Axis for Control of Energy Balance

David E. Cummings, University of Washington, USA
Potential Roles for Ghrelin in Meal Initiation and Energy Homeostasis

Christopher D. Morrison, Pennington Biomedical Research Center, USA
Short Talk: Leptin Regulation of Hypothalamic Npy and Agrp, But Not Socs3, Gene Expression is Dependent on PI3K

Matthew Wortman, University of Cincinnati, USA
Short Talk: A Role for Glucose Utilization in the Effects of C75 to Reduce Food Intake

9:20—9:40 AM
Coffee Break

Quandary Peak Foyer
11:00 AM—1:00 PM
Poster Setup

Longs Peak
1:00—10:00 PM
Poster Viewing

Longs Peak
4:30—5:00 PM
Coffee & Snacks Available

Quandary Peak Foyer
5:00—7:15 PM
Stimulus-Secretion Coupling II
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 3
* Mark A. Magnuson, Vanderbilt School of Medicine, USA

* Christopher B. Newgard, Duke University Medical Center, USA

Joseph Bryan, Pacific Northwest Research Institute, USA
KATP Channels: More than 1st Phase Insulin Secretion

George G. Holz, New York University Medical Center, USA
Incretin Hormone Regulation of Pancreatic Beta-Cell Function

Claes B. Wollheim, University of Geneva Medical Centre, Switzerland
Role of Mitochondria in Beta- and Alpha-Cell Stimulus-Secretion Coupling

* Michael L. McDaniel, Washington University School of Medicine, USA
Links Between the Beta-Cell Mitochondria and mTOR Signaling

Sven O. Göpel, Lund University, Sweden
Short Talk: Modeling of Electrical Activity in Glucagon Secreting Pancreatic A-Cells

5:00—7:00 PM
Model Organisms and Novel Approaches
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 1-2
Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
Identification of Hundreds of C. elegans Fat Regulatory Genes by Systematic RNAi of 16,000 Genes

Andreas Schröder, Ingenium Pharmaceuticals AG, Germany
A Genome-Wide Screen for Mutations Leading to Obesity and Diabetes

Ronald P. Kühnlein, Max-Planck-Institut für Biophysikalische Chemie, Germany
Short Talk: Drosophila Fat Storage Control by the PAT-Domain Encoding Gene Lsd2

* Gregory S. Barsh, Stanford University Medical Center, USA
Genetic Approaches to Imaging Neuronal Activity in Real Time

7:00—8:00 PM
Social Hour

Longs Peak
8:00—10:00 PM
Poster Session 3: Stimulus-Secretion Coupling/Genetics, Auto-Antigens and Transplantation in Type 1 Diabetes

Longs Peak

SATURDAY, JANUARY 25

7:00—8:00 AM
Breakfast

Grays Peak
8:00—11:00 AM
Stimulus-Secretion Coupling III
Meeting has ended...abstracts no longer viewable online.

Quandry Peak 3
* Joseph Bryan, Pacific Northwest Research Institute, USA

* Michael L. McDaniel, Washington University School of Medicine, USA

Christopher B. Newgard, Duke University Medical Center, USA
New Insights into Mechanisms of Fuel-Stimulated Insulin Secretion: An Interdisciplinary Approach

Marc Prentki, , Canada
Lipid Signaling and ß-Cell Function in Health and Diabetes

Guy A. Rutter, Imperial College London, UK
Dynamic Imaging of Calcium Stores in Pancreatic Beta-Cells

Frans C. Schuit, Katholieke Universiteit Leuven, Belgium
Molecular Reappraisal of the Pancreatic Beta Cell Phenotype

Peter Drain, University of Pittsburgh School of Medicine, USA
Short Talk: The Insulin Secretory Granule is the Major Site of K-ATP Channels of the Endocrine Pancreas

8:00—11:00 AM
Genetics, Genomics and New Technologies
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 1-2
* Rudolph L. Leibel, Columbia University, USA

Philippe Froguel, Imperial College of London, UK
Genetic Linkage Analysis of Human Obesity

Roger D. Cone, University of Michigan, USA
Stayed 1/21 - 1/23

William F. Colmers, University of Alberta, Canada
The Electrophysiology of Obesity

David R. Cox, Perlegen Sciences, Inc., USA
Genome-Based Association Using SNPs

I. Sadaf Farooqi, University of Cambridge, UK
Lessons from Monogenic Obesity Syndromes

Jonathan B. Singer, Whitehead Institute for Biomedical Research, USA
Short Talk: Mapping Mouse QTLs Affecting Body Weight and Weight Gain Using Chromosome Substitution Strains

Angelo DelParigi, Pfizer Global Research & Development, USA
Short Talk: Abnormal Hypothalamic Activity in Response to a Meal in Prader-Willi Syndrome

9:20—9:40 AM
Coffee Break

Quandary Peak Foyer
4:30—5:00 PM
Coffee & Snacks Available

Quandary Peak Foyer
5:00—7:00 PM
Insulin Dependent-Diabetes: Genetics, Autoantigens and Transplantation. Session Sponsored by the Juvenile Diabetes Research Foundation International.
Meeting has ended...abstracts no longer viewable online.

Quandry Peak 3
* George S. Eisenbarth, University of Colorado Health Sciences Center, USA
The Role of the Islet: Insulin as Primary Autoantigen

Linda S. Wicker, University of Cambridge, UK
Type 1 Diabetes: Genomic Analysis of a Complex Disease

Kevan C. Herold, Yale University, USA
Preservation of Insulin Production in Type 1 Diabetes (T1DM) with a FcR Non-Binding Anti-CD3 mAb (hOKT3g1(Ala-Ala)

Jonas Ahnfelt-Røenne, Hagedorn Research Institute, Denmark
Short Talk: Irx1 and Irx2 are Expressed Selectively in the Alpha-Cell Lineage

5:00—7:00 PM
Approaches to Obesity Treatment
Meeting has ended...abstracts no longer viewable online.

Quandary Peak 1-2
* Louis A. Tartaglia, Millennium Pharmaceuticals, Inc., USA

Rudolph L. Leibel, Columbia University, USA
Metabolic Adaptations to Reduced Body Weight

Neil Ruderman, Boston University Medical Center, USA
Pharmacological Activation of AMP-Activated Protein Kinase (AMPK): A Target for the Treatment of Obesity

Tung Ming Fong, Forest Research Institute, USA
Drug Development Efforts Aimed at Modulation of CNS Neuropeptides and Their Receptors for the Treatment of Obesity

Chi-Liang Eric Yen, Gladstone Institute of Cardiovascular Disease, USA
Short Talk: Identification of a Gene Encoding MGAT2, an Intestinal Monoacylglycerol Acyltransferase

7:00—8:00 PM
Social Hour

Grays/Longs Peak
8:00—11:00 PM
Entertainment

Grays/Longs Peak

SUNDAY, JANUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK063897-01




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