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This meeting took place in 2014
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Immune Evolution in Cancer (X2)
Organizer(s) Suzanne Ostrand-Rosenberg, Olivera J. Finn and Lisa M. Coussens
March 9—14, 2014
Fairmont Chateau Whistler • Whistler, British Columbia Canada
Discounted Abstract Deadline: Nov 6, 2013
Abstract Deadline: Dec 10, 2013
Scholarship Deadline: Nov 6, 2013
Discounted Registration Deadline: Jan 9, 2014
Sponsored by Bristol-Myers Squibb Company, Genentech, Inc., OncoMed Pharmaceuticals, Inc., Roche and Vertex Pharmaceuticals Incorporated
Joint Meeting:
Inflammation, Infection and Cancer (X1)
Summary of Meeting:
Neoplastic progression is initiated by accumulations of somatic mutations in proliferating cells that cause “healthy” cells to sustain survival programs and resist embedded tissue-based programs designed to restrain their unchecked proliferation. Concurrent with neoplastic progression, the immune system sculpts the neoplastic cell repertoire by eliminating immunogenic cells while allowing outgrowth of less immunogenic variants, a process known as immunoediting. As neoplasms undergo early progression, they often resemble a chronic “wound” wherein activated tissue remodeling, and immune and angiogenic programs, facilitate the survival of potentially malignant cells. Cells of the adaptive and innate immune systems are particularly important during wound healing; however, during cancer development, many immune cells are co-opted and effectively “reprogrammed” toward a tumor-promoting phenotype. As a result, malignant cells condition their environment to facilitate their progression by co-opting multiple immune effector cell populations. Presentations at this conference will focus on how the tumor microenvironment perturbs lymphoid and myeloid cells, the mechanisms used by immune cells to promote tumor growth, and the strategies being developed to counteract tumor-induced immune suppression to generate anti-tumor immunity. Many of the tumor-promoting effects of the immune system are regulated by leukocyte infiltration (e.g., chronic inflammation); therefore, this conference, in conjunction with the companion conference on Inflammation, Infection and Cancer, will provide an in-depth examination of the current understanding of tumor progression, and will facilitate interactions between tumor immunologists and cancer biologists.
View Scholarships/Awards
Neoplastic progression is initiated by accumulations of somatic mutations in proliferating cells that cause “healthy” cells to sustain survival programs and resist embedded tissue-based programs designed to restrain their unchecked proliferation. Concurrent with neoplastic progression, the immune system sculpts the neoplastic cell repertoire by eliminating immunogenic cells while allowing outgrowth of less immunogenic variants, a process known as immunoediting. As neoplasms undergo early progression, they often resemble a chronic “wound” wherein activated tissue remodeling, and immune and angiogenic programs, facilitate the survival of potentially malignant cells. Cells of the adaptive and innate immune systems are particularly important during wound healing; however, during cancer development, many immune cells are co-opted and effectively “reprogrammed” toward a tumor-promoting phenotype. As a result, malignant cells condition their environment to facilitate their progression by co-opting multiple immune effector cell populations. Presentations at this conference will focus on how the tumor microenvironment perturbs lymphoid and myeloid cells, the mechanisms used by immune cells to promote tumor growth, and the strategies being developed to counteract tumor-induced immune suppression to generate anti-tumor immunity. Many of the tumor-promoting effects of the immune system are regulated by leukocyte infiltration (e.g., chronic inflammation); therefore, this conference, in conjunction with the companion conference on Inflammation, Infection and Cancer, will provide an in-depth examination of the current understanding of tumor progression, and will facilitate interactions between tumor immunologists and cancer biologists.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, MARCH 9
MONDAY, MARCH 10
TUESDAY, MARCH 11
WEDNESDAY, MARCH 12
THURSDAY, MARCH 13
FRIDAY, MARCH 14
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MARCH 9
08:00—10:00
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.
