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This meeting took place in 2007
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Genome Instability and Repair (A5)
Organizer(s) Nancy Maizels, Ian D. Hickson and David B. Roth
January 17—22, 2007
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Sep 18, 2006
Late Abstract Deadline: Oct 20, 2006
Scholarship Deadline: Sep 18, 2006
Early Registration Deadline: Nov 17, 2006
Sponsored by Genentech, Inc.
Summary of Meeting:
Genomic instability is a key event in aging, cancer and some heritable diseases. Highly conserved pathways have evolved to detect the presence of genome damage and to effect its repair. This meeting will explore recent advances in our understanding of the nature and causes of genomic instability, the mechanisms of DNA repair, and the consequences of failure in DNA repair with regard to human health and disease. The program will emphasize advances that provide mechanistic understanding of pathways that maintain genomic integrity, and the intersection of these pathways with normal cellular development, aging, and tumorigenesis. The molecular and mechanistic emphasis is designed to attract a broad cross-section of researchers. The goals of this meeting are to identify new avenues for investigation, to define therapeutic strategies for maintenance of genomic integrity, to stimulate collaborations, and to foster the long-term development of this rapidly emerging research area by encouraging participation of young investigators.
View Scholarships/Awards
Genomic instability is a key event in aging, cancer and some heritable diseases. Highly conserved pathways have evolved to detect the presence of genome damage and to effect its repair. This meeting will explore recent advances in our understanding of the nature and causes of genomic instability, the mechanisms of DNA repair, and the consequences of failure in DNA repair with regard to human health and disease. The program will emphasize advances that provide mechanistic understanding of pathways that maintain genomic integrity, and the intersection of these pathways with normal cellular development, aging, and tumorigenesis. The molecular and mechanistic emphasis is designed to attract a broad cross-section of researchers. The goals of this meeting are to identify new avenues for investigation, to define therapeutic strategies for maintenance of genomic integrity, to stimulate collaborations, and to foster the long-term development of this rapidly emerging research area by encouraging participation of young investigators.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
WEDNESDAY, JANUARY 17
THURSDAY, JANUARY 18
FRIDAY, JANUARY 19
SATURDAY, JANUARY 20
SUNDAY, JANUARY 21
MONDAY, JANUARY 22
Conference Program Print | View meeting in 24 hr (international) time
WEDNESDAY, JANUARY 17
7:30—8:30 PM
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Frederick W. Alt,
Boston Children's Hospital, USA
NHEJ and the Double-strand Break Response in IgH Class Switch Recombination and Suppression of Translocations and Lymphoma
NHEJ and the Double-strand Break Response in IgH Class Switch Recombination and Suppression of Translocations and Lymphoma
8:00—11:15 AM
Avoiding DNA Damage
Meeting has ended...abstracts no longer viewable online.
*
Curtis C. Harris,
NCI, National Institutes of Health, USA
p53 Biological Network: Inflammation, microRNA and Cancer
p53 Biological Network: Inflammation, microRNA and Cancer
Simon J. Boulton,
London Research Institute, Clare Hall Laboratories, UK
Short Talk: HCLK2 is Essential for the Mammalian S-Phase Checkpoint and Impacts on Chk1Stability
Short Talk: HCLK2 is Essential for the Mammalian S-Phase Checkpoint and Impacts on Chk1Stability
Dipanjan Chowdhury,
Dana-Farber Cancer Institute, Harvard Medical School, USA
Short Talk: Role of phosphatases in removal of Gamma-H2AX
Short Talk: Role of phosphatases in removal of Gamma-H2AX
Keith W. Caldecott,
University of Sussex, UK
DNA Single-Strand Breaks and Neurodegeneration
DNA Single-Strand Breaks and Neurodegeneration
5:00—7:00 PM
Chromatin, DNA Damage and Repair
Meeting has ended...abstracts no longer viewable online.
