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This meeting took place in 2004



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Natural Variation and Quantitative Genetics in Model Organisms (J2)


Organizer(s) Detlef Weigel and Bruce Walsh
January 8—13, 2004
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Oct 15, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 10, 2003

Supported by Keystone Symposia


Summary of Meeting:
Despite tremendous advances in the genetic analysis of many biological processes, the molecular basis of the variation seen within and between species remains largely unknown. ·Standard genetic analyses in model organisms have focused on laboratory-induced mutations with large phenotypic effects, which contrasts with the variation seen in natural populations, which is mostly continuous. The phenotypic variation seen within or between closely related species also contrasts with the phenotypic variation seen between more distantly related species. It seems likely, however, that intra- and interspecific variation are two sides of the same coin, although a unifying molecular framework has not yet been developed. Now is an exciting time to revisit these questions because of several major technological advances. These include new analytical tools, such as high-throughput genotyping, new statistical and computational methods, comprehensive transcriptome and proteome profiling, as well as opportunities to compare entire genomes between closely and distantly related organisms. Understanding the molecular basis of natural variation has important implications both for understanding the evolution of new traits, as well as for understanding how selection has shaped genomes, including the human genome. The meeting will have as a major focus both animal and plant model organisms, in which the use of quantitative genetics is experiencing a renaissance. The molecular study of Quantitative Trait Loci, several of which have been traced back to individual genes, is allowing important conclusions as to the type of genes and type of changes that underlie quantitative phenotypic variation. A second focus of the meeting will be recent discoveries of how changes in key regulatory factors cause major phenotypic differences in more distantly related taxa. The overall goal of this meeting is to bring together a diverse group of investigators that includes scientists interested in the evolution of developmental diversity, quantitative geneticists and population geneticists. ·Finally, the proposed meeting, which will focus on genetic model organisms such as Drosophila and Arabidopsis, will be an excellent complement to the meeting that is to be held concurrently, on Human Genetic Diversity.

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Conference Program    Print  |   View meeting in 24 hr (international) time


THURSDAY, JANUARY 8

3:00—7:00 PM
Registration

Foyer
6:15—7:15 PM
Refreshments

Foyer
7:15—7:30 PM
Orientation

Peaks 4-5
7:30—9:30 PM
Keynote Session: Genetic Dissection of Complex Traits (Joint)
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* David M. Altshuler, Vertex Pharmaceuticals Incorporated, USA

* Detlef Weigel, Max Planck Institute for Developmental Biology, Germany

Charles H. Langley, University of California, Davis, USA
Polymorphism and Divergence Across the Drosophila Genome

Aravinda Chakravarti, Johns Hopkins University School of Medicine, USA
The Nature of Variation in Complex Disease


FRIDAY, JANUARY 9

7:00—8:00 AM
Breakfast

Peaks 6-12
8:00—11:00 AM
QTL in Animals I
Meeting has ended...abstracts no longer viewable online.

Peaks 1-3
* Trudy F.C. Mackay, North Carolina State University, USA

Catherine (Katie) L. Peichel, Fred Hutchinson Cancer Research Center, USA
Genetic Analysis of Reproductive Isolation in Sticklebacks

Peter D. Keightley, University of Edinburgh, UK
Analysing Quantitative Genetic Variation for Growth in Mice

Kari J. Buck, Oregon Health & Science University, USA
Genetic Control of Physical Dependence and Associated Withdrawal Episodes in Mice

Thomas E. Johnson, University of Colorado, USA
QTLs in Mice and Worms; Use of Recombinant Inbred Strains

8:00—11:00 AM
Patterns of Human Genome Sequence Variation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Peter Donnelly, University of Oxford, UK

Mark Daly, Massachusetts General Hospital, USA
Human Haplotype Structure

Lon Cardon, University of Oxford, UK
Haplotype Structure Across Chromosomes

Kelly A. Frazer, University of California, San Diego, USA
Genetic Variation and Human Disease

Andrew G. Clark, Cornell University, USA
Lessons from Candidate Gene Studies about the Genetics of Complex Traits

9:20—9:40 AM
Coffee Break

Foyer
11:00 AM—1:00 PM
Poster Setup

Peaks 14-16
1:00—10:00 PM
Poster Viewing

Peaks 14-16
4:30—5:00 PM
Coffee & Snacks Available

Foyer
5:00—7:00 PM
Exploiting Inbred Strains to Understand Complex Traits (Joint)
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Peter D. Keightley, University of Edinburgh, UK