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Johanna A. Joyce,
University of Lausanne, Switzerland
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Suzanne Ostrand-Rosenberg,
University of Maryland, USA
Robert D. Schreiber,
Washington University School of Medicine, USA
Using Genomics to Define Cancer Immunoediting Mechanisms and Inform Cancer Immunotherapy
Using Genomics to Define Cancer Immunoediting Mechanisms and Inform Cancer Immunotherapy
Alexander Y. Rudensky,
HHMI/Memorial Sloan Kettering Cancer Center, USA
Differentiation and Function of Regulatory T Cells and Cancer
Differentiation and Function of Regulatory T Cells and Cancer
10:20—12:15
Inflammation and Immunity in the Tumor Microenvironment (Joint)
Meeting has ended...abstracts no longer viewable online.
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Timothy C. Wang,
Columbia University, USA
Andrew J. Dannenberg,
Weill Medical College of Cornell University, USA
The Obesity-Inflammation Connection: Implications for Breast Cancer
The Obesity-Inflammation Connection: Implications for Breast Cancer
Lisa M. Coussens,
Oregon Health & Science University, USA
Impact of Innate and Adaptive Immunity on Cancer-Associated Chronic Inflammation
Impact of Innate and Adaptive Immunity on Cancer-Associated Chronic Inflammation
Allison S. Harney,
Albert Einstein College of Medicine, USA
Short Talk: Perivascular Macrophages Induce Localized, Transient Blood Vessel Permeability and Tumor Cell Intravasation
Short Talk: Perivascular Macrophages Induce Localized, Transient Blood Vessel Permeability and Tumor Cell Intravasation
Florian R. Greten,
Institute for Tumor Biology and Experimental Therapy, Germany
Short Talk: Stat3 Controlled Lysosomal Membrane Permeabilization in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumor Initiation
Short Talk: Stat3 Controlled Lysosomal Membrane Permeabilization in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumor Initiation
Jeffrey W. Pollard,
Queen's Medical Research Institute, UK
Macrophage Promotion of Tumor Progression and Metastasis
Macrophage Promotion of Tumor Progression and Metastasis
14:30—16:30
Workshop 1: High-Throughput Approaches to Analyze and Target Immune Cell Functions in Cancer (Joint)
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Ming O. Li,
Memorial Sloan Kettering Cancer Center, USA
Matthew H. Spitzer,
Stanford University, USA
Revealing the Tumor-Immune Network via Single-Cell Mass Cytometry
Revealing the Tumor-Immune Network via Single-Cell Mass Cytometry
Zlatko Trajanoski,
Medical University of Innsbruck, Austria
Intratumoral Immune Landscape, Tumor Immunogenicity and Antigenome in Human Colorectal Cancer
Intratumoral Immune Landscape, Tumor Immunogenicity and Antigenome in Human Colorectal Cancer
Lisa Sevenich,
Memorial Sloan Kettering Cancer Center, USA
A Brain Metastasis-Promoting Role for Cathepsin S Identified from Analysis of Tumor- and Stroma-Supplied Proteolytic Networks
A Brain Metastasis-Promoting Role for Cathepsin S Identified from Analysis of Tumor- and Stroma-Supplied Proteolytic Networks
Neta Erez,
Tel Aviv University, Israel
Pro-Inflammatory Signaling by Cancer-Associated Fibroblasts Co-Evolves during Mammary Carcinogenesis
Pro-Inflammatory Signaling by Cancer-Associated Fibroblasts Co-Evolves during Mammary Carcinogenesis
Kaisa Thorell,
Gothenburg University, Sweden
Differential Expression of Kynurenine Pathway Enzymes in Early Stomach Cancer Development
Differential Expression of Kynurenine Pathway Enzymes in Early Stomach Cancer Development
Matthew M. Gubin,
Washington University in St. Louis, USA
Using Genomics to Identify Antigenic Targets of Checkpoint Blockade Therapy
Using Genomics to Identify Antigenic Targets of Checkpoint Blockade Therapy
Niels van de Roemer,
TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg, Germany
The Pharmacodynamics of Actively Personalized RNA-Based Anti-Tumor Vaccination
The Pharmacodynamics of Actively Personalized RNA-Based Anti-Tumor Vaccination
Serena Zilio,
University of Miami, USA
4PD Functionalized PAMAM Dendrimer Allows the in vivo Rehabilitation of Tumor Educated Myeloid Cells
4PD Functionalized PAMAM Dendrimer Allows the in vivo Rehabilitation of Tumor Educated Myeloid Cells
17:00—19:15
Location, Location, Location: Stromal Cell Effects
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Alberto Mantovani,
Humanitas University, Italy
Ronen Alon,
Weizmann Institute of Science, Israel
How Do Tumors Educate the Vasculature to Recruit Tumor Helper Cells?