*
Michael J. Lichten,
National Cancer Institute, National Institutes of Health, USA
Controlling the Outcome of Meiotic Double-Strand Break Repair
Controlling the Outcome of Meiotic Double-Strand Break Repair
Geneviève Almouzni,
Centre National de la Recherche Scientifique, France
Chromatin Assembly Factors, Histone H3 Variants and Cell Cycle
Chromatin Assembly Factors, Histone H3 Variants and Cell Cycle
Jac A. Nickoloff,
Colorado State University, USA
Short Talk: INO80-Dependent Chromatin Remodeling Regulates the Kinetics and Efficiency of DSB Repair by Homologous Recombination
Short Talk: INO80-Dependent Chromatin Remodeling Regulates the Kinetics and Efficiency of DSB Repair by Homologous Recombination
Andrés Aguilera,
University of Seville, CABIMER, Spain
Mechanisms of Transcription-Associated Genetic Instability
Mechanisms of Transcription-Associated Genetic Instability
8:00—11:15 AM
Intersection of Damage, Repair and the Cell Cycle
Meeting has ended...abstracts no longer viewable online.
*
Craig B. Thompson,
Memorial Sloan Kettering Cancer Center, USA
DNA Damage and Cell Death
DNA Damage and Cell Death
XiaoZhe Wang,
Dana-Farber Cancer Institute, USA
Short Talk: The role of Chk1 in the Fanconi Anemia/BRCA Pathway
Short Talk: The role of Chk1 in the Fanconi Anemia/BRCA Pathway
Michael B. Kastan,
St. Jude Children's Research Hospital, USA
Roles of ATM and NBS1 in Modulating Chromatin Structure Changes and Repair of DNA Breaks
Roles of ATM and NBS1 in Modulating Chromatin Structure Changes and Repair of DNA Breaks
Sandy Chang,
University of Texas MD Anderson Cancer Center, USA
Telomere End Protection in Senescence and Cancer
Telomere End Protection in Senescence and Cancer
Travis H. Stracker,
IRB Barcelona, Spain
Short Talk: The Apoptotic Functions of Chk2 Suppress Tumorigenesis in Mre11 Deficient Mice
Short Talk: The Apoptotic Functions of Chk2 Suppress Tumorigenesis in Mre11 Deficient Mice
Guillermina Lozano,
University of Texas MD Anderson Cancer Center, USA
p53 Cell Cycle Control and Maintenance of Chromosomal Stability
p53 Cell Cycle Control and Maintenance of Chromosomal Stability
2:30—4:30 PM
Workshop 1: Dynamics, Modulation and Regulation of DNA Repair
*
Raymond J. Monnat Jr.,
University of Washington, USA
Prasad Tekkatte Krishnamurthy,
Columbia University, USA
Visualizing Dynamics of Rdh54 on Single Double-Stranded DNA Molecule
Visualizing Dynamics of Rdh54 on Single Double-Stranded DNA Molecule
Lisa Postow,
Rockefeller University, USA
Damage-Dependent Ubiquitination and Degradation of Ku80
Damage-Dependent Ubiquitination and Degradation of Ku80
Eric T. Larson,
University of Washington, USA
MutSalpha and UNG Direct Redundant Pathways for Faithful as well as Mutagenic Repair of U/G Mismatches
MutSalpha and UNG Direct Redundant Pathways for Faithful as well as Mutagenic Repair of U/G Mismatches
Marie Dutreix,
Center National Scientific Research, Institut Curie, France
Baiting Double-Strand Break Repair Complex by Short Inhibitory DNA (siDNA)
Baiting Double-Strand Break Repair Complex by Short Inhibitory DNA (siDNA)
David O. Ferguson,
University of Michigan Medical School, USA
TPP1 and Mre11: Two Tales of Genomic Instability
TPP1 and Mre11: Two Tales of Genomic Instability
Jillian L. Youds,
University of British Columbia, Canada
Characterization of BRIP1/FANCJ Homologs in ICL Repair in C. elegans
Characterization of BRIP1/FANCJ Homologs in ICL Repair in C. elegans
Yannick Doyon,
Laval University, Canada
High-Efficiency Targeted Integration in Human Cells using Designed Zinc Finger Nucleases
High-Efficiency Targeted Integration in Human Cells using Designed Zinc Finger Nucleases
Wojciech Niedzwiedz,
Institute of Cancer Research, UK
The Possible Role for FANCM in DNA Cross-Links Repair
The Possible Role for FANCM in DNA Cross-Links Repair
Sachin Katyal,
St. Jude Children's Research Hospital, USA
Defective DNA Damage Responses in Mice Lacking TDP1
Defective DNA Damage Responses in Mice Lacking TDP1
5:00—7:30 PM
Mechanisms of Processing Repair Intermediates
Meeting has ended...abstracts no longer viewable online.