Keith R. Davis, Icoria, Inc, USA
High-Throughput Plant Gene Function Analysis in Arabidopsis

Wayne Frankel, The Jackson Laboratory, USA
Effects of Genetic Background on Induced and Spontaneous, Monogenic and Polygenic Models for Epilepsy in Mice

Michael P. Snyder, Stanford University School of Medicine, USA
Identification of Functional Regions in the Genomes of Yeast and Humans

6:45—7:20 PM
Comparative Genomics
Meeting has ended...abstracts no longer viewable online.

Eric S. Lander, Broad Institute, Massachusetts Institute of Technology, USA

7:20—8:00 PM
Social Hour

Peaks 14-16
7:30—10:00 PM
Poster Session 1

Peaks 14-16

SATURDAY, JANUARY 10

7:00—8:00 AM
Breakfast

Peaks 6-12
8:00—11:00 AM
QTL in Animals II
Meeting has ended...abstracts no longer viewable online.

Peaks 1-3
* Catherine (Katie) L. Peichel, Fred Hutchinson Cancer Research Center, USA

Trudy F.C. Mackay, North Carolina State University, USA
Molecular Quantitative Genetics of Drosophila Life Span

Chung-I Wu, Chinese Academy of Sciences, China
Molecular Genetics of Speciation

John H. Werren, University of Rochester, USA
Evolutionary Genetics of Species Differences in Nasonia

Marta L. Wayne, University of Florida, USA
Sex Dimorphism and Non-Additivity in Gene Expression in Drosophila melanogaster

8:00—11:00 AM
Molecular Forces Shaping Genome Sequence Variation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Andrew G. Clark, Cornell University, USA

Peter Donnelly, University of Oxford, UK
Understanding Fine-Scale Variation in Recombination Rates

Richard Hudson, University of Chicago, USA
Fine-Scale Mapping with Linkage Disequilibrium

Chris Toomajian, University of Southern California, USA
The Pattern of Polymorphism in the Arabidopsis Genome

Evan E. Eichler, HHMI/University of Washington, USA
Structural Variation and Large-Scale Polymorphism within Segmental Duplications

Richard M. Durbin, Wellcome Trust Sanger Institute, UK
Short Talk: Significant Correspondence of Recombination Events in Pedigrees with Haplotype Block Boundaries

9:20—9:40 AM
Coffee Break

Foyer
4:30—5:00 PM
Coffee & Snacks Available

Foyer
5:00—7:00 PM
QTL in Plants I
Meeting has ended...abstracts no longer viewable online.

Peaks 1-3
* Joanne Chory, The Salk Institute, USA

Masahiro Yano, National Institute of Agrobiological Resources, Japan
Natural Variation in Flowering Time in Rice

Leonie C. Moyle, University of California, Davis, USA
Salad Speciation: Genetics of Species Differences and Hybrid Incompatibility in Lycopersicon

Justin O. Borevitz, University of Chicago, USA
Towards the Arabidopsis Haplotype Map Using Arrays

5:00—7:00 PM
Population History and Human Sequence Variation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Stephen J. O'Brien, National Cancer Institute, National Institutes of Health, USA

David B. Goldstein, Duke University, USA
Haployptes, Human History, and Pharmacogenetics

John Raelson, Galileo Genomics, Canada
Short Talk: General Extent of LD in the Quebec Founder Population

Mark Patterson, Public Library of Science, UK
Short Talk: Public Library of Science

7:00—8:00 PM
Social Hour

Peaks 14-16

SUNDAY, JANUARY 11

7:00—8:00 AM
Breakfast

Peaks 6-12
8:00—11:00 AM
Inherited Variation in Gene Expression (Joint)
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Leonid Kruglyak, Princeton University, USA
Regulatory Variation in Yeast

Kevin P. White, University of Chicago, USA
Evolution of Gene Expression in Drosophila

Stephanie Monks, University of Washington, USA
The Genetics of Gene Expression in Mice

Justin Fay, Washington University, USA
Short Talk: Genetic Variation in Gene Expression is Associated with Phenotypic Variation Sequence Divergence

Matthew Rockman, New York University, USA
Short Talk: Cis-Regulated Polymorphism: Evolution, Natural Variation, and Common Disease

9:20—9:40 AM
Coffee Break

Foyer
4:30—5:00 PM
Coffee & Snacks Available

Foyer
5:00—7:00 PM
QTL in Plants II
Meeting has ended...abstracts no longer viewable online.

