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This meeting took place in 2009
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Cell Death Pathways (X5)
Organizer(s) Eric H. Baehrecke and Guy S. Salvesen
March 22—27, 2009
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Nov 25, 2008
Late Abstract Deadline: Dec 23, 2008
Scholarship Deadline: Nov 25, 2008
Early Registration Deadline: Jan 22, 2009
Supported by the Directors' Fund
Joint Meeting:
Mitochondrial Dynamics and Physiology (X6)
Summary of Meeting:
Programmed cell death plays a critical role during development and adult homeostasis by eliminating unneeded and damaged cells, and defects in cell death can result in a wide range of diseases. While studies of apoptotic cell death have defined central regulatory mechanisms including a role for mitochondria, the relationship between core apoptosis factors, mitochondrial physiology, and how this relates to normal and aberrant development remains unsolved. The purpose of this meeting is to define the relationship between mitochondria and cell death pathways. The meeting will focus on the relationship between apoptosis regulatory pathways, mitochondrial physiology, metabolism, and non-apoptotic death mechanisms in the context of normal development and pathological situations including degenerative disorders and cancer. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting “Mitochondrial Dynamics and Physiology”, which will share a keynote address and two plenary sessions with this meeting.
View Scholarships/Awards
Programmed cell death plays a critical role during development and adult homeostasis by eliminating unneeded and damaged cells, and defects in cell death can result in a wide range of diseases. While studies of apoptotic cell death have defined central regulatory mechanisms including a role for mitochondria, the relationship between core apoptosis factors, mitochondrial physiology, and how this relates to normal and aberrant development remains unsolved. The purpose of this meeting is to define the relationship between mitochondria and cell death pathways. The meeting will focus on the relationship between apoptosis regulatory pathways, mitochondrial physiology, metabolism, and non-apoptotic death mechanisms in the context of normal development and pathological situations including degenerative disorders and cancer. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting “Mitochondrial Dynamics and Physiology”, which will share a keynote address and two plenary sessions with this meeting.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, MARCH 22
MONDAY, MARCH 23
TUESDAY, MARCH 24
WEDNESDAY, MARCH 25
THURSDAY, MARCH 26
FRIDAY, MARCH 27
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MARCH 22
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.
Douglas R. Green,
St. Jude Children's Research Hospital, USA
The Mitochondrial Pathway of Apoptosis
The Mitochondrial Pathway of Apoptosis
Richard J. Youle,
NINDS, National Institutes of Health, USA
Mitochondrial Morphogenesis and Apoptosis
Mitochondrial Morphogenesis and Apoptosis
08:00—11:15
Mitochondrial Dynamics and Cell Death (Joint)
Meeting has ended...abstracts no longer viewable online.
*
J. Marie Hardwick,
Johns Hopkins University Schools of Public Health and Medicine, USA
Jean-Claude Martinou,
University of Geneva, Switzerland
Mechanisms of Bax Activation
Mechanisms of Bax Activation
Barbara Conradt,
Ludwig-Maximilians-Universitat, Germany
Mitochondrial Fusion and Fission, as Regulated by the Bcl-2 homolog CED-9