*
Ian D. Hickson,
University of Copenhagen, Denmark
Functions of the BLM Protein at Damaged Replication Forks
Functions of the BLM Protein at Damaged Replication Forks
Maria Jasin,
Memorial Sloan Kettering Cancer Center, USA
Choosing a Pathway for Break Repair
Choosing a Pathway for Break Repair
Bernard S. Lopez,
Institut Gustave Roussy, France
Short Talk: PKBĄ/AKT1 Inhibits Homologous Recombination by Cytoplasmic Retention of BRCA1 and Rad51, Mediated by FOXO1a
Short Talk: PKBĄ/AKT1 Inhibits Homologous Recombination by Cytoplasmic Retention of BRCA1 and Rad51, Mediated by FOXO1a
Tanya T. Paull,
University of Texas at Austin, USA
DNA Repair Activities of Mre11/Rad50 Complexes
DNA Repair Activities of Mre11/Rad50 Complexes
Stephen C. West,
Francis Crick Institute, UK
Resolution of Abortive DNA Ligation Intermediates by Aprataxin
Resolution of Abortive DNA Ligation Intermediates by Aprataxin
8:00—11:15 AM
Pathways of Break Repair
Meeting has ended...abstracts no longer viewable online.
*
David B. Roth,
New York University School of Medicine, USA
The Recombinase as Gatekeeper: Linking V(D)J Recombination to DNA Repair
The Recombinase as Gatekeeper: Linking V(D)J Recombination to DNA Repair
Piero R. Bianco,
University at Buffalo, State University of New York, USA
Short Talk: Rad54 Protein Translocates and Cross-Bridges dsDNA to Stimulate the Synapsis Stage of Homologous Recombination
Short Talk: Rad54 Protein Translocates and Cross-Bridges dsDNA to Stimulate the Synapsis Stage of Homologous Recombination
Minoru Takata,
Radiation Biology Center, Japan
Interplay Between FANCD2, the Fanconi Anemia Core Complex, and FancJ in DNA Repair
Interplay Between FANCD2, the Fanconi Anemia Core Complex, and FancJ in DNA Repair
John A. Tainer,
The Scripps Research Institute, USA
The Double-Strand Break Repair Machinery
The Double-Strand Break Repair Machinery
Les A. Hanakahi,
University of Illinois at Chicago, Rockford Campus, USA
Short Talk: Inhibition of Non-Homologous End-Joining by Adenoviral Oncoproteins: Inactivation of DNA Repair Protein XRCC4
Short Talk: Inhibition of Non-Homologous End-Joining by Adenoviral Oncoproteins: Inactivation of DNA Repair Protein XRCC4
Graeme C. M. Smith,
KuDOS Pharmaceuticals Ltd., UK
DNA Repair Pathways as Targets for Cancer Therapeutics
DNA Repair Pathways as Targets for Cancer Therapeutics
2:30—4:30 PM
Workshop 2: Genomic Instability in Aging, Cancer and Genetic Disease
Evi Soutoglou,
Institute of Genetics and Molecular and Cellular Biology, France
Positional Stability of Single Double Strand Breaks in Living Mammalian Cells
Positional Stability of Single Double Strand Breaks in Living Mammalian Cells
Kok Lung Chan,
Weatherall Institute of Molecular Medicine, UK
The Localization of BLM Defines a Novel Class of Anaphase Bridges
The Localization of BLM Defines a Novel Class of Anaphase Bridges
Bin Wang,
University of Texas MD Anderson Cancer Center, USA
Identification of a Novel Brca1 Associated Protein Complex that is Involved in the DNA Damage Response
Identification of a Novel Brca1 Associated Protein Complex that is Involved in the DNA Damage Response
Ciaran G. Morrison,
National University of Ireland, Galway, Ireland
Distinct BRCT Domains in Mcph1/Brit1 Mediate Gamma-H2AX Interaction and Centrosomal Localisation
Distinct BRCT Domains in Mcph1/Brit1 Mediate Gamma-H2AX Interaction and Centrosomal Localisation
Patrick Ryan Potts,
University of Texas Southwestern Medical Center, USA
Human SMC5/6 Complex Is Required for Telomere Recombination and Maintenance in ALT Cells
Human SMC5/6 Complex Is Required for Telomere Recombination and Maintenance in ALT Cells
Susanna Maxwell Lewis,
Harvard Medical School, USA
Coming and Going: Controlling Palindromy in Mammalian Genomes
Coming and Going: Controlling Palindromy in Mammalian Genomes
Robert Hromas,
University of New Mexico, USA
The Human Transposase Metnase Mediates NHEJ repair, HIV Integration, and Progression Through the Decatenation Cell Cycle Checkpoint
The Human Transposase Metnase Mediates NHEJ repair, HIV Integration, and Progression Through the Decatenation Cell Cycle Checkpoint
Patricia L. Opresko,
University of Pittsburgh, USA
Processing of Telomere Ends by the Werner Syndrome Protein and Telomeric POT1 Protein
Processing of Telomere Ends by the Werner Syndrome Protein and Telomeric POT1 Protein
5:00—7:00 PM
Aging
Meeting has ended...abstracts no longer viewable online.