How Do Tumors Educate the Vasculature to Recruit Tumor Helper Cells?
Kornelia Polyak,
Dana-Farber Cancer Institute, Harvard Medical School, USA
Leukocytes in Breast Tumor Progression
Leukocytes in Breast Tumor Progression
Sven Brandau,
University Duisburg-Essen, Germany
Short Talk: Bi-Directional Interaction of Stromal Neutrophils and Tumor Cells Promotes Metastasis by Inducing an Invasive, NK-Resistant Tumor Cell Phenotype
Short Talk: Bi-Directional Interaction of Stromal Neutrophils and Tumor Cells Promotes Metastasis by Inducing an Invasive, NK-Resistant Tumor Cell Phenotype
Martina Seiffert,
German Cancer Research Center, Germany
Short Talk: Chronic Lymphocytic Leukemia Patients Show Abnormalities within their Myeloid Cell Compartment
Short Talk: Chronic Lymphocytic Leukemia Patients Show Abnormalities within their Myeloid Cell Compartment
Shannon J. Turley,
Genentech, Inc., USA
Influence of the Stromal Niche on Leukocyte Function in Solid Tumors
Influence of the Stromal Niche on Leukocyte Function in Solid Tumors
17:00—19:15
Chronic Inflammation and Cancer
Meeting has ended...abstracts no longer viewable online.
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Wendy S. Garrett,
Harvard School of Public Health, USA
Timothy C. Wang,
Columbia University
GI Infection, Inflammation and Tumor Microenvironment
GI Infection, Inflammation and Tumor Microenvironment
Fiona M. Powrie,
University of Oxford, UK
Cellular and Molecular Pathways that Promote Inflammation-Driven Cancer
Cellular and Molecular Pathways that Promote Inflammation-Driven Cancer
Nuray Gül,
VU University Medical Center, Netherlands
Short Talk: Colon Resection-Induced Inflammation Stimulates Outgrowth of Liver Metastases from Circulating Tumor Cells
Short Talk: Colon Resection-Induced Inflammation Stimulates Outgrowth of Liver Metastases from Circulating Tumor Cells
Curtis J. Henry,
Emory University School of Medicine, USA
Short Talk: Inflamm-Aging Reduces B-Progenitor Function Leading to Increased Selection for Oncogenically-Initiated B-Cells
Short Talk: Inflamm-Aging Reduces B-Progenitor Function Leading to Increased Selection for Oncogenically-Initiated B-Cells
Robert F. Schwabe,
Columbia University, USA
Liver Cancer: Microbiome and Myofibroblasts Fuel the Flames
Liver Cancer: Microbiome and Myofibroblasts Fuel the Flames
08:00—11:15
Co-Opting of Anti-Tumor Immunity by Myeloid-Derived Suppressor Cells
Meeting has ended...abstracts no longer viewable online.
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Robert H. Vonderheide,
University of Pennsylvania School of Medicine, USA
Olivera J. Finn,
University of Pittsburgh School of Medicine, USA
MDSC in Premalignant Disease
MDSC in Premalignant Disease
Vincenzo Bronte,
University of Verona, Italy
Tumor-Induced Immune Suppression by MDSC.
Tumor-Induced Immune Suppression by MDSC.