Mitochondrial Fusion and Fission, as Regulated by the Bcl-2 homolog CED-9
Seamus J. Martin,
Trinity College Dublin, Ireland
Short Talk: Mitochondrial Fission-Fusion Dynamics and Apoptosis
Short Talk: Mitochondrial Fission-Fusion Dynamics and Apoptosis
Luca Scorrano,
University of Padova, Italy
EMBO Young Investigator Lecture: Multiple Fuctional Roles of Mitochondrial-Shaping Proteins
EMBO Young Investigator Lecture: Multiple Fuctional Roles of Mitochondrial-Shaping Proteins
Donald D. Newmeyer,
La Jolla Institute for Allergy and Immunology, USA
Short Talk: Multiple Mitochondrial Events Critical for Cell Death
Short Talk: Multiple Mitochondrial Events Critical for Cell Death
David C. Chan,
California Institute of Technology, USA
Mitochondrial Dynamiscs, mtDNA Stability and Tolerance of mtDNA Mutations
Mitochondrial Dynamiscs, mtDNA Stability and Tolerance of mtDNA Mutations
17:00—19:00
Caspases and IAPs
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Domagoj Vucic,
Genentech, Inc., USA
Targeting IAPs: TNFalpha and Ubiquitin Connections
Targeting IAPs: TNFalpha and Ubiquitin Connections
Francesco Cecconi,
University of Rome Tor Vergata, Italy
Short Talk: Molecular Analysis of Synaptic Degeneration at the Onset of Alzheimer’s Disease
Short Talk: Molecular Analysis of Synaptic Degeneration at the Onset of Alzheimer’s Disease
Pascal Meier,
Institute of Cancer Research, UK
Regulation of Caspases by Ubiquitin and Ubiquitin-like Proteins
Regulation of Caspases by Ubiquitin and Ubiquitin-like Proteins
17:00—19:00
Molecular Mechanisms of Mitochondrial Fusion
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*
Jodi Nunnari,
University of California, Davis, USA
The Molecular Mechanism of Mitochondrial Fusion
The Molecular Mechanism of Mitochondrial Fusion
Zhongyan Zhang,
John Hopkins University School of Medicine, USA
Role of Opa1 in Pancreatic Beta Cells
Role of Opa1 in Pancreatic Beta Cells
György Hajnóczky,
Thomas Jefferson University, USA
Short Talk: Interdependence of Mitochondrial Fusion- Fission and Motility Dynamics
Short Talk: Interdependence of Mitochondrial Fusion- Fission and Motility Dynamics
Astrid C. Schauss,
University of Ottawa Heart Institute, Canada
Short Talk: Characterization of a Bimolecular Complementation Assay to Quantify Mammalian Mitochondrial Fusion in vitro
Short Talk: Characterization of a Bimolecular Complementation Assay to Quantify Mammalian Mitochondrial Fusion in vitro
08:00—11:15
Cell Survival and Death Signaling during Development
Meeting has ended...abstracts no longer viewable online.
Andreas Bergmann,
University of Massachusetts Medical School, USA
Genetic Regulation of Programmed Cell Death during Drosophila Development
Genetic Regulation of Programmed Cell Death during Drosophila Development
Kim McCall,
Boston University, USA
Short Talk: Cell-Autonomous Requirement for DNaseII and Lysosomal Genes during Non-Apoptotic Cell Death in the Drosophila Ovary
Short Talk: Cell-Autonomous Requirement for DNaseII and Lysosomal Genes during Non-Apoptotic Cell Death in the Drosophila Ovary
W. Brent Derry,
Hospital for Sick Children, Canada
Genetic Regulation of Cell Death during Germline Development in C. elegans
Genetic Regulation of Cell Death during Germline Development in C. elegans
Laura A. Johnston,
Columbia University, USA
Competitive Interactions during Growth in Drosophila: A Mechanism for Tissue Homeostasis
Competitive Interactions during Growth in Drosophila: A Mechanism for Tissue Homeostasis
08:00—11:15
Mitochondrial Fission and Evolution of the Division Apparatus
Meeting has ended...abstracts no longer viewable online.