Peaks 1-3
* Masahiro Yano, National Institute of Agrobiological Resources, Japan

Joanne Chory, The Salk Institute, USA
and

Olivier Loudet, Institut National de La Recherche Agronomique, France
Natural Variation in Light Signaling in Arabidopsis

Carlos Alonso-Blanco, Centro Nacional de Biotecnologia, CSIC, Spain
Natural Variation for Life History Traits in Arabidopsis

Dani Zamir, Cornell University, USA
Real Time QTL of Tomato Yield

5:00—7:00 PM
Genetic Architecture of Human Disease
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Lon Cardon, University of Oxford, UK

Stephen J. O'Brien, National Cancer Institute, National Institutes of Health, USA
Architecture of Disease: Lessons from HIV Resistance

Nicholas Katsanis, Duke University Medical Center, USA
Modeling Oligogenic Disorders

John A. Phillips, Vanderbilt University School of Medicine, USA
Short Talk: PPH is a Complex Disease Caused by Rare and Common Variants

Hua Tang, University of Chicago, USA
Short Talk: Genetic Diseases and Natural Selection in Human

Örjan Carlborg, Roslin Institute, Scotland
Short Talk: The Use of Epistasis in Genetic Dissection of Complex Traits

7:00—8:00 PM
Social Hour

Peaks 14-16

MONDAY, JANUARY 12

7:00—8:00 AM
Breakfast

Peaks 6-12
8:00—11:00 AM
Evolution of Adaptive Traits
Meeting has ended...abstracts no longer viewable online.

Peaks 1-3
* Neelima Sinha, University of California, Davis, USA

June B. Nasrallah, Cornell University, USA
Diversification of Self-Incompatibility Genes in the Brassicaceae

Thomas Mitchell-Olds, Duke University, USA
Nucleotide Polymorphism and Quantitative Trait Variation in Arabidopsis and Related Species

Sean B. Carroll, University of Wisconsin-Madison, USA
Genetic and Developmental Mechanisms Underlying Divergent and Convergent Patterns of Evolution

Ying Tan, University of Massachusetts-Boston, USA
Molecular Evolution of Color Vision Genes in Primates

8:00—11:00 AM
Genetic Determinants of Common Disease
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Francis S. Collins, Director, National Institutes of Health, USA

Richard P. Lifton, HHMI/Yale University School of Medicine, USA
Genetic Dissection of Hypertension

Gilles Thomas, NCI - National Institutes of Health, USA
The Genetics of CARD15, a Susceptibility Gene for an Inflammatory Bowel Disease

David M. Altshuler, Vertex Pharmaceuticals Incorporated, USA
Genetic Analysis of Diabetes

David Hunter, Harvard Medical School, USA
Gene-Environment Interactions

9:20—9:40 AM
Coffee Break

Foyer
4:30—5:00 PM
Coffee & Snacks Available

Foyer
5:00—7:00 PM
Variation between Distant Taxa
Meeting has ended...abstracts no longer viewable online.

Peaks 1-3
* Ying Tan, University of Massachusetts-Boston, USA

Nipam H. Patel, University of California, Berkeley, USA
The Evolution of Arthropod Pattern Formation

Neelima Sinha, University of California, Davis, USA
The Development and Evolution of Leaves

Marie-Anne Felix, Institut Jacques Monod, France
Evolution of Nematode Vulva Development: A Microevolutionary Approach

5:00—7:00 PM
Application to Biology, Medicine and Society
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Richard P. Lifton, HHMI/Yale University School of Medicine, USA

Georgia Dunston, Howard University, USA
The GRAD Biobank: A Resource for Exploring Genome Variation and Environment Interaction in Common Complex Diseases

Klaus Lindpaintner, F. Hoffmann-La Roche AG, Switzerland
Pharmacogenetics: A Realistic View

Francis S. Collins, Director, National Institutes of Health, USA
Applying Genetics to Medicine and Society

7:00—8:00 PM
Social Hour

Peaks 14-16
8:00—11:00 PM
Entertainment

Peaks 4-5

TUESDAY, JANUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 GM070207-01




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