Kebin Liu,
Medical College of Georgia, USA
Short Talk: Deregulation of Apoptotic Factors Bcl-xL and Bax Confers Apoptotic Resistance to Myeloid-Derived Suppressive Cells and Contributes to Their Persistence in Cancers
Short Talk: Deregulation of Apoptotic Factors Bcl-xL and Bax Confers Apoptotic Resistance to Myeloid-Derived Suppressive Cells and Contributes to Their Persistence in Cancers
Viktor Umansky,
German Cancer Research Center, Germany
Short Talk: Neutralizing Immunosuppressive Melanoma Microenvironment
Short Talk: Neutralizing Immunosuppressive Melanoma Microenvironment
Suzanne Ostrand-Rosenberg,
University of Maryland, USA
Inflammation and Alarmins as Drivers of Immune Suppressive Myeloid Cells and Tumor Progression
Inflammation and Alarmins as Drivers of Immune Suppressive Myeloid Cells and Tumor Progression
Dmitry I. Gabrilovich,
Wistar Institute, USA
The Fate of Myeloid-Derived Suppressor Cells is Regulated Through TRAIL Receptors Mediated Apoptosis
The Fate of Myeloid-Derived Suppressor Cells is Regulated Through TRAIL Receptors Mediated Apoptosis
08:00—11:15
Infection and Cancer Initiation
Meeting has ended...abstracts no longer viewable online.
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Fiona M. Powrie,
University of Oxford, UK
Martyn Plummer,
International Agency for Research on Cancer, France
The Global Burden of Cancer Attributable to Infection
The Global Burden of Cancer Attributable to Infection
Cynthia L. Sears,
Johns Hopkins University School of Medicine, USA
Colonic Commensals, B. fragilis and Colorectal Cancer (CRC)
Colonic Commensals, B. fragilis and Colorectal Cancer (CRC)
Nicole Antonio,
University of Bristol, UK
Short Talk: Live Imaging Studies of the Competing Inflammatory Responses to Tumors, Wounds and Infections in Adult and Larval Zebrafish
Short Talk: Live Imaging Studies of the Competing Inflammatory Responses to Tumors, Wounds and Infections in Adult and Larval Zebrafish
Johanna Classon,
Karolinska Institutet, Sweden
Short Talk: Human Cytomegalovirus and Androgen Signaling in Prostate Cancer Progression
Short Talk: Human Cytomegalovirus and Androgen Signaling in Prostate Cancer Progression
Xiao-Fan Wang,
Duke University Medical Center, USA
Tumor Microenvironment: MicroRNAs and Metastasis
Tumor Microenvironment: MicroRNAs and Metastasis
Elizabeth P. Murchison,
University of Cambridge, UK
Clonally Transmissible Cancers in Dogs and Tasmanian Devils
Clonally Transmissible Cancers in Dogs and Tasmanian Devils
17:00—19:15
Re-Educating Tumor-Promoting Macrophages (Joint)
Meeting has ended...abstracts no longer viewable online.
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Lisa M. Coussens,
Oregon Health & Science University, USA
Jo A. Van Ginderachter,
VIB-Vrije Universiteit Brussel, Belgium
Macrophage plasticity in the tumor microenvironment
Macrophage plasticity in the tumor microenvironment
Johanna A. Joyce,
University of Lausanne, Switzerland
Re-Educating Macrophages in the Tumor Microenvironment
Re-Educating Macrophages in the Tumor Microenvironment
Charlotte Rolny,
Karolinska Institute, Sweden
Short Talk: SEMA3A Dictates a Pro-Inflammatory Program that Restricts Tumor Growth
Short Talk: SEMA3A Dictates a Pro-Inflammatory Program that Restricts Tumor Growth
David Liberg,
Cantargia AB, Sweden
Short Talk: Inhibition of S100A9/Receptor Interactions by Novel Small Molecules Reduces Tumor Growth and Promotes CD8+ T Cell Infiltration
Short Talk: Inhibition of S100A9/Receptor Interactions by Novel Small Molecules Reduces Tumor Growth and Promotes CD8+ T Cell Infiltration
Alberto Mantovani,
Humanitas University, Italy
Inflammation, Macrophage Polarization, and Cancer
Inflammation, Macrophage Polarization, and Cancer
08:00—11:15
Evolving Immune Suppressive Mechanisms in the Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.