Janet M. Shaw,
University of Utah, USA
Recruitment and Assembly of the Mitochondrial Membrane Fission Machinery
Recruitment and Assembly of the Mitochondrial Membrane Fission Machinery
*
Alexander M. van der Bliek,
University of California, Los Angeles, USA
Mitochondrial Fission and Fusion in C. elegans
Mitochondrial Fission and Fusion in C. elegans
Heidi M. McBride,
McGill University, Canada
Mitochondrial Derived Vesicles as a New Vehicle for Intracellular Transport
Mitochondrial Derived Vesicles as a New Vehicle for Intracellular Transport
Tsuneyoshi Kuroiwa,
Rikkyo (St. Paul’s) University, Japan
Isolation of Mitochondrial Division Machineries
Isolation of Mitochondrial Division Machineries
Naotada Ishihara,
Kurume University, Japan
Short Talk: Fis1 Acts as Mitochondrial Receptor for Novel Protein that Regulates Mitochondrial Morphology
Short Talk: Fis1 Acts as Mitochondrial Receptor for Novel Protein that Regulates Mitochondrial Morphology
Sarah R. Horn,
Duke University Medical Center, USA
Short Talk: Degradation of the Mitochondrial Fission Protein Drp1 by the APCcdh1 Ubiquitin Ligase
Short Talk: Degradation of the Mitochondrial Fission Protein Drp1 by the APCcdh1 Ubiquitin Ligase
14:30—16:30
Workshop 1: Relationship between Autophagy and Cell Death
Kevin M. Ryan,
Beatson Institute for Cancer Research, UK
Identifying the Factors that Determine Specificity in the Autophagy Response
Identifying the Factors that Determine Specificity in the Autophagy Response
Ying-Chen Claire Hou,
British Columbia Cancer Agency, Canada
Molecular Mechanism of Effector Caspase Dcp-1 in Starvation-Induced Autophagy
Molecular Mechanism of Effector Caspase Dcp-1 in Starvation-Induced Autophagy
Marc Germain,
University of Ottawa, Canada
MCL-1 is a Key Regulator of Autophagy
MCL-1 is a Key Regulator of Autophagy
Natasha Chang,
McGill University, Canada
Antagonism of Beclin 1 by Bcl-2 is Mediated by the Endoplasmic Reticulum Protein, Naf-1
Antagonism of Beclin 1 by Bcl-2 is Mediated by the Endoplasmic Reticulum Protein, Naf-1
Katja Simon,
University of Oxford, UK
Hematopoietic Cells Require Mitophagy Mediated by the Core Autophagy Gene Atg7 for Survival in vivo
Hematopoietic Cells Require Mitophagy Mediated by the Core Autophagy Gene Atg7 for Survival in vivo
Mondira Kundu,
St. Jude Children's Hospital, USA
Hsp90 Regulates Ulk1-Mediated Autophagic Clearance of Mitochondria
Hsp90 Regulates Ulk1-Mediated Autophagic Clearance of Mitochondria
14:30—16:30
Workshop 1: Mitochondrial Dynamics and Parkinson’s Disease
*
Edward A. Fon,
McGill University, Canada
Konstanze F. Winklhofer,
Ruhr University Bochum, Germany
A Role of Parkin and PINK1 in the Regulation of Mitochondrial Dynamics
A Role of Parkin and PINK1 in the Regulation of Mitochondrial Dynamics
Alex J. Whitworth,
University of Sheffield, UK
Rhomboid-7 Cleaves the Parkinson Disease Factors PINK1 and Omi/HtrA2 and Promotes Mitochondrial Fission
Rhomboid-7 Cleaves the Parkinson Disease Factors PINK1 and Omi/HtrA2 and Promotes Mitochondrial Fission
Vanessa A. Morais,
Katholieke Universiteit Leuven & VIB, Belgium
PINK1 Primarily Regulates Complex I Activity and Synaptic Function
PINK1 Primarily Regulates Complex I Activity and Synaptic Function
Lian Li,
Emory University School of Medicine, USA
The PINK1 Mitochondrial Signaling Pathways and Pakinson Disease
The PINK1 Mitochondrial Signaling Pathways and Pakinson Disease
Isabella Irrcher,
Ottawa Health Research Institute/University of Ottawa, Canada
Loss of the Parkinson’s Disease-Linked Gene DJ-1 Results in Abnormal Mitochondrial Dynamics
Loss of the Parkinson’s Disease-Linked Gene DJ-1 Results in Abnormal Mitochondrial Dynamics
Olga Corti,
INSERM, France
A Differential Proteomic Screen to Identify Proteins Altered in Abundance in Parkin-deficient Mice
A Differential Proteomic Screen to Identify Proteins Altered in Abundance in Parkin-deficient Mice
17:00—19:00
Bcl-2 Family
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*
Sally A. Kornbluth,
Duke University Medical Center, USA
J. Marie Hardwick,
Johns Hopkins University Schools of Public Health and Medicine, USA
Bcl-2 Proteins Regulate Mitochondria in Neurons and Yeast…Where the Trail Leads
Bcl-2 Proteins Regulate Mitochondria in Neurons and Yeast…Where the Trail Leads
Evris Gavathiotis,
Albert Einstein College of Medicine, USA
Short Talk: Structural and Functional Characterization of the Trigger Mechanism for BH3-Induced Direct BAX Activation
Short Talk: Structural and Functional Characterization of the Trigger Mechanism for BH3-Induced Direct BAX Activation
Andreas Villunger,
Medical University Innsbruck, Austria
Role and Function of the BH3-Only Protein Bmf in Development and Disease
Role and Function of the BH3-Only Protein Bmf in Development and Disease
Emily H. Cheng,
Washington University Medical School, USA
The VDAC2-BAK Axis Controls Survival of Thymocytes
The VDAC2-BAK Axis Controls Survival of Thymocytes
17:00—19:00
Regulation of Mitochondrial Dynamics
Meeting has ended...abstracts no longer viewable online.