Jung-Hyun Min,
Memorial Sloan-Kettering Cancer Center, USA
JoAnn M. Sekiguchi,
University of Michigan, USA
Short Talk: Dysfunctional Nuclease Activity Leads to Partial Immunodeficiency and Genomic Instability
Short Talk: Dysfunctional Nuclease Activity Leads to Partial Immunodeficiency and Genomic Instability
Ronald A. DePinho,
University of Texas MD Anderson Cancer Center, USA
Substantial Overlap in Acquired Chromosomal Aberrations in a Murine Model of Genomic Instability and Human Cancer
Substantial Overlap in Acquired Chromosomal Aberrations in a Murine Model of Genomic Instability and Human Cancer
8:00—11:15 AM
Programmed Genomic Instability in the Immune Response
Meeting has ended...abstracts no longer viewable online.
*
Nancy Maizels,
University of Washington School of Medicine, USA
Molecular Mechanisms of Immunoglobulin Gene Diversification
Molecular Mechanisms of Immunoglobulin Gene Diversification
Ronald Chalmers,
University of Nottingham Medical School, UK
Short Talk: The Mechanism of Base Flipping and DNA Bending in V(D)J Recombination and DNA Transposition
Short Talk: The Mechanism of Base Flipping and DNA Bending in V(D)J Recombination and DNA Transposition
Michael S. Neuberger,
Medical Research Council, UK
Immunity through DNA Deamination
Immunity through DNA Deamination
Myron F. Goodman,
University of Southern California, USA
Biochemical Scanning Mechanisms of DNA Cytidine Deaminases AID and Apo3G
Biochemical Scanning Mechanisms of DNA Cytidine Deaminases AID and Apo3G
Katheryn D. Meek,
Michigan State University, USA
Short Talk: The RAG Complex Physically Directs DSBs into the NHEJ Pathway
Short Talk: The RAG Complex Physically Directs DSBs into the NHEJ Pathway
Bertrand Nadel,
CNRS-INSERM - Universite de la Medditerranee, France
Reactive DNA Ends as Byproducts of Lymphocyte Receptor Construction
Reactive DNA Ends as Byproducts of Lymphocyte Receptor Construction
5:00—7:00 PM
Outcomes of Genomic Instability
Meeting has ended...abstracts no longer viewable online.
*
André Nussenzweig,
NCI, National Institutes of Health, USA
Relationship between DNA Damage Detection and Signaling in Vivo
Relationship between DNA Damage Detection and Signaling in Vivo
Jiri Bartek,
Danish Cancer Society, Denmark
Coordination of DNA Repair with DNA Damage Checkpoints and Their Role in Cancer Pathogenesis
Coordination of DNA Repair with DNA Damage Checkpoints and Their Role in Cancer Pathogenesis
Chengming (Ben) Zhu,
University of Texas MD Anderson Cancer Center, USA
Short Talk: Role of p53-Dependent Cell Cycle Arrest in Tumor Suppression
Short Talk: Role of p53-Dependent Cell Cycle Arrest in Tumor Suppression
Peter J. McKinnon,
St. Jude Children's Research Hospital, USA
Linking DNA Damage, Neurodegeneration and Brain Tumors
Linking DNA Damage, Neurodegeneration and Brain Tumors
*Session Chair †Invited, not yet responded.
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