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Vincenzo Bronte,
University of Verona, Italy
Ruth Ganss,
Harry Perkins Institute of Medical Research, Australia
Tumor-Targeted Therapy to Modulate Stroma
Tumor-Targeted Therapy to Modulate Stroma
Andrea Schietinger,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Initial Tumor-Antigen Encounters in Pre-/Early Malignant Lesions Lead to CD8 T Cell Dysfunction
Short Talk: Initial Tumor-Antigen Encounters in Pre-/Early Malignant Lesions Lead to CD8 T Cell Dysfunction
Jay A. Berzofsky,
NCI, National Institutes of Health, USA
Short Talk: Blockade of TGF-beta to Overcome Negative Regulation in the Tumor Microenvironment: From Mice to Cancer Patients
Short Talk: Blockade of TGF-beta to Overcome Negative Regulation in the Tumor Microenvironment: From Mice to Cancer Patients
Arthur Hurwitz,
NCI, National Institutes of Health, USA
The Highs and Lows of T Cell Avidity: Tumor Immunity Meets Immune Suppression
The Highs and Lows of T Cell Avidity: Tumor Immunity Meets Immune Suppression
Bill C. Dougall,
Amgen, USA
Distinct Roles of RANKL in Cancer: RANKL-Dependent Osteoclasts in the Tumor/Bone Microenvironment and Direct effects of RANKL on Breast Tumor Initiation and Progression
Distinct Roles of RANKL in Cancer: RANKL-Dependent Osteoclasts in the Tumor/Bone Microenvironment and Direct effects of RANKL on Breast Tumor Initiation and Progression
08:00—11:00
The Impact of the Microbiome on Cancer
Meeting has ended...abstracts no longer viewable online.
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Cynthia L. Sears,
Johns Hopkins University School of Medicine, USA
Wendy S. Garrett,
Harvard School of Public Health, USA
Fusobacteria and Colon Cancer
Fusobacteria and Colon Cancer
Eric G. Pamer,
Memorial Sloan Kettering Cancer Center, USA
The Effects of Intestinal Tract Bacterial Diversity on Mortality Following Allogeneic Hematopoietic Stem Cell Transplantation
The Effects of Intestinal Tract Bacterial Diversity on Mortality Following Allogeneic Hematopoietic Stem Cell Transplantation
Yiping W. Han,
Case Western Reserve University, USA
Short Talk: A Novel Mechanism by which Oral Commensal Fusobacterium nucleatum Promotes Colorectal Cancer
Short Talk: A Novel Mechanism by which Oral Commensal Fusobacterium nucleatum Promotes Colorectal Cancer
Lei Chen,
Hong Kong Baptist University, China
Short Talk: The Impacts of Herbal Triterpenoid Saponins on Gut Microbiota and Cancer in ApcMin/+ Mice
Short Talk: The Impacts of Herbal Triterpenoid Saponins on Gut Microbiota and Cancer in ApcMin/+ Mice
Johanna W. Lampe,
Fred Hutchinson Cancer Research Center, USA
Effects of Diet and Modulation of Inflammation on Cancer Risk
Effects of Diet and Modulation of Inflammation on Cancer Risk
11:15—00:15
Meet the Editors Roundtable
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Teodoro Pulvirenti,
Journal of Experimental Medicine, USA
Christine Borowski,
Nature Publishing Group, USA
Zoltan Fehervari,
Nature Publishing Group, UK
14:30—16:30
Workshop 2: Insights into Immune Cell Function from Live Imaging (Joint)
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Mikael J. Pittet,
Massachusetts General Hospital, USA
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Ronen Alon,
Weizmann Institute of Science, Israel
Miranda L. Broz,
Bristol Myers Squibb, USA
Distinct Lineages of Tolerogenic and Activating Myeloid Cells from Tumors
Distinct Lineages of Tolerogenic and Activating Myeloid Cells from Tumors
Esther N. Arwert,
Francis Crick Institute, UK
Identification of Molecular and Functional Differences in Tumour Associated Macrophage Subsets
Identification of Molecular and Functional Differences in Tumour Associated Macrophage Subsets