*
Richard J. Youle,
NINDS, National Institutes of Health, USA
Thomas Langer,
CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Membrane Dynamics
Proteolytic Control of Mitochondrial Membrane Dynamics
Andreas S. Reichert,
Goethe University Frankfurt am Main, Germany
Molecular Insights into Mitochondrial Membrane Dynamics and Structure
Molecular Insights into Mitochondrial Membrane Dynamics and Structure
Katsuyoshi Mihara,
Kyushu University, Japan
The Physiologic Importance of Mammalian Mitochondrial Fission Factor Drp1
The Physiologic Importance of Mammalian Mitochondrial Fission Factor Drp1
Daniel Tondera,
Dana-Faber Cancer Institute, USA
Short Talk: Key Players and Physiological Role of Stress-Induced Mitochondrial Hyperfusion
Short Talk: Key Players and Physiological Role of Stress-Induced Mitochondrial Hyperfusion
08:00—11:15
Mitochondrial Factors, Cell Death and Disease (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Eileen P. White,
Rutgers University, USA
Jeffrey C. Rathmell,
Vanderbilt University, USA
Glucose Metabolism and Bcl-2 Family Proteins
Glucose Metabolism and Bcl-2 Family Proteins
Nils-Goran Larsson,
Max Planck Institute for the Biology of Aging, Germany
Regulation of Mammalian mtDNA Gene Expression
Regulation of Mammalian mtDNA Gene Expression
Andreas E. Strasser,
Walter and Eliza Hall Institute of Medical Research, Australia
The Role of Endogenous Pro-Survival Bcl-2 Family Members in Tumor Development and Sustained Tumor Growth
The Role of Endogenous Pro-Survival Bcl-2 Family Members in Tumor Development and Sustained Tumor Growth
David W. Andrews,
Sunnybrook Research Institute, Canada
Bcl-2 Family Proteins as Therapeutic Targets
Bcl-2 Family Proteins as Therapeutic Targets
17:00—19:00
Alternative Forms of Cell Death
Meeting has ended...abstracts no longer viewable online.
*
Douglas R. Green,
St. Jude Children's Research Hospital, USA
Francis Ka-Ming Chan,
Duke University, USA
Short Talk: A RNA Interference Screen Identifies Novel Regulators of TNF-Induced Programmed Necrosis
Short Talk: A RNA Interference Screen Identifies Novel Regulators of TNF-Induced Programmed Necrosis
Marja Jäättelä,
Danish Cancer Society Research Center, Denmark
Lysosomal control of transformation and cell death
Lysosomal control of transformation and cell death
Eric H. Baehrecke,
University of Massachusetts Medical School, USA
Role of a Phagocytosis Receptor, Draper, in Developmental Autophagic Cell Death in Drosophila
Role of a Phagocytosis Receptor, Draper, in Developmental Autophagic Cell Death in Drosophila
17:00—19:15
Mitochondrial Disease in Humans and Animal Models
Meeting has ended...abstracts no longer viewable online.
*
Nils-Goran Larsson,
Max Planck Institute for the Biology of Aging, Germany
Marcela Votruba,
Cardiff University, UK
OPA1 and OPA3 Mutations in Mouse Models of Inherited Optic Atrophy
OPA1 and OPA3 Mutations in Mouse Models of Inherited Optic Atrophy
Hugo J. Bellen,
Baylor College of Medicine, USA
The Mitochondrial Methionyl-tRNA Synthetase's Role in Neurodegeneration
The Mitochondrial Methionyl-tRNA Synthetase's Role in Neurodegeneration
Francesca Maltecca,
San Raffaele Scientific Institute, Italy
Short Talk: The Mitochondrial Protease AFG3L2 is a Key Player in the Development and Maintenance of Cerebellum and Spinal Cord
Short Talk: The Mitochondrial Protease AFG3L2 is a Key Player in the Development and Maintenance of Cerebellum and Spinal Cord
Dominik Mousa Haddad,
University of California, USA
Short Talk: Systematic Analysis of Genes Implicated in Human Neuronal Disease
Short Talk: Systematic Analysis of Genes Implicated in Human Neuronal Disease
08:00—11:15
Cell Death and Cancer
Meeting has ended...abstracts no longer viewable online.
Scott W. Lowe,
Memorial Sloan Kettering Cancer Center, USA
Dissecting Tumor Suppressor Gene Networks in vivo
Dissecting Tumor Suppressor Gene Networks in vivo
Henning Walczak,
University College London, Cancer Institute, UK
Short Talk: Identification of Axin 1 as a Factor Required for TRAIL-Induced Apoptosis
Short Talk: Identification of Axin 1 as a Factor Required for TRAIL-Induced Apoptosis
Linda Z. Penn,
Princess Margaret Cancer Centre, Canada
Short Talk: Characterizing HMG-CoA Reductase as a Novel Metabolic Oncogene
Short Talk: Characterizing HMG-CoA Reductase as a Novel Metabolic Oncogene
Ricky W. Johnstone,
Peter MacCallum Cancer Centre, Australia
Anti-Cancer Activities of HDAC Inhibitors Used Alone and in Combination with other Pro-Apoptotic Agents
Anti-Cancer Activities of HDAC Inhibitors Used Alone and in Combination with other Pro-Apoptotic Agents
Jan Paul Medema,
Academic Medical Center, Netherlands
Betulinic Acid-induced Death
Betulinic Acid-induced Death
Eileen P. White,
Rutgers University, USA
Role of Autophagy in Cancer and Therapy
Role of Autophagy in Cancer and Therapy
08:00—11:00
Mitochondrial Transport in Polarized Cells
Meeting has ended...abstracts no longer viewable online.
*
Liza A. Pon,
Columbia University Medical Center, USA
Mitochondrial Inheritance Contributes to Lifespan Control in Budding Yeast
Mitochondrial Inheritance Contributes to Lifespan Control in Budding Yeast
William M. Saxton,
University of California, Santa Cruz, USA
Organizing Cytoplasm via Filament-Based Transport Mechanisms
Organizing Cytoplasm via Filament-Based Transport Mechanisms
Thomas L. Schwarz,
Children's Hospital Boston and Harvard Medical School, USA
The Regulation of Mitochondrial Motility by Ca++ and Other Signaling Pathways
The Regulation of Mitochondrial Motility by Ca++ and Other Signaling Pathways
Albert L. Misko,
Washington University in St. Louis, USA
Short Talk: Mitofusin 2 is Essential for the Axonal Transport of Mitochondria
Short Talk: Mitofusin 2 is Essential for the Axonal Transport of Mitochondria
Konrad E. Zinsmaier,
University of Arizona, USA
Short Talk: Drosophila Miro is Required for Both Anterograde and Retrograde Axonal Mitochondrial Transport
Short Talk: Drosophila Miro is Required for Both Anterograde and Retrograde Axonal Mitochondrial Transport
Myrrhe van Spronsen,
Erasmus Medical Center, Netherlands
Short Talk: Milton Proteins Regulate Trafficking of Mitochondria in Neurons
Short Talk: Milton Proteins Regulate Trafficking of Mitochondria in Neurons
14:30—16:30
Workshop 2: Biomarkers of Cell Death for Disease Diagnosis and Therapy Response
Huseyin Mehmet,