Liane Babes,
University of Calgary, Canada
Visualizing Tumor Cell Killing by Immune Cells in the Liver
Visualizing Tumor Cell Killing by Immune Cells in the Liver
Guy Shakhar,
Weizmann Institute of Science, Israel
Intravital Imaging of Melanoma Reveals that Target Cytolysis by CTLs Is Strictly Contact and Antigen-Dependent
Intravital Imaging of Melanoma Reveals that Target Cytolysis by CTLs Is Strictly Contact and Antigen-Dependent
Tali Feferman,
Weizmann Institute of Science, Israel
Angiogenesis Promotes Intratumoral CTL Dissemination and Cytotoxicity
Angiogenesis Promotes Intratumoral CTL Dissemination and Cytotoxicity
David Askew,
Case Western Reserve University, USA
Heterogeneity of T Cell Acute Lymphoblastic Leukemia Cells Derived from Constitutive Expression of Intracellular Notch 1
Heterogeneity of T Cell Acute Lymphoblastic Leukemia Cells Derived from Constitutive Expression of Intracellular Notch 1
Derek William Laux,
Queen's Medical Research Institute, University of Edinburgh, UK
A Trophic Role for Innate Immunity in Cancer Progression
A Trophic Role for Innate Immunity in Cancer Progression
14:30—16:30
Workshop 3: Immune Suppressive Myeloid Cells (Joint)
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Lisa H. Butterfield,
University of Pittsburgh, USA
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Rolf Kiessling,
Karolinska Institute, Sweden
Yago Pico de Coaña,
Karolinska Institutet, Sweden
Effects of Ipilimumab on Myeloid Derived Suppressor Cells in Advanced Melanoma Patients
Effects of Ipilimumab on Myeloid Derived Suppressor Cells in Advanced Melanoma Patients
Erik Thiele Orberg,
Johns Hopkins School of Medicine, USA
Immature Myeloid Cells as a Link between Inflammation and Tumorigenesis in Bacterial Colitis-Associated Carcinogenesis
Immature Myeloid Cells as a Link between Inflammation and Tumorigenesis in Bacterial Colitis-Associated Carcinogenesis
Xianming Huang,
University of Texas Southwestern Medical Center Dallas, USA
Phosphatidylserine-Targeting Antibodies Induce M1 Macrophage Polarization, Promote Myeloid Derived Suppressor Cell Differentiation and Boost Tumor-Specific Immunity
Phosphatidylserine-Targeting Antibodies Induce M1 Macrophage Polarization, Promote Myeloid Derived Suppressor Cell Differentiation and Boost Tumor-Specific Immunity
Nelly Vey,
Cancer Research Centre of Lyon, France
The Antimicrobial Peptide LL37 Activates Plasmacytoid Dendritic Cells in Breast Cancer
The Antimicrobial Peptide LL37 Activates Plasmacytoid Dendritic Cells in Breast Cancer
Rinat Zaynagetdinov,
Vanderbilt University, USA
Alveolar Macrophages Promote Lung Tumorigenesis in the Context of Chronic Airway Inflammation through Differentiation of Regulatory T Cells (Tregs)
Alveolar Macrophages Promote Lung Tumorigenesis in the Context of Chronic Airway Inflammation through Differentiation of Regulatory T Cells (Tregs)
Seth B. Coffelt,
Netherlands Cancer Institute, Netherlands
Gamma delta T Cells and Neutrophils Conspire together to Promote Breast Cancer Metastasis
Gamma delta T Cells and Neutrophils Conspire together to Promote Breast Cancer Metastasis
Kellie A. Charles,
University of Sydney, Australia
Monocytic Myeloid Derived Suppressor Cells (Mo-MDSC) Decrease with 5FU-based Chemotherapy in Colorectal Cancer Patients
Monocytic Myeloid Derived Suppressor Cells (Mo-MDSC) Decrease with 5FU-based Chemotherapy in Colorectal Cancer Patients
Ofer Levy,
Compugen Ltd., Israel
Identification of Novel Immune Checkpoints as Potential Targets for Cancer Immunotherapy
Identification of Novel Immune Checkpoints as Potential Targets for Cancer Immunotherapy
17:00—19:00
Antigen Presentation in the Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.
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Olivera J. Finn,
University of Pittsburgh School of Medicine, USA
Jose Conejo-Garcia,
Wistar Institute, USA
Dynamic Expression of the Genomic Organizer SATB1 Regulates Dendritic Cell Differentiation and Immunostimulatory Functions in Cancer
Dynamic Expression of the Genomic Organizer SATB1 Regulates Dendritic Cell Differentiation and Immunostimulatory Functions in Cancer
Lisa H. Butterfield,
University of Pittsburgh, USA
Short Talk: Tumor-Derived alpha-Fetoprotein Impairs the Differentiation and T Cell Stimulatory Activity of Human Dendritic Cells
Short Talk: Tumor-Derived alpha-Fetoprotein Impairs the Differentiation and T Cell Stimulatory Activity of Human Dendritic Cells
Brad H. Nelson,
BC Cancer Agency, Canada
Short Talk: Surveillance of the Tumor Mutanome by T Cells during Progression from Primary to Recurrent Ovarian Cancer
Short Talk: Surveillance of the Tumor Mutanome by T Cells during Progression from Primary to Recurrent Ovarian Cancer
Eduardo M. Sotomayor,
Moffitt Cancer Center and Research Institute, USA
Epigenetic Manipulation of Antigen-Presenting Cells to Influence Immune Activation versus Immune Tolerance
Epigenetic Manipulation of Antigen-Presenting Cells to Influence Immune Activation versus Immune Tolerance
17:00—19:15
Origins and Therapeutic Targeting of Myeloid Cells in Physiology and Cancer
Meeting has ended...abstracts no longer viewable online.
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Eric G. Pamer,
Memorial Sloan Kettering Cancer Center, USA
Frederic Geissmann,
Memorial Sloan Kettering Cancer Center, USA
In vivo Characterisation of the YS Progenitor for Tissue Resident Macrophages
In vivo Characterisation of the YS Progenitor for Tissue Resident Macrophages
Alessia Zoso,
University of Miami, USA
Short Talk: Molecular and Functional Characterization of IDO-Expressing Human Fibrocytic Myeloid Derived Suppressor Cells
Short Talk: Molecular and Functional Characterization of IDO-Expressing Human Fibrocytic Myeloid Derived Suppressor Cells
Mary Christine Hollander,
NCI/National Institutes of Health, USA
Short Talk: Myeloid Specific TGF-beta Signaling and Cancer Metastasis
Short Talk: Myeloid Specific TGF-beta Signaling and Cancer Metastasis
Miriam Merad,
Mount Sinai School of Medicine, USA
Tracing the Cell of Origin for Resident Macrophage Populations
Tracing the Cell of Origin for Resident Macrophage Populations
08:00—11:00
Overcoming Immune Suppression in the Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.