Zafgen, Inc., USA
Omics Approach to Apoptosis Biomarker Discovery
Omics Approach to Apoptosis Biomarker Discovery
Chris Peter Reutelingsperger,
Maastricht University, Netherlands
Cell Surface Expressed Phosphatidylserine: A Biomarker of Cell Death
Cell Surface Expressed Phosphatidylserine: A Biomarker of Cell Death
Caroline Dive,
Cancer Research UK Manchester Institute, UK
Blood Borne Biomarkers of Cell Death Applied to Early Clinical Trials of Novel Mechanism Based Anticancer Drugs
Blood Borne Biomarkers of Cell Death Applied to Early Clinical Trials of Novel Mechanism Based Anticancer Drugs
Claudia Maier,
Oregon State University, USA
Mitochondrial Protein Markers of Oxidative Stress
Mitochondrial Protein Markers of Oxidative Stress
James A. Wells,
University of California, San Francisco, USA
New Tools for Dissecting and Triggering Apoptosis
New Tools for Dissecting and Triggering Apoptosis
14:30—16:30
Workshop 2: Mitochondrial Dynamics and Mitophagy
*
Koji Okamoto,
Osaka University, Japan
Molecular Basis of Mitophagy, Degradation of Mitochondria via Autophagy-Related Membrane Dynamics in Yeast
Molecular Basis of Mitophagy, Degradation of Mitochondria via Autophagy-Related Membrane Dynamics in Yeast
*
Orian S. Shirihai,
University of California, Los Angeles, USA
Simulation of Mitochondrial Dynamics: Frequency and Selectivity of Mitochondrial Fusion are Key to its Quality Maintenance Function
Simulation of Mitochondrial Dynamics: Frequency and Selectivity of Mitochondrial Fusion are Key to its Quality Maintenance Function
Hagai Abeliovich,
Hebrew University of Jerusalem, Israel
Regulation of Mitochondrial Autophagy in S. cerevisiae
Regulation of Mitochondrial Autophagy in S. cerevisiae
Hector Sandoval,
Baylor College of Medicine, USA
Essential Roles for Bnip3L/Nix in Autophagic Maturation of Erythroid Cells
Essential Roles for Bnip3L/Nix in Autophagic Maturation of Erythroid Cells
Eun Hee Kim,
Ajou University, South Korea
Superoxide Anion Induces Mitophagy in Glioma Cells
Superoxide Anion Induces Mitophagy in Glioma Cells
Lígia Carinha Gomes,
Venetian Institute of Molecular Medicine, Italy
Mitochondrial Fusion is an Early and Protective Step of Autophagy
Mitochondrial Fusion is an Early and Protective Step of Autophagy
17:00—19:00
Metabolism and Cell Death
Meeting has ended...abstracts no longer viewable online.
Craig B. Thompson,
Memorial Sloan Kettering Cancer Center, USA
Apoptosis, Mitochondria and Cancer
Apoptosis, Mitochondria and Cancer
Mariia Yuneva,
Francis Crick Institute, UK
Short Talk: Glutamine Metabolism as a Target for Selective Elimination of Myc Over-Expressing Cells
Short Talk: Glutamine Metabolism as a Target for Selective Elimination of Myc Over-Expressing Cells
Sally A. Kornbluth,
Duke University Medical Center, USA
Regulation of Caspase 2
Regulation of Caspase 2
17:00—19:00
The Shape of Things to Come: Strategies for Remodeling Biological Membranes
Meeting has ended...abstracts no longer viewable online.
*
Harvey T. McMahon,
MRC Laboratory of Molecular Biology, UK
Membrane Curvature and Mechanisms of Dynamic Cell Membrane Remodeling
Membrane Curvature and Mechanisms of Dynamic Cell Membrane Remodeling
Benoit Kornmann,
ETH Zurich, Switzerland
An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen
An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen
Christian A. Wurm,
MPI for biophys. Chemistry, Germany
Short Talk: Protein Distributions within Mitochondria - STED Microscopy as a Tool in Mitochondria Research
Short Talk: Protein Distributions within Mitochondria - STED Microscopy as a Tool in Mitochondria Research
*Session Chair †Invited, not yet responded.
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