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Dmitry I. Gabrilovich,
Wistar Institute, USA
Martin Oft,
ARMO BioSciences, USA
All TILs, no TAMs - or how PEG-IL-10 Activates Intratumoral CD8 T Cell Cytotoxicity
All TILs, no TAMs - or how PEG-IL-10 Activates Intratumoral CD8 T Cell Cytotoxicity
George Coukos,
University Hospital of Lausanne - CHUV, Switzerland
Immune Escape and Angiogenesis
Immune Escape and Angiogenesis
Brian Ruffell,
Oregon Health & Science University, USA
Short Talk: TH2 Cytokines Limit Chemotherapeutic Efficacy by Repressing Dendritic Cell Production of IL12
Short Talk: TH2 Cytokines Limit Chemotherapeutic Efficacy by Repressing Dendritic Cell Production of IL12
Sadna Budhu,
Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Blockade of Treg Derived TGF-beta Abrogates Suppression of Effector T Cell Function within the Tumor Microenvironment
Short Talk: Blockade of Treg Derived TGF-beta Abrogates Suppression of Effector T Cell Function within the Tumor Microenvironment
Alan Serrels,
University of Edinburgh, UK
Short Talk: Evading the Anti-Tumor Immune Response - A Novel Role for Focal Adhesion Kinase
Short Talk: Evading the Anti-Tumor Immune Response - A Novel Role for Focal Adhesion Kinase
Thomas Blankenstein,
Max Delbruck Center for Molecular Medicine, Germany
Spontaneous and Therapy-Induced T Cell Responses to Cancer
Spontaneous and Therapy-Induced T Cell Responses to Cancer
08:00—11:15
Inflammation as a Target and Modulator of Cancer Therapeutics
Meeting has ended...abstracts no longer viewable online.
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Giorgio Trinchieri,
NCI, National Institutes of Health, USA
Michael Karin,
University of California, San Diego, USA
Liver Inflammation, Obesity and Cancer
Liver Inflammation, Obesity and Cancer
Napoleone Ferrara,
University of California, San Diego, USA
Myeloid Cells and VEGF?Independent Tumor Angiogenesis
Myeloid Cells and VEGF?Independent Tumor Angiogenesis
Mauricio da Silva Caetano,
University of Texas MD Anderson Cancer Center, USA
Short Talk: Pharmacologic Targeting of IL-6 Suppresses Tumor Progression in a K-ras Mutant Lung Cancer Mouse Model through Re-Educating the Tumor Microenvironment
Short Talk: Pharmacologic Targeting of IL-6 Suppresses Tumor Progression in a K-ras Mutant Lung Cancer Mouse Model through Re-Educating the Tumor Microenvironment
Maryse Dagenais,
McGill University, Canada
Short Talk: The Role of the Cellular Inhibitor of Apoptosis Protein cIAP2 in Colitis and Colitis-Associated Colorectal Cancer
Short Talk: The Role of the Cellular Inhibitor of Apoptosis Protein cIAP2 in Colitis and Colitis-Associated Colorectal Cancer
Carola H. Ries,
Roche Innovation Center Munich, Germany
Targeting Tumor-Associated Macrophages in Cancer Patients
Targeting Tumor-Associated Macrophages in Cancer Patients
Martin Brown,
Stanford University, USA
Myeloid Cells Govern the Response of Tumors to Irradiation
Myeloid Cells Govern the Response of Tumors to Irradiation
17:00—19:15
Therapeutic Manipulation of the Tumor Microenvironment (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Johanna A. Joyce,
University of Lausanne, Switzerland
*
Suzanne Ostrand-Rosenberg,
University of Maryland, USA
Robert H. Vonderheide,
University of Pennsylvania School of Medicine, USA
Inflammatory Networks and Immune Privilege in Carcinoma
Inflammatory Networks and Immune Privilege in Carcinoma
Giorgio Trinchieri,
NCI, National Institutes of Health, USA
The Role of Inflammation in Carcinogenesis and Response to Cancer Therapy
The Role of Inflammation in Carcinogenesis and Response to Cancer Therapy
Frances R. Balkwill,
Barts Cancer Institute, Queen Mary University of London, UK
Targeting Inflammatory Cytokines and Chemokines
Targeting Inflammatory Cytokines and Chemokines
*Session Chair †Invited, not yet responded.
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If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: Sarah Lavicka, Assistant
Director of Development, Email: sarahl@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org, Phone:+1 970-262-2676 |
